• 25899 Citations
  • 89 h-Index
1969 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Publications

Filter
Article
2019
2016

Allosteric modulation of the calcium-sensing receptor rectifies signaling abnormalities associated with G-protein α-11 mutations causing hypercalcemic and hypocalcemic disorders

Babinsky, V. N., Hannan, F. M., Gorvin, C. M., Howles, S. A., Nesbit, M. A., Rust, N., Hanyaloglu, A. C., Hu, J., Spiegel, A. M. & Thakker, R. V., May 13 2016, In : Journal of Biological Chemistry. 291, 20, p. 10876-10885 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2015

Foreword

Spiegel, A. M., Jan 1 2015, In : Unknown Journal. p. v-vi

Research output: Contribution to journalArticle

The calcilytic agent NPS 2143 rectifies hypocalcemia in a mouse model with an activating calcium-sensing receptor (CaSR) mutation: Relevance to autosomal dominant hypocalcemia type 1 (ADH1)

Hannan, F. M., Walls, G. V., Babinsky, V. N., Nesbit, M. A., Kallay, E., Hough, T. A., Fraser, W. D., Cox, R. D., Hu, J., Spiegel, A. M. & Thakker, R. V., Sep 1 2015, In : Endocrinology. 156, 9, p. 3114-3121 8 p.

Research output: Contribution to journalArticle

34 Scopus citations
2013

The stem cell wars: a dispatch from the front.

Spiegel, A. M., 2013, In : Transactions of the American Clinical and Climatological Association. 124, p. 94-110 17 p.

Research output: Contribution to journalArticle

3 Scopus citations
2012
10 Scopus citations
2011

Good news for advanced-stage pancreatic neuroendocrine tumors

Spiegel, A. M. & Libutti, S. K., May 1 2011, In : Nature Reviews Clinical Oncology. 8, 5, p. 258-259 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
2010

Future diagnostic and therapeutic trends in endocrine cancers

Spiegel, A. M. & Libutti, S. K., Dec 1 2010, In : Seminars in oncology. 37, 6, p. 691-695 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
2009

Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of men 1

Jennifer Shen, H. C., He, M., Powell, A., Adem, A., Lorang, D., Heller, C., Grover, A. C., Ylaya, K., Hewitt, S. M., Marx, S. J., Spiegel, A. M. & Libutti, S. K., Mar 1 2009, In : Cancer Research. 69, 5, p. 1858-1866 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
2008

Albert Einstein College of Medicine

Spiegel, A., May 2008, In : Academic Medicine. 83, 5, 1 p.

Research output: Contribution to journalArticle

Parathyroid tumor development involves deregulation of homeobox genes

Shen, H. C. J., Rosen, J. E., Yang, L. M., Savage, S. A., Burns, A. L., Mateo, C. M., Agarwal, S. K., Chandrasekharappa, S. C., Spiegel, A. M., Collins, F. S., Marx, S. J. & Libutti, S. K., Mar 1 2008, In : Endocrine-Related Cancer. 15, 1, p. 267-275 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2007

Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation

Agarwal, S. K., Impey, S., McWeeney, S., Scacheri, P. C., Collins, F. S., Goodman, R. H., Spiegel, A. M. & Marx, S. J., Feb 2007, In : Neoplasia. 9, 2, p. 101-107 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Functional effects of monoclonal antibodies to the purified amino-terminal extracellular domain of the human Ca2+ receptor

Hu, J., Reyes-Cruz, G., Goldsmith, P. K., Gantt, N. M., Miller, J. L. & Spiegel, A. M., Apr 1 2007, In : Journal of Bone and Mineral Research. 22, 4, p. 601-608 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Parathyroid-specific double knockout of Gq and G11 α-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+-sensing receptor

Wettschureck, N., Lee, E. A., Libutti, S. K., Offermanns, S., Robey, P. G. & Spiegel, A. M., Jan 2007, In : Molecular Endocrinology. 21, 1, p. 274-280 7 p.

Research output: Contribution to journalArticle

83 Scopus citations
89 Scopus citations

The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations

Ozawa, A., Agarwal, S. K., Mateo, C. M., Burns, A. L., Rice, T. S., Kennedy, P. A., Quigley, C. M., Simonds, W. F., Weinstein, L. S., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M. & Marx, S. J., May 2007, In : Journal of Clinical Endocrinology and Metabolism. 92, 5, p. 1948-1951 4 p.

Research output: Contribution to journalArticle

66 Scopus citations
2006

A missense mutation in the seven-transmembrane domain of the human Ca 2+ receptor converts a negative allosteric modulator into a positive allosteric modulator

Hu, J., Jiang, J., Costanzi, S., Thomas, C., Yang, W., Feyen, J. H. M., Jacobson, K. A. & Spiegel, A. M., Jul 28 2006, In : Journal of Biological Chemistry. 281, 30, p. 21558-21565 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

Genetic interactions between Drosophila melanogaster menin and Jun/Fos

Cerrato, A., Parisi, M., Anna, S. S., Missirlis, F., Guru, S., Agarwal, S., Sturgill, D., Talbot, T., Spiegel, A., Collins, F., Chandrasekharappa, S., Marx, S. & Oliver, B., Oct 1 2006, In : Developmental Biology. 298, 1, p. 59-70 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis

Scacheri, P. C., Davis, S., Odom, D. T., Crawford, G. E., Perkins, S., Halawi, M. J., Agarwal, S. K., Marx, S. J., Spiegel, A. M., Meltzer, P. S. & Collins, F. S., Apr 2006, In : PLoS genetics. 2, 4, p. 406-419 14 p., e51.

Research output: Contribution to journalArticle

152 Scopus citations
2005

A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+

Hu, J., McLarnon, S. J., Mora, S., Jiang, J., Thomas, C., Jacobson, K. A. & Spiegel, A. M., Feb 11 2005, In : Journal of Biological Chemistry. 280, 6, p. 5113-5120 8 p.

Research output: Contribution to journalArticle

74 Scopus citations

Executive summary of the Strategic Plan for National Institutes of Health Obesity Research.

Spiegel, A. M. & Alving, B. M., Jul 2005, In : The American journal of clinical nutrition. 82, 1 Suppl, p. 211S-214S

Research output: Contribution to journalArticle

35 Scopus citations

Gland size is associated with changes in gene expression profiles in sporadic parathyroid adenomas

Rosen, J. E., Costouros, N. G., Lorang, D., Lee Burns, A., Alexander, H. R., Skarulis, M. C., Cochran, C., Pingpank, J. F., Marx, S. J., Spiegel, A. M. & Libutti, S. K., May 1 2005, In : Annals of Surgical Oncology. 12, 5, p. 1-5 5 p.

Research output: Contribution to journalArticle

11 Scopus citations
2004

Autosomal dominant hypocalcemia in monozygotic twins caused by a de novo germline mutation near the amino-terminus of the human calcium receptor

Hu, J., Mora, S., Weber, G., Zamproni, I., Proverbio, M. C. & Spiegel, A. M., Apr 1 2004, In : Journal of Bone and Mineral Research. 19, 4, p. 578-586 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1

Scacheri, P. C., Crabtree, J. S., Kennedy, A. L., Swain, G. P., Ward, J. M., Marx, S. J., Spiegel, A. M. & Collins, F. S., Nov 1 2004, In : Mammalian Genome. 15, 11, p. 872-877 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Pancreatic insulinomas in multiple endocrine neoplasia, type I knockout mice can develop in the absence of chromosome instability or microsatellite instability

Scacheri, P. C., Kennedy, A. L., Chin, K., Miller, M. T., Hodgson, J. G., Gray, J. W., Marx, S. J., Spiegel, A. M. & Collins, F. S., Oct 1 2004, In : Cancer research. 64, 19, p. 7039-7044 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
2003

Of mice and MEN1: Insulinomas in a conditional mouse knockout

Crabtree, J. S., Scacheri, P. C., Ward, J. M., McNally, S. R., Swain, G. P., Montagna, C., Hager, J. H., Hanahan, D., Edlund, H., Magnuson, M. A., Garrett-Beal, L., Burns, A. L., Ried, T., Chandrasekharappa, S. C., Marx, S. J., Spiegel, A. M. & Collins, F. S., Sep 1 2003, In : Molecular and cellular biology. 23, 17, p. 6075-6085 11 p.

Research output: Contribution to journalArticle

160 Scopus citations

Parathyroid Gland-specific Deletion of the Mouse Men1 Gene Results in Parathyroid Neoplasia and Hypercalcemic Hyperparathyroidism

Libutti, S. K., Crabtree, J. S., Lorang, D., Burns, A. L., Mazzanti, C., Hewitt, S. M., O'Connor, S., Ward, J. M., Emmert-Buck, M. R., Remaley, A., Miller, M., Turner, E., Alexander, H. R., Arnold, A., Marx, S. J., Collins, F. S. & Spiegel, A. M., Nov 15 2003, In : Cancer Research. 63, 22, p. 8022-8028 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene

Sukhodolets, K. E., Hickman, A. B., Agarwal, S. K., Sukhodolets, M. V., Obungu, V. H., Novotny, E. A., Crabtree, J. S., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M., Burns, A. L. & Marx, S. J., Jan 1 2003, In : Molecular and cellular biology. 23, 2, p. 493-509 17 p.

Research output: Contribution to journalArticle

99 Scopus citations

Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter

Agarwal, S. K., Novotny, E. A., Crabtree, J. S., Weitzman, J. B., Yaniv, M., Burns, A. L., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M. & Marx, S. J., Sep 16 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 19, p. 10770-10775 6 p.

Research output: Contribution to journalArticle

96 Scopus citations
2002

Autosomal Dominant Hypocalcemia Caused by a Novel Mutation in the Loop 2 Region of the Human Calcium Receptor Extracellular Domain

Hu, J., Mora, S., Colussi, G., Proverbio, M. C., Jones, K. A., Bolzoni, L., De Ferrari, M. E., Civati, G. & Spiegel, A. M., Jan 1 2002, In : Journal of Bone and Mineral Research. 17, 8, p. 1461-1469 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Hyperparathyroidism in hereditary syndromes: Special expressions and special managements

Marx, S. J., Simonds, W. F., Agarwal, S. K., Burns, A. L., Weinstein, L. S., Cochran, C., Skarulis, M. C., Spiegel, A. M., Libutti, S. K., Alexander, H. R., Chen, C. C., Chang, R., Chandrasekharappa, S. C. & Collins, F. S., Nov 1 2002, In : Journal of Bone and Mineral Research. 17, SUPPL. 2, p. N37-N43

Research output: Contribution to journalArticle

129 Scopus citations
79 Scopus citations
2001

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

Crabtree, J. S., Scacheri, P. C., Ward, J. M., Garrett-Beal, L., Emmert-Buck, M. R., Edgemon, K. A., Lorang, D., Libutti, S. K., Chandrasekharappa, S. C., Marx, S. J., Spiegel, A. M. & Collins, F. S., Jan 30 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 3, p. 1118-1123 6 p.

Research output: Contribution to journalArticle

351 Scopus citations

Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice

Scacheri, P. C., Crabtree, J. S., Novotny, E. A., Garrett-Beal, L., Chen, A., Edgemon, K. A., Marx, S. J., Spiegel, A. M., Chandrasekharappa, S. C. & Collins, F. S., Sep 15 2001, In : Genesis. 30, 4, p. 259-263 5 p.

Research output: Contribution to journalArticle

69 Scopus citations

Characterization of a MEN1 ortholog from Drosophila melanogaster

Guru, S. C., Prasad, N. B., Shin, E. J., Hemavathy, K., Lu, J., Ip, Y. T., Agarwal, S. K., Marx, S. J., Spiegel, A. M., Collins, F. S., Oliver, B. & Chandrasekharappa, S. C., Jan 24 2001, In : Gene. 263, 1-2, p. 31-38 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Human Ca2+ receptor extracellular domain. Analysis of function of lobe I loop deletion mutants

Reyes-Cruz, G., Hu, J., Goldsmith, P. K., Steinbach, P. J. & Spiegel, A. M., Aug 24 2001, In : Journal of Biological Chemistry. 276, 34, p. 32145-32151 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Production and purification of human menin from Drosophila melanogaster S2 cells using stirred tank reactor

Valle, M. A., Kester, M. B., Burns, A. L., Marx, S. J., Spiegel, A. M. & Shiloach, J., Oct 20 2001, In : Cytotechnology. 35, 2, p. 127-135 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

The tumor suppressor protein menin interacts with NF-κb proteins and inhibits NF-κb-mediated transactivation

Heppner, C., Bilimoria, K. Y., Agarwal, S. K., Kester, M. B., Whitty, L. J., Guru, S. C., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M., Marx, S. J. & Burns, A. L., Aug 16 2001, In : Oncogene. 20, 36, p. 4917-4925 9 p.

Research output: Contribution to journalArticle

199 Scopus citations

The Venus's-flytrap and Cysteine-rich Domains of the Human Ca2+ Receptor are Not Linked by Disulfide Bonds

Hu, J., Reyes-Cruz, G., Goldsmith, P. K. & Spiegel, A. M., Mar 9 2001, In : Journal of Biological Chemistry. 276, 10, p. 6901-6904 4 p.

Research output: Contribution to journalArticle

19 Scopus citations

Workshop on hypoglycemia and the brain

Alavi, A., Chamberlain, J., Cherrington, A. D., Convit, A., Craft, S., Cryer, P. E., Davis, S. N., Davison, S., De Leon, M., DeRosa, M., Drucker, D., Albert, M., Evans, M., Feldman, E., Fischbach, G. D., Fradkin, J., Furlanetto, R., Galassetti, P., Garfield, S., Ginsberg, M. D. & 62 others, Goldberg, M. P., Goldstein, R., Amiel, S. A., Gruetter, R., Guastaferro, C., Harmon, J., Herbel, G., Himelfarb, M., Hurlbert, M., Jacobson, L., Kumagai, A. K., Landis, D., Laughlin, M., Atwell, C. W., Levin, B. E., Linder, B., McCall, A., Mobbs, C., Moncrief, M. B., Novotny, J., Pampanelli, S., Pellerin, L., Penn, A., Petersen, M., Banarer, S., Porro, J., Powers, W. J., Puczynski, S., Queenan, C., Ransom, B., Reagan, L., Ritter, S., Rothman, D. L., Rothman, S. M., Routh, V., Behar, T., Ryan, C., Schnieder, V., Seaquist, E. R., Sharp, F. R., Sherwin, R. S., Siegel, B., Sigal, C., Shiota, C., Simpson, I. A., Smith, P. F., Bolli, G. B., Sokoloff, L., Spiegel, A. M., Stoffel, M., Swanson, R., Tamborlane, W., Tekkök, S. B., Tkacs, N. C., Vannucci, S., Wieloch, T., Ye, Z., Boyle, P., Ying, W., Winfield, D., Pekar, N. & Brown, A., 2001, In : Diabetes Technology and Therapeutics. 3, 3, p. 469-516 48 p.

Research output: Contribution to journalArticle

2000

Effects of a calcimimetic compound and naturally activating mutations on the human Ca2+ receptor and on Ca2+ receptor/metabotropic glutamate chimeric receptors

Hauache, O. M., Hu, J., Ray, K., Xie, R., Jacobson, K. A. & Spiegel, A. M., Jan 1 2000, In : Endocrinology. 141, 11, p. 4156-4163 8 p.

Research output: Contribution to journalArticle

Open Access
76 Scopus citations

Expression of the calcium-sensing receptor in gastrinomas

Goebel, S. U., Peghini, P. L., Goldsmith, P. K., Spiegel, A. M., Gibril, F., Raffeld, M., Jensen, R. T. & Serrano, J., 2000, In : Journal of Clinical Endocrinology and Metabolism. 85, 11, p. 4131-4137 7 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations

Functional interactions between the extracellular domain and the seven-transmembrane domain in Ca 2+ receptor activation

Hauache, O. M., Hu, J., Ray, K. & Spiegel, A. M., Sep 28 2000, In : Endocrine. 13, 1, p. 63-70 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Genotype/phenotype correlation of multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas

Goebel, S. U., Heppner, C., Burns, A. L., Marx, S. J., Spiegel, A. M., Zhuang, Z., Lubensky, I. A., Gibril, F., Jensen, R. T. & Serrano, J., Jan 1 2000, In : Journal of Clinical Endocrinology and Metabolism. 85, 1, p. 116-123 8 p.

Research output: Contribution to journalArticle

Open Access
82 Scopus citations

G protein defects in signal transduction

Spiegel, A. M., 2000, In : Hormone Research. 53, SUPPL. 3, p. 17-22 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Human Ca2+ receptor cysteine-rich domain: Analysis of function of mutant and chimeric receptors

Hu, J., Hauache, O. & Spiegel, A. M., May 26 2000, In : Journal of Biological Chemistry. 275, 21, p. 16382-16389 8 p.

Research output: Contribution to journalArticle

84 Scopus citations

Identification and characterization of JunD missense mutants that lack menin binding

Knapp, J. I., Heppner, C., Hickman, A. B., Burns, A. L., Chandrasekharappa, S. C., Collins, F. S., Marx, S. J., Spiegel, A. M. & Agarwal, S. K., Sep 28 2000, In : Oncogene. 19, 41, p. 4706-4712 7 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Isolation, characterization, expression and functional analysis of the zebrafish ortholog of MEN1

Manickam, P., Vogel, A. M., Agarwal, S. K., Oda, T., Spiegel, A. M., Marx, S. J., Collins, F. S., Weinstein, B. M. & Chandrasekharappa, S. C., Jul 6 2000, In : Mammalian Genome. 11, 6, p. 448-454 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

MEN1 gene mutation analysis of high-grade neuroendocrine lung carcinoma

Debelenko, L. V., Swalwell, J. I., Kelley, M. J., Brambilla, E., Manickam, P., Baibakov, G., Agarwal, S. K., Spiegel, A. M., Marx, S. J., Chandrasekharappa, S. C., Collins, F. S., Travis, W. D. & Emmert-Buck, M. R., May 1 2000, In : Genes Chromosomes and Cancer. 28, 1, p. 58-65 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic changes in non-McCune-Albright fibrous dysplasia of bone

Bianco, P., Riminucci, M., Majolagbe, A., Kuznetsov, S. A., Collins, M. T., Mankani, M. H., Corsi, A., Bone, H. G., Wientroub, S., Spiegel, A. M., Fisher, L. W. & Gehron Robey, P., Jan 1 2000, In : Journal of Bone and Mineral Research. 15, 1, p. 120-128 9 p.

Research output: Contribution to journalArticle

183 Scopus citations