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  Molecular Mechanism of Brown Adipose Tissue Regression

  Feng, D. & Pessin, J. E.

  National Institute of Diabetes and Digestive and Kidney Diseases

  4/15/21 → 2/28/22

  Project: Research project

  • Brown Adipocytes 100%
  • Pyroptosis 74%
  • Brown Adipose Tissue 68%
  • Receptor Protein-Tyrosine Kinases 30%
  • Knockout Mice 25%

• HIV/ART, low birth weight, and mortality in HIV-exposed uninfected children: a translational mechanistic study

  Yotebieng, M.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  4/15/21 → 3/31/22

  Project: Research project

  • Low Birth Weight Infant 100%
  • HIV 89%
  • Mortality 36%
  • Child 32%
  • Therapeutics 15%

• Diet Related Inflammation and Kidney Function Decline in Racial/Ethnic Minorities

  Johns, T. S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  4/15/21 → 12/31/21

  Project: Research project

  • Chronic Renal Insufficiency 100%
  • Inflammation 50%
  • Kidney 50%
  • Diet 48%
  • Research Personnel 43%

• Habenula Developmental Trajectories in the ABCD Study

  Ely, B. A. & Gabbay, V.

  National Institute of Mental Health

  4/1/21 → 3/31/22

  Project: Research project

  • Habenula 100%
  • Brain 20%
  • Mental Disorders 15%
  • Reward 13%
  • Anxiety 10%

• Analyzing the Hypersensitivity of MMR-deficient Colorectal Cancers to mTOR Inhibition and the Response of Cancer Stem Cells

  Edelmann, W.

  National Cancer Institute

  4/1/21 → 3/31/22

  Project: Research project

  • DNA Mismatch Repair 100%
  • Neoplastic Stem Cells 59%
  • Colorectal Neoplasms 55%
  • Hypersensitivity 35%
  • Sirolimus 34%

• Contribution of macrophages in the HSC niche

  Frenette, P. S.

  National Heart, Lung, and Blood Institute

  4/1/21 → 2/28/22

  Project: Research project

  • Stem Cell Niche 100%
  • Macrophages 91%
  • Hematopoietic Stem Cells 88%
  • Bone Marrow 74%
  • Regeneration 21%

• THE EFFECT OF TUMOR MICROENVIRONMENT ON METASTASIS

  Condeelis, J. S., Entenberg, D. R. & Oktay, M. H.

  National Cancer Institute

  3/1/21 → 2/28/22

  Project: Research project

  • Tumor Microenvironment 100%
  • Neoplasm Metastasis 71%
  • Neoplasms 46%
  • Breast Neoplasms 25%
  • Drug Therapy 23%

• Intraventricular Hemorrhage Disrupts the Blood Brain Barrier in Premature Infants

  Ballabh, P.

  National Institute of Neurological Disorders and Stroke

  3/1/21 → 2/28/22

  Project: Research project

  • Blood-Brain Barrier 100%
  • Hemorrhage 66%
  • Premature Infants 61%
  • Hydrocephalus 43%
  • Adherens Junctions 42%

• Human Gut Microbiome and Incident Diabetes Risk in U.S. Populations

  Qi, Q.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/19/21 → 12/31/21

  Project: Research project

  • Microbiota 100%
  • Type 2 Diabetes Mellitus 75%
  • Gastrointestinal Microbiome 74%
  • Metabolome 42%
  • Qi 34%

• Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer

  Guha, C.

  National Cancer Institute

  1/14/21 → 12/31/21

  Project: Research project

  • Heavy Ion Radiotherapy 100%
  • Pancreatic Neoplasms 47%
  • Linear Energy Transfer 32%
  • Proton Therapy 20%
  • Antigen Presentation 16%

• Exhaled small RNA biomarkers to detect and monitor airway disease

  Loudig, O. D. & Spivack, S. D.

  National Heart, Lung, and Blood Institute

  1/1/21 → 12/31/21

  Project: Research project

  • Biomarkers 100%
  • Exosomes 96%
  • Chronic Obstructive Pulmonary Disease 91%
  • RNA 86%
  • Asthma 80%

• Identifying mechanisms that detect and eliminate aneuploid cells

  Baker, N. E.

  NATIONAL EYE INSTITUTE

  1/1/21 → 12/31/21

  Project: Research project

  • aneuploidy 100%
  • cells 40%
  • macular degeneration 30%
  • glaucoma 28%
  • cataract 26%

• Optimizing SARS-CoV-2 wastewater based surveillance in urban and university campus settings.

  Chandran, K.

  1/1/21 → 12/31/21

  Project: Research project

  • Waste Water 100%
  • SARS Virus 44%
  • Disease Outbreaks 11%
  • Coronavirus 10%
  • Microfluidics 10%

• TB Phage therapy: Optimizing delivery methods of mycobacteriophages to target intracellular Mycobacterium tuberculosis

  Jacobs Jr., W. R.

  National Institute of Allergy and Infectious Diseases

  12/7/20 → 11/30/21

  Project: Research project

  • Mycobacteriophages 100%
  • Phage Therapy 55%
  • Mycobacterium tuberculosis 47%
  • Tuberculosis 40%
  • Mycobacterium smegmatis 9%

• The Pathogenic Role of Interneurons in Huntington's Disease

  Molero, A. E.

  National Institute of Neurological Disorders and Stroke

  12/1/20 → 11/30/21

  Project: Research project

  • Interneurons 100%
  • Huntington Disease 57%
  • polyglutamine 26%
  • Cell Cycle 15%
  • Optogenetics 12%

• Structure-based design of stapled peptides to target Gag-Pol and INI1 interaction to block assembly

  Kalpana, G. V.

  National Institute of Allergy and Infectious Diseases

  11/13/20 → 10/31/21

  Project: Research project

  • Integrases 100%
  • Peptides 32%
  • HIV-1 28%
  • Response Elements 19%
  • RNA 10%

• The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age

  Derby, C. A.

  9/30/20 → 8/31/21

  Project: Research project

  • menopause 100%
  • health 76%
  • old age 38%
  • mortality 10%
  • bone disease 9%

• Evaluation of the Asthma Management Program to Promote Activity for Students in Schools (Asthma-PASS)

  Reznik, M.

  9/24/20 → 8/31/21

  Project: Research project

  • Asthma 100%
  • Exercise 32%
  • Students 25%
  • Primary Care Physicians 14%
  • Child 11%

• Presynaptic forms of long-term plasticity in the CNS

  Castillo, P. E.

  9/21/20 → 7/31/21

  Project: Research project

  • Synapses 100%
  • Axons 95%
  • Presynaptic Terminals 80%
  • Brain-Derived Neurotrophic Factor 76%
  • Neuronal Plasticity 69%

• Following mRNA from birth to death at single-molecule resolution

  Singer, R. H.

  9/17/20 → 8/31/21

  Project: Research project

  • Messenger RNA 100%
  • Photobleaching 56%
  • Cytoplasm 31%
  • Parturition 27%
  • Organized Financing 22%

• Deciphering the enigmatic role of IGF-1 signaling in cognitive decline and Alzheimer's disease

  Huffman, D. M.

  9/15/20 → 8/31/21

  Project: Research project

  • Insulin-Like Growth Factor I 100%
  • Cognitive Dysfunction 52%
  • Alzheimer Disease 38%
  • Amyloidosis 31%
  • Insulin 28%

• Utility of Centrally Acting Angiotensin Converting Enzyme Inhibitors to slow the progression of Dementia

  George, C. J.

  9/15/20 → 5/31/22

  Project: Research project

  • Cognitive Dysfunction 100%
  • Angiotensin-Converting Enzyme Inhibitors 85%
  • Gait 66%
  • Retirement 41%
  • Organized Financing 41%

• ANKS1B haploinsufficiency in a novel brain disorder

  Jordan, B. A.

  9/15/20 → 8/31/21

  Project: Research project

  • Haploinsufficiency 100%
  • Neurodevelopmental Disorders 68%
  • N-Methyl-D-Aspartate Receptors 58%
  • Autistic Disorder 38%
  • Brain Diseases 37%

• BTBD9, a novel regulator of manganese-induced neurotoxicity

  Chen, P.

  9/10/20 → 8/31/21

  Project: Research project

  • Manganese 100%
  • Somatomedins 41%
  • Restless Legs Syndrome 40%
  • Caenorhabditis elegans 14%
  • Neurobiology 10%

• Th2A cells mediate outcomes of aspirin-exacerbated respiratory disease

  Jerschow, E.

  9/3/20 → 8/31/21

  Project: Research project

  • Aspirin 100%
  • Th2 Cells 66%
  • Prostaglandin D2 62%
  • Nasal Polyps 30%
  • prostaglandin R2 D-isomerase 14%

• Einstein/Rwanda/DRC Consortium for Research in HIV/HPV/Malignancies

  Adedimeji, A. A., Anastos, K. & Anastos, K.

  9/1/20 → 8/31/21

  Project: Research project

  • Rwanda 100%
  • Democratic Republic of the Congo 42%
  • Military 24%
  • grant 14%
  • productivity 14%

• Adverse pregnancy outcomes in women with systemic lupus erythematosus: improving and validating risk prediction

  Kim, M.

  9/1/20 → 8/31/21

  Project: Research project

  • Pregnancy Outcome 100%
  • Systemic Lupus Erythematosus 70%
  • Pregnancy 15%
  • Biostatistics 12%
  • Research Personnel 11%

• Uncovering links between neuronal transcriptomic and functional profiles in opioid addiction

  Sjulson, L. L.

  9/1/20 → 7/31/21

  Project: Research project

  • Substance-Related Disorders 100%
  • Opioid-Related Disorders 69%
  • Self Administration 67%
  • Opioid Analgesics 50%
  • Optogenetics 36%

• Role of HCAR1 in glucose homeostasis

  Jo, Y.

  8/15/20 → 8/31/21

  Project: Research project

  • brown adipose tissue 100%
  • receptors 57%
  • acids 37%
  • lactates 35%
  • glucose 32%

• Multiplex Imaging of Signaling Pathways in Cell Motility

  Hodgson, L.

  8/1/20 → 7/31/21

  Project: Research project

  • Biosensing Techniques 100%
  • Energy Transfer 76%
  • rho GTP-Binding Proteins 58%
  • GTP Phosphohydrolases 53%
  • Cell Movement 48%

• Control of cardiomyocyte cell cycle by REST in heart failure and regeneration

  Zheng, D.

  National Heart, Lung, and Blood Institute

  7/15/20 → 4/30/22

  Project: Research project

  • RE1-silencing transcription factor 100%
  • Cardiac Myocytes 56%
  • Cell Cycle Checkpoints 32%
  • Regeneration 30%
  • Heart 26%

• AIF1/Iba1 in microglial function and stroke

  Sibinga, N. E. S.

  7/1/20 → 6/30/22

  Project: Research project

  • Stroke 100%
  • Microglia 89%
  • Wounds and Injuries 42%
  • Inflammation Mediators 18%
  • Cell Lineage 15%

• CCL2-CCR2b signaling in HIV-1 fitness and disease; Role of host genetic polymorphisms

  Prasad, V. R.

  7/1/20 → 5/31/22

  Project: Research project

  • HIV-1 100%
  • Endosomal Sorting Complexes Required for Transport 70%
  • Actins 48%
  • HIV 47%
  • Viruses 46%

• Structure-based Vaccine Design for CCHFV

  Chandran, K.

  6/25/20 → 5/31/22

  Project: Research project

  • Crimean-Congo hemorrhagic fever virus 100%
  • National Institute of Allergy and Infectious Diseases (U.S.) 27%
  • Glycoproteins 23%
  • Ticks 21%
  • Vaccines 20%

• Trajectories and modifiable risk factors of brain, gait, and cognitive decline in aging and pre-dementia

  Blumen, H. M.

  National Institute on Aging

  6/15/20 → 3/31/22

  Project: Research project

  • Gait 100%
  • Dementia 69%
  • Cognitive Dysfunction 67%
  • Brain 42%
  • Social Networking 30%

• Single cell RNA-seq and single molecule RNA-FISH approaches to study stochasticity of latent HIV-1 reactivation

  Kalpana, G. V.

  5/20/20 → 4/30/22

  Project: Research project

  • HIV-1 100%
  • RNA 47%
  • Proviruses 44%
  • RNA-Seq 26%
  • Fluorescent Antibody Technique 19%

• Molecular basis of recognition in the Immunological Synapse

  Fiser, A.

  National Institute of General Medical Sciences

  5/1/20 → 4/30/22

  Project: Research project

  • Synapses 100%
  • Immunological Synapses 97%
  • Ligands 46%
  • Proteins 32%
  • Protein Engineering 29%

• Head-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving Animals

  Verkhusha, V.

  5/1/20 → 4/30/23

  Project: Research project

  • image analysis 100%
  • brain 84%
  • animals 75%
  • electrodes 57%
  • electric potential difference 55%

• AQP4 isoforms and brain edema

  Spray, D. C.

  5/1/20 → 10/31/21

  Project: Research project

  • brain 100%
  • homeostasis 52%
  • water 39%
  • blood 35%
  • distribution 23%

• A systems approach for identifying geroprotector synergy in Alzheimer's disease

  Huffman, D. M.

  5/1/20 → 4/30/22

  Project: Research project

  • Alzheimer Disease 100%
  • Systems Analysis 58%
  • Amyloidosis 28%
  • Gene Regulatory Networks 28%
  • Cognition 20%

• Characterization of CNS protein aggregate components during acute and chronic EAE

  Shafit-Zagardo, B.

  5/1/20 → 10/31/21

  Project: Research project

  • Protein Aggregates 100%
  • Multiple Sclerosis 34%
  • Proteins 32%
  • Myelin Sheath 30%
  • Macroautophagy 27%

• Training in Intellectual and Developmental Disabilities (IDD) Research

  Molholm, S. & Walkley, S. U.

  5/1/20 → 4/30/22

  Project: Research project

  • Developmental Disabilities 100%
  • Intellectual Disability 81%
  • Education 15%
  • Minority Groups 7%
  • Mentoring 6%

• Positive and Negative Valence Systems Underlying Suicide in Youth

  Gabbay, V.

  4/10/20 → 4/9/22

  Project: Research project

  • Reward 100%
  • Habenula 71%
  • Suicide 71%
  • Anhedonia 68%
  • Completed Suicide 37%

• Regulation of the TGF-beta superfamily in the remodeling and failing heart

  Frangogiannis, N. G.

  National Heart, Lung, and Blood Institute

  4/3/20 → 3/31/22

  Project: Research project

  • Cardiac Myocytes 100%
  • Pressure 69%
  • Heart 61%
  • Fibroblasts 59%
  • Transforming Growth Factor beta 55%

• Determination of genome-wide splicing kinetics and their underlying regulation

  Gamble, M. J.

  National Institute of General Medical Sciences

  4/1/20 → 3/31/22

  Project: Research project

  • Kinetics 100%
  • Genome 52%
  • Introns 47%
  • Transcriptome 45%
  • Chromatin 43%

• Biobehavioral Predictors of Illness Progression in Adolescent Depression

  Gabbay, V.

  4/1/20 → 1/31/22

  Project: Research project

  • Anhedonia 100%
  • Reward 88%
  • Depression 54%
  • Kynurenine 33%
  • gamma-Aminobutyric Acid 32%

• Metabolic control in vascular remodeling

  Sibinga, N. E. S.

  National Heart, Lung, and Blood Institute

  3/1/20 → 1/31/22

  Project: Research project

  • Vascular Remodeling 100%
  • Smooth Muscle Myocytes 96%
  • Electron Transport Complex I 54%
  • Embryonic Development 27%
  • Vascular Diseases 19%

• Characterization of brain dysfunction during development in survivors of childhood acute lymphoblastic leukemia

  Wagshul, M. E., Cole, P. D. & Sussman, E. S.

  National Cancer Institute

  3/1/20 → 2/28/22

  Project: Research project

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 100%
  • Survivors 81%
  • Brain 54%
  • Drug Therapy 21%
  • Therapeutics 18%

• CHALO!: A mobile technology based intervention to accelerate HIV testing and linkage to prevention and treatment

  Patel, V. V.

  National Institute of Mental Health

  3/1/20 → 1/31/22

  Project: Research project

  • HIV 100%
  • Technology 50%
  • Therapeutics 14%
  • Internet-Based Intervention 14%
  • HIV Infections 9%

• Role of the histone modifier MLL3 mutation in breast cancer cell plasticity

  Guo, W.

  National Cancer Institute

  3/1/20 → 2/28/22

  Project: Research project

  • Cell Plasticity 100%
  • Mutation 54%
  • Histones 49%
  • Breast Neoplasms 45%
  • Breast 33%