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  Analyzing the Hypersensitivity of MMR-deficient Colorectal Cancers to mTOR Inhibition and the Response of Cancer Stem Cells

  Edelmann, W.

  National Cancer Institute

  4/1/21 → 3/31/22

  Project: Research project

  • DNA Mismatch Repair
  • Neoplastic Stem Cells
  • Hypersensitivity
  • Colorectal Neoplasms
  • Sirolimus

• Contribution of macrophages in the HSC niche

  Frenette, P. S.

  National Heart, Lung, and Blood Institute

  4/1/21 → 2/28/22

  Project: Research project

  • Stem Cell Niche
  • Hematopoietic Stem Cells
  • Macrophages
  • Bone Marrow
  • Regeneration

• Habenula Developmental Trajectories in the ABCD Study

  Ely, B. A. & Gabbay, V.

  National Institute of Mental Health

  4/1/21 → 3/31/22

  Project: Research project

  • Habenula
  • Brain
  • Reward
  • Psychiatry
  • Anxiety

• Intraventricular Hemorrhage Disrupts the Blood Brain Barrier in Premature Infants

  Ballabh, P.

  National Institute of Neurological Disorders and Stroke

  3/1/21 → 2/28/22

  Project: Research project

  • Blood-Brain Barrier
  • Premature Infants
  • Hemorrhage
  • Adherens Junctions
  • Tight Junctions

• THE EFFECT OF TUMOR MICROENVIRONMENT ON METASTASIS

  Condeelis, J. S., Entenberg, D. R. & Oktay, M. H.

  National Cancer Institute

  3/1/21 → 2/28/22

  Project: Research project

  • Tumor Microenvironment
  • Neoplasm Metastasis
  • Neoplasms
  • Breast Neoplasms
  • Drug Therapy

• Human Gut Microbiome and Incident Diabetes Risk in U.S. Populations

  Qi, Q.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/19/21 → 12/31/21

  Project: Research project

  • Microbiota
  • Gastrointestinal Microbiome
  • Type 2 Diabetes Mellitus
  • Metabolome
  • Population

• Relative Immunological Effectiveness (RIE) of Carbon Ion Radiation Therapy for Pancreatic Cancer

  Guha, C.

  National Cancer Institute

  1/14/21 → 12/31/21

  Project: Research project

  • Heavy Ion Radiotherapy
  • Pancreatic Neoplasms
  • Linear Energy Transfer
  • Proton Therapy
  • Antigen Presentation

• Exhaled small RNA biomarkers to detect and monitor airway disease

  Loudig, O. D. & Spivack, S. D.

  National Heart, Lung, and Blood Institute

  1/1/21 → 12/31/21

  Project: Research project

  • Exosomes
  • RNA
  • Biomarkers
  • Chronic Obstructive Pulmonary Disease
  • Asthma

• Identifying mechanisms that detect and eliminate aneuploid cells

  Baker, N. E.

  NATIONAL EYE INSTITUTE

  1/1/21 → 12/31/21

  Project: Research project

  • aneuploidy
  • cells
  • macular degeneration
  • glaucoma
  • cataract

• Optimizing SARS-CoV-2 wastewater based surveillance in urban and university campus settings.

  Chandran, K.

  1/1/21 → 12/31/21

  Project: Research project

• TB Phage therapy: Optimizing delivery methods of mycobacteriophages to target intracellular Mycobacterium tuberculosis

  Jacobs Jr., W. R.

  National Institute of Allergy and Infectious Diseases

  12/7/20 → 11/30/21

  Project: Research project

  • Mycobacteriophages
  • Phage Therapy
  • Mycobacterium tuberculosis
  • Tuberculosis
  • Mycobacterium smegmatis

• The Pathogenic Role of Interneurons in Huntington's Disease

  Molero, A. E.

  National Institute of Neurological Disorders and Stroke

  12/1/20 → 11/30/21

  Project: Research project

  • Huntington Disease
  • Interneurons
  • polyglutamine
  • Cell Cycle
  • Optogenetics

• Structure-based design of stapled peptides to target Gag-Pol and INI1 interaction to block assembly

  Kalpana, G. V.

  National Institute of Allergy and Infectious Diseases

  11/13/20 → 10/31/21

  Project: Research project

  • Integrases
  • Peptides
  • HIV-1
  • RNA
  • Integrase Inhibitors

• The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age

  Derby, C. A.

  National Institute on Aging

  9/30/20 → 8/31/21

  Project: Research project

  • menopause
  • old age
  • health
  • mortality

• Evaluation of the Asthma Management Program to Promote Activity for Students in Schools (Asthma-PASS)

  Reznik, M.

  9/24/20 → 8/31/21

  Project: Research project

• Presynaptic forms of long-term plasticity in the CNS

  Castillo, P. E.

  9/21/20 → 7/31/21

  Project: Research project

• Following mRNA from birth to death at single-molecule resolution

  Singer, R. H.

  National Institute of General Medical Sciences

  9/17/20 → 8/31/21

  Project: Research project

  • Parturition
  • Messenger RNA
  • Photobleaching
  • Cytoplasm
  • Organized Financing

• ANKS1B haploinsufficiency in a novel brain disorder

  Jordan, B. A.

  9/15/20 → 8/31/21

  Project: Research project

• Deciphering the enigmatic role of IGF-1 signaling in cognitive decline and Alzheimer's disease

  Huffman, D. M.

  9/15/20 → 8/31/21

  Project: Research project

• Utility of Centrally Acting Angiotensin Converting Enzyme Inhibitors to slow the progression of Dementia

  George, C. J.

  National Institute on Aging

  9/15/20 → 5/31/21

  Project: Research project

  • Angiotensin-Converting Enzyme Inhibitors
  • Dementia
  • Cognitive Dysfunction
  • Gait
  • Retirement

• BTBD9, a novel regulator of manganese-induced neurotoxicity

  Chen, P.

  9/10/20 → 8/31/21

  Project: Research project

• Th2A cells mediate outcomes of aspirin-exacerbated respiratory disease

  Jerschow, E.

  National Institute of Allergy and Infectious Diseases

  9/3/20 → 8/31/21

  Project: Research project

  • Th2 Cells
  • Aspirin
  • Prostaglandin D2
  • Nasal Polyps
  • prostaglandin R2 D-isomerase

• Adverse pregnancy outcomes in women with systemic lupus erythematosus: improving and validating risk prediction

  Kim, M.

  9/1/20 → 8/31/21

  Project: Research project

• Einstein/Rwanda/DRC Consortium for Research in HIV/HPV/Malignancies

  Adedimeji, A. A., Anastos, K. & Anastos, K.

  9/1/20 → 8/31/21

  Project: Research project

• Uncovering links between neuronal transcriptomic and functional profiles in opioid addiction

  Sjulson, L. L.

  9/1/20 → 7/31/21

  Project: Research project

• Cell fate choices by Tbx1 in forming the mammalian heart

  Morrow, B. E. & Zheng, D.

  8/20/20 → 4/30/21

  Project: Research project

• Role of HCAR1 in glucose homeostasis

  Jo, Y.

  8/15/20 → 8/31/21

  Project: Research project

• Predictive analytics for cognitive decline and Alzheimer?s disease

  Ezzati, A.

  8/1/20 → 4/30/21

  Project: Research project

• Multiplex Imaging of Signaling Pathways in Cell Motility

  Hodgson, L.

  National Institute of General Medical Sciences

  8/1/20 → 7/31/21

  Project: Research project

  • Biosensing Techniques
  • Energy Transfer
  • Cell Movement
  • rho GTP-Binding Proteins
  • GTP Phosphohydrolases

• Investigations Into The Molecular Pathogenesis Of Cervical Glandular Neoplasias

  Burk, R. D. & Strickler, H.

  National Cancer Institute

  7/2/20 → 6/30/21

  Project: Research project

  • Adenocarcinoma
  • Virus Integration
  • Neoplasms
  • Squamous Cell Carcinoma
  • Uterine Cervical Neoplasms

• AIF1/Iba1 in microglial function and stroke

  Sibinga, N. E. S.

  National Institute of Neurological Disorders and Stroke

  7/1/20 → 6/30/22

  Project: Research project

  • Stroke
  • Microglia
  • Wounds and Injuries
  • Inflammation Mediators
  • Cell Lineage

• TMEM, MENAcalc, and MENAINV as Prognostic and Predictive Markers for Breast Cancer Metastasis

  Condeelis, J. S. & Rohan, T. E.

  National Cancer Institute

  7/1/20 → 6/30/21

  Project: Research project

  • Breast Neoplasms
  • Neoplasm Metastasis
  • Neoplasms
  • Carcinoma
  • Recurrence

• CCL2-CCR2b signaling in HIV-1 fitness and disease; Role of host genetic polymorphisms

  Prasad, V. R.

  National Institute of Allergy and Infectious Diseases

  7/1/20 → 5/31/21

  Project: Research project

  • Genetic Polymorphisms
  • HIV-1
  • Endosomal Sorting Complexes Required for Transport
  • Actins
  • HIV

• Structure-based Vaccine Design for CCHFV

  Chandran, K.

  National Institute of Allergy and Infectious Diseases

  6/25/20 → 5/31/21

  Project: Research project

  • Crimean-Congo hemorrhagic fever virus
  • Vaccines
  • National Institute of Allergy and Infectious Diseases (U.S.)
  • Glycoproteins
  • Ticks

• Trajectories and modifiable risk factors of brain, gait, and cognitive decline in aging and pre-dementia

  Blumen, H. M.

  National Institute on Aging

  6/15/20 → 3/31/22

  Project: Research project

  • Gait
  • Dementia
  • Cognitive Dysfunction
  • Brain
  • Social Networking

• Single cell RNA-seq and single molecule RNA-FISH approaches to study stochasticity of latent HIV-1 reactivation

  Kalpana, G. V.

  National Institute of Allergy and Infectious Diseases

  5/20/20 → 4/30/21

  Project: Research project

  • HIV-1
  • RNA
  • Proviruses
  • Fluorescent Antibody Technique
  • Genes

• A Randomized Clinical Trial to Assess the Effectiveness of Ablative Treatments for Cervical-Cancer Risk Reduction in HIV+ Women living in Mozambique

  Castle, P. E.

  5/12/20 → 4/30/21

  Project: Research project

• Training in Intellectual and Developmental Disabilities (IDD) Research

  Molholm, S. & Walkley, S. U.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  5/1/20 → 4/30/21

  Project: Research project

  • Developmental Disabilities
  • Intellectual Disability
  • Education
  • Minority Groups
  • Mentoring

• Characterization of CNS protein aggregate components during acute and chronic EAE

  Shafit-Zagardo, B.

  National Institute of Neurological Disorders and Stroke

  5/1/20 → 10/31/21

  Project: Research project

  • Protein Aggregates
  • Multiple Sclerosis
  • Proteins
  • Myelin Sheath
  • Autophagy

• AQP4 isoforms and brain edema

  Spray, D. C.

  National Institute of Neurological Disorders and Stroke

  5/1/20 → 10/31/21

  Project: Research project

  • brain
  • homeostasis
  • water
  • blood
  • distribution

• Molecular basis of recognition in the Immunological Synapse

  Fiser, A.

  National Institute of General Medical Sciences

  5/1/20 → 4/30/21

  Project: Research project

  • Immunological Synapses
  • Synapses
  • Ligands
  • Proteins
  • Protein Engineering

• Head-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving Animals

  Verkhusha, V.

  National Institute of Neurological Disorders and Stroke

  5/1/20 → 4/30/23

  Project: Research project

  • image analysis
  • brain
  • electrodes
  • electric potential difference
  • animal models

• A systems approach for identifying geroprotector synergy in Alzheimer's disease

  Huffman, D. M.

  National Institute on Aging

  5/1/20 → 4/30/21

  Project: Research project

  • Systems Analysis
  • Alzheimer Disease
  • Amyloidosis
  • Gene Regulatory Networks
  • Cognition

• Positive and Negative Valence Systems Underlying Suicide in Youth

  Gabbay, V.

  National Institute of Mental Health

  4/10/20 → 4/9/22

  Project: Research project

  • Suicide
  • Reward
  • Habenula
  • Anhedonia
  • Pain

• Regulation of the TGF-beta superfamily in the remodeling and failing heart

  Frangogiannis, N. G.

  National Heart, Lung, and Blood Institute

  4/3/20 → 3/31/22

  Project: Research project

  • Cardiac Myocytes
  • Transforming Growth Factor beta
  • Pressure
  • Heart
  • Fibroblasts

• Determination of genome-wide splicing kinetics and their underlying regulation

  Gamble, M. J.

  National Institute of General Medical Sciences

  4/1/20 → 3/31/22

  Project: Research project

  • Kinetics
  • Genome
  • Introns
  • Transcriptome
  • Chromatin

• Biobehavioral Predictors of Illness Progression in Adolescent Depression

  Gabbay, V.

  National Institute of Mental Health

  4/1/20 → 1/31/22

  Project: Research project

  • Anhedonia
  • Reward
  • Depression
  • Kynurenine
  • gamma-Aminobutyric Acid

• Activity-dependent Transcriptional Pathways Underlying Synaptic Mechanisms for Memory Discrimination and Generalization.

  Castillo, P. E.

  National Institute of Neurological Disorders and Stroke

  3/1/20 → 12/31/21

  Project: Research project

  • Generalization (Psychology)
  • Discrimination (Psychology)
  • Memory
  • Panic Disorder
  • Dentate Gyrus

• Role of the histone modifier MLL3 mutation in breast cancer cell plasticity

  Guo, W.

  National Cancer Institute

  3/1/20 → 2/28/22

  Project: Research project

  • Cell Plasticity
  • Histones
  • Breast Neoplasms
  • Mutation
  • Breast

• CHALO!: A mobile technology based intervention to accelerate HIV testing and linkage to prevention and treatment

  Patel, V. V.

  National Institute of Mental Health

  3/1/20 → 1/31/22

  Project: Research project

  • HIV
  • Technology
  • Therapeutics
  • India
  • HIV Infections