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  Structure-based Vaccine Design for CCHFV

  Chandran, K.

  National Institute of Allergy and Infectious Diseases

  6/25/20 → 5/31/21

  Project: Research project

  • Crimean-Congo hemorrhagic fever virus
  • Vaccines
  • National Institute of Allergy and Infectious Diseases (U.S.)
  • Glycoproteins
  • Ticks

• GPI-ADAMTS13-Cultured Red Blood Cells

  Bouhassira, E. E. & Westhoff, C. M.

  6/15/20 → 6/30/21

  Project: Research project

• Trajectories and modifiable risk factors of brain, gait, and cognitive decline in aging and pre-dementia

  Blumen, H. M.

  6/15/20 → 3/31/21

  Project: Research project

• Plasmodium phospholipase A2s as potential novel drug targets

  Daily, J. P.

  6/1/20 → 5/31/21

  Project: Research project

• Single cell RNA-seq and single molecule RNA-FISH approaches to study stochasticity of latent HIV-1 reactivation

  Kalpana, G. V.

  National Institute of Allergy and Infectious Diseases

  5/20/20 → 4/30/21

  Project: Research project

  • HIV-1
  • RNA
  • Proviruses
  • Fluorescent Antibody Technique
  • Genes

• A Randomized Clinical Trial to Assess the Effectiveness of Ablative Treatments for Cervical-Cancer Risk Reduction in HIV+ Women living in Mozambique

  Castle, P. E.

  5/12/20 → 4/30/21

  Project: Research project

• Molecular basis of recognition in the Immunological Synapse

  Fiser, A.

  National Institute of General Medical Sciences

  5/1/20 → 4/30/21

  Project: Research project

  • Immunological Synapses
  • Synapses
  • Ligands
  • Proteins
  • Protein Engineering

• Head-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving Animals

  Verkhusha, V.

  National Institute of Neurological Disorders and Stroke

  5/1/20 → 4/30/23

  Project: Research project

  • image analysis
  • brain
  • electrodes
  • electric potential difference
  • animal models

• Microsporidia: invasion apparatus

  Weiss, L. M.

  5/1/20 → 4/30/21

  Project: Research project

• Novel Strategies for the Discovery of Microbial Metabolic Pathways

  Almo, S. C.

  National Institute of General Medical Sciences

  5/1/20 → 4/30/21

  Project: Research project

  • Carrier Proteins
  • Ligands
  • Proteins
  • Metabolic Networks and Pathways
  • Microbiota

• A systems approach for identifying geroprotector synergy in Alzheimer?s disease

  Huffman, D. M.

  National Institute on Aging

  5/1/20 → 4/30/21

  Project: Research project

  • Systems Analysis
  • Alzheimer Disease
  • Amyloidosis
  • Gene Regulatory Networks
  • Cognition

• AQP4 isoforms and brain edema

  Spray, D. C.

  National Institute of Neurological Disorders and Stroke

  5/1/20 → 10/31/21

  Project: Research project

  • brain
  • homeostasis
  • water
  • blood
  • distribution

• Characterization of CNS protein aggregate components during acute and chronic EAE

  Shafit-Zagardo, B.

  National Institute of Neurological Disorders and Stroke

  5/1/20 → 10/31/21

  Project: Research project

  • Protein Aggregates
  • Multiple Sclerosis
  • Proteins
  • Myelin Sheath
  • Autophagy

• Regulation of the TGF-beta superfamily in the remodeling and failing heart

  Frangogiannis, N. G.

  National Heart, Lung, and Blood Institute

  4/3/20 → 3/31/21

  Project: Research project

  • Cardiac Myocytes
  • Transforming Growth Factor beta
  • Pressure
  • Heart
  • Fibroblasts

• Determination of genome-wide splicing kinetics and their underlying regulation

  Gamble, M. J.

  National Institute of General Medical Sciences

  4/1/20 → 3/31/21

  Project: Research project

  • Kinetics
  • Genome
  • Introns
  • Transcriptome
  • Chromatin

• Characterization of brain dysfunction during development in survivors of childhood acute lymphoblastic leukemia

  Wagshul, M. E., Cole, P. D. & Sussman, E. S.

  National Cancer Institute

  3/1/20 → 2/28/21

  Project: Research project

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Survivors
  • Brain
  • Drug Therapy
  • Therapeutics

• Activity-dependent Transcriptional Pathways Underlying Synaptic Mechanisms for Memory Discrimination and Generalization.

  Castillo, P. E.

  National Institute of Neurological Disorders and Stroke

  3/1/20 → 12/31/20

  Project: Research project

  • Generalization (Psychology)
  • Discrimination (Psychology)
  • Memory
  • Panic Disorder
  • Dentate Gyrus

• Metabolic control in vascular remodeling

  Sibinga, N. E. S.

  3/1/20 → 1/31/24

  Project: Research project

• Role of the histone modifier MLL3 mutation in breast cancer cell plasticity

  Guo, W.

  National Cancer Institute

  3/1/20 → 2/28/21

  Project: Research project

  • Cell Plasticity
  • Histones
  • Breast Neoplasms
  • Mutation
  • Breast

• CHALO!: A mobile technology based intervention to accelerate HIV testing and linkage to prevention and treatment

  Patel, V. V.

  3/1/20 → 1/31/21

  Project: Research project

• Cardiac Calcification and Cholesterol Efflux in Older Adults

  Bortnick, A.

  National Heart, Lung, and Blood Institute

  2/15/20 → 1/31/21

  Project: Research project

  • Cholesterol
  • Calcification of Aortic Valve
  • Parents
  • Longevity
  • Coronary Vessels

• Role of the Kinesin KIF1A in Neurological Disease

  Gennerich, A.

  National Institute of Neurological Disorders and Stroke

  2/15/20 → 12/31/20

  Project: Research project

  • Kinesin
  • Mutation
  • Brain-Derived Neurotrophic Factor
  • Biophysics
  • Optic Atrophy

• The Rv2623-Rv1747 interaction: regulation of the in vivo fate of M. tuberculosis

  Chan, J.

  National Institute of Allergy and Infectious Diseases

  1/16/20 → 12/31/20

  Project: Research project

  • phosphatidylinositol mannoside
  • Mycobacterium tuberculosis
  • Tuberculosis
  • Cell Wall
  • Growth

• Novel effectors of insulin action in the liver

  Yang, F.

  1/3/20 → 11/30/23

  Project: Research project

• Regulation of Histone Chaperone Function by Glutamylation

  Shechter, D.

  National Institute of General Medical Sciences

  1/1/20 → 12/31/20

  Project: Research project

  • Histone Chaperones
  • Histones
  • Chromatin Assembly and Disassembly
  • Nucleoplasmins
  • Chromatin

• Beta Cell Intracellular Calcium and Diabetes

  Santulli, G.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/1/20 → 11/30/20

  Project: Research project

  • Calcium
  • Type 2 Diabetes Mellitus
  • Autophagy
  • Mitochondrial Degradation
  • Insulin Secretion

• Emergence of bedaquiline and clofazimine resistance after interruption of drug-resistant TB therapy in a high HIV prevalence setting

  Brust, J. C. M.

  12/26/19 → 11/30/24

  Project: Research project

• Synaptic Mechanisms for Contextual Memory Formation

  Castillo, P. E.

  National Institute of Mental Health

  12/1/19 → 11/30/20

  Project: Research project

  • Memory
  • Learning
  • Neuronal Plasticity
  • Pyramidal Cells
  • Hippocampus

• Allosteric inhibitors targeting oncogenic BRAF V600E dimers

  Gavathiotis, E.

  National Cancer Institute

  12/1/19 → 11/30/20

  Project: Research project

  • ponatinib
  • Thyroid Neoplasms
  • Melanoma
  • Colorectal Neoplasms
  • Neoplasms

• Early Phase Pain Investigation Clinical Network: Greater New York Clinical Center

  Lipton, R. B.

  9/30/19 → 3/31/24

  Project: Research project

• Prometastatic Effects of Neoadjuvant Chemotherapy in Breast Cancer

  Karagiannis, G.

  National Cancer Institute

  9/16/19 → 8/31/21

  Project: Research project

  • Breast Neoplasms
  • Drug Therapy
  • Neoplasm Metastasis
  • Neoplasms
  • Tumor Microenvironment

• Circadian Mechanisms of Diabetes Prevention in Aged mice

  Singh, R.

  National Institute on Aging

  9/15/19 → 5/31/21

  Project: Research project

  • Autophagy
  • Gluconeogenesis
  • Caloric Restriction
  • Type 2 Diabetes Mellitus
  • lysosomal proteins

• Migraine Clinical Outcome Assessment System (MiCOAS)

  Lipton, R. B.

  9/10/19 → 8/31/23

  Project: Research project

• Pannexin 1 channels, new players in diabetic bladder dysfunction

  Suadicani, S. O.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/3/19 → 6/30/21

  Project: Research project

  • Urinary Bladder
  • Cellular Mechanotransduction
  • Underactive Urinary Bladder
  • Up-Regulation
  • Down-Regulation

• Virtual Reality-Enhanced Haptic Simulation to Improve Self-Regulation of Applied Delivery Force During Shoulder Dystocia

  Gurewitsch Allen, E. D.

  9/1/19 → 7/31/24

  Project: Research project

• A Fluorescence-Based High-Throughput Platform for Glycotyping the Hematopoietic Cell Lineage

  Steidl, U. G.

  National Cancer Institute

  9/1/19 → 8/31/21

  Project: Research project

  • Heparitin Sulfate
  • Cell Lineage
  • Fluorescence
  • Single-Chain Antibodies
  • Polysaccharides

• Regulation of SAMHD1 antiviral activity

  Diaz-Griffero, F.

  National Institute of Allergy and Infectious Diseases

  9/1/19 → 6/30/21

  Project: Research project

  • Antiviral Agents
  • HIV-2
  • Phosphorylation
  • Dendritic Cells
  • Reverse Transcription

• Crosstalk of Splicing and Signaling during HSC Formation

  Bowman, T. V.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/1/19 → 6/30/21

  Project: Research project

  • Hematopoietic Stem Cells
  • RNA Splicing
  • RNA Splicing Factors
  • Hemangioblasts
  • Protein Isoforms

• A system for whole-brain recording and control of activated neurons with near-infrared light

  Shcherbakova, D.

  NATIONAL EYE INSTITUTE

  9/1/19 → 8/31/21

  Project: Research project

  • Light
  • Neurons
  • Brain
  • Technology
  • Optogenetics

• Modeling CRB1-related retinal disease using 3-D human retinal organoids

  Liu, W.

  8/1/19 → 7/31/21

  Project: Research project

• Impact of multiple stigmas on HIV care continuum outcomes for key populations

  Patel, V. V.

  National Institute of Mental Health

  7/17/19 → 6/30/21

  Project: Research project

  • Continuity of Patient Care
  • HIV
  • Population
  • India
  • Retention in Care

• Cellular mechanisms by which Neisseria gonorrhoeae infects the female reproductive tract

  Stein, D. T.

  7/5/19 → 6/30/23

  Project: Research project

• Dynamic visualization of polyribosomes

  Yoon, Y. J.

  National Institute of Mental Health

  6/13/19 → 5/31/21

  Project: Research project

  • Fragile X Mental Retardation Protein
  • Polyribosomes
  • Microscopy
  • Optical Imaging
  • Ribosome Subunits

• Hypothalamic NF-kB and astrocytic programs in obesity

  Cai, D.

  National Institute of Diabetes and Digestive and Kidney Diseases

  6/1/19 → 3/31/21

  Project: Research project

  • NF-kappa B
  • Obesity
  • Astrocytes
  • Neurons
  • Hypothalamus

• FOOD-BASED BIOMARKERS, DIET QUALITY, AND CARDIOMETABOLIC HEALTH

  Qi, Q.

  4/15/19 → 3/31/24

  Project: Research project

• Somatotropic Signaling and Resilience to Aging and Alzheimer's Disease

  Milman, S.

  National Institute on Aging

  4/15/19 → 1/31/21

  Project: Research project

  • Alzheimer Disease
  • Aged, 80 and over
  • Exome
  • Autophagy
  • Dementia

• Application of ambulatory methods for assessing short- and long-term associations of sleep health with cognitive decline in older adults

  Derby, C. A.

  National Institute on Aging

  4/15/19 → 1/31/21

  Project: Research project

  • Cognitive Dysfunction
  • Sleep
  • Health
  • Cognition
  • Ecological Momentary Assessment

• Vulnerability of SCLC based on bi-allelic genetic inactivation of RB1 and TP53

  Schwartz, E. L. & Zhao, H.

  National Cancer Institute

  4/12/19 → 3/31/21

  Project: Research project

  • Small Cell Lung Carcinoma
  • Drug Therapy
  • Heterografts
  • Ubiquitination
  • Neoplasms

• Cell-cell adhesion-mediated signaling determines epithelial polarization in the liver

  Muesch, A.

  4/4/19 → 3/31/22

  Project: Research project

• Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS)

  Sharma, A. & Anastos, K.

  National Heart, Lung, and Blood Institute

  4/1/19 → 3/31/21

  Project: Research project

  • Acquired Immunodeficiency Syndrome
  • Cohort Studies
  • HIV
  • Cardiovascular Diseases
  • Alcohols