• 25899 Citations
  • 89 h-Index
1969 …2019

Research output per year

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Publications

2019
2018

A double negative: Inhibition of hepatic gi signaling improves glucose homeostasis

Spiegel, A. M., Feb 1 2018, In : Journal of Clinical Investigation. 128, 2, p. 567-569 3 p.

Research output: Contribution to journalReview article

2016

Allosteric modulation of the calcium-sensing receptor rectifies signaling abnormalities associated with G-protein α-11 mutations causing hypercalcemic and hypocalcemic disorders

Babinsky, V. N., Hannan, F. M., Gorvin, C. M., Howles, S. A., Nesbit, M. A., Rust, N., Hanyaloglu, A. C., Hu, J., Spiegel, A. M. & Thakker, R. V., May 13 2016, In : Journal of Biological Chemistry. 291, 20, p. 10876-10885 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2015

Foreword

Spiegel, A. M., Jan 1 2015, In : Unknown Journal. p. v-vi

Research output: Contribution to journalArticle

Research in academic medical centers: Two threats to sustainable support

Levine, A. S., Alpern, R. J., Andrews, N. C., Antman, K., Balser, J. R., Berg, J. M., Davis, P. B., Fitz, J. G., Golden, R. N., Goldman, L., Jameson, J. L., Lee, V. S., Polonsky, K. S., Rappley, M. D., Reece, E. A., Rothman, P. B., Schwinn, D. A., Shapiro, L. J. & Spiegel, A. M., May 27 2015, In : Science translational medicine. 7, 289, 289fs22.

Research output: Contribution to journalShort survey

10 Scopus citations

The calcilytic agent NPS 2143 rectifies hypocalcemia in a mouse model with an activating calcium-sensing receptor (CaSR) mutation: Relevance to autosomal dominant hypocalcemia type 1 (ADH1)

Hannan, F. M., Walls, G. V., Babinsky, V. N., Nesbit, M. A., Kallay, E., Hough, T. A., Fraser, W. D., Cox, R. D., Hu, J., Spiegel, A. M. & Thakker, R. V., Sep 1 2015, In : Endocrinology. 156, 9, p. 3114-3121 8 p.

Research output: Contribution to journalArticle

34 Scopus citations
2013

G proteins - The disease spectrum expands

Spiegel, A. M., Jan 1 2013, In : New England Journal of Medicine. 368, 26, p. 2515-2516 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Gsα, Pseudohypoparathyroidism, Fibrous Dysplasia, and McCune-Albright Syndrome

Weinstein, L. S., Collins, M. T. & Spiegel, A. M., Aug 29 2013, Genetics of Bone Biology and Skeletal Disease. Elsevier Inc., p. 425-440 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

The stem cell wars: a dispatch from the front.

Spiegel, A. M., 2013, In : Transactions of the American Clinical and Climatological Association. 124, p. 94-110 17 p.

Research output: Contribution to journalArticle

3 Scopus citations
2012
10 Scopus citations
2011

Good news for advanced-stage pancreatic neuroendocrine tumors

Spiegel, A. M. & Libutti, S. K., May 1 2011, In : Nature Reviews Clinical Oncology. 8, 5, p. 258-259 2 p.

Research output: Contribution to journalArticle

2 Scopus citations
2010

Commentary: New guidelines for nih peer review: Improving the system or undermining it?

Spiegel, A. M., May 2010, In : Academic Medicine. 85, 5, p. 746-748 3 p.

Research output: Contribution to journalReview article

2 Scopus citations

Future diagnostic and therapeutic trends in endocrine cancers

Spiegel, A. M. & Libutti, S. K., Dec 1 2010, In : Seminars in oncology. 37, 6, p. 691-695 5 p.

Research output: Contribution to journalArticle

3 Scopus citations
2009

Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of men 1

Jennifer Shen, H. C., He, M., Powell, A., Adem, A., Lorang, D., Heller, C., Grover, A. C., Ylaya, K., Hewitt, S. M., Marx, S. J., Spiegel, A. M. & Libutti, S. K., Mar 1 2009, In : Cancer Research. 69, 5, p. 1858-1866 9 p.

Research output: Contribution to journalArticle

39 Scopus citations
2008

Albert Einstein College of Medicine

Spiegel, A., May 2008, In : Academic Medicine. 83, 5, 1 p.

Research output: Contribution to journalArticle

Parathyroid tumor development involves deregulation of homeobox genes

Shen, H. C. J., Rosen, J. E., Yang, L. M., Savage, S. A., Burns, A. L., Mateo, C. M., Agarwal, S. K., Chandrasekharappa, S. C., Spiegel, A. M., Collins, F. S., Marx, S. J. & Libutti, S. K., Mar 1 2008, In : Endocrine-Related Cancer. 15, 1, p. 267-275 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2007

Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation

Agarwal, S. K., Impey, S., McWeeney, S., Scacheri, P. C., Collins, F. S., Goodman, R. H., Spiegel, A. M. & Marx, S. J., Feb 2007, In : Neoplasia. 9, 2, p. 101-107 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Functional effects of monoclonal antibodies to the purified amino-terminal extracellular domain of the human Ca2+ receptor

Hu, J., Reyes-Cruz, G., Goldsmith, P. K., Gantt, N. M., Miller, J. L. & Spiegel, A. M., Apr 1 2007, In : Journal of Bone and Mineral Research. 22, 4, p. 601-608 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Inherited endocrine diseases involving G proteins and G protein-coupled receptors

Spiegel, A., Dec 1 2007, Congenital Endocrinopathies: New Insights into Endocrine Diseases and Diabetes Workshop. Lorini, R., D'Annunzio, G., Maghnie, M., Loche, S. & Savage, M. (eds.). p. 133-144 12 p. (Endocrine Development; vol. 11).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Parathyroid-specific double knockout of Gq and G11 α-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+-sensing receptor

Wettschureck, N., Lee, E. A., Libutti, S. K., Offermanns, S., Robey, P. G. & Spiegel, A. M., Jan 2007, In : Molecular Endocrinology. 21, 1, p. 274-280 7 p.

Research output: Contribution to journalArticle

83 Scopus citations
89 Scopus citations

The parathyroid/pituitary variant of multiple endocrine neoplasia type 1 usually has causes other than p27Kip1 mutations

Ozawa, A., Agarwal, S. K., Mateo, C. M., Burns, A. L., Rice, T. S., Kennedy, P. A., Quigley, C. M., Simonds, W. F., Weinstein, L. S., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M. & Marx, S. J., May 2007, In : Journal of Clinical Endocrinology and Metabolism. 92, 5, p. 1948-1951 4 p.

Research output: Contribution to journalArticle

66 Scopus citations
2006

A missense mutation in the seven-transmembrane domain of the human Ca 2+ receptor converts a negative allosteric modulator into a positive allosteric modulator

Hu, J., Jiang, J., Costanzi, S., Thomas, C., Yang, W., Feyen, J. H. M., Jacobson, K. A. & Spiegel, A. M., Jul 28 2006, In : Journal of Biological Chemistry. 281, 30, p. 21558-21565 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

Genetic interactions between Drosophila melanogaster menin and Jun/Fos

Cerrato, A., Parisi, M., Anna, S. S., Missirlis, F., Guru, S., Agarwal, S., Sturgill, D., Talbot, T., Spiegel, A., Collins, F., Chandrasekharappa, S., Marx, S. & Oliver, B., Oct 1 2006, In : Developmental Biology. 298, 1, p. 59-70 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis

Scacheri, P. C., Davis, S., Odom, D. T., Crawford, G. E., Perkins, S., Halawi, M. J., Agarwal, S. K., Marx, S. J., Spiegel, A. M., Meltzer, P. S. & Collins, F. S., Apr 2006, In : PLoS genetics. 2, 4, p. 406-419 14 p., e51.

Research output: Contribution to journalArticle

152 Scopus citations

NIH research on obesity and type 2 diabetes: Providing the scientific evidence base for actions to improve health

Spiegel, A. M. & Nabel, E. G., Jan 1 2006, In : Nature Medicine. 12, 1, p. 67-69 3 p.

Research output: Contribution to journalComment/debate

10 Scopus citations
2005

A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+

Hu, J., McLarnon, S. J., Mora, S., Jiang, J., Thomas, C., Jacobson, K. A. & Spiegel, A. M., Feb 11 2005, In : Journal of Biological Chemistry. 280, 6, p. 5113-5120 8 p.

Research output: Contribution to journalArticle

74 Scopus citations

Executive summary of the Strategic Plan for National Institutes of Health Obesity Research.

Spiegel, A. M. & Alving, B. M., Jul 2005, In : The American journal of clinical nutrition. 82, 1 Suppl, p. 211S-214S

Research output: Contribution to journalArticle

35 Scopus citations

Gland size is associated with changes in gene expression profiles in sporadic parathyroid adenomas

Rosen, J. E., Costouros, N. G., Lorang, D., Lee Burns, A., Alexander, H. R., Skarulis, M. C., Cochran, C., Pingpank, J. F., Marx, S. J., Spiegel, A. M. & Libutti, S. K., May 1 2005, In : Annals of Surgical Oncology. 12, 5, p. 1-5 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Menin molecular interactions: Insights into normal functions and tumorigenesis

Agarwal, S. K., Kennedy, P. A., Scacheri, P. C., Novotny, E. A., Hickman, A. B., Cerrato, A., Rice, T. S., Moore, J. B., Rao, S., Ji, Y., Mateo, C., Libutti, S. K., Oliver, B., Chandrasekharappa, S. C., Burns, A. L., Collins, F. S., Spiegel, A. M. & Marx, S. J., Jun 1 2005, In : Hormone and Metabolic Research. 37, 6, p. 369-374 6 p.

Research output: Contribution to journalReview article

98 Scopus citations

National Institutes of Health Consensus Development Conference statement on Celiac Disease, June 28-30, 2004

Elson, C. O., Ballew, M., Barnard, J. A., Bernstein, S. J., Check, I. J., Cohen, M. B., Fazio, S., Johanson, J. F., Lindor, N. M., Montgomery, E., Richardson, L. H., Rogers, D., Vijan, S., Bushara, K. O., Case, S., Catassi, C., Ciclitira, P. J., Collin, P., Cranney, A., Eisenbarth, G. S. & 38 others, Fasano, A., Green, P. H. R., Hill, I. D., Hoffenberg, E. J., Kagnoff, M. F., Kelly, C. P., Kupper, C., Murray, J. A., Pietzak, M. M., Rewers, M. J., Rostom, A., Zone, J. J., James, S. P., Atkins, D., Bray, E. A., Everhart, J., Gallo-Torres, H., Grave, G. D., Hamilton, F. A., Hubbard, V. S., Kramer, B. S., Marciel, K. K., Monarch, E., Nerurkar, L. S., Patrias, K., Pennington, J., Rossi, S., Rothermel, A., Siegel, J. N., Spence, J. T., Willard, C., Wilson, W., Spiegel, A. M., Crawford, L. M., Veneman, A. M., Alexander, D., Von Eschenbach, A. C. & Fauci, A. S., Apr 1 2005, In : Gastroenterology. 128, 4, p. S1-S9

Research output: Contribution to journalEditorial

124 Scopus citations

Obesity on the brain

Spiegel, A., Nabel, E., Volkow, N., Landis, S. & Li, T. K., May 1 2005, In : Nature Neuroscience. 8, 5, p. 552-553 2 p.

Research output: Contribution to journalEditorial

27 Scopus citations
2004

Autosomal dominant hypocalcemia in monozygotic twins caused by a de novo germline mutation near the amino-terminus of the human calcium receptor

Hu, J., Mora, S., Weber, G., Zamproni, I., Proverbio, M. C. & Spiegel, A. M., Apr 1 2004, In : Journal of Bone and Mineral Research. 19, 4, p. 578-586 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Focus on hereditary endocrine neoplasia

Spiegel, A. M., Oct 1 2004, In : Cancer Cell. 6, 4, p. 327-332 6 p.

Research output: Contribution to journalReview article

7 Scopus citations

Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1

Scacheri, P. C., Crabtree, J. S., Kennedy, A. L., Swain, G. P., Ward, J. M., Marx, S. J., Spiegel, A. M. & Collins, F. S., Nov 1 2004, In : Mammalian Genome. 15, 11, p. 872-877 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Inherited diseases involving G proteins and G protein-coupled receptors

Spiegel, A. M. & Weinstein, L. S., Mar 19 2004, In : Annual Review of Medicine. 55, p. 27-39 13 p.

Research output: Contribution to journalReview article

187 Scopus citations

Molecular pathology of the MEN1 gene

Agarwal, S. K., Burns, A. L., Sukhodolets, K. E., Kennedy, P. A., Obungu, V. H., Hickman, A. B., Mullendore, M. E., Whitten, I., Skarulis, M. C., Simonds, W. F., Mateo, C., Crabtree, J. S., Scacheri, P. C., Ji, Y., Novotny, E. A., Garrett-Beal, L., Ward, J. M., Libutti, S. K., Alexander, H. R., Cerrato, A. & 7 others, Parisi, M. J., Anna-A, S. S., Oliver, B., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M. & Marx, S. J., Jan 1 2004, In : Annals of the New York Academy of Sciences. 1014, p. 189-198 10 p.

Research output: Contribution to journalReview article

117 Scopus citations

Pancreatic insulinomas in multiple endocrine neoplasia, type I knockout mice can develop in the absence of chromosome instability or microsatellite instability

Scacheri, P. C., Kennedy, A. L., Chin, K., Miller, M. T., Hodgson, J. G., Gray, J. W., Marx, S. J., Spiegel, A. M. & Collins, F. S., Oct 1 2004, In : Cancer research. 64, 19, p. 7039-7044 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
2003

G protein-regulated signaling dysfunction in human disease: A personal historical perspective

Spiegel, A. M., Jul 2003, In : Journal of Investigative Medicine. 51, 4, p. 192-193 2 p.

Research output: Contribution to journalEditorial

108 Scopus citations

Of mice and MEN1: Insulinomas in a conditional mouse knockout

Crabtree, J. S., Scacheri, P. C., Ward, J. M., McNally, S. R., Swain, G. P., Montagna, C., Hager, J. H., Hanahan, D., Edlund, H., Magnuson, M. A., Garrett-Beal, L., Burns, A. L., Ried, T., Chandrasekharappa, S. C., Marx, S. J., Spiegel, A. M. & Collins, F. S., Sep 1 2003, In : Molecular and cellular biology. 23, 17, p. 6075-6085 11 p.

Research output: Contribution to journalArticle

160 Scopus citations

Parathyroid Gland-specific Deletion of the Mouse Men1 Gene Results in Parathyroid Neoplasia and Hypercalcemic Hyperparathyroidism

Libutti, S. K., Crabtree, J. S., Lorang, D., Burns, A. L., Mazzanti, C., Hewitt, S. M., O'Connor, S., Ward, J. M., Emmert-Buck, M. R., Remaley, A., Miller, M., Turner, E., Alexander, H. R., Arnold, A., Marx, S. J., Collins, F. S. & Spiegel, A. M., Nov 15 2003, In : Cancer Research. 63, 22, p. 8022-8028 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene

Sukhodolets, K. E., Hickman, A. B., Agarwal, S. K., Sukhodolets, M. V., Obungu, V. H., Novotny, E. A., Crabtree, J. S., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M., Burns, A. L. & Marx, S. J., Jan 1 2003, In : Molecular and cellular biology. 23, 2, p. 493-509 17 p.

Research output: Contribution to journalArticle

99 Scopus citations

Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter

Agarwal, S. K., Novotny, E. A., Crabtree, J. S., Weitzman, J. B., Yaniv, M., Burns, A. L., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M. & Marx, S. J., Sep 16 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 19, p. 10770-10775 6 p.

Research output: Contribution to journalArticle

96 Scopus citations

β-arrestin - Not just for G protein-coupled receptors

Spiegel, A., Sep 5 2003, In : Science. 301, 5638, p. 1338-1339 2 p.

Research output: Contribution to journalReview article

12 Scopus citations
2002

Autosomal Dominant Hypocalcemia Caused by a Novel Mutation in the Loop 2 Region of the Human Calcium Receptor Extracellular Domain

Hu, J., Mora, S., Colussi, G., Proverbio, M. C., Jones, K. A., Bolzoni, L., De Ferrari, M. E., Civati, G. & Spiegel, A. M., Jan 1 2002, In : Journal of Bone and Mineral Research. 17, 8, p. 1461-1469 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Hyperparathyroidism in hereditary syndromes: Special expressions and special managements

Marx, S. J., Simonds, W. F., Agarwal, S. K., Burns, A. L., Weinstein, L. S., Cochran, C., Skarulis, M. C., Spiegel, A. M., Libutti, S. K., Alexander, H. R., Chen, C. C., Chang, R., Chandrasekharappa, S. C. & Collins, F. S., Nov 1 2002, In : Journal of Bone and Mineral Research. 17, SUPPL. 2, p. N37-N43

Research output: Contribution to journalArticle

129 Scopus citations
79 Scopus citations
2001

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

Crabtree, J. S., Scacheri, P. C., Ward, J. M., Garrett-Beal, L., Emmert-Buck, M. R., Edgemon, K. A., Lorang, D., Libutti, S. K., Chandrasekharappa, S. C., Marx, S. J., Spiegel, A. M. & Collins, F. S., Jan 30 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 3, p. 1118-1123 6 p.

Research output: Contribution to journalArticle

351 Scopus citations

Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice

Scacheri, P. C., Crabtree, J. S., Novotny, E. A., Garrett-Beal, L., Chen, A., Edgemon, K. A., Marx, S. J., Spiegel, A. M., Chandrasekharappa, S. C. & Collins, F. S., Sep 15 2001, In : Genesis. 30, 4, p. 259-263 5 p.

Research output: Contribution to journalArticle

69 Scopus citations