• 25324 Citations
  • 89 h-Index
1969 …2018
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Fingerprint Dive into the research topics where Allen M. Spiegel is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 3 Similar Profiles
GTP-Binding Proteins Medicine & Life Sciences
Multiple Endocrine Neoplasia Type 1 Medicine & Life Sciences
Adenylyl Cyclases Medicine & Life Sciences
Guanine Nucleotides Medicine & Life Sciences
Primary Hyperparathyroidism Medicine & Life Sciences
Parathyroid Hormone Medicine & Life Sciences
Parathyroid Neoplasms Medicine & Life Sciences
Mutation Medicine & Life Sciences

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Grants 1990 2014

VESTIBULAR EFFERENT CELL AND MOLECULAR BIOLOGY

Spiegel, A. M., Wackym, P. A., Morell, R., Dibello, P. & Wackym, P. A.

National Institutes of Health

7/1/91 → …

Project: Research project

Multiple Endocrine Neoplasia Type 1
National Human Genome Research Institute (U.S.)
Genes
Proteins
Drosophila
Multiple Endocrine Neoplasia Type 1
Genes
National Human Genome Research Institute (U.S.)
Proteins
Tumor Suppressor Genes
Calcium-Sensing Receptors
Calcium
GTP-Binding Proteins
G-Protein-Coupled Receptors
Monoclonal Antibodies
Stem Cell Research
Stem Cells
Translational Medical Research
Research Personnel
Research
Facility Design and Construction
Communicable Diseases
Translational Medical Research
Genomics
Mycobacterium tuberculosis

Publications 1969 2018

A double negative: Inhibition of hepatic gi signaling improves glucose homeostasis

Spiegel, A. M., Feb 1 2018, In : Journal of Clinical Investigation. 128, 2, p. 567-569 3 p.

Research output: Contribution to journalReview article

Homeostasis
Glucose
Liver
Glucagon
Hepatocytes
15 Citations (Scopus)

Allosteric modulation of the calcium-sensing receptor rectifies signaling abnormalities associated with G-protein α-11 mutations causing hypercalcemic and hypocalcemic disorders

Babinsky, V. N., Hannan, F. M., Gorvin, C. M., Howles, S. A., Nesbit, M. A., Rust, N., Hanyaloglu, A. C., Hu, J., Spiegel, A. M. & Thakker, R. V., May 13 2016, In : Journal of Biological Chemistry. 291, 20, p. 10876-10885 10 p.

Research output: Contribution to journalArticle

Calcium-Sensing Receptors
GTP-Binding Proteins
Modulation
Mutation
Phosphorylation

Foreword

Spiegel, A. M., Jan 1 2015, In : Unknown Journal. p. v-vi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Research in academic medical centers: Two threats to sustainable support

Levine, A. S., Alpern, R. J., Andrews, N. C., Antman, K., Balser, J. R., Berg, J. M., Davis, P. B., Fitz, J. G., Golden, R. N., Goldman, L., Jameson, J. L., Lee, V. S., Polonsky, K. S., Rappley, M. D., Reece, E. A., Rothman, P. B., Schwinn, D. A., Shapiro, L. J. & Spiegel, A. M., May 27 2015, In : Science Translational Medicine. 7, 289, 289fs22.

Research output: Contribution to journalArticle

Clinical Medicine
Biomedical Research
Research
27 Citations (Scopus)

The calcilytic agent NPS 2143 rectifies hypocalcemia in a mouse model with an activating calcium-sensing receptor (CaSR) mutation: Relevance to autosomal dominant hypocalcemia type 1 (ADH1)

Hannan, F. M., Walls, G. V., Babinsky, V. N., Nesbit, M. A., Kallay, E., Hough, T. A., Fraser, W. D., Cox, R. D., Hu, J., Spiegel, A. M. & Thakker, R. V., Sep 1 2015, In : Endocrinology. 156, 9, p. 3114-3121 8 p.

Research output: Contribution to journalArticle

Calcium-Sensing Receptors
Hypocalcemia
Calcium
Mutation
HEK293 Cells