Projects per year
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- 3 Similar Profiles
GTP-Binding Proteins
Medicine & Life Sciences
Multiple Endocrine Neoplasia Type 1
Medicine & Life Sciences
Adenylyl Cyclases
Medicine & Life Sciences
Guanine Nucleotides
Medicine & Life Sciences
Primary Hyperparathyroidism
Medicine & Life Sciences
Parathyroid Hormone
Medicine & Life Sciences
Parathyroid Neoplasms
Medicine & Life Sciences
Hyperparathyroidism
Medicine & Life Sciences
Network
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Grants 1990 2014
VESTIBULAR EFFERENT CELL AND MOLECULAR BIOLOGY
Spiegel, A. M., Wackym, P. A., Morell, R., Dibello, P. & Wackym, P. A.
7/1/91 → …
Project: Research project
Multiple Endocrine Neoplasia Type 1
National Human Genome Research Institute (U.S.)
Genes
Proteins
Drosophila
STUDIES ON A CALCIUM SENSING RECEPTOR
Project: Research project
Calcium-Sensing Receptors
Calcium
GTP-Binding Proteins
G-Protein-Coupled Receptors
Monoclonal Antibodies
STRUCTURE ANS FUNCTION OF THE MEN1 GENE AND ITS PROTEIN PRODUCT, MENIN
Project: Research project
Multiple Endocrine Neoplasia Type 1
Genes
National Human Genome Research Institute (U.S.)
Proteins
Tumor Suppressor Genes
Stem Cell Research
Stem Cells
Translational Medical Research
Research Personnel
Research
PAR04-122 Extramural Research Facilities Construction C*
Spiegel, A. M. & Purpura, D.
9/22/05 → 6/30/10
Project: Research project
Facility Design and Construction
Communicable Diseases
Translational Medical Research
Genomics
Mycobacterium tuberculosis
Publications 1969 2018
A double negative: Inhibition of hepatic gi signaling improves glucose homeostasis
Spiegel, A. M., Feb 1 2018, In : Journal of Clinical Investigation. 128, 2, p. 567-569 3 p.Research output: Contribution to journal › Review article
Homeostasis
Glucose
Liver
Glucagon
Hepatocytes
15
Citations
(Scopus)
Allosteric modulation of the calcium-sensing receptor rectifies signaling abnormalities associated with G-protein α-11 mutations causing hypercalcemic and hypocalcemic disorders
Babinsky, V. N., Hannan, F. M., Gorvin, C. M., Howles, S. A., Nesbit, M. A., Rust, N., Hanyaloglu, A. C., Hu, J., Spiegel, A. M. & Thakker, R. V., May 13 2016, In : Journal of Biological Chemistry. 291, 20, p. 10876-10885 10 p.Research output: Contribution to journal › Article
Calcium-Sensing Receptors
GTP-Binding Proteins
Modulation
Mutation
Phosphorylation
Foreword
Spiegel, A. M., Jan 1 2015, In : Unknown Journal. p. v-viResearch output: Contribution to journal › Article
9
Citations
(Scopus)
Research in academic medical centers: Two threats to sustainable support
Levine, A. S., Alpern, R. J., Andrews, N. C., Antman, K., Balser, J. R., Berg, J. M., Davis, P. B., Fitz, J. G., Golden, R. N., Goldman, L., Jameson, J. L., Lee, V. S., Polonsky, K. S., Rappley, M. D., Reece, E. A., Rothman, P. B., Schwinn, D. A., Shapiro, L. J. & Spiegel, A. M., May 27 2015, In : Science Translational Medicine. 7, 289, 289fs22.Research output: Contribution to journal › Article
Clinical Medicine
Biomedical Research
Research
26
Citations
(Scopus)
The calcilytic agent NPS 2143 rectifies hypocalcemia in a mouse model with an activating calcium-sensing receptor (CaSR) mutation: Relevance to autosomal dominant hypocalcemia type 1 (ADH1)
Hannan, F. M., Walls, G. V., Babinsky, V. N., Nesbit, M. A., Kallay, E., Hough, T. A., Fraser, W. D., Cox, R. D., Hu, J., Spiegel, A. M. & Thakker, R. V., Sep 1 2015, In : Endocrinology. 156, 9, p. 3114-3121 8 p.Research output: Contribution to journal › Article
Calcium-Sensing Receptors
Hypocalcemia
Calcium
Mutation
HEK293 Cells