• 25862 Citations
  • 89 h-Index
1969 …2019

Research output per year

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Publications

1997

Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region

Manickam, P., Guru, S. C., Debelenko, L. V., Agarwal, S. K., Olufemi, S. E., Weisemann, J. M., Boguski, M. S., Crabtree, J. S., Wang, Y., Roe, B. A., Lubensky, I. A., Zhuang, Z., Rester, M. B., Burns, A. L., Spiegel, A. M., Marx, S. J., Liotta, L. A., Emmert-Buck, M. R., Collins, F. S. & Chandrasekharappa, S. C., Dec 1 1997, In : Human Genetics. 101, 1, p. 102-108 7 p.

Research output: Contribution to journalArticle

55 Scopus citations

Fibrous dysplasia of bone in the McCune-Albright syndrome: Abnormalities in bone formation

Riminucci, M., Fisher, L. W., Shenker, A., Spiegel, A. M., Bianco, P. & Robey, P. G., Dec 1 1997, In : American Journal of Pathology. 151, 6, p. 1587-1600 14 p.

Research output: Contribution to journalArticle

186 Scopus citations

Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states

Agarwal, S. K., Kester, M. B., Debelenko, L. V., Heppner, C., Emmert-Buck, M. R., Skarulis, M. C., Doppman, J. L., Kim, Y. S., Lubensky, I. A., Zhuang, Z., Green, J. S., Guru, S. C., Manickam, P., Olufemi, S. E., Liotta, L. A., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M., Lee Burns, A. & Marx, S. J., Jul 1 1997, In : Human molecular genetics. 6, 7, p. 1169-1175 7 p.

Research output: Contribution to journalArticle

385 Scopus citations

Haplotype analysis defines a minimal interval for the multiple endocrine neoplasia type 1 (MEN1) gene

Debelenko, L. V., Emmert-Buck, M. R., Manickam, P., Kester, M., Guru, S. C., DiFranco, E. M., Olufemi, S. E., Agarwal, S., Lubensky, I. A., Zhuang, Z., Lee Burns, A., Spiegel, A. M., Liotta, L. A., Collins, F. S., Marx, S. J. & Chandrasekharappa, S. C., Apr 9 1997, In : Cancer Research. 57, 6, p. 1039-1042 4 p.

Research output: Contribution to journalArticle

40 Scopus citations

Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung

Debelenko, L. V., Brambilla, E., Agarwal, S. K., Swalwell, J. I., Kester, M. B., Lubensky, I. A., Zhuang, Z., Guru, S. C., Manickam, P., Olufemi, S. E., Chandrasekharappa, S. C., Crabtree, J. S., Kirn, Y. S., Heppner, C., Burns, A. L., Spiegel, A. M., Marx, S. J., Liotta, L. A., Collins, F. S., Travis, W. D. & 1 others, Emmert-Buck, M. R., Dec 1997, In : Human molecular genetics. 6, 13, p. 2285-2290 6 p.

Research output: Contribution to journalArticle

Open Access
223 Scopus citations
39 Scopus citations

Localization of the multiple endocrine neoplasia type I (MEN1) gene based on tumor loss of heterozygosity analysis

Emmert-Buck, M. R., Lubensky, I. A., Dong, Q., Manickam, P., Guru, S. C., Kester, M. B., Olufemi, S. E., Agarwal, S., Burns, A. L., Spiegel, A. M., Collins, F. S., Marx, S. J., Zhuang, Z., Liotta, L. A., Chandrasekharappa, S. C. & Debelenko, L. V., May 15 1997, In : Cancer Research. 57, 10, p. 1855-1858 4 p.

Research output: Contribution to journalArticle

72 Scopus citations

Loss of heterozygosity at 11q13: Analysis of pituitary tumors, lung carcinoids, lipomas, and other uncommon tumors in subjects with familial multiple endocrine neoplasia type 1

Dong, Q., Debelenko, L. V., Chandrasekharappa, S. C., Emmert-Buck, M. R., Zhuang, Z., Guru, S. C., Manickam, P., Skarulis, M., Lubensky, I. A., Liotta, L. A., Collins, F. S., Marx, S. J. & Spiegel, A. M., Jan 1 1997, In : Journal of Clinical Endocrinology and Metabolism. 82, 5, p. 1416-1420 5 p.

Research output: Contribution to journalArticle

Open Access
113 Scopus citations
43 Scopus citations

Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1

Darling, T. N., Skarulis, M. C., Steinberg, S. M., Marx, S. J., Spiegel, A. M. & Turner, M., Aug 22 1997, In : Archives of Dermatology. 133, 7, p. 853-857 5 p.

Research output: Contribution to journalArticle

235 Scopus citations

Mutational analysis of the carboxyl-terminal region of the human calcium-sensing receptor

Ray, K., Fan, G. F., Goldsmith, P. K. & Spiegel, A. M., Dec 1 1997, In : FASEB Journal. 11, 9, p. A1168

Research output: Contribution to journalArticle

Mutations of the MEN1 tumor suppressor gene in pituitary tumors

Zhuang, Z., Ezzat, S. Z., Vortmeyer, A. O., Weil, R., Oldfield, E. H., Park, W. S., Pack, S., Huang, S., Agarwal, S. K., Guru, S. C., Manickam, P., Debelenko, L. V., Kester, M. B., Olufemi, S. E., Heppner, C., Crabtree, J. S., Burns, A. L., Spiegel, A. M., Marx, S. J., Chandrasekharappa, S. C. & 5 others, Collins, F. S., Emmert-Buck, M. R., Liotta, L. A., Asa, S. L. & Lubensky, I. A., Dec 15 1997, In : Cancer Research. 57, 24, p. 5446-5451 6 p.

Research output: Contribution to journalArticle

205 Scopus citations

N-linked glycosylation of the human Ca2+ receptor is essential for its expression at the cell surface

Fan, G., Goldsmith, P. K., Collins, R., Dunn, C. K., Krapcho, K. J., Rogers, K. V. & Spiegel, A. M., Jan 1 1997, In : Endocrinology. 138, 5, p. 1916-1922 7 p.

Research output: Contribution to journalArticle

Open Access
73 Scopus citations

Positional cloning of the gene for multiple endocrine neoplasia-type 1

Chandrasekharappa, S. C., Guru, S. C., Manickam, P., Olufemi, S. E., Collins, F. S., Emmert-Buck, M. R., Debelenko, L. V., Zhuang, Z., Lubensky, I. A., Liotta, L. A., Crabtree, J. S., Wang, Y., Roe, B. A., Weisemann, J., Boguski, M. S., Agarwal, S. K., Kester, M. B., Kim, Y. S., Heppner, C., Dong, Q. & 3 others, Spiegel, A. M., Burns, A. L. & Marx, S. J., Apr 18 1997, In : Science. 276, 5311, p. 404-406 3 p.

Research output: Contribution to journalArticle

1528 Scopus citations

Somatic mutation of the MEN1 gene in parathyroid tumours

Heppner, C., Kester, M. B., Agarwal, S. K., Debelenko, L. V., Emmert-Buck, M. R., Guru, S. C., Manickam, P., Olufemi, S. E., Skarulis, M. C., Doppman, J. L., Alexander, R. H., Kim, Y. S., Saggar, S. K., Lubensky, I. A., Zhuang, Z., Liotta, L. A., Chandrasekharappa, S. C., Collins, F. S., Spiegel, A. M., Burns, A. L. & 1 others, Marx, S. J., Aug 14 1997, In : Nature Genetics. 16, 4, p. 375-378 4 p.

Research output: Contribution to journalArticle

339 Scopus citations

Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas

Zhuang, Z., Vortmeyer, A. O., Pack, S., Huang, S., Pham, T. A., Wang, C., Park, W. S., Agarwal, S. K., Debelenko, L. V., Kester, M. B., Guru, S. C., Manickam, P., Olufemi, S. E., Yu, F., Heppner, C., Crabtree, J. S., Skarulis, M. C., Venzon, D. J., Emmert-Buck, M. R., Spiegel, A. M. & 7 others, Chandrasekharappa, S. C., Collins, F. S., Burns, A. L., Marx, S. J., Jensen, R. T., Liotta, L. A. & Lubensky, I. A., Nov 1 1997, In : Cancer Research. 57, 21, p. 4682-4686 5 p.

Research output: Contribution to journalArticle

255 Scopus citations

Sporadic hypoparathyroidism caused by de novo gain-of-function mutations of the Ca2+-sensing receptor

De Luca, F., Ray, K., Mancilla, E. E., Fan, G. F., Winer, K. K., Gore, P., Spiegel, A. M. & Baron, J., Aug 22 1997, In : Journal of Clinical Endocrinology and Metabolism. 82, 8, p. 2710-2715 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

The carboxyl terminus of the human calcium receptor. Requirements for cell-surface expression and signal transduction

Ray, K., Fan, G. F., Goldsmith, P. K. & Spiegel, A. M., Dec 12 1997, In : Journal of Biological Chemistry. 272, 50, p. 31355-31361 7 p.

Research output: Contribution to journalArticle

105 Scopus citations

The Molecular Basis of Disorders Caused by Defects in G Proteins

Spiegel, A. M., Jan 1 1997, In : Hormone Research in Paediatrics. 47, 3, p. 89-96 8 p.

Research output: Contribution to journalArticle

68 Scopus citations

The role of thyroid resection during reoperation for persistent or recurrent hyperparathyroidism

Libutti, S. K., Bartlett, D. L., Jaskowiak, N. T., Skarulis, M., Marx, S. J., Spiegel, A. M., Fraker, D. L., Doppman, J. L., Shawker, T. J. & Alexander, H. R., Dec 1997, In : Surgery. 122, 6, p. 1183-1188 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
1996

Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients

Lubensky, I. A., Debelenko, L. V., Zhuang, Z., Emmert-Buck, M. R., Dong, Q., Chandrasekharappa, S., Guru, S. C., Manickam, P., Olufemi, S. E., Marx, S. J., Spiegel, A. M., Collins, F. S. & Liotta, L. A., Nov 15 1996, In : Cancer Research. 56, 22, p. 5272-5278 7 p.

Research output: Contribution to journalArticle

125 Scopus citations

A prospective trial evaluating a standard approach to reoperation for missed parathyroid adenoma

Jaskowiak, N., Norton, J. A., Richard Alexander, H., Doppman, J. L., Shawker, T., Skarulis, M., Marx, S., Spiegel, A. & Fraker, D. L., Sep 26 1996, In : Annals of surgery. 224, 3, p. 308-322 15 p.

Research output: Contribution to journalArticle

177 Scopus citations

Defects in G protein-coupled signal transduction in human disease

Spiegel, A. M., Jan 1 1996, In : Annual review of physiology. 58, p. 143-170 28 p.

Research output: Contribution to journalReview article

180 Scopus citations

Expression and functional characterization of five v2 vasopressin receptor gene mutations identified in families with x-linked nephrogenic diabetes insipidus

Wenkert, D., Schoneberg, T., Merendino, J. J., Pena, M., Vinitsky, R., Goldsmith, P. K., Wess, J. & Spiegel, A. M., Jan 1 1996, In : Journal of Investigative Medicine. 44, 3, p. 225a

Research output: Contribution to journalArticle

1 Scopus citations

Functional characterization of five V2 vasopressin receptor gene mutations

Wenkert, D., Schoneberg, T., Merendino, J. J., Rodriguez Pena, M. S., Vinitsky, R., Goldsmith, P. K., Wess, J. & Spiegel, A. M., Nov 29 1996, In : Molecular and Cellular Endocrinology. 124, 1-2, p. 43-50 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

In vitro and in vivo growth inhibition of murine melanoma K-1735 cells by a dominant negative mutant α subunit of the Gi2 protein

Hermouet, S., Aznavoorian, S. & Spiegel, A. M., Mar 1996, In : Cellular Signalling. 8, 3, p. 159-166 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Mutations in G proteins and G protein-coupled receptors in endocrine disease

Spiegel, A. M., Aug 1 1996, In : Journal of Clinical Endocrinology and Metabolism. 81, 7, p. 2434-2442 9 p.

Research output: Contribution to journalReview article

119 Scopus citations

Parathyroid adenomas in the aortopulmonary window

Doppman, J. L., Skarulis, M. C., Chen, C. C., Chang, R., Pass, H. I., Fraker, D. L., Alexander, H. R., Niederle, B., Marx, S. J., Norton, J. A., Wells, S. A. & Spiegel, A. M., Nov 1996, In : RADIOLOGY. 201, 2, p. 456-462 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Screening of Candidate Oncogenes in Human Thyrotroph Tumors: Absence of Activating Mutations of the Gαq, Gα11, Gαs, or Thyrotropin-Releasing Hormone Receptor Genes

Dong, Q., Brucker-Davis, F., Weintraub, B. D., Smallridge, R. C., Carr, F. E., Battey, J., Spiegel, A. M. & Shenker, A., Dec 1 1996, In : Journal of Clinical Endocrinology and Metabolism. 81, 3, p. 1134-1140 7 p.

Research output: Contribution to journalArticle

66 Scopus citations
1995

Expression of g protein alpha-subunits in bovine parathyroid

Varrault, A., Pena, M. S. R., Goldsmith, P. K., Mithal, A., Brown, E. M. & Spiegel, A. M., Oct 1995, In : Endocrinology. 136, 10, p. 4390-4396 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

G protein gene knockout hits the gut

Spiegel, A. M., Jun 1995, In : Nature Medicine. 1, 6, p. 522-524 3 p.

Research output: Contribution to journalComment/debate

5 Scopus citations

High cervical intravagal hypercellular parathyroid gland as the etiology of severe persistent primary hyperparathyroidism

Buell, J. F., Fraker, D. L., Doppman, J. L., Shawker, T. H., Skarulis, M. C., Spiegel, A. M., Marx, S. J. & Alexander, H. R., Dec 1 1995, In : American Surgeon. 61, 11, p. 943-946 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Molecular cloning of human Gαq cDNA and chromosomal localization of the Gαq gene (GNAQ) and a processed pseudogene

Dong, Q., Shenker, A., Way, J., Haddad, B. R., Lin, K., Hughes, M. R., McBride, O. W., Spiegel, A. M. & Battey, J., Dec 10 1995, In : Genomics. 30, 3, p. 470-475 6 p.

Research output: Contribution to journalArticle

26 Scopus citations

Osteoblastic cells derived fronm isolated lesions of fibrous dysplasia contain activating somatic mutatuions of thje gsα gene

Shenker, A., Chanson, P., Welnstein, L. S., Chi, P., Spiegel, A. M., Lomri, A. & Marie, P. J., Sep 1 1995, In : Human molecular genetics. 4, 9, p. 1675-1676 2 p.

Research output: Contribution to journalComment/debate

62 Scopus citations

Tc-99m sestamibi imaging of a hyperfunctioning parathyroid autograft with Doppler ultrasound and MRI correlation

Chen, C. C., Premkumar, A., Hill, S. C., Skarulis, M. C. & Spiegel, A. M., Mar 21 1995, In : Clinical nuclear medicine. 20, 3, p. 222-225 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Technetium-99m-sestamibi imaging before reoperation for primary hyperparathyroidism

Chen, C. C., Skarulis, M. C., Fraker, D. L., Alexander, H. R., Marx, S. J. & Spiegel, A. M., Jan 1 1995, In : Journal of Nuclear Medicine. 36, 12, p. 2186-2191 6 p.

Research output: Contribution to journalArticle

79 Scopus citations
1994

An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome

Shenker, A., Weinstein, L. S., Sweet, D. E. & Spiegel, A. M., Sep 1994, In : Journal of Clinical Endocrinology and Metabolism. 79, 3, p. 750-755 6 p.

Research output: Contribution to journalArticle

195 Scopus citations

Down-regulation of parathyroid (PTH)/PTH-related peptide receptor immunoreactivity and PTH binding in opossum kidney cells by PTH and dexamethasone

Abou-Samra, A. B., Goldsmith, P. K., Xie, L. Y., Jüppner, H., Spiegel, A. M. & Segre, G. V., Dec 1994, In : Endocrinology. 135, 6, p. 2588-2594 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

G(q) - and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following α1-adrenergic stimulation

LaMorte, V. J., Thorburn, J., Absher, D., Spiegel, A., Brown, J. H., Chien, K. R., Feramisco, J. R. & Knowlton, K. U., Jan 1 1994, In : Journal of Biological Chemistry. 269, 18, p. 13490-13496 7 p.

Research output: Contribution to journalArticle

157 Scopus citations

Localization and operative management of undescended parathyroid adenomas in patients with persistent primary hyperparathyroidism

Billingsley, K. G., Fraker, D. L., Doppman, J. L., Norton, J. A., Shawker, T. H., Skarulis, M. C., Marx, S. J., Spiegel, A. M. & Alexander, H. R., Dec 1994, In : Surgery. 116, 6, p. 982-990 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Novel mutations in the V2 vasopressin receptor gene of patients with X-linked nephrogenic diabetes insipidus

Wenkert, D., Merendino, J. J., Shenker, A., Thambl, N., Robertson, G. L., Moses, A. M. & Spiegel, A. M., Aug 1 1994, In : Human molecular genetics. 3, 8, p. 1429-1430 2 p.

Research output: Contribution to journalComment/debate

32 Scopus citations

Palmitoylation of a G protein α(i) subunit requires membrane localization not myristoylation

Degtyarev, M. Y., Spiegel, A. M. & Jones, T. L. Z., Jan 1 1994, In : Journal of Biological Chemistry. 269, 49, p. 30898-30903 6 p.

Research output: Contribution to journalArticle

90 Scopus citations

Parathyroid adenoma within the vagus nerve

Doppman, J. L., Shawker, T. H., Fraker, D. L., Alexander, H. R., Skarulis, M. C., Lack, E. E. & Spiegel, A. M., Jan 1 1994, In : American Journal of Roentgenology. 163, 4, p. 943-945 3 p.

Research output: Contribution to journalArticle

10 Scopus citations

The membrane localization of the G protein αs subunit is not dependent on its tenir sequence or effector domain

Degtyarev, M. Y., Spiegel, A. M. & Jones, T. L. Z., Jan 1994, In : Cellular Signalling. 6, 1, p. 25-33 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Use of preoperative fine-needle aspiration in patients undergoing reoperation for primary hyperparathyroidism

MacFarlane, M. P., Fraker, D. L., Shawker, T. H., Norton, J. A., Doppman, J. L., Chang, R. A., Skarulis, M. C., Marx, S. J., Spiegel, A. M. & Richard Alexander, H., Dec 1994, In : Surgery. 116, 6, p. 959-965 7 p.

Research output: Contribution to journalArticle

37 Scopus citations
1993

Abnormalities in G protein-coupled signal transduction pathways in human disease

Spiegel, A. M., Weinstein, L. S. & Shenker, A., Sep 1993, In : Journal of Clinical Investigation. 92, 3, p. 1119-1125 7 p.

Research output: Contribution to journalReview article

Open Access
113 Scopus citations

A Mutation in the Vasopressin V2-Receptor Gene in a Kindred with X-Linked Nephrogenic Diabetes Insipidus

Merendino, J. J., Spiegel, A. M., Crawford, J. D., O'carroll, A. M., Brownstein, M. J. & Lolait, S. J., May 27 1993, In : New England Journal of Medicine. 328, 21, p. 1538-1541 4 p.

Research output: Contribution to journalArticle

59 Scopus citations

Baculovirus expression and purification of a soluble, mutant g-protein α subunit

Jones, T. L. Z., Woodard, C. & Spiegel, A. M., Feb 1993, In : Protein Expression and Purification. 4, 1, p. 64-71 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Biochemical and immunochemical localization of GTP-binding proteins in the rat ileal enterocyte

Pamukcu, R., Spiegel, A. M. & Chang, E. B., May 1993, In : The Journal of Laboratory and Clinical Medicine. 121, 5, p. 689-696 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Gerald D. Aurbach, 1927-1991

Spiegel, A. M., Dec 1 1993, In : Vitamins and Hormones. 47, C, p. xi-xii

Research output: Contribution to journalArticle