• 25862 Citations
  • 89 h-Index
1969 …2019

Research output per year

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Publications

1987

Human cDNA clones for an α subunit of G(i) signal-transduction protein

Bray, P., Carter, A., Guo, V., Puckett, C., Kamholz, J., Spiegel, A. & Nirenberg, M., Jan 1 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 15, p. 5115-5119 5 p.

Research output: Contribution to journalArticle

Open Access
57 Scopus citations

Immunoelectron microscopic localization of photoreceptor-specific markers in the monkey retina

Rodrigues, M., Hackett, J., Wiggert, B., Gery, I., Spiegel, A., Krishna, G., Stein, P. & Chader, G., Jan 1 1987, In : Current Eye Research. 6, 2, p. 369-380 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Insulin-like growth factor I receptors in retinal rod outer segments.

Zick, Y., Spiegel, A. M. & Sagi-Eisenberg, R., Jul 25 1987, In : Journal of Biological Chemistry. 262, 21, p. 10259-10264 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Localization of mRNAs encoding the α-subunits of signal-transducing G-proteins within rat brain and among peripheral tissues

Brann, M. R., Collins, R. M. & Spiegel, A., Sep 28 1987, In : FEBS Letters. 222, 1, p. 191-198 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

Localization of parathyroid adenomas in patients who have undergone surgery. Part I. Noninvasive imaging methods

Miller, D. L., Doppman, J. L., Shawker, T. H., Krudy, A. G., Norton, J. A., Vucich, J. J., Morrish, K. A., Marx, S. J., Spiegel, A. M. & Aurbach, G. D., Jan 1 1987, In : RADIOLOGY. 162, 1, p. 133-137 5 p.

Research output: Contribution to journalArticle

97 Scopus citations

Localization of parathyroid adenomas in patients who have undergone surgery. Part II. Invasive procedures

Miller, D. L., Doppman, J. L., Krudy, A. G., Shawker, T. H., Norton, J. A., Vucich, J. J., Morrish, K. A., Marx, S. J., Spiegel, A. M. & Aurbach, G. D., Jan 1 1987, In : RADIOLOGY. 162, 1, p. 138-141 4 p.

Research output: Contribution to journalArticle

44 Scopus citations

Purification and immunochemical characterization of the major pertussis‐toxin‐sensitive guanine‐nucleotide‐binding protein of bovine‐neutrophil membranes

GIERSCHIK, P., SIDIROPOULOS, D., SPIEGEL, A. & JAKOBS, K. H., May 1987, In : European Journal of Biochemistry. 165, 1, p. 185-194 10 p.

Research output: Contribution to journalArticle

58 Scopus citations

Reduced expression of multiple forms of the alpha subunit of the stimulatory GTP-binding protein in pseudohypoparathyroidism type Ia.

Carter, A., Bardin, C., Collins, R., Simons, C., Bray, P. & Spiegel, A., Oct 1987, In : Proceedings of the National Academy of Sciences of the United States of America. 84, 20, p. 7266-7269 4 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations

Signal transduction by guanine nucleotide binding proteins

Spiegel, A. M., Jan 1987, In : Molecular and Cellular Endocrinology. 49, 1, p. 1-16 16 p.

Research output: Contribution to journalReview article

221 Scopus citations

The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein

Senogles, S. E., Benovic, J. L., Amlaiky, N., Unson, C., Milligan, G., Vinitsky, R., Spiegel, A. M. & Caron, M. G., Jan 1 1987, In : Journal of Biological Chemistry. 262, 10, p. 4860-4867 8 p.

Research output: Contribution to journalArticle

108 Scopus citations

The use of high-resolution ultrasound to locate parathyroid tumors during reoperations for primary hyperparathyroidism

Kern, K. A., Shawker, T. H., Doppman, J. L., Miller, D. L., Marx, S. J., Spiegel, A. M., Aurbach, G. D. & Norton, J. A., Oct 1 1987, In : World Journal of Surgery. 11, 5, p. 579-585 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

The use of specific antibodies to identify and quantify guanine nucleotide-binding proteins

Milligan, G., Gierschik, P. & Spiegel, A. M., Jan 1 1987, In : Biochemical Society transactions. 15, 1, p. 42-45 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Tissue-Specific Regulation of GTP-Binding Protein and Muscarinic Acetylcholine Receptor Levels during Cardiac Development

Luetje, C. W., Nathanson, N. M., Gierschik, P., Milligan, G., Unson, C. & Spiegel, A., Jan 1 1987, In : Biochemistry. 26, 15, p. 4876-4884 9 p.

Research output: Contribution to journalArticle

25 Scopus citations
1986
117 Scopus citations

Changes in the guanine nucleotide-binding proteins, Gi and go, during differentiation of 3T3-L1 cells

Gierschik, P., Morrow, B., Milligan, G., Rubin, C. & Spiegel, A., Apr 7 1986, In : FEBS Letters. 199, 1, p. 103-106 4 p.

Research output: Contribution to journalArticle

34 Scopus citations

Detection of the major pertussis toxin substrate of human leukocytes with antisera raised against synthetic peptides

Falloon, J., Malech, H., Milligan, G., Unson, C., Kahn, R., Goldsmith, P. & Spiegel, A., Dec 15 1986, In : FEBS Letters. 209, 2, p. 352-356 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

Detection of α-transducin in retinal rods but not cones

Grunwald, G. B., Gierschik, P., Nirenberg, M. & Spiegel, A., Jan 1 1986, In : Science. 231, 4740, p. 856-859 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

Effects of phorbol esters and pertussis toxin on agonist-stimulated cyclic AMP production in rat osteosarcoma cells

Pines, M., Santora, A. & Spiegel, A., Oct 15 1986, In : Biochemical Pharmacology. 35, 20, p. 3639-3641 3 p.

Research output: Contribution to journalArticle

19 Scopus citations

Functional reconstitution of the α2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles

Cerione, R. A., Regan, J. W., Nakata, H., Codina, J., Benovic, J. L., Gierschik, P., Somers, R. L., Spiegel, A. M., Birnbaumer, L. & Lefkowitz, R. J., Dec 1 1986, In : Journal of Biological Chemistry. 261, 8, p. 3901-3909 9 p.

Research output: Contribution to journalArticle

122 Scopus citations

Human cDNA clones for four species of G(α(s)) signal transduction protein

Bray, P., Carter, A., Simons, C., Guo, V., Puckett, C., Kamholz, J., Spiegel, A. & Nirenberg, M., Jan 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 23, p. 8893-8897 5 p.

Research output: Contribution to journalArticle

Open Access
269 Scopus citations

Immunochemical Detection of Guanine Nucleotide Binding Proteins Mono-ADP-ribosylated by Bacterial Toxins

Eide, B., Gierschik, P. & Spiegel, A., Oct 1986, In : Biochemistry. 25, 21, p. 6711-6715 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Immunochemical evidence for a novel pertussis toxin substrate in human neutrophils

Gierschik, P., Falloon, J., Milligan, C., Pines, M., Gallin, J. I. & Spiegel, A., Dec 1 1986, In : Journal of Biological Chemistry. 261, 17, p. 8058-8062 5 p.

Research output: Contribution to journalArticle

68 Scopus citations

Intraoperative ultrasound and reoperative parathyroid surgery: An initial evaluation

Norton, J. A., Shawker, T. H., Jones, B. L., Spiegel, A. M., Marx, S. J., Fitzpatrick, L., Aurbach, G. D. & Doppman, J. L., Aug 1 1986, In : World Journal of Surgery. 10, 4, p. 631-638 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system

Cerione, R. A., Staniszewski, C., Gierschik, P., Codina, J., Somers, R. L., Birnbaumer, L., Spiegel, A. M., Caron, M. G. & Lefkowitz, R. J., Dec 1 1986, In : Journal of Biological Chemistry. 261, 20, p. 9514-9520 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Multisite phosphorylation of the α subunit of transducin by the insulin receptor kinase and protein kinase C

Zick, Y., Sagi-Eisenberg, R., Pines, M., Gierschik, P. & Spiegel, A. M., Jan 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 24, p. 9294-9297 4 p.

Research output: Contribution to journalArticle

Open Access
99 Scopus citations

Olfactory dysfunction in humans with deficient guanine nucleotide-binding protein

Weinstock, R. S., Wright, H. N., Spiegel, A. M., Levine, M. A. & Moses, A. M., Dec 1 1986, In : Nature. 322, 6080, p. 635-636 2 p.

Research output: Contribution to journalArticle

47 Scopus citations

Parathyroid Mitogenic Activity in Plasma from Patients with Familial Multiple Endocrine Neoplasia Type 1

Brandi, M. L., Aurbach, G. D., Fitzpatrick, L. A., Quarto, R., Spiegel, A. M., Bliziotes, M. M., Norton, J. A., Doppman, J. L. & Marx, S. J., May 15 1986, In : New England Journal of Medicine. 314, 20, p. 1287-1293 7 p.

Research output: Contribution to journalArticle

107 Scopus citations

Selective resistance to parathyroid hormone in cultured skin fibroblasts from patients with pseudohypoparathyroidism type ib

Caroline, S., Santora, A., Breslau, N., Moses, A. & Spiegel, A., Apr 1986, In : Journal of Clinical Endocrinology and Metabolism. 62, 4, p. 640-644 5 p.

Research output: Contribution to journalArticle

58 Scopus citations

The GTP-binding regulatory proteins of neuroblastoma × glioma, NG108-15, and glioma, C6, cells. Immunochemical evidence of a pertussis toxin substrate that is neither Ni nor No

Milligan, G., Gierschik, P., Spiegel, A. M. & Klee, W. A., Jan 20 1986, In : FEBS Letters. 195, 1-2, p. 225-230 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

The inhibitory guanine nucleotide regulatory protein modulates agonist-stimulated cAMP production in rat osteosarcoma cells

Pines, M., Santora, A., Gierschik, P., Menczel, J. & Spiegel, A., Nov 19 1986, In : Bone and Mineral. 1, 1, p. 15-26 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

The β subunit of the guanine nucleotide regulatory proteins: Identification of its location on two‐dimesional gels of brain tissue and its regional and subcellular distribution in brain

Heydorn, W. E., Gierschik, P., Creed, G. J., Milligan, G., Spiegel, A. & Jacobowitz, D. M., 1986, In : Journal of Neuroscience Research. 16, 3, p. 541-552 12 p.

Research output: Contribution to journalArticle

Use of specific antibodies to quantitate the guanine nucleotide-binding protein G(o) in brain

Gierschik, P., Milligan, G., Pines, M., Goldsmith, P., Codina, J., Klee, W. & Spiegel, A., Jan 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 7, p. 2258-2262 5 p.

Research output: Contribution to journalArticle

Open Access
113 Scopus citations

α-Transducin immunoreactivity in retinae and sensory pineal organs of adult vertebrates

van Veen, T., Ostholm, T., Gierschik, P., Spiegel, A., Somers, R., Korf, H. W. & Klein, D. C., Jan 1 1986, In : Proceedings of the National Academy of Sciences of the United States of America. 83, 4, p. 912-916 5 p.

Research output: Contribution to journalArticle

Open Access
81 Scopus citations
1985
23 Scopus citations
55 Scopus citations
97 Scopus citations

Chymotrypsin selectively decreases forskolin stimulation of adenylate cyclase

Gierschik, P. & Spiegel, A. M., Nov 1 1985, In : Archives of Biochemistry and Biophysics. 242, 2, p. 457-463 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Chymotrypsin selectively impairs forskolin stimulation of adenylate cyclase

Gierschik, P. & Spiegel, A., Jan 1 1985, In : Federation Proceedings. 44, 5, p. No. 8100

Research output: Contribution to journalArticle

Clinical Implications of Guanine Nucleotide–Binding Proteins as Receptor–Effector Couplers

Flier, J. S., Underhill, L. H., Spiegel, A. M., Gierschik, P., Levine, M. A. & Downs, R. W., Jan 3 1985, In : New England Journal of Medicine. 312, 1, p. 26-33 8 p.

Research output: Contribution to journalReview article

72 Scopus citations

Computerized technetium/thallium scans and parathyroid reoperation

Skibber, J. M., Reynolds, J. C., Spiegel, A. M., Marx, S. J., Fitzpatrick, L. A., Aurbach, G. D., Wesley, R. A. & Norton, J. A., Dec 1 1985, In : Surgery. 98, 6, p. 1077-1082 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Die Stromareaktion beim Mammacarcinom.

Translated title of the contribution: Stromal reaction in breast cancerCaselitz, J., Stegner, H. E. & Spiegel, A., Dec 1 1985, In : Verhandlungen der Deutschen Gesellschaft fur Pathologie. 69, p. 254-257 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Morphologic and functional studies of a rat hypercalcemia-associated testicular tumor maintained in cell culture

Saxe, A. W., Santora, A., Norton, J., Triche, T., Brennan, M. F. & Spiegel, A., Dec 1 1985, In : Surgery. 98, 6, p. 1013-1023 11 p.

Research output: Contribution to journalArticle

Parathymic parathyroid: CT, US, and angiographic findings

Doppman, J. L., Shawker, T. H., Krudy, A. G., Miller, D. L., Marx, S. J., Spiegel, A. M., Norton, J. A., Brennan, M. F., Schaaf, M. & Aurbach, G. D., Jan 1 1985, In : RADIOLOGY. 157, 2, p. 419-423 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Parathyroid gland morphology in nonparathyroid hormone-mediated hypercalcemia

Dufour, D. R., Marx, S. J. & Spiegel, A. M., Jan 1 1985, In : American Journal of Surgical Pathology. 9, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Specificity of the functional interactions of the β-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles

Cerione, R. A., Staniszewski, C., Benovic, J. L., Lefkowitz, R. J., Caron, M. G., Gierschik, P., Somers, R., Spiegel, A. M., Codina, J. & Birnbaumer, L., Jun 5 1985, In : Journal of Biological Chemistry. 260, 3, p. 1493-1500 8 p.

Research output: Contribution to journalArticle

129 Scopus citations

Susceptibility of the beta subunit of guanine nucleotide binding coupling proteins (G) to proteolytic cleavage

Pines, M., Gierschik, P. & Spiegel, A., Jan 1 1985, In : Federation Proceedings. 44, 3, p. No. 1693

Research output: Contribution to journalArticle

The inhibitory adenylate cyclase coupling protein in pseudohypoparathyroidism

Downs, R. W., Sekura, R. D., Levine, M. A. & Spiegel, A. M., Aug 1985, In : Journal of Clinical Endocrinology and Metabolism. 61, 2, p. 351-354 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

The tryptic and chymotryptic fragments of the β-subunit of guanine nucleotide binding proteins in brain are identical to those of retinal transducin

Pines, M., Gierschik, P. & Spiegel, A., Mar 25 1985, In : FEBS Letters. 182, 2, p. 355-359 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Transducin and the Inhibitory Nucleotide Regulatory Protein Inhibit the Stimulatory Nucleotide Regulatory Protein Mediated Stimulation of Adenylate Cyclase in Phospholipid Vesicle Systems†

Cerione, R. A., Kilpatrick, B. F., Staniszewski, C., Caron, M. G., Lefkowitz, R. J., Gierschik, P., Somers, R. L., Spiegel, A. M., Codina, J. & Birnbaumer, L., Aug 1 1985, In : Biochemistry. 24, 17, p. 4499-4503 5 p.

Research output: Contribution to journalArticle

24 Scopus citations
1984

Antibodies against a retinal guanine nucleotide-binding protein cross-react with a single plasma membrane protein in non-retinal tissues

Gierschik, P., Simons, C., Woodard, C., Somers, R. & Spiegel, A., Jul 9 1984, In : FEBS Letters. 172, 2, p. 321-325 5 p.

Research output: Contribution to journalArticle

33 Scopus citations