• 25862 Citations
  • 89 h-Index
1969 …2019

Research output per year

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Publications

Article

11q13 allelotype analysis in 27 Northern American MEN1 kindreds identifies two distinct founder chromosomes

Emmert-Buck, M. R., Debelenko, L. V., Agarwal, S., Kester, M. B., Manickam, P., Zhuang, Z., Guru, S. C., Olufemi, S. E., Burns, A. L., Chandrasekharappa, S. C., Lubensky, I. A., Liotta, L. A., Skarulis, M. C., Spiegel, A. M., Marx, S. J. & Collins, F. S., Feb 1998, In : Molecular Genetics and Metabolism. 63, 2, p. 151-155 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

12 Parathyroid hormone and vitamin D receptors

Spiegel, A. M. & Marx, S. J., Mar 1983, In : Clinics in Endocrinology and Metabolism. 12, 1, p. 221-241 21 p.

Research output: Contribution to journalArticle

3 Scopus citations

A 2.8-Mb clone contig of the multiple endocrine neoplasia type 1 (MEN1) region at 11q13

Guru, S. C., Olufemi, S. E., Manickam, P., Cummings, C., Gieser, L. M., Pike, B. L., Bittner, M. L., Jiang, Y., Chinault, A. C., Nowak, N. J., Brzozowska, A., Crabtree, J. S., Wang, Y., Roe, B., Weisemann, J. M., Boguski, M. S., Agarwal, S. K., Burns, A. L., Spiegele, A. M., Marx, S. J. & 4 others, Rejter, W. L., De Jong, P. J., Collins, F. S. & Chandrasekharappa, S. C., Jun 15 1997, In : Genomics. 42, 3, p. 436-445 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

Gawler, D., Milligan, G., Spiegel, A. M., Unson, C. G. & Houslay, M. D., Jan 1 1987, In : Nature. 327, 6119, p. 229-232 4 p.

Research output: Contribution to journalArticle

171 Scopus citations

Activating and inactivating mutations of the α subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells

Hermouet, S., Merendino, J. J., Silvio Gutkind, J. & Spiegel, A. M., Jan 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 23, p. 10455-10459 5 p.

Research output: Contribution to journalArticle

Open Access
103 Scopus citations

Activating mutations of the stimulatory g protein in the mcCune–albright syndrome

Weinstein, L. S., Shenker, A., Friedman, E., Spiegel, A. M., Gejman, P. V. & Merino, M. J., Dec 12 1991, In : New England Journal of Medicine. 325, 24, p. 1688-1695 8 p.

Research output: Contribution to journalArticle

1219 Scopus citations
117 Scopus citations

Adenosine 3', 5'-monophosphate response to parathyroid hormone: Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism

Marx, S. J., Spiegel, A. M., Sharp, M. E., Brown, E. M., Gardner, D. G., Downs, R. W., Attie, M. F. & Stock, J. L., Mar 1980, In : Journal of Clinical Endocrinology and Metabolism. 50, 3, p. 546-549 4 p.

Research output: Contribution to journalArticle

15 Scopus citations
23 Scopus citations

A familial syndrome of decrease in sensitivity to 1,25-dihydroxyvitamin D

Marx, S. J., Spiegel, A. M., Brown, E. M., Gardner, D. G., Downs, R. W., Attie, M., Hamstra, A. J. & Deluca, H. F., Dec 1978, In : Journal of Clinical Endocrinology and Metabolism. 47, 6, p. 1303-1310 8 p.

Research output: Contribution to journalArticle

98 Scopus citations

A heterozygous 4-bp deletion mutation in the Gsα gene (GNAS1) in a patient with albright hereditary osteodystrophy

Weinstein, L. S., Gejman, P. V., de Mazancourt, P., American, N. & Spiegel, A. M., Aug 1992, In : Genomics. 13, 4, p. 1319-1321 3 p.

Research output: Contribution to journalArticle

77 Scopus citations

Albert Einstein College of Medicine

Spiegel, A., May 2008, In : Academic Medicine. 83, 5, 1 p.

Research output: Contribution to journalArticle

Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors

Debelenko, L. V., Zhuang, Z., Emmert-Buck, M. R., Chandrasekharappa, S. C., Manickam, P., Guru, S. C., Marx, S. J., Skarulis, M. C., Spiegel, A. M., Collins, F. S., Jensen, R. T., Liotta, L. A. & Lubensky, I. A., Jun 1 1997, In : Cancer Research. 57, 11, p. 2238-2243 6 p.

Research output: Contribution to journalArticle

146 Scopus citations

Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients

Lubensky, I. A., Debelenko, L. V., Zhuang, Z., Emmert-Buck, M. R., Dong, Q., Chandrasekharappa, S., Guru, S. C., Manickam, P., Olufemi, S. E., Marx, S. J., Spiegel, A. M., Collins, F. S. & Liotta, L. A., Nov 15 1996, In : Cancer Research. 56, 22, p. 5272-5278 7 p.

Research output: Contribution to journalArticle

125 Scopus citations

Allelic Loss from Chromosome 11 in Parathyroid Tumors

Friedman, E., Spiege, A. M. & Marx, S. J., Dec 1992, In : Cancer Research. 52, 24, p. 6804-6809 6 p.

Research output: Contribution to journalArticle

96 Scopus citations

Allosteric modulation of the calcium-sensing receptor rectifies signaling abnormalities associated with G-protein α-11 mutations causing hypercalcemic and hypocalcemic disorders

Babinsky, V. N., Hannan, F. M., Gorvin, C. M., Howles, S. A., Nesbit, M. A., Rust, N., Hanyaloglu, A. C., Hu, J., Spiegel, A. M. & Thakker, R. V., May 13 2016, In : Journal of Biological Chemistry. 291, 20, p. 10876-10885 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Amino- and carboxy-terminal deletion mutants of gsα are localized to the particulate fraction of transfected COS cells

Juhnn, Y. S., Jones, T. L. Z. & Spiegel, A. M., Nov 1992, In : Journal of Cell Biology. 119, 3, p. 523-530 8 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

A missense mutation in the seventh transmembrane domain constitutively activates the human Ca2+ receptor

Zhao, X. M., Hauache, O., Goldsmith, P. K., Collins, R. & Spiegel, A. M., Apr 2 1999, In : FEBS Letters. 448, 1, p. 180-184 5 p.

Research output: Contribution to journalArticle

53 Scopus citations

A missense mutation in the seven-transmembrane domain of the human Ca 2+ receptor converts a negative allosteric modulator into a positive allosteric modulator

Hu, J., Jiang, J., Costanzi, S., Thomas, C., Yang, W., Feyen, J. H. M., Jacobson, K. A. & Spiegel, A. M., Jul 28 2006, In : Journal of Biological Chemistry. 281, 30, p. 21558-21565 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

Crabtree, J. S., Scacheri, P. C., Ward, J. M., Garrett-Beal, L., Emmert-Buck, M. R., Edgemon, K. A., Lorang, D., Libutti, S. K., Chandrasekharappa, S. C., Marx, S. J., Spiegel, A. M. & Collins, F. S., Jan 30 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 3, p. 1118-1123 6 p.

Research output: Contribution to journalArticle

350 Scopus citations

A Mutation in the Vasopressin V2-Receptor Gene in a Kindred with X-Linked Nephrogenic Diabetes Insipidus

Merendino, J. J., Spiegel, A. M., Crawford, J. D., O'carroll, A. M., Brownstein, M. J. & Lolait, S. J., May 27 1993, In : New England Journal of Medicine. 328, 21, p. 1538-1541 4 p.

Research output: Contribution to journalArticle

59 Scopus citations

An activating Gs alpha mutation is present in fibrous dysplasia of bone in the McCune-Albright syndrome

Shenker, A., Weinstein, L. S., Sweet, D. E. & Spiegel, A. M., Sep 1994, In : Journal of Clinical Endocrinology and Metabolism. 79, 3, p. 750-755 6 p.

Research output: Contribution to journalArticle

195 Scopus citations

Analysis of recurrent germline mutations in the MEN1 gene encountered in apparently unrelated families

Agarwal, S. K., Debelenko, L. V., Kester, M. B., Guru, S. C., Manickam, P., Olufemi, S. E., Skarulis, M. C., Hcppner, C., Crabtree, J. S., Lubensky, I. A., Zhuang, Z., Kim, Y. S., Chandrasekharappa, S. C., Collins, F. S., Liotta, L. A., Spiegel, A. M., Burns, A. L., Emmert-Buck, M. R. & Marx, S. J., Jul 8 1998, In : Human Mutation. 12, 2, p. 75-82 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

An antibody directed against the carboxyl-terminal decapeptide of the α subunit of the retinal GTP-binding protein, transducin. Effects on transducin function

Cerione, R. A., Kroll, S., Rajaram, R., Unson, C., Goldsmith, P. & Spiegel, A. M., Jan 1 1988, In : Journal of Biological Chemistry. 263, 19, p. 9345-9352 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

An Association between Neonatal Severe Primary Hyperparathyroidism and Familial Hypocalciuric Hypercalcemia in Three Kindreds

Marx, S. J., Attie, M. F., Spiegel, A. M., Levine, M. A., Lasker, R. D. & Fox, M., Feb 4 1982, In : New England Journal of Medicine. 306, 5, p. 257-264 8 p.

Research output: Contribution to journalArticle

131 Scopus citations

Angiographic ablation of parathyroid adenomas

Doppman, J. L., Brown, E. M., Brennan, M. F., Spiegel, A., Marx, S. J. & Aurbach, G. D., Jan 1 1979, In : Unknown Journal. 130, 3, p. 577-582 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Angiographic ablation of parathyroid adenomas: Lessons from a 10-year experience

Miller, D. L., Doppman, J. L., Chang, R., Thayer, S. J., O'Leary, T. J., Norton, J. A., Spiegel, A. M., Marx, S. J. & Aurbach, G. D., Jan 1 1987, In : RADIOLOGY. 165, 3, p. 601-607 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Antibodies against a retinal guanine nucleotide-binding protein cross-react with a single plasma membrane protein in non-retinal tissues

Gierschik, P., Simons, C., Woodard, C., Somers, R. & Spiegel, A., Jul 9 1984, In : FEBS Letters. 172, 2, p. 321-325 5 p.

Research output: Contribution to journalArticle

33 Scopus citations

Antibodies against synthetic peptides as probes of G protein structure and function

Spiegel, A. M., Simonds, W. F., Jones, T. L. Z., Goldsmith, P. K. & Unson, C. G., Jan 1 1990, In : Journal of General Physiology. 43 rd ANN. SYMP., p. 185-195 11 p.

Research output: Contribution to journalArticle

27 Scopus citations
55 Scopus citations

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

Goldsmith, P., Gierschik, P., Milligan, G., Unson, C. G., Vinitsky, R., Malech, H. L. & Spiegel, A. M., Oct 25 1987, In : The Journal of biological chemistry. 262, 30, p. 14683-14688 6 p.

Research output: Contribution to journalArticle

244 Scopus citations
38 Scopus citations
97 Scopus citations
Open Access
15 Scopus citations

A prospective trial evaluating a standard approach to reoperation for missed parathyroid adenoma

Jaskowiak, N., Norton, J. A., Richard Alexander, H., Doppman, J. L., Shawker, T., Skarulis, M., Marx, S., Spiegel, A. & Fraker, D. L., Sep 26 1996, In : Annals of surgery. 224, 3, p. 308-322 15 p.

Research output: Contribution to journalArticle

177 Scopus citations

A region in the seven-transmembrane domain of the human Ca2+ receptor critical for response to Ca2+

Hu, J., McLarnon, S. J., Mora, S., Jiang, J., Thomas, C., Jacobson, K. A. & Spiegel, A. M., Feb 11 2005, In : Journal of Biological Chemistry. 280, 6, p. 5113-5120 8 p.

Research output: Contribution to journalArticle

74 Scopus citations

Aspiration of enlarged parathyroid glands for parathyroid hormone assay

Doppman, J. L., Krudy, A. G., Marx, S. J., Saxe, A., Schneider, P., Norton, J. A., Spiegel, A. M., Downs, R. W., Schaaf, M., Brennan, M. E., Schneider, A. B. & Aurbach, G. D., Jan 1 1983, In : Unknown Journal. 148, 1, p. 31-35 5 p.

Research output: Contribution to journalArticle

73 Scopus citations

Assessment of techniques for preoperative parathyroid gland localization in patients undergoing reoperation for hyperparathyroidism

Brennan, M. F., Doppman, J. L., Kurdy, A. G., Marx, S. J., Spiegel, A. M. & Aurbach, G. D., Jan 1982, In : Surgery. 91, 1, p. 6-11 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus

Guru, S. C., Agarwal, S. K., Manickam, P., Olufemi, S. E., Crabtree, J. S., Weisemann, J. M., Kester, M. B., Kim, Y. S., Wang, Y., Emmert-Buck, M. R., Liotta, L. A., Spiegel, A. M., Boguski, M. S., Roe, B. A., Collins, F. S., Marx, S. J., Burns, L. & Chandrasekharappa, S. C., Jul 1997, In : Genome research. 7, 7, p. 725-735 11 p.

Research output: Contribution to journalArticle

Open Access
90 Scopus citations

Autosomal Dominant Hypocalcemia Caused by a Novel Mutation in the Loop 2 Region of the Human Calcium Receptor Extracellular Domain

Hu, J., Mora, S., Colussi, G., Proverbio, M. C., Jones, K. A., Bolzoni, L., De Ferrari, M. E., Civati, G. & Spiegel, A. M., Jan 1 2002, In : Journal of Bone and Mineral Research. 17, 8, p. 1461-1469 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Autosomal dominant hypocalcemia in monozygotic twins caused by a de novo germline mutation near the amino-terminus of the human calcium receptor

Hu, J., Mora, S., Weber, G., Zamproni, I., Proverbio, M. C. & Spiegel, A. M., Apr 1 2004, In : Journal of Bone and Mineral Research. 19, 4, p. 578-586 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Autotransplantation of cryopreserved parathyroid tissue in man

Brennan, M. F., Brown, E. M., Spiegel, A. M., Marx, S. J., Doppman, J. L., Jones, D. C. & Aurbach, G. D., Jan 1 1979, In : Unknown Journal. 189, 2, p. 139-142 4 p.

Research output: Contribution to journalArticle

44 Scopus citations

Baculovirus expression and purification of a soluble, mutant g-protein α subunit

Jones, T. L. Z., Woodard, C. & Spiegel, A. M., Feb 1993, In : Protein Expression and Purification. 4, 1, p. 64-71 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice

Scacheri, P. C., Crabtree, J. S., Novotny, E. A., Garrett-Beal, L., Chen, A., Edgemon, K. A., Marx, S. J., Spiegel, A. M., Chandrasekharappa, S. C. & Collins, F. S., Sep 15 2001, In : Genesis. 30, 4, p. 259-263 5 p.

Research output: Contribution to journalArticle

69 Scopus citations
51 Scopus citations

Biochemical and immunochemical localization of GTP-binding proteins in the rat ileal enterocyte

Pamukcu, R., Spiegel, A. M. & Chang, E. B., May 1993, In : The Journal of Laboratory and Clinical Medicine. 121, 5, p. 689-696 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Bordetella pertussis does not induce β-adrenergic blockade

Hewlett, E., Spiegel, A., Wolff, J., Aurbach, G. & Manclark, C. R., Dec 1 1978, In : Infection and Immunity. 22, 2, p. 430-434 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Calcium-regulated parathyroid hormone release in primary hyperparathyroidism. Studies in vitro with dispersed parathyroid cells

Brown, E. M., Gardner, D. G., Brennan, M. F., Marx, S. J., Spiegel, A. M., Attie, M. F., Downs, R. W., Doppman, J. L. & Aurbach, G. D., Jun 1979, In : The American Journal of Medicine. 66, 6, p. 923-931 9 p.

Research output: Contribution to journalArticle

136 Scopus citations

Carboxyl methylation and COOH-terminal processing of the brain G-protein γ-subunit

Backlund, P. S., Simonds, W. F. & Spiegel, A. M., Oct 11 1990, In : Journal of Biological Chemistry. 265, 26, p. 15572-15576 5 p.

Research output: Contribution to journalArticle

27 Scopus citations

Changes in the guanine nucleotide-binding proteins, Gi and go, during differentiation of 3T3-L1 cells

Gierschik, P., Morrow, B., Milligan, G., Rubin, C. & Spiegel, A., Apr 7 1986, In : FEBS Letters. 199, 1, p. 103-106 4 p.

Research output: Contribution to journalArticle

34 Scopus citations