• 25862 Citations
  • 89 h-Index
1969 …2019

Research output per year

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Publications

1990

Genetic abnormalities in sporadic parathyroid adenomas

Friedman, E., Bale, A. E., Marx, S. J., Norton, J. A., Arnold, A., Tu, T., Aurbach, G. D. & Spiegel, A. M., Aug 1990, In : Journal of Clinical Endocrinology and Metabolism. 71, 2, p. 293-297 5 p.

Research output: Contribution to journalArticle

61 Scopus citations

Immunolocalization of G protein α-subunits in the Drosophila CNS

Wolfgang, W. J., Quan, F., Goldsmith, P., Unson, C., Spiegel, A. & Forte, M., Jan 1 1990, In : Journal of Neuroscience. 10, 3, p. 1014-1024 11 p.

Research output: Contribution to journalArticle

Open Access
44 Scopus citations

Immunoprecipitation of Adenylate Cyclase with an Antibody to a Carboxyl-Terminal Peptide from Gsα

Morris, D., McHugh-Sutkowski, E., Moos, M., Seamon, K. B., Simonds, W. F. & Spiegel, A. M., Sep 1 1990, In : Biochemistry. 29, 38, p. 9079-9084 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Isoprenylation of an inhibitory G protein α subunit occurs only upon mutagenesis of the carboxyl terminus

Jones, T. L. Z. & Spiegel, A. M., Dec 17 1990, In : Journal of Biological Chemistry. 265, 32, p. 19389-19392 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mutations of the Gs α-subunit gene in Albright hereditary osteodystrophy detected by denaturing gradient gel electrophoresis

Weinstein, L. S., Gejman, P. V., Friedman, E., Kadowaki, T., Collins, R. M., Gershon, E. S. & Spiegel, A. M., Jan 1 1990, In : Proceedings of the National Academy of Sciences of the United States of America. 87, 21, p. 8287-8290 4 p.

Research output: Contribution to journalArticle

Open Access
227 Scopus citations

Myristoylation of an inhibitory GTP-binding protein α subunit is essential for its membrane attachment

Jones, T. L. Z., Simonds, W. F., Merendino, J. J., Brann, M. R. & Spiegel, A. M., Jan 1 1990, In : Proceedings of the National Academy of Sciences of the United States of America. 87, 2, p. 568-572 5 p.

Research output: Contribution to journalArticle

Open Access
161 Scopus citations

Parathyroid tumors in familial multiple endocrine neoplasia type 1: The role of direct acting oncogenes and tumor suppressor genes

Friedman, E., Tu, T., Bale, A. E., Norton, J. A., Sakaguchi, K., Aurbach, G. D., Spiegel, A. M. & Marx, S. J., Jan 1 1990, Calcium regulation and bone metabolism. Basic and clinical aspects: proceedings of the 10th International Conference on calcium regulating hormones and bone metabolism. ICS886. Cohn, D. V., Glorieux, F. H., Martin, T. J., Cohn, D. V., Glorieux, F. H. & Martin, T. J. (eds.). Elsevier Science Publishers B.V., p. 113-117 5 p. (Calcium regulation and bone metabolism. Basic and clinical aspects: proceedings of the 10th International Conference on calcium regulating hormones and bone metabolism. ICS886).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Specificity of receptor-G protein interactions. Discrimination of G(i) subtypes by the D2 dopamine receptor in a reconstituted system

Senogles, S. E., Spiegel, A. M., Padrell, E., Iyengar, R. & Caron, M. G., Mar 30 1990, In : Journal of Biological Chemistry. 265, 8, p. 4507-4514 8 p.

Research output: Contribution to journalArticle

127 Scopus citations

Undescended parathyroid adenoma: An important etiology for failed operations for primary hyperparathyroidism

Fraker, D. L., Doppman, J. L., Shawker, T. H., Marx, S. J., Spiegel, A. M. & Norton, J. A., May 1 1990, In : World Journal of Surgery. 14, 3, p. 342-348 7 p.

Research output: Contribution to journalArticle

40 Scopus citations
1989

Clonality of Parathyroid Tumors in Familial Multiple Endocrine Neoplasia Type 1

Friedman, E., Sakaguchi, K., Bale, A. E., Falchetti, A., Streeten, E., Zimering, M. B., Weinstein, L. S., Mcbride, W. O., Nakamura, Y., Brandi, M. L., Norton, J. A., Aurbach, G. D., Spiegel, A. M. & Marx, S. J., Jul 27 1989, In : New England Journal of Medicine. 321, 4, p. 213-218 6 p.

Research output: Contribution to journalArticle

265 Scopus citations

G(i2) mediates α2-adrenergic inhibition of adenylyl cyclase in platelet membranes: In situ identification with G(α) C-terminal antibodies

Simonds, W. F., Goldsmith, P. K., Codina, J., Unson, C. G. & Spiegel, A. M., Jan 1 1989, In : Proceedings of the National Academy of Sciences of the United States of America. 86, 20, p. 7809-7813 5 p.

Research output: Contribution to journalArticle

Open Access
307 Scopus citations

G-Protein Involvement in Matrix-mediated Motility and Invasion of High and Low Experimental Metastatic B16 Melanoma Clones

Lester, B. R., McCarthy, J. B., Sun, Z., Smith, R. S., Furcht, L. T. & Spiegel, A. M., Nov 1 1989, In : Cancer Research. 49, 21, p. 5940-5948 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

G proteins couple α-adrenergic and GABA(b) receptors to inhibition of peptide secretion from peripheral sensory neurons

Holz IV, G. G., Kream, R. M., Spiegel, A. & Dunlap, K., Jan 1 1989, In : Journal of Neuroscience. 9, 2, p. 657-666 10 p.

Research output: Contribution to journalArticle

74 Scopus citations

Identification of multiple Gi subtypes and a novel G protein in bovine kidney cortex

Takeshi, M., Rossiter, K., Spiegel, A. M. & Sacktor, B., Dec 15 1989, In : Biochemical Pharmacology. 38, 24, p. 4502-4505 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Immunological and molecular characterization of G(oα)-like proteins in the Drosophila central nervous system

Thambi, N. C., Quan, F., Wolfgang, W. J., Spiegel, A. & Forte, M., Jan 1 1989, In : Journal of Biological Chemistry. 264, 31, p. 18552-18560 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Lipopolysaccharide response is linked to the GTP binding protein, Gi2, in the promonocytic cell line U937

Daniel-Issakani, S., Spiegel, A. M. & Strulovici, B., Dec 20 1989, In : Journal of Biological Chemistry. 264, 34, p. 20240-20247 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

Membrane attachment of recombinant G-protein α-subunits in excess of βγ subunits in a eukaryotic expression system

Simonds, W. F., Collins, R. M., Spiegel, A. M. & Brann, M. R., Oct 16 1989, In : Biochemical and Biophysical Research Communications. 164, 1, p. 46-53 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
114 Scopus citations

Protein kinase C-mediated phosphorylation of retinal rod outer segment membrane proteins

Sagi-Eisenberg, R., Traub, L. M., Spiegel, A. M. & Zick, Y., 1989, In : Cellular Signalling. 1, 5, p. 519-531 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Receptor and effector interactions of Gs Functional studies with antibodies to the αs carboxyl-terminal decapeptide

Simonds, W. F., Goldsmith, P. K., Woodard, C. J., Unson, C. G. & Spiegel, A. M., Jun 5 1989, In : FEBS Letters. 249, 2, p. 189-194 6 p.

Research output: Contribution to journalArticle

147 Scopus citations

Receptor-effector coupling by G-proteins implications for endocrinology

Spiegel, A. M., Jan 1 1989, In : Trends in Endocrinology and Metabolism. 1, 2, p. 72-76 5 p.

Research output: Contribution to journalReview article

13 Scopus citations
1988

An antibody directed against the carboxyl-terminal decapeptide of the α subunit of the retinal GTP-binding protein, transducin. Effects on transducin function

Cerione, R. A., Kroll, S., Rajaram, R., Unson, C., Goldsmith, P. & Spiegel, A. M., Jan 1 1988, In : Journal of Biological Chemistry. 263, 19, p. 9345-9352 8 p.

Research output: Contribution to journalArticle

41 Scopus citations
38 Scopus citations
Open Access
15 Scopus citations

Cloning and characterization of the human gene for the α-subunit of Gi2, a GTP-binding signal transduction protein

Weinstein, L. S., Spiegel, A. M. & Carter, A. D., May 23 1988, In : FEBS Letters. 232, 2, p. 333-340 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

G-proteins as Receptor-Effector Couplers

Spiegel, A. M., Jan 1988, In : Annual Reports in Medicinal Chemistry. 23, C, p. 235-242 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

G proteins in clinical medicine

Spiegel, A. M., Jan 1 1988, In : Hospital Practice. 23, 6, p. 93-112 20 p.

Research output: Contribution to journalArticle

3 Scopus citations

GTP analogues promote release of the α subunit of the guanine nucleotide binding protein, G(i)2, from membranes of rat glioma C6 BU1 cells

Milligan, G., Mullaney, I., Unson, C. G., Marshall, L., Spiegel, A. M. & McArdle, H., Jan 1 1988, In : Biochemical Journal. 254, 2, p. 391-396 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Guanine Nucleotide Binding Proteins and Signal Transduction

Spiegel, A. M., Jan 1 1988, In : Vitamins and Hormones. 44, C, p. 47-101 55 p.

Research output: Contribution to journalArticle

11 Scopus citations

Identification of proteins in retinas and IPM from eyes with retinitis pigmentosa

Schmidt, S. Y., Heth, C. A., Edwards, R. B., Brandt, J. T., Adler, A. J., Spiegel, A., Shichi, H. & Berson, E. L., Dec 22 1988, In : Investigative Ophthalmology and Visual Science. 29, 11, p. 1585-1593 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Identification of the GTP-binding protein encoded by Gi3 complementary DNA.

Goldsmith, P., Rossiter, K., Carter, A., Simonds, W., Unson, C. G., Vinitsky, R. & Spiegel, A. M., May 15 1988, In : The Journal of biological chemistry. 263, 14, p. 6476-6479 4 p.

Research output: Contribution to journalArticle

123 Scopus citations

Immunochemical and Electrophoretic Characterization of the Major Pertussis Toxin Substrate of the RAW264 Macrophage Cell Line

Backlund, P. S., Aksamit, R. R., Unson, C. G., Goldsmith, P., Spiegel, A. M. & Milligan, G., Mar 1 1988, In : Biochemistry. 27, 6, p. 2040-2046 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Immunochemical studies of the 36-kDa common β subunit of guanine nucleotide-binding proteins: Identification of a major epitope

Zaremba, T., Gierschik, P., Pines, M., Bray, P., Carter, A., Kahn, R., Simons, C., Vinitsky, R., Goldsmith, P. & Spiegel, A., Jan 1 1988, In : Molecular Pharmacology. 33, 3, p. 257-264 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Prospective analysis of intraoperative and postoperative urinary cyclic adenosine 3′,5′-monophosphate levels to predict outcome of patients undergoing reoperations for primary hyperparathyroidism

Darling, G. E., Marx, S. J., Spiegel, A. M., Aurbach, G. D. & Norton, J. A., Dec 1988, In : Surgery. 104, 6, p. 1128-1136 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Purification of Heterotrimeric GTP-Binding Proteins from Brain: Identification of a Novel Form of G

Goldsmith, P., Backlund, P. S., Rossiter, K., Carter, A., Milligan, G. & Spiegel, A., Sep 1 1988, In : Biochemistry. 27, 18, p. 7085-7090 6 p.

Research output: Contribution to journalArticle

107 Scopus citations

Selective deficiency of guanine nucleotide-binding protein go in two dopamine-resistant pituitary tumors

Collu, R., Bouvier, C., Lagace, G., Unson, C. G., Milligan, G., Goldsmith, P. & Spiegel, A. M., Mar 1 1988, In : Endocrinology. 122, 3, p. 1176-1178 3 p.

Research output: Contribution to journalArticle

41 Scopus citations

Signal transduction by guanine nucleotide-binding proteins.

Spiegel, A., Carter, A., Brann, M., Collins, R., Goldsmith, P., Simonds, W., Vinitsky, R., Eide, B., Rossiter, K. & Weinstein, L., 1988, In : Recent progress in hormone research. 44, p. 337-375 39 p.

Research output: Contribution to journalReview article

21 Scopus citations

Subcellular localization of G(iα) in human neutrophils

Rotrosen, D., Gallin, J. I., Spiegel, A. M. & Malech, H. L., Jan 1 1988, In : Journal of Biological Chemistry. 263, 22, p. 10958-10964 7 p.

Research output: Contribution to journalArticle

60 Scopus citations

The use of anti-peptide antisera to probe interactions between receptors and guanine nucleotide binding proteins

McKenzie, F. R., Mullaney, I., Unson, C. G., Spiegel, A. M. & Milligan, G., Jan 1 1988, In : Biochemical Society transactions. 16, 4, p. 434-437 4 p.

Research output: Contribution to journalReview article

11 Scopus citations
1987

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

Gawler, D., Milligan, G., Spiegel, A. M., Unson, C. G. & Houslay, M. D., Jan 1 1987, In : Nature. 327, 6119, p. 229-232 4 p.

Research output: Contribution to journalArticle

171 Scopus citations

Angiographic ablation of parathyroid adenomas: Lessons from a 10-year experience

Miller, D. L., Doppman, J. L., Chang, R., Thayer, S. J., O'Leary, T. J., Norton, J. A., Spiegel, A. M., Marx, S. J. & Aurbach, G. D., Jan 1 1987, In : RADIOLOGY. 165, 3, p. 601-607 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophil and brain.

Goldsmith, P., Gierschik, P., Milligan, G., Unson, C. G., Vinitsky, R., Malech, H. L. & Spiegel, A. M., Oct 25 1987, In : The Journal of biological chemistry. 262, 30, p. 14683-14688 6 p.

Research output: Contribution to journalArticle

244 Scopus citations
36 Scopus citations

Detection of multiple forms of G in HL60 cells

Murphy, P. M., Eide, B., Goldsmith, P., Brann, M., Gierschik, P., Spiegel, A. & Malech, H. L., Aug 31 1987, In : FEBS Letters. 221, 1, p. 81-86 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Development of opiate receptors and GTP-binding regulatory proteins in neonatal rat brain

Milligan, G., Streaty, R. A., Gierschik, P., Spiegel, A. M. & Klee, W. A., Sep 17 1987, In : Journal of Biological Chemistry. 262, 18, p. 8626-8630 5 p.

Research output: Contribution to journalArticle

64 Scopus citations

Differential distribution of signal-transducing G-proteins in retina

Lad, R. P., Simons, C., Gierschik, P., Milligan, G., Woodaard, C., Griffo, M., Goldsmith, P., Ornberg, R., Gerfen, C. R. & Spiegel, A., Oct 13 1987, In : Brain Research. 423, 1-2, p. 237-246 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Erratum: Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi in diabetes (Nature (1987) 327, (229-232)

Gawler, D., Milligan, G., Spiegel, A. M., Unson, C. G. & Houslay, M. D., Jan 1 1987, In : Nature. 327, 6124, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Functional Differences in the βγ Complexes of Transducin and the Inhibitory Guanine Nucleotide Regulatory Protein

Cerione, R. A., Gierschik, P., Staniszewski, C., Benovic, J. L., Lefkowitz, R. J., Caron, M. G., Codina, J., Birnbaumer, L., Somers, R. & Spiegel, A. M., Jan 1 1987, In : Biochemistry. 26, 5, p. 1485-1491 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

GTP-Binding proteins in brain and neutrophil are tethered to the plasma membrane via their amino termini

Eide, B., Gierschik, P., Milligan, G., Mullaney, I., Unson, C., Goldsmith, P. & Spiegel, A., Nov 13 1987, In : Biochemical and Biophysical Research Communications. 148, 3, p. 1398-1405 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Guanine Nucleotide‐Binding Stimulatory Protein: A Requisite for Human Odorant Perception

WRIGHT, H. N., WEINSTOCK, R. S., SPIEGEL, A. M., LEVINE, M. A. & Mosesc, A. M., Nov 1987, In : Annals of the New York Academy of Sciences. 510, 1, p. 719-722 4 p.

Research output: Contribution to journalArticle

5 Scopus citations