• 25862 Citations
  • 89 h-Index
1969 …2019

Research output per year

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Publications

1993

G proteins: from basic to clinical studies.

Spiegel, A. M., Weinstein, L. S., Shenker, A., Hermouet, S. & Merendino, J. J., 1993, In : Advances in Second Messenger and Phosphoprotein Research. 28, p. 37-46 10 p.

Research output: Contribution to journalReview article

6 Scopus citations

Increased palmitoylation of the G(s) protein α subunit after activation by the β-adrenergic receptor or cholera toxin

Degtyarev, M. Y., Spiegel, A. M. & Jones, T. L. Z., Jan 1 1993, In : Journal of Biological Chemistry. 268, 32, p. 23769-23772 4 p.

Research output: Contribution to journalArticle

153 Scopus citations

Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2

Lamorte, V. J., Harootunian, A. T., Spiegel, A. M., Tsien, R. Y. & Feramisco, J. R., Apr 1993, In : Journal of Cell Biology. 121, 1, p. 91-99 9 p.

Research output: Contribution to journalArticle

Open Access
89 Scopus citations

Mitogenic effects of pertussis toxin-sensitive G-protein α subunits: The mitogenic action of αi2 in NIH 3T3 cells is mimicked by αi1, but not αi3

Hermouet, S., de Mazancourt, P. & Spiegel, A. M., Mar 1993, In : Cellular Signalling. 5, 2, p. 215-225 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Pheromone action regulates G-protein α-subunit myristoylation in the yeast Saccharomyces cerevisiae

Dohlman, H. G., Goldsmith, P., Spiegel, A. M. & Thorner, J., Oct 15 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 20, p. 9688-9692 5 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations

Prospective evaluation of selective venous sampling for parathyroid hormone concentration in patients undergoing reoperations for primary hyperparathyroidism

Sugg, S. L., Fraker, D. L., Alexander, H. R., Doppman, J. L., Miller, D. L., Chang, R., Skarulis, M. C., Marx, S. J., Spiegel, A. M. & Norton, J. A., Dec 1993, In : Surgery. 114, 6, p. 1004-1010 7 p.

Research output: Contribution to journalArticle

54 Scopus citations

Severe endocrine and nonendocrine manifestations of the McCune-Albright syndrome associated with activating mutations of stimulatory G protein Gs

Shenker, A., Weinstein, L. S., Moran, A., Pescovitz, O. H., Charest, N. J., Boney, C. M., Van Wyk, J. J., Merino, M. J., Feuillan, P. P. & Spiegel, A. M., Oct 1993, In : The Journal of Pediatrics. 123, 4, p. 509-518 10 p.

Research output: Contribution to journalArticle

253 Scopus citations

Stable changes in expression or activation of G protein αi or αq subunits affect the expression of both β1 and β2 subunits

Hermouet, S., Murakami, T. & Spiegel, A. M., Jul 26 1993, In : FEBS Letters. 327, 2, p. 183-188 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

The G Protein αs Subunit Incorporates [3H]Palmitic Acid and Mutation of Cysteine-3 Prevents This Modification

Degtyarev, M. Y., Spiegel, A. M. & Jones, T. L. Z., Aug 17 1993, In : Biochemistry. 32, 32, p. 8057-8061 5 p.

Research output: Contribution to journalArticle

84 Scopus citations
1992

A heterozygous 4-bp deletion mutation in the Gsα gene (GNAS1) in a patient with albright hereditary osteodystrophy

Weinstein, L. S., Gejman, P. V., de Mazancourt, P., American, N. & Spiegel, A. M., Aug 1992, In : Genomics. 13, 4, p. 1319-1321 3 p.

Research output: Contribution to journalArticle

77 Scopus citations

Allelic Loss from Chromosome 11 in Parathyroid Tumors

Friedman, E., Spiege, A. M. & Marx, S. J., Dec 1992, In : Cancer Research. 52, 24, p. 6804-6809 6 p.

Research output: Contribution to journalArticle

96 Scopus citations

Amino- and carboxy-terminal deletion mutants of gsα are localized to the particulate fraction of transfected COS cells

Juhnn, Y. S., Jones, T. L. Z. & Spiegel, A. M., Nov 1992, In : Journal of Cell Biology. 119, 3, p. 523-530 8 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Differential Isoprenylation of Carboxy-Terminal Mutants of an Inhibitory G-Protein α-Subunit: Neither Farnesylation nor Geranylgeranylation Is Sufficient for Membrane Attachment

Butrynski, J. E., Backlund, P. S., Spiegel, A. M. & Jones, T. L. Z., Feb 1 1992, In : Biochemistry. 31, 34, p. 8030-8035 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

G proteins in cellular control

Spiegel, A. M., Jan 1 1992, In : Current Opinion in Cell Biology. 4, 2, p. 203-211 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Heterotrimeric GTPbinding proteins: An expanding family of signal transducers

Spiegel, A. M., Jan 1992, In : Medicinal Research Reviews. 12, 1, p. 55-71 17 p.

Research output: Contribution to journalArticle

13 Scopus citations

High level expression of transfected G protein αi3 subunit is required for plasma membrane targeting and adenylyl cyclase inhibition in NIH 3T3 fibroblasts

Hermouet, S., de Mazancourt, P., Spiegel, A. M., Farquhar, M. G. & Wilson, B. S., Nov 9 1992, In : FEBS Letters. 312, 2-3, p. 223-228 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Inhibition of DNA synthesis in living cells by microinjection of G(i2) antibodies

LaMorte, V. J., Goldsmith, P. K., Spiegel, A. M., Meinkoth, J. L. & Feramisco, J. R., Jan 1 1992, In : Journal of Biological Chemistry. 267, 2, p. 691-694 4 p.

Research output: Contribution to journalArticle

47 Scopus citations

Inhibition of thyrotropin-induced DNA synthesis in thyroid follicular cells by microinjection of an antibody to the stimulatory G protein of adenylate cyclase, G(s)

Meinkoth, J. L., Goldsmith, P. K., Spiegel, A. M., Feramisco, J. R. & Burrow, G. N., Jan 1 1992, In : Journal of Biological Chemistry. 267, 19, p. 13239-13245 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

In memoriam Gerald D. Aurbach.

Potts, J. T. & Spiegel, A. M., Nov 1 1992, In : Journal of Clinical Endocrinology and Metabolism. 75, 5, p. 1386-1388 3 p.

Research output: Contribution to journalArticle

In memoriam Gerald D. Aurbach.

Potts, J. T. & Spiegel, A. M., Nov 1 1992, In : Molecular endocrinology (Baltimore, Md.). 6, 11, p. 1982-1984 3 p.

Research output: Contribution to journalArticle

Receptor-effector coupling by g proteins: Implications for normal and abnormal signal transduction

Spiegel, A. M., Shenker, A. & Weinstein, L. S., Aug 1992, In : Endocrine reviews. 13, 3, p. 536-565 30 p.

Research output: Contribution to journalArticle

299 Scopus citations

Results of a multidisciplinary strategy for management of mediastinal parathyroid adenoma as a cause of persistent primary hyperparathyroidism

Doherty, G. M., Doppman, J. L., Miller, D. L., Gee, M. S., Marx, S. J., Spiegel, A. M., Aurbach, G. D., Pass, H. I., Brennan, M. F. & Norton, J. A., Jan 1 1992, In : Annals of surgery. 215, 2, p. 101-106 6 p.

Research output: Contribution to journalArticle

64 Scopus citations

Role of G proteins in signal transduction.

Spiegel, A. M., 1992, In : Clinical neuropharmacology. 15 Suppl 1 Pt A, p. 200A-201A

Research output: Contribution to journalArticle

1 Scopus citations

Site-Specific Antibodies Directed Against G Protein β and γ Subunits: Effects on α and βγ Subunit Interaction

Murakami, T., Simonds, W. F. & Spiege, A. M., Mar 1 1992, In : Biochemistry. 31, 11, p. 2905-2911 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Spontaneous Intracellular Calcium Oscillations and Gsα Subunit Expression are Inversely Correlated with Secretory Granule Content in Pituitary Cells

Chiavaroli, C., Cooper, D. M. F., Boyajian, C. L., Murray‐Whelan, R., Demaurex, N., Spiegel, A. M. & Schlegel, W., Aug 1992, In : Journal of Neuroendocrinology. 4, 4, p. 473-481 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Studies in a kindred with parathyroid carcinoma

Streeten, E. A., Weinstein, L. S., Norton, J. A., Mulvihill, J. J., White, B. J., Friedman, E. A., Jaffe, G., Brandi, M. L., Stewart, K., Zimering, M. B., Spiegel, A. M., Aurbach, G. D. & Marx, S. J., Aug 1992, In : Journal of Clinical Endocrinology and Metabolism. 75, 2, p. 362-366 5 p.

Research output: Contribution to journalArticle

45 Scopus citations
1991

Activating and inactivating mutations of the α subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells

Hermouet, S., Merendino, J. J., Silvio Gutkind, J. & Spiegel, A. M., Jan 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 23, p. 10455-10459 5 p.

Research output: Contribution to journalArticle

Open Access
103 Scopus citations

Activating mutations of the stimulatory g protein in the mcCune–albright syndrome

Weinstein, L. S., Shenker, A., Friedman, E., Spiegel, A. M., Gejman, P. V. & Merino, M. J., Dec 12 1991, In : New England Journal of Medicine. 325, 24, p. 1688-1695 8 p.

Research output: Contribution to journalArticle

1219 Scopus citations

Discussion section I

Spiegel, A. M., Marx, S. J. & Melton, L. J., Jan 1 1991, In : Journal of Bone and Mineral Research. 6, SUPPL. 2, p. S31-S32

Research output: Contribution to journalArticle

Dual couplings of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein

Fargin, A., Yamamoto, K., Cotecchia, S., Goldsmith, P. K., Spiegel, A. M., Lapetina, E. G., Caron, M. G. & Lefkowitz, R. J., 1991, In : Cellular Signalling. 3, 6, p. 547-557 11 p.

Research output: Contribution to journalArticle

66 Scopus citations

Evidence for direct interaction of G(s)α with the Ca2+ channel of skeletal muscle

Hamilton, S. L., Codina, J., Hawkes, M. J., Yatani, A., Sawada, T., Strickland, F. M., Froehner, S. C., Spiegel, A. M., Toro, L., Stefani, E., Birnbaumer, L. & Brown, A. M., Nov 26 1991, In : Journal of Biological Chemistry. 266, 29, p. 19528-19535 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Expression of GTP-binding proteins and prostaglandin E2 receptors during human T cell activation

Holter, W., Spiegel, A. M., Howard, B. H., Weber, S. & Brannt, M. R., May 1991, In : Cellular Immunology. 134, 2, p. 287-295 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Genetic mapping of the Gs-α subunit gene (GNAS1) to the distal long arm of chromosome 20 using a polymorphism detected by denaturing gradient gel electrophoresis

Gejman, P. V., Weinstein, L. S., Martinez, M., Spiegel, A. M., Cao, Q., Hsieh, W. T., Hoehe, M. R. & Gershon, E. S., Apr 1991, In : Genomics. 9, 4, p. 782-783 2 p.

Research output: Contribution to journalArticle

63 Scopus citations

G-protein βγ dimers. Membrane targeting requires subunit coexpression and intact γ C-A-A-X domain

Simonds, W. F., Butrynski, J. E., Gautam, N., Unson, C. G. & Spiegel, A. M., Oct 22 1991, In : Journal of Biological Chemistry. 266, 9, p. 5363-5366 4 p.

Research output: Contribution to journalArticle

171 Scopus citations

Heterogeneous size of the parathyroid glands in familial multiple endocrine neoplasia type 1

Marx, S. J., Menczel, J., Campbell, G., Aurbach, G. D., Spiegel, A. M. & Norton, J. A., Dec 1991, In : Clinical Endocrinology. 35, 6, p. 521-526 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Identification of G protein α-subunits in RINm5F cells and their selective interaction with galanin receptor

Cormont, M., Marchand-Brustel, Y. L., Van Obberghen, E., Spiegel, A. M. & Sharp, G. W. G., Jan 1 1991, In : Diabetes. 40, 9, p. 1170-1176 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

Locally recurrent parathyroid neoplasms as a cause for recurrent and persistent primary hyperparathyroidism

Fraker, D. L., Travis, W. D., Merendino, J. J., Zimering, M. B., Streeten, E. A., Weinstein, L. S., Marx, S. J., Spiegel, A. M., Aurbach, G. D., Doppman, J. L. & Norton, J. A., Jan 1 1991, In : Annals of surgery. 213, 1, p. 58-65 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Pathophysiology of primary hyperparathyroidism

Spiegel, A. M., Oct 1991, In : Journal of Bone and Mineral Research. 6, 2 S, p. S15-S17

Research output: Contribution to journalArticle

13 Scopus citations

Regulation of guanine nucleotide binding regulatory proteins in cultured adrenal cells by adrenocorticotropin and angiotensin-ii

Bégeot, M., Langlois, D., Spiegel, A. M., Saez, J. M. & Saez, J. M., Jun 1991, In : Endocrinology. 128, 6, p. 3162-3168 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

The G protein connection: molecular basis of membrane association

Spiegel, A. M., Backlund, P. S., Butrynski, J. E., Jones, T. L. Z. & Simonds, W. F., 1991, In : Trends in Biochemical Sciences. 16, C, p. 338-341 4 p.

Research output: Contribution to journalArticle

91 Scopus citations

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel G(q) family

Shenker, A., Goldsmith, P., Unson, C. G. & Spiegel, A. M., Jul 22 1991, In : Journal of Biological Chemistry. 266, 14, p. 9309-9313 5 p.

Research output: Contribution to journalArticle

285 Scopus citations

The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family.

Shenker, A., Goldsmith, P., Unson, C. G. & Spiegel, A. M., 1991, In : Transactions of the Association of American Physicians. 104, p. 11-20 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
1990

Albright's hereditary osteodystrophy and defective g proteins

Spiegel, A. M., May 17 1990, In : New England Journal of Medicine. 322, 20, p. 1461-1462 2 p.

Research output: Contribution to journalEditorial

27 Scopus citations

Antibodies against synthetic peptides as probes of G protein structure and function

Spiegel, A. M., Simonds, W. F., Jones, T. L. Z., Goldsmith, P. K. & Unson, C. G., Jan 1 1990, In : Journal of General Physiology. 43 rd ANN. SYMP., p. 185-195 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Antibodies as probes of G-protein receptor-effector coupling and of G-protein membrane attachment

Spiegel, A. M., Simonds, W. F., Zones, T. L. Z., Goldsmith, P. K. & Unson, C. G., Oct 3 1990, In : Biochemical Society Symposia. 56, p. 61-69 9 p.

Research output: Contribution to journalReview article

14 Scopus citations

Carboxyl methylation and COOH-terminal processing of the brain G-protein γ-subunit

Backlund, P. S., Simonds, W. F. & Spiegel, A. M., Oct 11 1990, In : Journal of Biological Chemistry. 265, 26, p. 15572-15576 5 p.

Research output: Contribution to journalArticle

27 Scopus citations

Chapter 22 Receptor-effector coupling by G-proteins: Implications for neuronal plasticity

Spiegel, A. M., Jan 1 1990, In : Progress in Brain Research. 86, C, p. 269-276 8 p.

Research output: Contribution to journalArticle

3 Scopus citations

Characterization of the promoter of the human Gi2 α-subunit gene

Weinstein, L. S., Kats, I., Spiegel, A. M. & Carter, A. D., Jul 1990, In : Molecular Endocrinology. 4, 7, p. 958-964 7 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Differential expression of low molecular weight form of Gs-α in neostriatum and cerebellum: correlation with expression of calmodulin-independent adenylyl cyclase

Cooper, D. M. F., Boyajian, C. L., Goldsmith, P. K., Unson, C. G. & Spiegel, A., Jul 16 1990, In : Brain research. 523, 1, p. 143-146 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

Erratum: Identification of multiple G(i) subtypes and a novel G protein in bovine kidney cortex (Biochemical Pharmacology, Vol. 38 (1989) 4502-4505)

Murakami, T., Rossiter, K., Spiegel, A. M. & Sacktor, B., Jan 1 1990, In : Biochemical Pharmacology. 39, 11, 1 p.

Research output: Contribution to journalComment/debate