• 10124 Citations
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1979 …2019

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2019

A mouse model for the most common form of heart failure

Amgalan, D. & Kitsis, R. N., Apr 18 2019, In : Nature. 568, 7752, p. 324-325 2 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Fundamental mechanisms of regulated cell death and implications for heart disease

Del Re, D. P., Amgalan, D., Linkermann, A., Liu, Q. & Kitsis, R. N., Jul 2019, In : Physiological Reviews. 99, 4, p. 1765-1817 53 p.

Research output: Contribution to journalArticle

23 Scopus citations

Small-molecule allosteric inhibitors of BAX

Garner, T. P., Amgalan, D., Reyna, D. E., Li, S., Kitsis, R. N. & Gavathiotis, E., Apr 1 2019, In : Nature Chemical Biology. 15, 4, p. 322-330 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2018

An Akt3 splice variant lacking the serine 472 phosphorylation site promotes apoptosis and suppresses mammary tumorigenesis

Suyama, K., Yao, J., Liang, H., Benard, O., Loudig, O. D., Amgalan, D., McKimpson, W. M., Phillips, G. R., Segall, J., Wang, Y., Fineberg, S., Norton, L., Kitsis, R. N. & Hazan, R. B., Jan 1 2018, In : Cancer research. 78, 1, p. 103-114 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A

Rocha, A. G., Franco, A., Krezel, A. M., Rumsey, J. M., Alberti, J. M., Knight, W. C., Biris, N., Zacharioudakis, E., Janetka, J. W., Baloh, R. H., Kitsis, R. N., Mochly-Rosen, D., Townsend, R. R., Gavathiotis, E. & Dorn, G. W., Apr 20 2018, In : Science. 360, 6386, p. 336-341 6 p.

Research output: Contribution to journalArticle

43 Scopus citations

Ryanodine receptor calcium leak in circulating B-lymphocytes as a biomarker in heart failure

Kushnir, A., Santulli, G., Reiken, S. R., Coromilas, E., Godfrey, S. J., Brunjes, D. L., Colombo, P. C., Yuzefpolskaya, M., Sokol, S. I., Kitsis, R. N. & Marks, A. R., Jan 1 2018, In : Circulation. 138, 11, p. 1144-1154 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy

Feng, D., Amgalan, D., Singh, R., Wei, J., Wen, J., Wei, T. P., McGraw, T. E., Kitsis, R. N. & Pessin, J. E., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 3941-3956 16 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

A myeloid tumor suppressor role for NOL3

Stanley, R. F., Piszczatowski, R. T., Bartholdy, B., Mitchell, K., McKimpson, W. M., Narayanagari, S., Walter, D., Todorova, T. I., Hirsch, C., Makishima, H., Will, B., McMahon, C., Gritsman, K., Maciejewski, J. P., Kitsis, R. N. & Steidl, U., Mar 6 2017, In : The Journal of experimental medicine. 214, 3, p. 753-771 19 p.

Research output: Contribution to journalArticle

2 Scopus citations

Apoptosis repressor with caspase recruitment domain ameliorates amyloid-induced b-cell apoptosis and JNK pathway activation

Templin, A. T., Samarasekera, T., Meier, D. T., Hogan, M. F., Mellati, M., Crow, M. T., Kitsis, R. N., Zraika, S., Hull, R. L. & Kahn, S. E., Oct 1 2017, In : Diabetes. 66, 10, p. 2636-2645 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

Hammerling, B. C., Najor, R. H., Cortez, M. Q., Shires, S. E., Leon, L. J., Gonzalez, E. R., Boassa, D., Phan, S., Thor, A., Jimenez, R. E., Li, H., Kitsis, R. N., Ii, G. W. D., Sadoshima, J., Ellisman, M. H. & Gustafsson, Å. B., Jan 30 2017, In : Nature communications. 8, 14050.

Research output: Contribution to journalArticle

61 Scopus citations

ARC is essential for maintaining pancreatic islet structure and β-cell viability during type 2 diabetes

McKimpson, W. M., Zheng, M., Chua, Jr., S. C., Pessin, J. E. & Kitsis, R. N., Dec 1 2017, In : Scientific Reports. 7, 1, 7019.

Research output: Contribution to journalArticle

1 Scopus citations

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1

Wang, Y., Wu, B., Lu, P., Zhang, D., Wu, B., Varshney, S., Del Monte-Nieto, G., Zhuang, Z., Charafeddine, R., Kramer, A. H., Sibinga, N. E., Frangogiannis, N. G., Kitsis, R. N., Adams, R. H., Alitalo, K., Sharp, D. J., Harvey, R. P., Stanley, P. & Zhou, B., Dec 1 2017, In : Nature communications. 8, 1, 578.

Research output: Contribution to journalArticle

12 Scopus citations
2016

Correcting mitochondrial fusion by manipulating mitofusin conformations

Franco, A., Kitsis, R. N., Fleischer, J. A., Gavathiotis, E., Kornfeld, O. S., Gong, G., Biris, N., Benz, A., Qvit, N., Donnelly, S. K., Chen, Y., Mennerick, S., Hodgson, L., Mochly-Rosen, D. & Dorn, G. W., Dec 1 2016, In : Nature. 540, 7631, p. 74-79 6 p.

Research output: Contribution to journalArticle

86 Scopus citations

Evaluating mitochondrial autophagy in the mouse heart

Shirakabe, A., Fritzky, L., Saito, T., Zhai, P., Miyamoto, S., Gustafsson, Å. B., Kitsis, R. N. & Sadoshima, J., Mar 1 2016, In : Journal of Molecular and Cellular Cardiology. 92, p. 134-139 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement from the American Heart Association

On behalf of the American Heart Association Council on Basic Cardiovascular Sciences, Council on Clinical Cardiology, and Council on Functional Genomics and Translational Biology, Jun 10 2016, In : Circulation research. 118, 12, p. 1960-1991 32 p.

Research output: Contribution to journalArticle

106 Scopus citations

Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise

Mera, P., Laue, K., Ferron, M., Confavreux, C., Wei, J., Galán-Díez, M., Lacampagne, A., Mitchell, S. J., Mattison, J. A., Chen, Y., Bacchetta, J., Szulc, P., Kitsis, R. N., De Cabo, R., Friedman, R. A., Torsitano, C., McGraw, T. E., Puchowicz, M., Kurland, I. & Karsenty, G., Jun 14 2016, In : Cell metabolism. 23, 6, p. 1078-1092 15 p.

Research output: Contribution to journalArticle

125 Scopus citations
2015

Interdependence of parkin-mediated mitophagy and mitochondrial fission in adult mouse hearts

Song, M., Gong, G., Burelle, Y., Gustafsson, Å. B., Kitsis, R. N., Matkovich, S. J. & Dorn, G. W., Jul 1 2015, In : Circulation research. 117, 4, p. 346-351 6 p.

Research output: Contribution to journalArticle

85 Scopus citations

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

Chen, H., Ruiz, P. D., McKimpson, W. M., Novikov, L., Kitsis, R. N. & Gamble, M. J., Sep 3 2015, In : Molecular Cell. 59, 5, p. 719-731 13 p.

Research output: Contribution to journalArticle

81 Scopus citations

Recent progress in research on molecular mechanisms of autophagy in the heart

Maejima, Y., Chen, Y., Isobe, M., Gustafsson, Å. B., Kitsis, R. N. & Sadoshima, J., 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 4, p. H259-H268

Research output: Contribution to journalArticle

The cell death inhibitor ARC is induced in a tissue-specific manner by deletion of the tumor suppressor gene Men1, but not required for tumor development and growth

McKimpson, W. M., Yuan, Z., Zheng, M., Crabtree, J. S., Libutti, S. K. & Kitsis, R. N., Dec 1 2015, In : PLoS One. 10, 12, e0145792.

Research output: Contribution to journalArticle

2 Scopus citations
2014

A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis

Kung, G., Dai, P., Deng, L. & Kitsis, R. N., Apr 1 2014, In : Cell Death and Differentiation. 21, 4, p. 634-644 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
2013

Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle

Davis, J., Kwong, J. Q., Kitsis, R. N. & Molkentin, J. D., Dec 2 2013, In : PloS one. 8, 12, e82053.

Research output: Contribution to journalArticle

8 Scopus citations

Novel mechanisms for caspase inhibition protecting cardiac function with chronic pressure overload

Park, M., Vatner, S. F., Yan, L., Gao, S., Yoon, S., Lee, G. J. A., Xie, L. H., Kitsis, R. N. & Vatner, D. E., Jan 1 2013, In : Basic research in cardiology. 108, 1, 324.

Research output: Contribution to journalArticle

14 Scopus citations

The apoptosis inhibitor ARC alleviates the ER stress response to promote β-cell survival

McKimpson, W. M., Weinberger, J., Czerski, L., Zheng, M., Crow, M. T., Pessin, J. E., Chua, S. C. & Kitsis, R. N., Jan 1 2013, In : Diabetes. 62, 1, p. 183-193 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
2012

Bax regulates primary necrosis through mitochondrial dynamics

Whelan, R. S., Konstantinidis, K., Wei, A. C., Chen, Y., Reyna, D. E., Jha, S., Yang, Y., Calvert, J. W., Lindsten, T., Thompson, C. B., Crow, M. T., Gavathiotis, E., Dorn, G. W., O'Rourke, B. & Kitsis, R. N., Apr 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 17, p. 6566-6571 6 p.

Research output: Contribution to journalArticle

186 Scopus citations

Cardiovascular Biology: Escaped DNA inflames the heart

Konstantinidis, K. & Kitsis, R. N., May 9 2012, In : Nature. 485, 7397, p. 179-180 2 p.

Research output: Contribution to journalArticle

15 Scopus citations

Tbx6 is a determinant of cardiac and neural cell fate decisions in multipotent P19CL6 cells

Gavrilov, S., Nührenberg, T. G., Ashton, A. W., Peng, C. F., Moore, J. C., Konstantinidis, K., Mummery, C. L. & Kitsis, R. N., Sep 2012, In : Differentiation. 84, 2, p. 176-184 9 p.

Research output: Contribution to journalArticle

5 Scopus citations
2011

A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension

Zaiman, A. L., Damico, R., Thoms-Chesley, A., Clark Files, D., Kesari, P., Johnston, L., Swaim, M., Mozammel, S., Myers, A. C., Halushka, M., El-Haddad, H., Shimoda, L. A., Peng, C. F., Hassoun, P. M., Champion, H. C., Kitsis, R. N. & Crow, M. T., Dec 6 2011, In : Circulation. 124, 23, p. 2533-2542 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistance

Medina-Ramirez, C. M., Goswami, S., Smirnova, T., Bamira, D., Benson, B., Ferrick, N., Segall, J., Pollard, J. W. & Kitsis, R. N., Dec 15 2011, In : Cancer research. 71, 24, p. 7705-7715 11 p.

Research output: Contribution to journalArticle

35 Scopus citations
53 Scopus citations
2010

Induction of the apoptosis inhibitor ARC by Ras in human cancers

Wu, L., Nam, Y. J., Kung, G., Crow, M. T. & Kitsis, R. N., Jun 18 2010, In : Journal of Biological Chemistry. 285, 25, p. 19235-19245 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2009

Apoptosis predominates in nonmyocytes in heart failure

Park, M., Shen, Y. T., Gaussin, V., Heyndrickx, G. R., Bartunek, J., Resuello, R. R. G., Natividad, F. F., Kitsis, R. N., Vatner, D. E. & Vatner, S. F., Aug 1 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 2, p. H785-H791

Research output: Contribution to journalArticle

46 Scopus citations
2008

ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer

Mercier, I., Vuolo, M., Jasmin, J. F., Medina, C. M., Williams, M., Mariadason, J. M., Qian, H., Xue, X., Pestell, R. G., Lisanti, M. P. & Kitsis, R. N., Jun 1 2008, In : Cell Cycle. 7, 11, p. 1640-1647 8 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

Edmund H. Sonnenblick, MD (1932-2007).

Kitsis, R. N., Mar 2008, In : American journal of hypertension : journal of the American Society of Hypertension. 21, 3, p. 241-242 2 p.

Research output: Contribution to journalArticle

2007

Regulation of p53 tetramerization and nuclear export by ARC

Foo, R. S. Y., Nam, Y. J., Ostreicher, M. J., Metzl, M. D., Whelan, R. S., Peng, C. F., Ashton, A. W., Fu, W., Mani, K., Chin, S. F., Provenzano, E., Ellis, I., Figg, N., Pinder, S., Bennett, M. R., Caldas, C. & Kitsis, R. N., Dec 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20826-20831 6 p.

Research output: Contribution to journalArticle

73 Scopus citations

The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: Identification of a degradation-resistant mutant

Nam, Y. J., Mani, K., Wu, L., Peng, C. F., Calvert, J. W., Foo, R. S. Y., Krishnamurthy, B., Miao, W., Ashton, A. W., Lefer, D. J. & Kitsis, R. N., Feb 23 2007, In : Journal of Biological Chemistry. 282, 8, p. 5522-5528 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2

Foo, R. S. Y., Chan, L. K. W., Kitsis, R. N. & Bennett, M. R., Feb 23 2007, In : Journal of Biological Chemistry. 282, 8, p. 5529-5535 7 p.

Research output: Contribution to journalArticle

63 Scopus citations
2006

Limiting Myocardial Damage during Acute Myocardial Infarction by Inhibiting C-Reactive Protein

Kitsis, R. N. & Jialal, I., Aug 3 2006, In : New England Journal of Medicine. 355, 5, p. 513-515 3 p.

Research output: Contribution to journalArticle

28 Scopus citations
2005

Fat apoptosis through targeted activation of caspase 8: A new mouse model of inducible and reversible lipoatrophy

Pajvani, U. B., Trujillo, M. E., Combs, T. P., Iyengar, P., Jelicks, L. A., Roth, K. A., Kitsis, R. N. & Scherer, P. E., Jul 1 2005, In : Nature Medicine. 11, 7, p. 797-803 7 p.

Research output: Contribution to journalArticle

201 Scopus citations

Impaired phagocytosis in caveolin-1 deficient macrophages

Li, J., Scherl, A., Medina, F., Frank, P. G., Kitsis, R. N., Tanowitz, H. B., Sotgia, F. & Lisanti, M. P., Nov 2005, In : Cell Cycle. 4, 11, p. 1599-1607 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

MCP-1/CCL2 protects cardiac myocytes from hypoxia-induced apoptosis by a Gαi-independent pathway

Tarzami, S. T., Calderon, T. M., Deguzman, A., Lopez, L., Kitsis, R. N. & Berman, J. W., Oct 7 2005, In : Biochemical and Biophysical Research Communications. 335, 4, p. 1008-1016 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease

Tanowitz, H. B., Huang, H., Jelicks, L. A., Chandra, M., Loredo, M. L., Weiss, L. M., Factor, S. M., Shtutin, V., Mukherjee, S., Kitsis, R. N., Christ, G. J., Wittner, M., Shirani, J., Kisanuki, Y. Y. & Yanagisawa, M., Apr 2005, In : Infection and immunity. 73, 4, p. 2496-2503 8 p.

Research output: Contribution to journalArticle

71 Scopus citations
2004

Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes

Young, D. A., Gavrilov, S., Pennington, C. J., Nuttall, R. K., Edwards, D. R., Kitsis, R. N. & Clark, I. M., Sep 24 2004, In : Biochemical and Biophysical Research Communications. 322, 3, p. 759-765 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions

Nam, Y. J., Mani, K., Ashton, A. W., Peng, C. F., Krishnamurthy, B., Hayakawa, Y., Lee, P., Korsmeyer, S. J. & Kitsis, R. N., Sep 24 2004, In : Molecular Cell. 15, 6, p. 901-912 12 p.

Research output: Contribution to journalArticle

138 Scopus citations
2003

Activation of transcription factors AP-1 and NF-κB in murine chagasic myocarditis

Huang, H., Petkova, S. B., Cohen, A. W., Bouzahzah, B., Chan, J., Zhou, J. N., Factor, S. M., Weiss, L. M., Krishnamachary, M., Mukherjee, S., Wittner, M., Kitsis, R. N., Pestell, R. G., Lisanti, M. P., Albanese, C. & Tanowitz, H. B., May 1 2003, In : Infection and immunity. 71, 5, p. 2859-2867 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

A mechanistic role for cardiac myocyte apoptosis in heart failure

Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C. & Kitsis, R. N., May 2003, In : Journal of Clinical Investigation. 111, 10, p. 1497-1504 8 p.

Research output: Contribution to journalArticle

575 Scopus citations

Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts

Cohen, A. W., Park, D. S., Woodman, S. E., Williams, T. M., Chandra, M., Shirani, J., De Souza, A. P., Kitsis, R. N., Russell, R. G., Weiss, L. M., Tang, B., Jelicks, L. A., Factor, S. M., Shtutin, V., Tanowitz, H. B. & Lisanti, M. P., Feb 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 2 53-2, p. C457-C474

Research output: Contribution to journalArticle

195 Scopus citations

Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo

Lee, P., Sata, M., Lefer, D. J., Factor, S. M., Walsh, K. & Kitsis, R. N., Feb 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 2 53-2, p. H456-H463

Research output: Contribution to journalArticle

168 Scopus citations

Inhibition of Cardiac Myocyte Apoptosis Improves Cardiac Function and Abolishes Mortality in the Peripartum Cardiomyopathy of Gαq Transgenic Mice

Hayakawa, Y., Chandra, M., Miao, W., Shirani, J., Brown, J. H., Dorn, G. W., Armstrong, R. C. & Kitsis, R. N., Dec 16 2003, In : Circulation. 108, 24, p. 3036-3041 6 p.

Research output: Contribution to journalArticle

188 Scopus citations

Microarray analysis of changes in gene expression in a murine model of chronic chagasic cardiomyopathy

Mukherjee, S., Belbin, T. J., Spray, D. C., Iacobas, D. A., Weiss, L. M., Kitsis, R. N., Wittner, M., Jelicks, L. A., Scherer, P. E., Ding, A. & Tanowitz, H. B., Oct 1 2003, In : Parasitology Research. 91, 3, p. 187-196 10 p.

Research output: Contribution to journalArticle

56 Scopus citations