• 10373 Citations
  • 50 h-Index
1979 …2019

Research output per year

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Publications

A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension

Zaiman, A. L., Damico, R., Thoms-Chesley, A., Clark Files, D., Kesari, P., Johnston, L., Swaim, M., Mozammel, S., Myers, A. C., Halushka, M., El-Haddad, H., Shimoda, L. A., Peng, C. F., Hassoun, P. M., Champion, H. C., Kitsis, R. N. & Crow, M. T., Dec 6 2011, In : Circulation. 124, 23, p. 2533-2542 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis

Albanese, C., D'Amico, M., Reutens, A. T., Fu, M., Watanabe, G., Lee, R. J., Kitsis, R. N., Henglein, B., Avantaggiati, M., Somasundaram, K., Thimmapaya, B. & Pestell, R. G., Nov 26 1999, In : Journal of Biological Chemistry. 274, 48, p. 34186-34195 10 p.

Research output: Contribution to journalArticle

166 Scopus citations

Activation of transcription factors AP-1 and NF-κB in murine chagasic myocarditis

Huang, H., Petkova, S. B., Cohen, A. W., Bouzahzah, B., Chan, J., Zhou, J. N., Factor, S. M., Weiss, L. M., Krishnamachary, M., Mukherjee, S., Wittner, M., Kitsis, R. N., Pestell, R. G., Lisanti, M. P., Albanese, C. & Tanowitz, H. B., May 1 2003, In : Infection and immunity. 71, 5, p. 2859-2867 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Akt promotes survival of cardiomyocytes in vitro and protects against lschemia-reperfusion injury in mouse heart

Fujio, Y., Nguyen, T., Wencker, D., Kitsis, R. N. & Walsh, K., Feb 15 2000, In : Circulation. 101, 6, p. 660-667 8 p.

Research output: Contribution to journalArticle

Open Access
689 Scopus citations

A mechanistic role for cardiac myocyte apoptosis in heart failure

Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C. & Kitsis, R. N., May 2003, In : Journal of Clinical Investigation. 111, 10, p. 1497-1504 8 p.

Research output: Contribution to journalArticle

584 Scopus citations

A microRNA links prolactin to peripartum cardiomyopathy

Yang, Y., Rodriguez, J. E. & Kitsis, R. N., May 1 2013, In : Journal of Clinical Investigation. 123, 5, p. 1925-1927 3 p.

Research output: Contribution to journalReview article

8 Scopus citations

A mouse model for the most common form of heart failure

Amgalan, D. & Kitsis, R. N., Apr 18 2019, In : Nature. 568, 7752, p. 324-325 2 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

A myeloid tumor suppressor role for NOL3

Stanley, R. F., Piszczatowski, R. T., Bartholdy, B., Mitchell, K., McKimpson, W. M., Narayanagari, S., Walter, D., Todorova, T. I., Hirsch, C., Makishima, H., Will, B., McMahon, C., Gritsman, K., Maciejewski, J. P., Kitsis, R. N. & Steidl, U., Mar 6 2017, In : The Journal of experimental medicine. 214, 3, p. 753-771 19 p.

Research output: Contribution to journalArticle

2 Scopus citations

An Akt3 splice variant lacking the serine 472 phosphorylation site promotes apoptosis and suppresses mammary tumorigenesis

Suyama, K., Yao, J., Liang, H., Benard, O., Loudig, O. D., Amgalan, D., McKimpson, W. M., Phillips, G. R., Segall, J., Wang, Y., Fineberg, S., Norton, L., Kitsis, R. N. & Hazan, R. B., Jan 1 2018, In : Cancer research. 78, 1, p. 103-114 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

A New Role for the ER Unfolded Protein Response Mediator ATF6: Induction of a Generalized Antioxidant Program

McKimpson, W. M. & Kitsis, R. N., Mar 3 2017, In : Circulation research. 120, 5, p. 759-761 3 p.

Research output: Contribution to journalReview article

5 Scopus citations

A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis

Kung, G., Dai, P., Deng, L. & Kitsis, R. N., Apr 1 2014, In : Cell Death and Differentiation. 21, 4, p. 634-644 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Apoptosis and the heart: A decade of progress

Kitsis, R. N. & Mann, D. L., Jan 1 2005, In : Journal of Molecular and Cellular Cardiology. 38, 1, p. 1-2 2 p.

Research output: Contribution to journalReview article

40 Scopus citations

Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistance

Medina-Ramirez, C. M., Goswami, S., Smirnova, T., Bamira, D., Benson, B., Ferrick, N., Segall, J., Pollard, J. W. & Kitsis, R. N., Dec 15 2011, In : Cancer research. 71, 24, p. 7705-7715 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Apoptosis predominates in nonmyocytes in heart failure

Park, M., Shen, Y. T., Gaussin, V., Heyndrickx, G. R., Bartunek, J., Resuello, R. R. G., Natividad, F. F., Kitsis, R. N., Vatner, D. E. & Vatner, S. F., Aug 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 2, p. H785-H791

Research output: Contribution to journalArticle

46 Scopus citations

Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle

Davis, J., Kwong, J. Q., Kitsis, R. N. & Molkentin, J. D., Dec 2 2013, In : PloS one. 8, 12, e82053.

Research output: Contribution to journalArticle

8 Scopus citations

Apoptosis repressor with caspase recruitment domain ameliorates amyloid-induced b-cell apoptosis and JNK pathway activation

Templin, A. T., Samarasekera, T., Meier, D. T., Hogan, M. F., Mellati, M., Crow, M. T., Kitsis, R. N., Zraika, S., Hull, R. L. & Kahn, S. E., Oct 1 2017, In : Diabetes. 66, 10, p. 2636-2645 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Apoptotic cell death "nixed" by an ER-mitochondrial necrotic pathway

Kitsis, R. N. & Molkentin, J. D., May 18 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 20, p. 9031-9032 2 p.

Research output: Contribution to journalComment/debate

36 Scopus citations

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

Hammerling, B. C., Najor, R. H., Cortez, M. Q., Shires, S. E., Leon, L. J., Gonzalez, E. R., Boassa, D., Phan, S., Thor, A., Jimenez, R. E., Li, H., Kitsis, R. N., Ii, G. W. D., Sadoshima, J., Ellisman, M. H. & Gustafsson, Å. B., Jan 30 2017, In : Nature communications. 8, 14050.

Research output: Contribution to journalArticle

65 Scopus citations

ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance [3]

Mercier, I., Vuolo, M., Madan, R., Xue, X., Levalley, A. J., Ashton, A. W., Jasmin, J. F., Czaja, M. T., Lin, E. Y., Armstrong, R. C., Pollard, J. W. & Kitsis, R. N., Jun 1 2005, In : Cell Death and Differentiation. 12, 6, p. 682-686 5 p.

Research output: Contribution to journalLetter

53 Scopus citations

ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer

Mercier, I., Vuolo, M., Jasmin, J. F., Medina, C. M., Williams, M., Mariadason, J. M., Qian, H., Xue, X., Pestell, R. G., Lisanti, M. P. & Kitsis, R. N., Jun 1 2008, In : Cell Cycle. 7, 11, p. 1640-1647 8 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations

ARC is essential for maintaining pancreatic islet structure and β-cell viability during type 2 diabetes

McKimpson, W. M., Zheng, M., Chua, Jr., S. C., Pessin, J. E. & Kitsis, R. N., Dec 1 2017, In : Scientific Reports. 7, 1, 7019.

Research output: Contribution to journalArticle

1 Scopus citations

Bax regulates primary necrosis through mitochondrial dynamics

Whelan, R. S., Konstantinidis, K., Wei, A. C., Chen, Y., Reyna, D. E., Jha, S., Yang, Y., Calvert, J. W., Lindsten, T., Thompson, C. B., Crow, M. T., Gavathiotis, E., Dorn, G. W., O'Rourke, B. & Kitsis, R. N., Apr 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 17, p. 6566-6571 6 p.

Research output: Contribution to journalArticle

189 Scopus citations

Behavior of genes directly injected into the rat heart in vivo

Buttrick, P. M., Kass, A., Kitsis, R. N., Kaplan, M. L. & Leinwand, L. A., 1992, In : Circulation research. 70, 1, p. 193-198 6 p.

Research output: Contribution to journalArticle

Open Access
122 Scopus citations

Beyond Mitophagy: The Diversity and Complexity of Parkin Function

Shires, S. E., Kitsis, R. N. & Gustafsson, Å. B., Apr 14 2017, In : Circulation research. 120, 8, p. 1234-1236 3 p.

Research output: Contribution to journalReview article

7 Scopus citations

Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo. An apoptosis-independent model of dilated heart failure

De Windt, L. J., Lim, H. W., Taigen, T., Wencker, D., Condorelli, G., Dorn, G. W., Kitsis, R. N. & Molkentin, J. D., Feb 18 2000, In : Circulation research. 86, 3, p. 255-263 9 p.

Research output: Contribution to journalArticle

Open Access
192 Scopus citations

Cardiomyocyte life-death decisions in response to chronic β-adrenergic signaling

Whelan, R. S., Konstantinidis, K., Xiao, R. P. & Kitsis, R. N., Feb 1 2013, In : Circulation research. 112, 3, p. 408-410 3 p.

Research output: Contribution to journalReview article

6 Scopus citations

Cardiovascular Biology: Escaped DNA inflames the heart

Konstantinidis, K. & Kitsis, R. N., May 9 2012, In : Nature. 485, 7397, p. 179-180 2 p.

Research output: Contribution to journalArticle

15 Scopus citations

Catch me if you can: Targeting the mitochondrial permeability transition pore in myocardial infarction

Linkermann, A., Konstantinidis, K. & Kitsis, R. N., Jan 1 2016, In : Cell Death and Differentiation. 23, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

11 Scopus citations

Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation

Liu, J., Lee, P., Galbiati, F., Kitsis, R. N. & Lisanti, M. P., Jan 1 2001, In : American Journal of Physiology - Cell Physiology. 280, 4 49-4, p. C823-C835

Research output: Contribution to journalArticle

91 Scopus citations

Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts

Cohen, A. W., Park, D. S., Woodman, S. E., Williams, T. M., Chandra, M., Shirani, J., De Souza, A. P., Kitsis, R. N., Russell, R. G., Weiss, L. M., Tang, B., Jelicks, L. A., Factor, S. M., Shtutin, V., Tanowitz, H. B. & Lisanti, M. P., Feb 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 2 53-2, p. C457-C474

Research output: Contribution to journalArticle

197 Scopus citations

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

Woodman, S. E., Park, D. S., Cohen, A. W., Cheung, M. W. C., Chandra, M., Shirani, J., Tang, B., Jelicks, L. A., Kitsis, R. N., Christ, G. J., Factor, S. M., Tanowitz, H. B. & Lisanti, M. P., Oct 11 2002, In : Journal of Biological Chemistry. 277, 41, p. 38988-38997 10 p.

Research output: Contribution to journalArticle

237 Scopus citations

Cell death in the cardiovascular system

Kaplinskiy, V., Bennett, M. R. & Kitsis, R. N., Jan 1 2011, Apoptosis: Physiology and Pathology. Cambridge University Press, p. 295-312 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell death in the pathogenesis of heart disease: Mechanisms and significance

Whelan, R. S., Kaplinskiy, V. & Kitsis, R. N., Mar 17 2009, In : Annual review of physiology. 72, p. 19-44 26 p.

Research output: Contribution to journalReview article

458 Scopus citations

Chemokine expression in myocardial ischemia: MIP-2 dependent MCP-1 expression protects cardiomyocytes from cell death

Tarzami, S. T., Cheng, R., Miao, W., Kitsis, R. N. & Berman, J. W., Feb 1 2002, In : Journal of Molecular and Cellular Cardiology. 34, 2, p. 209-221 13 p.

Research output: Contribution to journalArticle

73 Scopus citations

cis-Acting sequences that mediate induction of β-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction

Hasegawa, K., Lee, S. J., Jobe, S. M., Markham, B. E. & Kitsis, R. N., Jan 1 1997, In : Circulation. 96, 11, p. 3943-3953 11 p.

Research output: Contribution to journalArticle

146 Scopus citations

Correcting mitochondrial fusion by manipulating mitofusin conformations

Franco, A., Kitsis, R. N., Fleischer, J. A., Gavathiotis, E., Kornfeld, O. S., Gong, G., Biris, N., Benz, A., Qvit, N., Donnelly, S. K., Chen, Y., Mennerick, S., Hodgson, L., Mochly-Rosen, D. & Dorn, G. W., Dec 1 2016, In : Nature. 540, 7631, p. 74-79 6 p.

Research output: Contribution to journalArticle

91 Scopus citations

Correlations and dissociations between myosin isoenzymes and cardiac function

Kitsis, R. N. & Scheuer, J., Jan 1 1988, In : Journal of Applied Cardiology. 3, 5, p. 327-337 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

DAMP—Induced Allograft and Tumor Rejection: The Circle Is Closing

Land, W. G., Agostinis, P., Gasser, S., Garg, A. D., Linkermann, A., Abendroth, D. K., Adam, D., Anders, H. J., Arbogast, H. P., Baan, C., Bahram, S., Becker, J. U., Bonventre, J. V., Bräsen, J. H., Cantley, L. G., Chandraker, A., Daar, A., Daehn, I., Dragun, D., Dubernard, J. M. & 54 others, Falk, C. S., Georgel, P., Green, D. R., Grinyo, J., Haberal, M., Haller, H., Halloran, P. F., Heller, J. O., Hertig, A., Hilbrands, L., Huber, T. B., Janssen, O., Jevnikar, A. M., Kirk, A. D., Kitsis, R. N., Kupiec-Weglinski, J., Kunzendorf, U., Kroemer, G., Kurts, C., Ma, D., Maltzman, J., Margreiter, R., Massard, G., Messmer, K., Morris, R., Murphy, J., Nashan, B., Oberst, A., Ortiz, A., Overholtzer, M., Ponticelli, C., Rothstein, D. M., Sanz, A. B., Schiffer, M., Schröppel, B., Schulte, K., Seong, S. Y., Sibilia, J., Siedlecki, A. M., Sollinger, H. W., Strom, T. B., Stockwell, B. R., Szabó, A. J., Tonnus, W., Trivedi, H. L., Tullius, S. G., Turka, L. A., Turnquist, H., Vandenabeele, P., Vanden Berghe, T., Walczak, H., Weinberg, J. M., Wolf, P. & Zierleyn, A., Dec 1 2016, In : American Journal of Transplantation. 16, 12, p. 3322-3337 16 p.

Research output: Contribution to journalReview article

33 Scopus citations

Death begets failure in the heart

Foo, R. S. Y., Mani, K. & Kitsis, R. N., Mar 2005, In : Journal of Clinical Investigation. 115, 3, p. 565-571 7 p.

Research output: Contribution to journalReview article

Open Access
250 Scopus citations

Death receptor signaling in the heart: Cell survival, apoptosis, and necroptosis

Amgalan, D., Chen, Y. & Kitsis, R. N., Aug 1 2017, In : Circulation. 136, 8, p. 743-746 4 p.

Research output: Contribution to journalReview article

6 Scopus citations

Discordance between gene regulation in vitro and in vivo.

Kitsis, R. N. & Leinwand, L. A., 1992, In : Gene expression. 2, 4, p. 313-318 6 p.

Research output: Contribution to journalReview article

22 Scopus citations

Distinct behavior of cardiac myosin heavy chain gene constructs in vivo: Discordance with in vitro results

Buttrick, P. M., Kaplan, M. L., Kitsis, R. N. & Leinwand, L. A., 1993, In : Circulation research. 72, 6, p. 1211-1217 7 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus

McGrew, M. J., Bogdanova, N., Hasegawa, K., Hughes, S. H., Kitsis, R. N. & Rosenthal, N., 1996, In : Molecular and cellular biology. 16, 8, p. 4524-4534 11 p.

Research output: Contribution to journalArticle

Open Access
62 Scopus citations

Does Autophagy Mediate Cardiac Myocyte Death during Stress?

Nah, J., Fernández, Á. F., Kitsis, R. N., Levine, B. & Sadoshima, J., Sep 30 2016, In : Circulation research. 119, 8, p. 893-895 3 p.

Research output: Contribution to journalComment/debate

17 Scopus citations

Eat your heart out

Kitsis, R. N., Peng, C. F. & Cuervo, A. M., May 1 2007, In : Nature Medicine. 13, 5, p. 539-541 3 p.

Research output: Contribution to journalShort survey

25 Scopus citations

Echocardiographic assessment of left ventricular mass and systolic function in mice

Gardin, J. M., Siri, F. M., Kitsis, R. N., Edwards, J. G. & Leinwand, L. A., May 1995, In : Circulation research. 76, 5, p. 907-914 8 p.

Research output: Contribution to journalArticle

167 Scopus citations

Edmund H. Sonnenblick, MD (1932-2007).

Kitsis, R. N., Mar 2008, In : American journal of hypertension : journal of the American Society of Hypertension. 21, 3, p. 241-242 2 p.

Research output: Contribution to journalArticle

Erratum: Cardiomyocyte life-death decisions in response to chronic β-adrenergic signaling (Circulation Research (2013) 112 (408-410) DOI: 10.1161/CIRCRESAHA.113.300805)

Whelan, R. S., Konstantinidis, K., Xiao, R. P. & Kitsis, R. N., Jun 7 2013, In : Circulation research. 112, 12, p. e181

Research output: Contribution to journalComment/debate

Erratum: Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise (Cell Metabolism (2016) 23(6) (1078–1092)(S1550413116302224)(10.1016/j.cmet.2016.05.004))

Mera, P., Laue, K., Ferron, M., Confavreux, C., Wei, J., Galán-Díez, M., Lacampagne, A., Mitchell, S. J., Mattison, J. A., Chen, Y., Bacchetta, J., Szulc, P., Kitsis, R. N., de Cabo, R., Friedman, R. A., Torsitano, C., McGraw, T. E., Puchowicz, M., Kurland, I. & Karsenty, G., Jan 10 2017, In : Cell metabolism. 25, 1, 1 p.

Research output: Contribution to journalComment/debate

10 Scopus citations

Evaluating mitochondrial autophagy in the mouse heart

Shirakabe, A., Fritzky, L., Saito, T., Zhai, P., Miyamoto, S., Gustafsson, Å. B., Kitsis, R. N. & Sadoshima, J., Mar 1 2016, In : Journal of Molecular and Cellular Cardiology. 92, p. 134-139 6 p.

Research output: Contribution to journalArticle

9 Scopus citations