• 10373 Citations
  • 50 h-Index
1979 …2019

Research output per year

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Publications

Article

A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension

Zaiman, A. L., Damico, R., Thoms-Chesley, A., Clark Files, D., Kesari, P., Johnston, L., Swaim, M., Mozammel, S., Myers, A. C., Halushka, M., El-Haddad, H., Shimoda, L. A., Peng, C. F., Hassoun, P. M., Champion, H. C., Kitsis, R. N. & Crow, M. T., Dec 6 2011, In : Circulation. 124, 23, p. 2533-2542 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis

Albanese, C., D'Amico, M., Reutens, A. T., Fu, M., Watanabe, G., Lee, R. J., Kitsis, R. N., Henglein, B., Avantaggiati, M., Somasundaram, K., Thimmapaya, B. & Pestell, R. G., Nov 26 1999, In : Journal of Biological Chemistry. 274, 48, p. 34186-34195 10 p.

Research output: Contribution to journalArticle

166 Scopus citations

Activation of transcription factors AP-1 and NF-κB in murine chagasic myocarditis

Huang, H., Petkova, S. B., Cohen, A. W., Bouzahzah, B., Chan, J., Zhou, J. N., Factor, S. M., Weiss, L. M., Krishnamachary, M., Mukherjee, S., Wittner, M., Kitsis, R. N., Pestell, R. G., Lisanti, M. P., Albanese, C. & Tanowitz, H. B., May 1 2003, In : Infection and immunity. 71, 5, p. 2859-2867 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Akt promotes survival of cardiomyocytes in vitro and protects against lschemia-reperfusion injury in mouse heart

Fujio, Y., Nguyen, T., Wencker, D., Kitsis, R. N. & Walsh, K., Feb 15 2000, In : Circulation. 101, 6, p. 660-667 8 p.

Research output: Contribution to journalArticle

Open Access
689 Scopus citations

A mechanistic role for cardiac myocyte apoptosis in heart failure

Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C. & Kitsis, R. N., May 2003, In : Journal of Clinical Investigation. 111, 10, p. 1497-1504 8 p.

Research output: Contribution to journalArticle

584 Scopus citations

A mouse model for the most common form of heart failure

Amgalan, D. & Kitsis, R. N., Apr 18 2019, In : Nature. 568, 7752, p. 324-325 2 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

A myeloid tumor suppressor role for NOL3

Stanley, R. F., Piszczatowski, R. T., Bartholdy, B., Mitchell, K., McKimpson, W. M., Narayanagari, S., Walter, D., Todorova, T. I., Hirsch, C., Makishima, H., Will, B., McMahon, C., Gritsman, K., Maciejewski, J. P., Kitsis, R. N. & Steidl, U., Mar 6 2017, In : The Journal of experimental medicine. 214, 3, p. 753-771 19 p.

Research output: Contribution to journalArticle

2 Scopus citations

An Akt3 splice variant lacking the serine 472 phosphorylation site promotes apoptosis and suppresses mammary tumorigenesis

Suyama, K., Yao, J., Liang, H., Benard, O., Loudig, O. D., Amgalan, D., McKimpson, W. M., Phillips, G. R., Segall, J., Wang, Y., Fineberg, S., Norton, L., Kitsis, R. N. & Hazan, R. B., Jan 1 2018, In : Cancer research. 78, 1, p. 103-114 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis

Kung, G., Dai, P., Deng, L. & Kitsis, R. N., Apr 1 2014, In : Cell Death and Differentiation. 21, 4, p. 634-644 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistance

Medina-Ramirez, C. M., Goswami, S., Smirnova, T., Bamira, D., Benson, B., Ferrick, N., Segall, J., Pollard, J. W. & Kitsis, R. N., Dec 15 2011, In : Cancer research. 71, 24, p. 7705-7715 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Apoptosis predominates in nonmyocytes in heart failure

Park, M., Shen, Y. T., Gaussin, V., Heyndrickx, G. R., Bartunek, J., Resuello, R. R. G., Natividad, F. F., Kitsis, R. N., Vatner, D. E. & Vatner, S. F., Aug 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 2, p. H785-H791

Research output: Contribution to journalArticle

46 Scopus citations

Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle

Davis, J., Kwong, J. Q., Kitsis, R. N. & Molkentin, J. D., Dec 2 2013, In : PloS one. 8, 12, e82053.

Research output: Contribution to journalArticle

8 Scopus citations

Apoptosis repressor with caspase recruitment domain ameliorates amyloid-induced b-cell apoptosis and JNK pathway activation

Templin, A. T., Samarasekera, T., Meier, D. T., Hogan, M. F., Mellati, M., Crow, M. T., Kitsis, R. N., Zraika, S., Hull, R. L. & Kahn, S. E., Oct 1 2017, In : Diabetes. 66, 10, p. 2636-2645 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

Hammerling, B. C., Najor, R. H., Cortez, M. Q., Shires, S. E., Leon, L. J., Gonzalez, E. R., Boassa, D., Phan, S., Thor, A., Jimenez, R. E., Li, H., Kitsis, R. N., Ii, G. W. D., Sadoshima, J., Ellisman, M. H. & Gustafsson, Å. B., Jan 30 2017, In : Nature communications. 8, 14050.

Research output: Contribution to journalArticle

65 Scopus citations

ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer

Mercier, I., Vuolo, M., Jasmin, J. F., Medina, C. M., Williams, M., Mariadason, J. M., Qian, H., Xue, X., Pestell, R. G., Lisanti, M. P. & Kitsis, R. N., Jun 1 2008, In : Cell Cycle. 7, 11, p. 1640-1647 8 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations

ARC is essential for maintaining pancreatic islet structure and β-cell viability during type 2 diabetes

McKimpson, W. M., Zheng, M., Chua, Jr., S. C., Pessin, J. E. & Kitsis, R. N., Dec 1 2017, In : Scientific Reports. 7, 1, 7019.

Research output: Contribution to journalArticle

1 Scopus citations

Bax regulates primary necrosis through mitochondrial dynamics

Whelan, R. S., Konstantinidis, K., Wei, A. C., Chen, Y., Reyna, D. E., Jha, S., Yang, Y., Calvert, J. W., Lindsten, T., Thompson, C. B., Crow, M. T., Gavathiotis, E., Dorn, G. W., O'Rourke, B. & Kitsis, R. N., Apr 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 17, p. 6566-6571 6 p.

Research output: Contribution to journalArticle

189 Scopus citations

Behavior of genes directly injected into the rat heart in vivo

Buttrick, P. M., Kass, A., Kitsis, R. N., Kaplan, M. L. & Leinwand, L. A., 1992, In : Circulation research. 70, 1, p. 193-198 6 p.

Research output: Contribution to journalArticle

Open Access
122 Scopus citations

Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo. An apoptosis-independent model of dilated heart failure

De Windt, L. J., Lim, H. W., Taigen, T., Wencker, D., Condorelli, G., Dorn, G. W., Kitsis, R. N. & Molkentin, J. D., Feb 18 2000, In : Circulation research. 86, 3, p. 255-263 9 p.

Research output: Contribution to journalArticle

Open Access
192 Scopus citations

Cardiovascular Biology: Escaped DNA inflames the heart

Konstantinidis, K. & Kitsis, R. N., May 9 2012, In : Nature. 485, 7397, p. 179-180 2 p.

Research output: Contribution to journalArticle

15 Scopus citations

Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation

Liu, J., Lee, P., Galbiati, F., Kitsis, R. N. & Lisanti, M. P., Jan 1 2001, In : American Journal of Physiology - Cell Physiology. 280, 4 49-4, p. C823-C835

Research output: Contribution to journalArticle

91 Scopus citations

Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts

Cohen, A. W., Park, D. S., Woodman, S. E., Williams, T. M., Chandra, M., Shirani, J., De Souza, A. P., Kitsis, R. N., Russell, R. G., Weiss, L. M., Tang, B., Jelicks, L. A., Factor, S. M., Shtutin, V., Tanowitz, H. B. & Lisanti, M. P., Feb 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 2 53-2, p. C457-C474

Research output: Contribution to journalArticle

197 Scopus citations

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

Woodman, S. E., Park, D. S., Cohen, A. W., Cheung, M. W. C., Chandra, M., Shirani, J., Tang, B., Jelicks, L. A., Kitsis, R. N., Christ, G. J., Factor, S. M., Tanowitz, H. B. & Lisanti, M. P., Oct 11 2002, In : Journal of Biological Chemistry. 277, 41, p. 38988-38997 10 p.

Research output: Contribution to journalArticle

237 Scopus citations

Chemokine expression in myocardial ischemia: MIP-2 dependent MCP-1 expression protects cardiomyocytes from cell death

Tarzami, S. T., Cheng, R., Miao, W., Kitsis, R. N. & Berman, J. W., Feb 1 2002, In : Journal of Molecular and Cellular Cardiology. 34, 2, p. 209-221 13 p.

Research output: Contribution to journalArticle

73 Scopus citations

cis-Acting sequences that mediate induction of β-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction

Hasegawa, K., Lee, S. J., Jobe, S. M., Markham, B. E. & Kitsis, R. N., Jan 1 1997, In : Circulation. 96, 11, p. 3943-3953 11 p.

Research output: Contribution to journalArticle

146 Scopus citations

Correcting mitochondrial fusion by manipulating mitofusin conformations

Franco, A., Kitsis, R. N., Fleischer, J. A., Gavathiotis, E., Kornfeld, O. S., Gong, G., Biris, N., Benz, A., Qvit, N., Donnelly, S. K., Chen, Y., Mennerick, S., Hodgson, L., Mochly-Rosen, D. & Dorn, G. W., Dec 1 2016, In : Nature. 540, 7631, p. 74-79 6 p.

Research output: Contribution to journalArticle

91 Scopus citations

Correlations and dissociations between myosin isoenzymes and cardiac function

Kitsis, R. N. & Scheuer, J., Jan 1 1988, In : Journal of Applied Cardiology. 3, 5, p. 327-337 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Distinct behavior of cardiac myosin heavy chain gene constructs in vivo: Discordance with in vitro results

Buttrick, P. M., Kaplan, M. L., Kitsis, R. N. & Leinwand, L. A., 1993, In : Circulation research. 72, 6, p. 1211-1217 7 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus

McGrew, M. J., Bogdanova, N., Hasegawa, K., Hughes, S. H., Kitsis, R. N. & Rosenthal, N., 1996, In : Molecular and cellular biology. 16, 8, p. 4524-4534 11 p.

Research output: Contribution to journalArticle

Open Access
62 Scopus citations

Echocardiographic assessment of left ventricular mass and systolic function in mice

Gardin, J. M., Siri, F. M., Kitsis, R. N., Edwards, J. G. & Leinwand, L. A., May 1995, In : Circulation research. 76, 5, p. 907-914 8 p.

Research output: Contribution to journalArticle

167 Scopus citations

Edmund H. Sonnenblick, MD (1932-2007).

Kitsis, R. N., Mar 2008, In : American journal of hypertension : journal of the American Society of Hypertension. 21, 3, p. 241-242 2 p.

Research output: Contribution to journalArticle

Evaluating mitochondrial autophagy in the mouse heart

Shirakabe, A., Fritzky, L., Saito, T., Zhai, P., Miyamoto, S., Gustafsson, Å. B., Kitsis, R. N. & Sadoshima, J., Mar 1 2016, In : Journal of Molecular and Cellular Cardiology. 92, p. 134-139 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes

Young, D. A., Gavrilov, S., Pennington, C. J., Nuttall, R. K., Edwards, D. R., Kitsis, R. N. & Clark, I. M., Sep 24 2004, In : Biochemical and Biophysical Research Communications. 322, 3, p. 759-765 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Fas-FasL interaction modulates nitric oxide production in Trypanosoma cruzi-infected mice

Martins, G. A., Petkova, S. B., Machado, F. S., Kitsis, R. N., Weiss, L. M., Wittner, M., Tanowitz, H. B. & Silva, J. S., 2001, In : Immunology. 103, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo

Lee, P., Sata, M., Lefer, D. J., Factor, S. M., Walsh, K. & Kitsis, R. N., Feb 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 2 53-2, p. H456-H463

Research output: Contribution to journalArticle

169 Scopus citations

Fat apoptosis through targeted activation of caspase 8: A new mouse model of inducible and reversible lipoatrophy

Pajvani, U. B., Trujillo, M. E., Combs, T. P., Iyengar, P., Jelicks, L. A., Roth, K. A., Kitsis, R. N. & Scherer, P. E., Jul 1 2005, In : Nature Medicine. 11, 7, p. 797-803 7 p.

Research output: Contribution to journalArticle

202 Scopus citations

Fundamental mechanisms of regulated cell death and implications for heart disease

Del Re, D. P., Amgalan, D., Linkermann, A., Liu, Q. & Kitsis, R. N., Jul 2019, In : Physiological Reviews. 99, 4, p. 1765-1817 53 p.

Research output: Contribution to journalArticle

35 Scopus citations

GATA-5 is involved in leukemia inhibitory factor-responsive transcription of the β-myosin heavy chain gene in cardiac myocytes

Morimoto, T., Hasegawa, K., Kaburagi, S., Kakita, T., Masutani, H., Kitsis, R. N., Matsumori, A. & Sasayama, S., Apr 30 1999, In : Journal of Biological Chemistry. 274, 18, p. 12811-12818 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Hepatocyte Growth Factor/Scatter Factor Blocks the Mitochondrial Pathway of Apoptosis Signaling in Breast Cancer Cells

Gao, M., Fan, S., Goldberg, I. D., Laterra, J., Kitsis, R. N. & Rosen, E. M., Dec 14 2001, In : Journal of Biological Chemistry. 276, 50, p. 47257-47265 9 p.

Research output: Contribution to journalArticle

45 Scopus citations
53 Scopus citations

Hormonal modulation of a gene injected into rat heart in vivo

Kitsis, R. N., Buttrick, P. M., McNally, E. M., Kaplan, M. L. & Leinwand, L. A., Jan 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 10, p. 4138-4142 5 p.

Research output: Contribution to journalArticle

Open Access
151 Scopus citations

Impaired phagocytosis in caveolin-1 deficient macrophages

Li, J., Scherl, A., Medina, F., Frank, P. G., Kitsis, R. N., Tanowitz, H. B., Sotgia, F. & Lisanti, M. P., Nov 2005, In : Cell Cycle. 4, 11, p. 1599-1607 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Induction of DNA synthesis and apoptosis in cardiac myocytes by E1A oncoprotein

Liu, Y. & Kitsis, R. N., Apr 1 1996, In : Journal of Cell Biology. 133, 2, p. 325-334 10 p.

Research output: Contribution to journalArticle

76 Scopus citations

Induction of the apoptosis inhibitor ARC by Ras in human cancers

Wu, L., Nam, Y. J., Kung, G., Crow, M. T. & Kitsis, R. N., Jun 18 2010, In : Journal of Biological Chemistry. 285, 25, p. 19235-19245 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions

Nam, Y. J., Mani, K., Ashton, A. W., Peng, C. F., Krishnamurthy, B., Hayakawa, Y., Lee, P., Korsmeyer, S. J. & Kitsis, R. N., Sep 24 2004, In : Molecular Cell. 15, 6, p. 901-912 12 p.

Research output: Contribution to journalArticle

140 Scopus citations

Inhibition of Cardiac Myocyte Apoptosis Improves Cardiac Function and Abolishes Mortality in the Peripartum Cardiomyopathy of Gαq Transgenic Mice

Hayakawa, Y., Chandra, M., Miao, W., Shirani, J., Brown, J. H., Dorn, G. W., Armstrong, R. C. & Kitsis, R. N., Dec 16 2003, In : Circulation. 108, 24, p. 3036-3041 6 p.

Research output: Contribution to journalArticle

188 Scopus citations

Interdependence of parkin-mediated mitophagy and mitochondrial fission in adult mouse hearts

Song, M., Gong, G., Burelle, Y., Gustafsson, Å. B., Kitsis, R. N., Matkovich, S. J. & Dorn, G. W., Jul 1 2015, In : Circulation research. 117, 4, p. 346-351 6 p.

Research output: Contribution to journalArticle

89 Scopus citations

Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo

Miao, W., Luo, Z., Kitsis, R. N. & Walsh, K., Jan 1 2000, In : Journal of Molecular and Cellular Cardiology. 32, 12, p. 2397-2402 6 p.

Research output: Contribution to journalArticle

119 Scopus citations

Intravascular ultrasound catheter evaluation of the left ventricle in mice: A feasibility study

Gardin, J. M., Siri, F., Kitsis, R. N. & Leinwand, L., Jan 1 1996, In : Echocardiography. 13, 6, p. 609-612 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Limiting Myocardial Damage during Acute Myocardial Infarction by Inhibiting C-Reactive Protein

Kitsis, R. N. & Jialal, I., Aug 3 2006, In : New England Journal of Medicine. 355, 5, p. 513-515 3 p.

Research output: Contribution to journalArticle

28 Scopus citations