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Publications 1979 2019

2019
2 Citations (Scopus)

A mouse model for the most common form of heart failure

Amgalan, D. & Kitsis, R. N., Apr 18 2019, In : Nature. 568, 7752, p. 324-325 2 p.

Research output: Contribution to journalArticle

Open Access
Heart Failure
Therapeutics
3 Citations (Scopus)

Fundamental mechanisms of regulated cell death and implications for heart disease

Del Re, D. P., Amgalan, D., Linkermann, A., Liu, Q. & Kitsis, R. N., Jul 1 2019, In : Physiological Reviews. 99, 4, p. 1765-1817 53 p.

Research output: Contribution to journalArticle

Heart Diseases
Cell Death
Death Domain Receptors
Reperfusion
Heart Failure
9 Citations (Scopus)

Small-molecule allosteric inhibitors of BAX

Garner, T. P., Amgalan, D., Reyna, D. E., Li, S., Kitsis, R. N. & Gavathiotis, E., Jan 1 2019, In : Nature Chemical Biology.

Research output: Contribution to journalArticle

Cell Death
Mitochondrial Membranes
Hydrogen Bonding
Pharmacology
Proteins
1 Citation (Scopus)

Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

Tian, R., Colucci, W. S., Arany, Z., Bachschmid, M. M., Ballinger, S. W., Boudina, S., Bruce, J. E., Busija, D. W., Dikalov, S., Dorn, G. W., Galis, Z. S., Gottlieb, R. A., Kelly, D. P., Kitsis, R. N., Kohr, M. J., Levy, D., Lewandowski, E. D., McClung, J. M., Mochly-Rosen, D., O'Brien, K. D. & 12 others, O'Rourke, B., Park, J. Y., Ping, P., Sack, M. N., Sheu, S. S., Shi, Y., Shiva, S., Wallace, D. C., Weiss, R. G., Vernon, H. J., Wong, R. & Schwartz Longacre, L., Oct 1 2019, In : Circulation. 140, 14, p. 1205-1216 12 p.

Research output: Contribution to journalArticle

National Heart, Lung, and Blood Institute (U.S.)
Cardiovascular System
Mitochondria
Heart Failure
Education
2018
4 Citations (Scopus)

An Akt3 splice variant lacking the serine 472 phosphorylation site promotes apoptosis and suppresses mammary tumorigenesis

Suyama, K., Yao, J., Liang, H., Benard, O., Loudig, O. D., Amgalan, D., McKimpson, W. M., Phillips, G. R., Segall, J. E., Wang, Y., Fineberg, S. A., Norton, L., Kitsis, R. N. & Hazan, R., Jan 1 2018, In : Cancer Research. 78, 1, p. 103-114 12 p.

Research output: Contribution to journalArticle

Serine
Protein Isoforms
Carcinogenesis
Breast
Phosphorylation
6 Citations (Scopus)

Heart Disease and Cancer

Kitsis, R. N., Riquelme, J. A. & Lavandero, S., Aug 14 2018, In : Circulation. 138, 7, p. 692-695 4 p.

Research output: Contribution to journalEditorial

Heart Neoplasms
Ceruloplasmin
Fibronectins
Heart Diseases
Heart Failure
32 Citations (Scopus)

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A

Rocha, A. G., Franco, A., Krezel, A. M., Rumsey, J. M., Alberti, J. M., Knight, W. C., Biris, N., Zacharioudakis, E., Janetka, J. W., Baloh, R. H., Kitsis, R. N., Mochly-Rosen, D., Townsend, R. R., Gavathiotis, E. & Dorn, G. W., Apr 20 2018, In : Science. 360, 6386, p. 336-341 6 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Peptides
Sciatic Nerve
Phosphotransferases
Phosphorylation
474 Citations (Scopus)

Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Annicchiarico-Petruzzelli, M., Antonov, A. V., Arama, E., Baehrecke, E. H., Barlev, N. A., Bazan, N. G., Bernassola, F., Bertrand, M. J. M., Bianchi, K., Blagosklonny, M. V. & 149 others, Blomgren, K., Borner, C., Boya, P., Brenner, C., Campanella, M., Candi, E., Carmona-Gutierrez, D., Cecconi, F., Chan, F. K. M., Chandel, N. S., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Cohen, G. M., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D'Angiolella, V., Dawson, T. M., Dawson, V. L., De Laurenzi, V., De Maria, R., Debatin, K. M., Deberardinis, R. J., Deshmukh, M., Di Daniele, N., Di Virgilio, F., Dixit, V. M., Dixon, S. J., Duckett, C. S., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Fimia, G. M., Fulda, S., García-Sáez, A. J., Garg, A. D., Garrido, C., Gavathiotis, E., Golstein, P., Gottlieb, E., Green, D. R., Greene, L. A., Gronemeyer, H., Gross, A., Hajnoczky, G., Hardwick, J. M., Harris, I. S., Hengartner, M. O., Hetz, C., Ichijo, H., Jäättelä, M., Joseph, B., Jost, P. J., Juin, P. P., Kaiser, W. J., Karin, M., Kaufmann, T., Kepp, O., Kimchi, A., Kitsis, R. N., Klionsky, D. J., Knight, R. A., Kumar, S., Lee, S. W., Lemasters, J. J., Levine, B., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Lowe, S. W., Luedde, T., Lugli, E., MacFarlane, M., Madeo, F., Malewicz, M., Malorni, W., Manic, G., Marine, J. C., Martin, S. J., Martinou, J. C., Medema, J. P., Mehlen, P., Meier, P., Melino, S., Miao, E. A., Molkentin, J. D., Moll, U. M., Muñoz-Pinedo, C., Nagata, S., Nuñez, G., Oberst, A., Oren, M., Overholtzer, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J. M., Pereira, D. M., Pervaiz, S., Peter, M. E., Piacentini, M., Pinton, P., Prehn, J. H. M., Puthalakath, H., Rabinovich, G. A., Rehm, M., Rizzuto, R., Rodrigues, C. M. P., Rubinsztein, D. C., Rudel, T., Ryan, K. M., Sayan, E., Scorrano, L., Shao, F., Shi, Y., Silke, J., Simon, H. U., Sistigu, A., Stockwell, B. R., Strasser, A., Szabadkai, G., Tait, S. W. G., Tang, D., Tavernarakis, N., Thorburn, A., Tsujimoto, Y., Turk, B., Vanden Berghe, T., Vandenabeele, P., Vander Heiden, M. G., Villunger, A., Virgin, H. W., Vousden, K. H., Vucic, D., Wagner, E. F., Walczak, H., Wallach, D., Wang, Y., Wells, J. A., Wood, W., Yuan, J., Zakeri, Z., Zhivotovsky, B., Zitvogel, L., Melino, G. & Kroemer, G., Mar 1 2018, In : Cell Death and Differentiation. 25, 3, p. 486-541 56 p.

Research output: Contribution to journalReview article

Terminology
Cell Death
Apoptosis
Cell Aging
Autophagy

PDCD5 says no to NO

Riascos-Bernal, D. F., Sibinga, N. E. S. & Kitsis, R. N., May 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4535-4537 3 p.

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

RCAN1-calcineurin axis and the set-point for myocardial damage during ischemia-reperfusion

Jose Corbalan, J. & Kitsis, R. N., Mar 1 2018, In : Circulation Research. 122, 6, p. 796-798 3 p.

Research output: Contribution to journalEditorial

Calcineurin
Reperfusion
Ischemia
7 Citations (Scopus)

Ryanodine Receptor Calcium Leak in Circulating B-Lymphocytes as a Biomarker in Heart Failure

Kushnir, A., Santulli, G., Reiken, S. R., Coromilas, E., Godfrey, S. J., Brunjes, D. L., Colombo, P. C., Yuzefpolskaya, M., Sokol, S. I., Kitsis, R. N. & Marks, A. R., Sep 11 2018, In : Circulation. 138, 11, p. 1144-1154 11 p.

Research output: Contribution to journalArticle

Ryanodine Receptor Calcium Release Channel
B-Lymphocytes
Heart Failure
Biomarkers
Calcium
4 Citations (Scopus)

SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy

Feng, D., Amgalan, D., Singh, R., Wei, J., Wen, J., Wei, T. P., McGraw, T. E., Kitsis, R. N. & Pessin, J. E., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 3941-3956 16 p.

Research output: Contribution to journalArticle

Autophagy
Adipocytes
Cell Death
SNARE Proteins
Congenital Generalized Lipodystrophy
2017

A myeloid tumor suppressor role for NOL3

Stanley, R. F., Piszczatowski, R. T., Bartholdy, B. A., Mitchell, K., McKimpson, W. M., Narayanagari, S-R., Walter, D., Todorova, T. I., Hirsch, C., Makishima, H., Will, B., McMahon, C., Gritsman, K., Maciejewski, J. P., Kitsis, R. N. & Steidl, U. G., Mar 6 2017, In : The Journal of experimental medicine. 214, 3, p. 753-771 19 p.

Research output: Contribution to journalArticle

Primary Myelofibrosis
Neoplasms
Nuclear Proteins
Cyclin-Dependent Kinase 6
Cell Biology
4 Citations (Scopus)

A New Role for the ER Unfolded Protein Response Mediator ATF6: Induction of a Generalized Antioxidant Program

McKimpson, W. M. & Kitsis, R. N., Mar 3 2017, In : Circulation Research. 120, 5, p. 759-761 3 p.

Research output: Contribution to journalReview article

4 Citations (Scopus)

Apoptosis repressor with caspase recruitment domain ameliorates amyloid-induced b-cell apoptosis and JNK pathway activation

Templin, A. T., Samarasekera, T., Meier, D. T., Hogan, M. F., Mellati, M., Crow, M. T., Kitsis, R. N., Zraika, S., Hull, R. L. & Kahn, S. E., Oct 1 2017, In : Diabetes. 66, 10, p. 2636-2645 10 p.

Research output: Contribution to journalArticle

AIDS-Related Complex
Amyloid
Phosphotransferases
Apoptosis
JNK Mitogen-Activated Protein Kinases
41 Citations (Scopus)

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

Hammerling, B. C., Najor, R. H., Cortez, M. Q., Shires, S. E., Leon, L. J., Gonzalez, E. R., Boassa, D., Phan, S., Thor, A., Jimenez, R. E., Li, H., Kitsis, R. N., Ii, G. W. D., Sadoshima, J., Ellisman, M. H. & Gustafsson, Å. B., Jan 30 2017, In : Nature Communications. 8, 14050.

Research output: Contribution to journalArticle

Mitochondria
mitochondria
clearances
Autophagy
Endosomes
1 Citation (Scopus)

ARC is essential for maintaining pancreatic islet structure and β-cell viability during type 2 diabetes

McKimpson, W. M., Zheng, M., Chua, Jr., S. C., Pessin, J. E. & Kitsis, R. N., Dec 1 2017, In : Scientific Reports. 7, 1, 7019.

Research output: Contribution to journalArticle

Islets of Langerhans
Type 2 Diabetes Mellitus
Cell Survival
Apoptosis
Transcription Factor CHOP
7 Citations (Scopus)

Beyond Mitophagy: The Diversity and Complexity of Parkin Function

Shires, S. E., Kitsis, R. N. & Gustafsson, Å. B., Apr 14 2017, In : Circulation Research. 120, 8, p. 1234-1236 3 p.

Research output: Contribution to journalReview article

Mitochondrial Degradation
Ubiquitin-Protein Ligases
Autophagy
Parkinson Disease
5 Citations (Scopus)

Death receptor signaling in the heart: Cell survival, apoptosis, and necroptosis

Amgalan, D., Chen, Y. & Kitsis, R. N., Aug 1 2017, In : Circulation. 136, 8, p. 743-746 4 p.

Research output: Contribution to journalReview article

TNF Receptor-Associated Factor 2
Death Domain Receptors
Cell Survival
Cell Death
Necrosis
4 Citations (Scopus)

Erratum: Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise (Cell Metabolism (2016) 23(6) (1078–1092)(S1550413116302224)(10.1016/j.cmet.2016.05.004))

Mera, P., Laue, K., Ferron, M., Confavreux, C., Wei, J., Galán-Díez, M., Lacampagne, A., Mitchell, S. J., Mattison, J. A., Chen, Y., Bacchetta, J., Szulc, P., Kitsis, R. N., de Cabo, R., Friedman, R. A., Torsitano, C., McGraw, T. E., Puchowicz, M., Kurland, I. & Karsenty, G., Jan 10 2017, In : Cell Metabolism. 25, 1, p. 218 1 p.

Research output: Contribution to journalComment/debate

Osteocalcin
Publications
10 Citations (Scopus)

Grounding Cardio-Oncology in Basic and Clinical Science

Moslehi, J., Amgalan, D. & Kitsis, R. N., Jul 4 2017, In : Circulation. 136, 1, p. 3-5 3 p.

Research output: Contribution to journalShort survey

Precision Medicine
Cardiomyopathies
Drug Therapy
31 Citations (Scopus)

Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering

Yanamandala, M., Zhu, W., Garry, D. J., Kamp, T. J., Hare, J. M., Jun, H. W., Yoon, Y. S., Bursac, N., Prabhu, S. D., Dorn, G. W., Bolli, R., Kitsis, R. N. & Zhang, J., Aug 8 2017, In : Journal of the American College of Cardiology. 70, 6, p. 766-775 10 p.

Research output: Contribution to journalReview article

Tissue Engineering
Cell- and Tissue-Based Therapy
Genetic Techniques
Genetic Engineering
Stem Cell Transplantation
5 Citations (Scopus)

Troponin Release Following Brief Myocardial Ischemia: Apoptosis Versus Necrosis

Amgalan, D., Pekson, R. & Kitsis, R. N., Apr 1 2017, In : JACC: Basic to Translational Science. 2, 2, p. 118-121 4 p.

Research output: Contribution to journalEditorial

Troponin
Myocardial Ischemia
Cell Death
Necrosis
Ischemia
9 Citations (Scopus)

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1

Wang, Y., Wu, B., Lu, P., Zhang, D., Wu, B., Varshney, S., Del Monte-Nieto, G., Zhuang, Z., Charafeddine, R., Kramer, A. H., Sibinga, N. E. S., Frangogiannis, N. G., Kitsis, R. N., Adams, R. H., Alitalo, K., Sharp, D. J., Harvey, R. P., Stanley, P. & Zhou, B., Dec 1 2017, In : Nature Communications. 8, 1, 578.

Research output: Contribution to journalArticle

arteries
mice
Coronary Vessels
anomalies
expansion
2016
11 Citations (Scopus)

Catch me if you can: Targeting the mitochondrial permeability transition pore in myocardial infarction

Linkermann, A., Konstantinidis, K. & Kitsis, R. N., Jan 1 2016, In : Cell Death and Differentiation. 23, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

Cyclophilins
Ventricular Remodeling
Enzyme Inhibitors
Percutaneous Coronary Intervention
Cyclosporine
75 Citations (Scopus)

Correcting mitochondrial fusion by manipulating mitofusin conformations

Franco, A., Kitsis, R. N., Fleischer, J. A., Gavathiotis, E., Kornfeld, O. S., Gong, G., Biris, N., Benz, A., Qvit, N., Donnelly, S. K., Chen, Y., Mennerick, S., Hodgson, L., Mochly-Rosen, D. & Dorn, G. W., Dec 1 2016, In : Nature. 540, 7631, p. 74-79 6 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Molecular Conformation
Organelles
Mitochondria
Fibroblasts
26 Citations (Scopus)

DAMP—Induced Allograft and Tumor Rejection: The Circle Is Closing

Land, W. G., Agostinis, P., Gasser, S., Garg, A. D., Linkermann, A., Abendroth, D. K., Adam, D., Anders, H. J., Arbogast, H. P., Baan, C., Bahram, S., Becker, J. U., Bonventre, J. V., Bräsen, J. H., Cantley, L. G., Chandraker, A., Daar, A., Daehn, I., Dragun, D., Dubernard, J. M. & 54 others, Falk, C. S., Georgel, P., Green, D. R., Grinyo, J., Haberal, M., Haller, H., Halloran, P. F., Heller, J. O., Hertig, A., Hilbrands, L., Huber, T. B., Janssen, O., Jevnikar, A. M., Kirk, A. D., Kitsis, R. N., Kupiec-Weglinski, J., Kunzendorf, U., Kroemer, G., Kurts, C., Ma, D., Maltzman, J., Margreiter, R., Massard, G., Messmer, K., Morris, R., Murphy, J., Nashan, B., Oberst, A., Ortiz, A., Overholtzer, M., Ponticelli, C., Rothstein, D. M., Sanz, A. B., Schiffer, M., Schröppel, B., Schulte, K., Seong, S. Y., Sibilia, J., Siedlecki, A. M., Sollinger, H. W., Strom, T. B., Stockwell, B. R., Szabó, A. J., Tonnus, W., Trivedi, H. L., Tullius, S. G., Turka, L. A., Turnquist, H., Vandenabeele, P., Vanden Berghe, T., Walczak, H., Weinberg, J. M., Wolf, P. & Zierleyn, A., Dec 1 2016, In : American Journal of Transplantation. 16, 12, p. 3322-3337 16 p.

Research output: Contribution to journalReview article

Allografts
Immunotherapy
Neoplasms
Necrosis
Inflammation
12 Citations (Scopus)

Does Autophagy Mediate Cardiac Myocyte Death during Stress?

Nah, J., Fernández, Á. F., Kitsis, R. N., Levine, B. & Sadoshima, J., Sep 30 2016, In : Circulation Research. 119, 8, p. 893-895 3 p.

Research output: Contribution to journalComment/debate

7 Citations (Scopus)

Evaluating mitochondrial autophagy in the mouse heart

Shirakabe, A., Fritzky, L., Saito, T., Zhai, P., Miyamoto, S., Gustafsson, Å. B., Kitsis, R. N. & Sadoshima, J., Mar 1 2016, In : Journal of Molecular and Cellular Cardiology. 92, p. 134-139 6 p.

Research output: Contribution to journalArticle

Autophagy
Fasting
Dependovirus
Mitochondria
Lysosomes
87 Citations (Scopus)

Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement from the American Heart Association

On behalf of the American Heart Association Council on Basic Cardiovascular Sciences, Council on Clinical Cardiology, and Council on Functional Genomics and Translational Biology, Jun 10 2016, In : Circulation Research. 118, 12, p. 1960-1991 32 p.

Research output: Contribution to journalArticle

Cardiovascular Diseases
Mitochondria
Cardiovascular Physiological Phenomena
Mitochondrial Diseases
Cardiomyopathies
97 Citations (Scopus)

Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise

Mera, P., Laue, K., Ferron, M., Confavreux, C., Wei, J., Galán-Díez, M., Lacampagne, A., Mitchell, S. J., Mattison, J. A., Chen, Y., Bacchetta, J., Szulc, P., Kitsis, R. N., De Cabo, R., Friedman, R. A., Torsitano, C., McGraw, T. E., Puchowicz, M., Kurland, I. J. & Karsenty, G., Jun 14 2016, In : Cell Metabolism. 23, 6, p. 1078-1092 15 p.

Research output: Contribution to journalArticle

Osteocalcin
Haplorhini
Interleukin-6
Fatty Acids
Exercise
2015
73 Citations (Scopus)

Interdependence of parkin-mediated mitophagy and mitochondrial fission in adult mouse hearts

Song, M., Gong, G., Burelle, Y., Gustafsson, Å. B., Kitsis, R. N., Matkovich, S. J. & Dorn, G. W., Jul 1 2015, In : Circulation Research. 117, 4, p. 346-351 6 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Mitochondrial Dynamics
Dynamins
Cardiac Myocytes
Proteins
71 Citations (Scopus)

MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype

Chen, H., Ruiz, P. D., McKimpson, W. M., Novikov, L., Kitsis, R. N. & Gamble, M. J., Sep 3 2015, In : Molecular Cell. 59, 5, p. 719-731 13 p.

Research output: Contribution to journalArticle

Phenotype
Endoplasmic Reticulum Stress
Oncogenes
Genes
Histones

Recent progress in research on molecular mechanisms of autophagy in the heart

Maejima, Y., Chen, Y., Isobe, M., Gustafsson, Å. B., Kitsis, R. N. & Sadoshima, J., 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 4, p. H259-H268

Research output: Contribution to journalArticle

Autophagy
Research
Heart Diseases
Organelles
Mitochondria
22 Citations (Scopus)

Recent progress in research on molecular mechanisms of autophagy in the heart

Maejima, Y., Chen, Y., Isobe, M., Gustafsson, Å. B., Kitsis, R. N. & Sadoshima, J., Feb 15 2015, In : American Journal of Physiology - Heart and Circulatory Physiology. 308, 4, p. H259-H268

Research output: Contribution to journalReview article

Autophagy
Research
Heart Diseases
Organelles
Mitochondria
2 Citations (Scopus)

The cell death inhibitor ARC is induced in a tissue-specific manner by deletion of the tumor suppressor gene Men1, but not required for tumor development and growth

McKimpson, W. M., Yuan, Z., Zheng, M., Crabtree, J. S., Libutti, S. K. & Kitsis, R. N., Dec 1 2015, In : PLoS One. 10, 12, e0145792.

Research output: Contribution to journalArticle

AIDS-Related Complex
tumor suppressor genes
Cell death
Tumor Suppressor Genes
Growth and Development
72 Citations (Scopus)
Mitochondrial Degradation
Mitochondrial Dynamics
Cell Death
Quality Control
Aptitude
2014
12 Citations (Scopus)

A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis

Kung, G., Dai, P., Deng, L. & Kitsis, R. N., Apr 2014, In : Cell Death and Differentiation. 21, 4, p. 634-644 11 p.

Research output: Contribution to journalArticle

AIDS-Related Complex
Necrosis
Apoptosis
Systemic Inflammatory Response Syndrome
Death Domain Receptors
2013
8 Citations (Scopus)

A microRNA links prolactin to peripartum cardiomyopathy

Yang, Y., Rodriguez, J. E. & Kitsis, R. N., May 1 2013, In : Journal of Clinical Investigation. 123, 5, p. 1925-1927 3 p.

Research output: Contribution to journalArticle

Peripartum Period
MicroRNAs
Cardiomyopathies
Prolactin
Microvessels
7 Citations (Scopus)

Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle

Davis, J., Kwong, J. Q., Kitsis, R. N. & Molkentin, J. D., Dec 2 2013, In : PLoS One. 8, 12, e82053.

Research output: Contribution to journalArticle

AIDS-Related Complex
Muscle
skeletal muscle
Skeletal Muscle
pathogenesis
6 Citations (Scopus)

Cardiomyocyte life-death decisions in response to chronic β-adrenergic signaling

Whelan, R. S., Konstantinidis, K., Xiao, R. P. & Kitsis, R. N., Feb 1 2013, In : Circulation Research. 112, 3, p. 408-410 3 p.

Research output: Contribution to journalArticle

Intracellular Signaling Peptides and Proteins
Receptors, Adrenergic, beta
Cyclic AMP-Dependent Protein Kinases
Cardiac Myocytes
Adrenergic Agents
Cardiac Myocytes
Adrenergic Agents
Research
13 Citations (Scopus)

Novel mechanisms for caspase inhibition protecting cardiac function with chronic pressure overload

Park, M., Vatner, S. F., Yan, L., Gao, S., Yoon, S., Lee, G. J. A., Xie, L. H., Kitsis, R. N. & Vatner, D. E., 2013, In : Basic Research in Cardiology. 108, 1, 324.

Research output: Contribution to journalArticle

Caspases
Muscle Cells
Pressure
Constriction
Apoptosis
16 Citations (Scopus)

The apoptosis inhibitor ARC alleviates the ER stress response to promote β-cell survival

McKimpson, W. M., Weinberger, J., Czerski, L., Zheng, M., Crow, M. T., Pessin, J. E., Chua, Jr., S. C. & Kitsis, R. N., Jan 2013, In : Diabetes. 62, 1, p. 183-193 11 p.

Research output: Contribution to journalArticle

AIDS-Related Complex
Endoplasmic Reticulum Stress
Cell Survival
Apoptosis
Transcription Factor CHOP
2012
181 Citations (Scopus)

Bax regulates primary necrosis through mitochondrial dynamics

Whelan, R. S., Konstantinidis, K., Wei, A. C., Chen, Y., Reyna, D. E., Jha, S., Yang, Y., Calvert, J. W., Lindsten, T., Thompson, C. B., Crow, M. T., Gavathiotis, E., Dorn, G. W., O'Rourke, B. & Kitsis, R. N., Apr 24 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 17, p. 6566-6571 6 p.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Necrosis
Mitochondria
Mitochondrial Membranes
Apoptosis
14 Citations (Scopus)

Cardiovascular Biology: Escaped DNA inflames the heart

Konstantinidis, K. & Kitsis, R. N., May 10 2012, In : Nature. 484, 7397, p. 179-180 2 p.

Research output: Contribution to journalArticle

cell organelle
disease prevalence
cardiovascular disease
Autophagy
Myocarditis
180 Citations (Scopus)

Mechanisms of cell death in heart disease.

Konstantinidis, K., Whelan, R. S. & Kitsis, R. N., 2012, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 32, 7, p. 1552-1562 11 p.

Research output: Contribution to journalReview article

Heart Diseases
Cell Death
Heart Failure
Apoptosis
Autophagy
5 Citations (Scopus)

Mitofusin 2 joins the sarcoplasmic reticulum and mitochondria at the hip to sustain cardiac energetics

Konstantinidis, K., Lederer, W. J., Rizzuto, R. & Kitsis, R. N., Sep 14 2012, In : Circulation Research. 111, 7, p. 821-823 3 p.

Research output: Contribution to journalArticle

Heart Mitochondria
Calcium Signaling
GTP Phosphohydrolases
Sarcoplasmic Reticulum
Cardiac Myocytes
1 Citation (Scopus)

Programmed cardiomyocyte death in heart disease

Dorn, G. W. & Kitsis, R. N., 2012, Muscle. Elsevier Inc., Vol. 1. p. 423-446 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Tbx6 is a determinant of cardiac and neural cell fate decisions in multipotent P19CL6 cells

Gavrilov, S., Nührenberg, T. G., Ashton, A. W., Peng, C. F., Moore, J. C., Konstantinidis, K., Mummery, C. L. & Kitsis, R. N., Sep 2012, In : Differentiation. 84, 2, p. 176-184 9 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Dimethyl Sulfoxide
Tretinoin
Cell Differentiation
Transcription Factors