• 10373 Citations
  • 50 h-Index
1979 …2019

Research output per year

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Publications

1979

Regulation of activity of chromatin receptors for thyroid hormone: Possible involvement of histone-like proteins

Eberhardt, N. L., Ring, J. C., Johnson, L. K., Latham, K. R., Apriletti, J. W., Kitsis, R. N. & Baxter, J. D., 1979, In : Proceedings of the National Academy of Sciences of the United States of America. 76, 10, p. 5005-5009 5 p.

Research output: Contribution to journalArticle

37 Scopus citations
1988

Correlations and dissociations between myosin isoenzymes and cardiac function

Kitsis, R. N. & Scheuer, J., Jan 1 1988, In : Journal of Applied Cardiology. 3, 5, p. 327-337 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
1991

Hormonal modulation of a gene injected into rat heart in vivo

Kitsis, R. N., Buttrick, P. M., McNally, E. M., Kaplan, M. L. & Leinwand, L. A., Jan 1 1991, In : Proceedings of the National Academy of Sciences of the United States of America. 88, 10, p. 4138-4142 5 p.

Research output: Contribution to journalArticle

Open Access
151 Scopus citations
1992

Behavior of genes directly injected into the rat heart in vivo

Buttrick, P. M., Kass, A., Kitsis, R. N., Kaplan, M. L. & Leinwand, L. A., 1992, In : Circulation research. 70, 1, p. 193-198 6 p.

Research output: Contribution to journalArticle

Open Access
122 Scopus citations

Discordance between gene regulation in vitro and in vivo.

Kitsis, R. N. & Leinwand, L. A., 1992, In : Gene expression. 2, 4, p. 313-318 6 p.

Research output: Contribution to journalReview article

22 Scopus citations
1993

Distinct behavior of cardiac myosin heavy chain gene constructs in vivo: Discordance with in vitro results

Buttrick, P. M., Kaplan, M. L., Kitsis, R. N. & Leinwand, L. A., 1993, In : Circulation research. 72, 6, p. 1211-1217 7 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

Peripartum versus idiopathic dilated cardiomyopathy in young women - a comparison of clinical, pathologic and prognostic features

van Hoeven, K. H., Kitsis, R. N., Katz, S. D. & Factor, S. M., Jun 15 1993, In : International Journal of Cardiology. 40, 1, p. 57-65 9 p.

Research output: Contribution to journalArticle

49 Scopus citations
1995

Echocardiographic assessment of left ventricular mass and systolic function in mice

Gardin, J. M., Siri, F. M., Kitsis, R. N., Edwards, J. G. & Leinwand, L. A., May 1995, In : Circulation research. 76, 5, p. 907-914 8 p.

Research output: Contribution to journalArticle

167 Scopus citations
1996

Distinct gene expression patterns in skeletal and cardiac muscle are dependent on common regulatory sequences in the MLC1/3 locus

McGrew, M. J., Bogdanova, N., Hasegawa, K., Hughes, S. H., Kitsis, R. N. & Rosenthal, N., 1996, In : Molecular and cellular biology. 16, 8, p. 4524-4534 11 p.

Research output: Contribution to journalArticle

Open Access
62 Scopus citations

Functional significance of alterations in cardiac contractile protein isoforms

Kitsis, R. N. & Scheuer, J., Jan 1996, In : Clinical Cardiology. 19, 1, p. 9-18 10 p.

Research output: Contribution to journalReview article

8 Scopus citations

Induction of DNA synthesis and apoptosis in cardiac myocytes by E1A oncoprotein

Liu, Y. & Kitsis, R. N., Apr 1 1996, In : Journal of Cell Biology. 133, 2, p. 325-334 10 p.

Research output: Contribution to journalArticle

76 Scopus citations

Intravascular ultrasound catheter evaluation of the left ventricle in mice: A feasibility study

Gardin, J. M., Siri, F., Kitsis, R. N. & Leinwand, L., Jan 1 1996, In : Echocardiography. 13, 6, p. 609-612 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
1997

cis-Acting sequences that mediate induction of β-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction

Hasegawa, K., Lee, S. J., Jobe, S. M., Markham, B. E. & Kitsis, R. N., Jan 1 1997, In : Circulation. 96, 11, p. 3943-3953 11 p.

Research output: Contribution to journalArticle

146 Scopus citations

Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53

Bialik, S., Geenen, D. L., Sasson, I. E., Cheng, R., Horner, J. W., Evans, S. M., Lord, E. M., Koch, C. J. & Kitsis, R. N., Sep 15 1997, In : Journal of Clinical Investigation. 100, 6, p. 1363-1372 10 p.

Research output: Contribution to journalArticle

Open Access
329 Scopus citations

Transcriptional coactivator p300 stimulates cell type-specific gene expression in cardiac myocytes

Hasegawa, K., Meyers, M. B. & Kitsis, R. N., Aug 8 1997, In : Journal of Biological Chemistry. 272, 32, p. 20049-20054 6 p.

Research output: Contribution to journalArticle

46 Scopus citations
1998

NF-κB inactivation converts a hepatocyte cell line TNF-α response from proliferation to apoptosis

Xu, Y., Bialik, S., Jones, B. E., Iimuro, Y., Kitsis, R. N., Srinivasan, A., Brenner, D. A. & Czaja, M. J., Oct 1998, In : American Journal of Physiology - Cell Physiology. 275, 4 44-4, p. C1058-C1066

Research output: Contribution to journalArticle

135 Scopus citations

β-Adrenergic stimulation causes cardiocyte apoptosis: Influence of tachycardia and hypertrophy

Shizukuda, Y., Buttrick, P. M., Geenen, D. L., Borczuk, A. C., Kitsis, R. N. & Sonnenblick, E. H., 1998, In : American Journal of Physiology - Heart and Circulatory Physiology. 275, 3 44-3, p. H961-H968

Research output: Contribution to journalArticle

147 Scopus citations
1999

Activation of the cyclin D1 gene by the E1A-associated protein p300 through AP-1 inhibits cellular apoptosis

Albanese, C., D'Amico, M., Reutens, A. T., Fu, M., Watanabe, G., Lee, R. J., Kitsis, R. N., Henglein, B., Avantaggiati, M., Somasundaram, K., Thimmapaya, B. & Pestell, R. G., Nov 26 1999, In : Journal of Biological Chemistry. 274, 48, p. 34186-34195 10 p.

Research output: Contribution to journalArticle

166 Scopus citations

GATA-5 is involved in leukemia inhibitory factor-responsive transcription of the β-myosin heavy chain gene in cardiac myocytes

Morimoto, T., Hasegawa, K., Kaburagi, S., Kakita, T., Masutani, H., Kitsis, R. N., Matsumori, A. & Sasayama, S., Apr 30 1999, In : Journal of Biological Chemistry. 274, 18, p. 12811-12818 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes

Bialik, S., Cryns, V. L., Drincic, A., Miyata, S., Wollowick, A. L., Srinivasan, A. & Kitsis, R. N., Sep 3 1999, In : Circulation research. 85, 5, p. 403-414 12 p.

Research output: Contribution to journalArticle

Open Access
228 Scopus citations
2000

Akt promotes survival of cardiomyocytes in vitro and protects against lschemia-reperfusion injury in mouse heart

Fujio, Y., Nguyen, T., Wencker, D., Kitsis, R. N. & Walsh, K., Feb 15 2000, In : Circulation. 101, 6, p. 660-667 8 p.

Research output: Contribution to journalArticle

Open Access
689 Scopus citations

Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo. An apoptosis-independent model of dilated heart failure

De Windt, L. J., Lim, H. W., Taigen, T., Wencker, D., Condorelli, G., Dorn, G. W., Kitsis, R. N. & Molkentin, J. D., Feb 18 2000, In : Circulation research. 86, 3, p. 255-263 9 p.

Research output: Contribution to journalArticle

Open Access
192 Scopus citations

Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo

Miao, W., Luo, Z., Kitsis, R. N. & Walsh, K., Jan 1 2000, In : Journal of Molecular and Cellular Cardiology. 32, 12, p. 2397-2402 6 p.

Research output: Contribution to journalArticle

119 Scopus citations

Modulation of vascular endothelial gene expression by physical training in patients with chronic heart failure

Testa, M., Ennezat, P. V., Vikstrom, K. L., Demopoulos, L., Gentilucci, M., Loperfido, F., Fanelli, R., Kitsis, R. N., Leinwand, L. A. & LeJemtel, T. H., Oct 7 2000, In : Italian Heart Journal. 1, 6, p. 426-430 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

Bueno, O. F., De Windt, L. J., Tymitz, K. M., Witt, S. A., Kimball, T. R., Klevitsky, R., Hewett, T. E., Jones, S. P., Lefer, D. J., Peng, C. F., Kitsis, R. N. & Molkentin, J. D., Dec 1 2000, In : EMBO Journal. 19, 23, p. 6341-6350 10 p.

Research output: Contribution to journalArticle

582 Scopus citations
2001

Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation

Liu, J., Lee, P., Galbiati, F., Kitsis, R. N. & Lisanti, M. P., Jan 1 2001, In : American Journal of Physiology - Cell Physiology. 280, 4 49-4, p. C823-C835

Research output: Contribution to journalArticle

91 Scopus citations

Fas-FasL interaction modulates nitric oxide production in Trypanosoma cruzi-infected mice

Martins, G. A., Petkova, S. B., Machado, F. S., Kitsis, R. N., Weiss, L. M., Wittner, M., Tanowitz, H. B. & Silva, J. S., 2001, In : Immunology. 103, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Hepatocyte Growth Factor/Scatter Factor Blocks the Mitochondrial Pathway of Apoptosis Signaling in Breast Cancer Cells

Gao, M., Fan, S., Goldberg, I. D., Laterra, J., Kitsis, R. N. & Rosen, E. M., Dec 14 2001, In : Journal of Biological Chemistry. 276, 50, p. 47257-47265 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Seeing death in the living

Gottlieb, R. A. & Kitsis, R. N., Jan 1 2001, In : Nature Medicine. 7, 12, p. 1277-1278 2 p.

Research output: Contribution to journalArticle

21 Scopus citations
2002

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

Woodman, S. E., Park, D. S., Cohen, A. W., Cheung, M. W. C., Chandra, M., Shirani, J., Tang, B., Jelicks, L. A., Kitsis, R. N., Christ, G. J., Factor, S. M., Tanowitz, H. B. & Lisanti, M. P., Oct 11 2002, In : Journal of Biological Chemistry. 277, 41, p. 38988-38997 10 p.

Research output: Contribution to journalArticle

237 Scopus citations

Chemokine expression in myocardial ischemia: MIP-2 dependent MCP-1 expression protects cardiomyocytes from cell death

Tarzami, S. T., Cheng, R., Miao, W., Kitsis, R. N. & Berman, J. W., Feb 1 2002, In : Journal of Molecular and Cellular Cardiology. 34, 2, p. 209-221 13 p.

Research output: Contribution to journalArticle

73 Scopus citations

Microarray analysis of global changes in gene expression during cardiac myocyte differentiation

Peng, C. F., Wei, Y., Levsky, J. M., McDonald, T. V., Childs, G. & Kitsis, R. N., Jul 2002, In : Physiological genomics. 2002, 9, p. 145-155 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

Taking the BAD out of adrenergic stimulation

Mani, K., Ashton, A. W. & Kitsis, R. N., Jul 1 2002, In : Journal of Molecular and Cellular Cardiology. 34, 7, p. 709-712 4 p.

Research output: Contribution to journalEditorial

5 Scopus citations
2003

Activation of transcription factors AP-1 and NF-κB in murine chagasic myocarditis

Huang, H., Petkova, S. B., Cohen, A. W., Bouzahzah, B., Chan, J., Zhou, J. N., Factor, S. M., Weiss, L. M., Krishnamachary, M., Mukherjee, S., Wittner, M., Kitsis, R. N., Pestell, R. G., Lisanti, M. P., Albanese, C. & Tanowitz, H. B., May 1 2003, In : Infection and immunity. 71, 5, p. 2859-2867 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

A mechanistic role for cardiac myocyte apoptosis in heart failure

Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C. & Kitsis, R. N., May 2003, In : Journal of Clinical Investigation. 111, 10, p. 1497-1504 8 p.

Research output: Contribution to journalArticle

584 Scopus citations

Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts

Cohen, A. W., Park, D. S., Woodman, S. E., Williams, T. M., Chandra, M., Shirani, J., De Souza, A. P., Kitsis, R. N., Russell, R. G., Weiss, L. M., Tang, B., Jelicks, L. A., Factor, S. M., Shtutin, V., Tanowitz, H. B. & Lisanti, M. P., Feb 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 2 53-2, p. C457-C474

Research output: Contribution to journalArticle

197 Scopus citations

Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo

Lee, P., Sata, M., Lefer, D. J., Factor, S. M., Walsh, K. & Kitsis, R. N., Feb 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 2 53-2, p. H456-H463

Research output: Contribution to journalArticle

169 Scopus citations

Inhibition of Cardiac Myocyte Apoptosis Improves Cardiac Function and Abolishes Mortality in the Peripartum Cardiomyopathy of Gαq Transgenic Mice

Hayakawa, Y., Chandra, M., Miao, W., Shirani, J., Brown, J. H., Dorn, G. W., Armstrong, R. C. & Kitsis, R. N., Dec 16 2003, In : Circulation. 108, 24, p. 3036-3041 6 p.

Research output: Contribution to journalArticle

188 Scopus citations

Microarray analysis of changes in gene expression in a murine model of chronic chagasic cardiomyopathy

Mukherjee, S., Belbin, T. J., Spray, D. C., Iacobas, D. A., Weiss, L. M., Kitsis, R. N., Wittner, M., Jelicks, L. A., Scherer, P. E., Ding, A. & Tanowitz, H. B., Oct 1 2003, In : Parasitology Research. 91, 3, p. 187-196 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Myocyte apoptosis: Programming ventricular remodeling

Mani, K. & Kitsis, R. N., Mar 5 2003, In : Journal of the American College of Cardiology. 41, 5, p. 761-764 4 p.

Research output: Contribution to journalEditorial

69 Scopus citations

Opposing Effects Mediated by the Chemokine Receptor CXCR2 on Myocardial Ischemia-Reperfusion Injury: Recruitment of Potentially Damaging Neutrophils and Direct Myocardial Protection

Tarzami, S. T., Miao, W., Mani, K., Lopez, L., Factor, S. M., Berman, J. W. & Kitsis, R. N., Nov 11 2003, In : Circulation. 108, 19, p. 2387-2392 6 p.

Research output: Contribution to journalArticle

71 Scopus citations
2004

Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes

Young, D. A., Gavrilov, S., Pennington, C. J., Nuttall, R. K., Edwards, D. R., Kitsis, R. N. & Clark, I. M., Sep 24 2004, In : Biochemical and Biophysical Research Communications. 322, 3, p. 759-765 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions

Nam, Y. J., Mani, K., Ashton, A. W., Peng, C. F., Krishnamurthy, B., Hayakawa, Y., Lee, P., Korsmeyer, S. J. & Kitsis, R. N., Sep 24 2004, In : Molecular Cell. 15, 6, p. 901-912 12 p.

Research output: Contribution to journalArticle

140 Scopus citations

The mitochondrial death pathway and cardiac myocyte apoptosis

Crow, M. T., Mani, K., Nam, Y. J. & Kitsis, R. N., Nov 12 2004, In : Circulation research. 95, 10, p. 957-970 14 p.

Research output: Contribution to journalReview article

459 Scopus citations
2005

Apoptosis and the heart: A decade of progress

Kitsis, R. N. & Mann, D. L., Jan 1 2005, In : Journal of Molecular and Cellular Cardiology. 38, 1, p. 1-2 2 p.

Research output: Contribution to journalReview article

40 Scopus citations

ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance [3]

Mercier, I., Vuolo, M., Madan, R., Xue, X., Levalley, A. J., Ashton, A. W., Jasmin, J. F., Czaja, M. T., Lin, E. Y., Armstrong, R. C., Pollard, J. W. & Kitsis, R. N., Jun 1 2005, In : Cell Death and Differentiation. 12, 6, p. 682-686 5 p.

Research output: Contribution to journalLetter

53 Scopus citations

Death begets failure in the heart

Foo, R. S. Y., Mani, K. & Kitsis, R. N., Mar 2005, In : Journal of Clinical Investigation. 115, 3, p. 565-571 7 p.

Research output: Contribution to journalReview article

Open Access
250 Scopus citations

Fat apoptosis through targeted activation of caspase 8: A new mouse model of inducible and reversible lipoatrophy

Pajvani, U. B., Trujillo, M. E., Combs, T. P., Iyengar, P., Jelicks, L. A., Roth, K. A., Kitsis, R. N. & Scherer, P. E., Jul 1 2005, In : Nature Medicine. 11, 7, p. 797-803 7 p.

Research output: Contribution to journalArticle

202 Scopus citations

Impaired phagocytosis in caveolin-1 deficient macrophages

Li, J., Scherl, A., Medina, F., Frank, P. G., Kitsis, R. N., Tanowitz, H. B., Sotgia, F. & Lisanti, M. P., Nov 2005, In : Cell Cycle. 4, 11, p. 1599-1607 9 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

MCP-1/CCL2 protects cardiac myocytes from hypoxia-induced apoptosis by a Gαi-independent pathway

Tarzami, S. T., Calderon, T. M., Deguzman, A., Lopez, L., Kitsis, R. N. & Berman, J. W., Oct 7 2005, In : Biochemical and Biophysical Research Communications. 335, 4, p. 1008-1016 9 p.

Research output: Contribution to journalArticle

52 Scopus citations