• 10373 Citations
  • 50 h-Index
1979 …2019

Research output per year

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Publications

2011

A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension

Zaiman, A. L., Damico, R., Thoms-Chesley, A., Clark Files, D., Kesari, P., Johnston, L., Swaim, M., Mozammel, S., Myers, A. C., Halushka, M., El-Haddad, H., Shimoda, L. A., Peng, C. F., Hassoun, P. M., Champion, H. C., Kitsis, R. N. & Crow, M. T., Dec 6 2011, In : Circulation. 124, 23, p. 2533-2542 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Apoptosis inhibitor ARC promotes breast tumorigenesis, metastasis, and chemoresistance

Medina-Ramirez, C. M., Goswami, S., Smirnova, T., Bamira, D., Benson, B., Ferrick, N., Segall, J., Pollard, J. W. & Kitsis, R. N., Dec 15 2011, In : Cancer research. 71, 24, p. 7705-7715 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Cell death in the cardiovascular system

Kaplinskiy, V., Bennett, M. R. & Kitsis, R. N., Jan 1 2011, Apoptosis: Physiology and Pathology. Cambridge University Press, p. 295-312 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

53 Scopus citations

Myocardial Basis for Heart Failure. Role of Cell Death

Jha, S. & Kitsis, R. N., Dec 1 2011, Heart Failure. Elsevier Inc., p. 85-102 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Programmed necrosis, not apoptosis, in the heart

Kung, G., Konstantinidis, K. & Kitsis, R. N., Apr 15 2011, In : Circulation research. 108, 8, p. 1017-1036 20 p.

Research output: Contribution to journalReview article

186 Scopus citations
2010

Apoptotic cell death "nixed" by an ER-mitochondrial necrotic pathway

Kitsis, R. N. & Molkentin, J. D., May 18 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 20, p. 9031-9032 2 p.

Research output: Contribution to journalComment/debate

36 Scopus citations

Induction of the apoptosis inhibitor ARC by Ras in human cancers

Wu, L., Nam, Y. J., Kung, G., Crow, M. T. & Kitsis, R. N., Jun 18 2010, In : Journal of Biological Chemistry. 285, 25, p. 19235-19245 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2009

Apoptosis predominates in nonmyocytes in heart failure

Park, M., Shen, Y. T., Gaussin, V., Heyndrickx, G. R., Bartunek, J., Resuello, R. R. G., Natividad, F. F., Kitsis, R. N., Vatner, D. E. & Vatner, S. F., Aug 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 2, p. H785-H791

Research output: Contribution to journalArticle

46 Scopus citations

Cell death in the pathogenesis of heart disease: Mechanisms and significance

Whelan, R. S., Kaplinskiy, V. & Kitsis, R. N., Mar 17 2009, In : Annual review of physiology. 72, p. 19-44 26 p.

Research output: Contribution to journalReview article

458 Scopus citations
2008

ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer

Mercier, I., Vuolo, M., Jasmin, J. F., Medina, C. M., Williams, M., Mariadason, J. M., Qian, H., Xue, X., Pestell, R. G., Lisanti, M. P. & Kitsis, R. N., Jun 1 2008, In : Cell Cycle. 7, 11, p. 1640-1647 8 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations

Edmund H. Sonnenblick, MD (1932-2007).

Kitsis, R. N., Mar 2008, In : American journal of hypertension : journal of the American Society of Hypertension. 21, 3, p. 241-242 2 p.

Research output: Contribution to journalArticle

Introduction - Cell death in heart failure

Kitsis, R. N. & Narula, J., Jun 1 2008, In : Heart Failure Reviews. 13, 2, p. 107-109 3 p.

Research output: Contribution to journalEditorial

14 Scopus citations
2007

Eat your heart out

Kitsis, R. N., Peng, C. F. & Cuervo, A. M., May 1 2007, In : Nature Medicine. 13, 5, p. 539-541 3 p.

Research output: Contribution to journalShort survey

25 Scopus citations

Nipping at cardiac remodeling

Whelan, R. S., Mani, K. & Kitsis, R. N., Oct 1 2007, In : Journal of Clinical Investigation. 117, 10, p. 2751-2753 3 p.

Research output: Contribution to journalReview article

9 Scopus citations

Regulation of p53 tetramerization and nuclear export by ARC

Foo, R. S. Y., Nam, Y. J., Ostreicher, M. J., Metzl, M. D., Whelan, R. S., Peng, C. F., Ashton, A. W., Fu, W., Mani, K., Chin, S. F., Provenzano, E., Ellis, I., Figg, N., Pinder, S., Bennett, M. R., Caldas, C. & Kitsis, R. N., Dec 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20826-20831 6 p.

Research output: Contribution to journalArticle

75 Scopus citations

The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: Identification of a degradation-resistant mutant

Nam, Y. J., Mani, K., Wu, L., Peng, C. F., Calvert, J. W., Foo, R. S. Y., Krishnamurthy, B., Miao, W., Ashton, A. W., Lefer, D. J. & Kitsis, R. N., Feb 23 2007, In : Journal of Biological Chemistry. 282, 8, p. 5522-5528 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Ubiquitination and degradation of the anti-apoptotic protein ARC by MDM2

Foo, R. S. Y., Chan, L. K. W., Kitsis, R. N. & Bennett, M. R., Feb 23 2007, In : Journal of Biological Chemistry. 282, 8, p. 5529-5535 7 p.

Research output: Contribution to journalArticle

63 Scopus citations
2006

Limiting Myocardial Damage during Acute Myocardial Infarction by Inhibiting C-Reactive Protein

Kitsis, R. N. & Jialal, I., Aug 3 2006, In : New England Journal of Medicine. 355, 5, p. 513-515 3 p.

Research output: Contribution to journalArticle

28 Scopus citations
2005

Apoptosis and the heart: A decade of progress

Kitsis, R. N. & Mann, D. L., Jan 1 2005, In : Journal of Molecular and Cellular Cardiology. 38, 1, p. 1-2 2 p.

Research output: Contribution to journalReview article

40 Scopus citations

ARC, an apoptosis suppressor limited to terminally differentiated cells, is induced in human breast cancer and confers chemo- and radiation-resistance [3]

Mercier, I., Vuolo, M., Madan, R., Xue, X., Levalley, A. J., Ashton, A. W., Jasmin, J. F., Czaja, M. T., Lin, E. Y., Armstrong, R. C., Pollard, J. W. & Kitsis, R. N., Jun 1 2005, In : Cell Death and Differentiation. 12, 6, p. 682-686 5 p.

Research output: Contribution to journalLetter

53 Scopus citations

Death begets failure in the heart

Foo, R. S. Y., Mani, K. & Kitsis, R. N., Mar 2005, In : Journal of Clinical Investigation. 115, 3, p. 565-571 7 p.

Research output: Contribution to journalReview article

Open Access
250 Scopus citations

Fat apoptosis through targeted activation of caspase 8: A new mouse model of inducible and reversible lipoatrophy

Pajvani, U. B., Trujillo, M. E., Combs, T. P., Iyengar, P., Jelicks, L. A., Roth, K. A., Kitsis, R. N. & Scherer, P. E., Jul 1 2005, In : Nature Medicine. 11, 7, p. 797-803 7 p.

Research output: Contribution to journalArticle

202 Scopus citations

Impaired phagocytosis in caveolin-1 deficient macrophages

Li, J., Scherl, A., Medina, F., Frank, P. G., Kitsis, R. N., Tanowitz, H. B., Sotgia, F. & Lisanti, M. P., Nov 2005, In : Cell Cycle. 4, 11, p. 1599-1607 9 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

MCP-1/CCL2 protects cardiac myocytes from hypoxia-induced apoptosis by a Gαi-independent pathway

Tarzami, S. T., Calderon, T. M., Deguzman, A., Lopez, L., Kitsis, R. N. & Berman, J. W., Oct 7 2005, In : Biochemical and Biophysical Research Communications. 335, 4, p. 1008-1016 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease

Tanowitz, H. B., Huang, H., Jelicks, L. A., Chandra, M., Loredo, M. L., Weiss, L. M., Factor, S. M., Shtutin, V., Mukherjee, S., Kitsis, R. N., Christ, G. J., Wittner, M., Shirani, J., Kisanuki, Y. Y. & Yanagisawa, M., Apr 2005, In : Infection and immunity. 73, 4, p. 2496-2503 8 p.

Research output: Contribution to journalArticle

71 Scopus citations
2004

Expression of metalloproteinases and inhibitors in the differentiation of P19CL6 cells into cardiac myocytes

Young, D. A., Gavrilov, S., Pennington, C. J., Nuttall, R. K., Edwards, D. R., Kitsis, R. N. & Clark, I. M., Sep 24 2004, In : Biochemical and Biophysical Research Communications. 322, 3, p. 759-765 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions

Nam, Y. J., Mani, K., Ashton, A. W., Peng, C. F., Krishnamurthy, B., Hayakawa, Y., Lee, P., Korsmeyer, S. J. & Kitsis, R. N., Sep 24 2004, In : Molecular Cell. 15, 6, p. 901-912 12 p.

Research output: Contribution to journalArticle

140 Scopus citations

The mitochondrial death pathway and cardiac myocyte apoptosis

Crow, M. T., Mani, K., Nam, Y. J. & Kitsis, R. N., Nov 12 2004, In : Circulation research. 95, 10, p. 957-970 14 p.

Research output: Contribution to journalReview article

459 Scopus citations
2003

Activation of transcription factors AP-1 and NF-κB in murine chagasic myocarditis

Huang, H., Petkova, S. B., Cohen, A. W., Bouzahzah, B., Chan, J., Zhou, J. N., Factor, S. M., Weiss, L. M., Krishnamachary, M., Mukherjee, S., Wittner, M., Kitsis, R. N., Pestell, R. G., Lisanti, M. P., Albanese, C. & Tanowitz, H. B., May 1 2003, In : Infection and immunity. 71, 5, p. 2859-2867 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

A mechanistic role for cardiac myocyte apoptosis in heart failure

Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C. & Kitsis, R. N., May 2003, In : Journal of Clinical Investigation. 111, 10, p. 1497-1504 8 p.

Research output: Contribution to journalArticle

584 Scopus citations

Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts

Cohen, A. W., Park, D. S., Woodman, S. E., Williams, T. M., Chandra, M., Shirani, J., De Souza, A. P., Kitsis, R. N., Russell, R. G., Weiss, L. M., Tang, B., Jelicks, L. A., Factor, S. M., Shtutin, V., Tanowitz, H. B. & Lisanti, M. P., Feb 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 2 53-2, p. C457-C474

Research output: Contribution to journalArticle

197 Scopus citations

Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo

Lee, P., Sata, M., Lefer, D. J., Factor, S. M., Walsh, K. & Kitsis, R. N., Feb 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 2 53-2, p. H456-H463

Research output: Contribution to journalArticle

169 Scopus citations

Inhibition of Cardiac Myocyte Apoptosis Improves Cardiac Function and Abolishes Mortality in the Peripartum Cardiomyopathy of Gαq Transgenic Mice

Hayakawa, Y., Chandra, M., Miao, W., Shirani, J., Brown, J. H., Dorn, G. W., Armstrong, R. C. & Kitsis, R. N., Dec 16 2003, In : Circulation. 108, 24, p. 3036-3041 6 p.

Research output: Contribution to journalArticle

188 Scopus citations

Microarray analysis of changes in gene expression in a murine model of chronic chagasic cardiomyopathy

Mukherjee, S., Belbin, T. J., Spray, D. C., Iacobas, D. A., Weiss, L. M., Kitsis, R. N., Wittner, M., Jelicks, L. A., Scherer, P. E., Ding, A. & Tanowitz, H. B., Oct 1 2003, In : Parasitology Research. 91, 3, p. 187-196 10 p.

Research output: Contribution to journalArticle

56 Scopus citations

Myocyte apoptosis: Programming ventricular remodeling

Mani, K. & Kitsis, R. N., Mar 5 2003, In : Journal of the American College of Cardiology. 41, 5, p. 761-764 4 p.

Research output: Contribution to journalEditorial

69 Scopus citations

Opposing Effects Mediated by the Chemokine Receptor CXCR2 on Myocardial Ischemia-Reperfusion Injury: Recruitment of Potentially Damaging Neutrophils and Direct Myocardial Protection

Tarzami, S. T., Miao, W., Mani, K., Lopez, L., Factor, S. M., Berman, J. W. & Kitsis, R. N., Nov 11 2003, In : Circulation. 108, 19, p. 2387-2392 6 p.

Research output: Contribution to journalArticle

71 Scopus citations
2002

Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade

Woodman, S. E., Park, D. S., Cohen, A. W., Cheung, M. W. C., Chandra, M., Shirani, J., Tang, B., Jelicks, L. A., Kitsis, R. N., Christ, G. J., Factor, S. M., Tanowitz, H. B. & Lisanti, M. P., Oct 11 2002, In : Journal of Biological Chemistry. 277, 41, p. 38988-38997 10 p.

Research output: Contribution to journalArticle

237 Scopus citations

Chemokine expression in myocardial ischemia: MIP-2 dependent MCP-1 expression protects cardiomyocytes from cell death

Tarzami, S. T., Cheng, R., Miao, W., Kitsis, R. N. & Berman, J. W., Feb 1 2002, In : Journal of Molecular and Cellular Cardiology. 34, 2, p. 209-221 13 p.

Research output: Contribution to journalArticle

73 Scopus citations

Microarray analysis of global changes in gene expression during cardiac myocyte differentiation

Peng, C. F., Wei, Y., Levsky, J. M., McDonald, T. V., Childs, G. & Kitsis, R. N., Jul 2002, In : Physiological genomics. 2002, 9, p. 145-155 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

Taking the BAD out of adrenergic stimulation

Mani, K., Ashton, A. W. & Kitsis, R. N., Jul 1 2002, In : Journal of Molecular and Cellular Cardiology. 34, 7, p. 709-712 4 p.

Research output: Contribution to journalEditorial

5 Scopus citations
2001

Caveolin-1 expression sensitizes fibroblastic and epithelial cells to apoptotic stimulation

Liu, J., Lee, P., Galbiati, F., Kitsis, R. N. & Lisanti, M. P., Jan 1 2001, In : American Journal of Physiology - Cell Physiology. 280, 4 49-4, p. C823-C835

Research output: Contribution to journalArticle

91 Scopus citations

Fas-FasL interaction modulates nitric oxide production in Trypanosoma cruzi-infected mice

Martins, G. A., Petkova, S. B., Machado, F. S., Kitsis, R. N., Weiss, L. M., Wittner, M., Tanowitz, H. B. & Silva, J. S., 2001, In : Immunology. 103, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Hepatocyte Growth Factor/Scatter Factor Blocks the Mitochondrial Pathway of Apoptosis Signaling in Breast Cancer Cells

Gao, M., Fan, S., Goldberg, I. D., Laterra, J., Kitsis, R. N. & Rosen, E. M., Dec 14 2001, In : Journal of Biological Chemistry. 276, 50, p. 47257-47265 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Seeing death in the living

Gottlieb, R. A. & Kitsis, R. N., Jan 1 2001, In : Nature Medicine. 7, 12, p. 1277-1278 2 p.

Research output: Contribution to journalArticle

21 Scopus citations
2000

Akt promotes survival of cardiomyocytes in vitro and protects against lschemia-reperfusion injury in mouse heart

Fujio, Y., Nguyen, T., Wencker, D., Kitsis, R. N. & Walsh, K., Feb 15 2000, In : Circulation. 101, 6, p. 660-667 8 p.

Research output: Contribution to journalArticle

Open Access
689 Scopus citations

Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo. An apoptosis-independent model of dilated heart failure

De Windt, L. J., Lim, H. W., Taigen, T., Wencker, D., Condorelli, G., Dorn, G. W., Kitsis, R. N. & Molkentin, J. D., Feb 18 2000, In : Circulation research. 86, 3, p. 255-263 9 p.

Research output: Contribution to journalArticle

Open Access
192 Scopus citations

Intracoronary, adenovirus-mediated Akt gene transfer in heart limits infarct size following ischemia-reperfusion injury in vivo

Miao, W., Luo, Z., Kitsis, R. N. & Walsh, K., Jan 1 2000, In : Journal of Molecular and Cellular Cardiology. 32, 12, p. 2397-2402 6 p.

Research output: Contribution to journalArticle

119 Scopus citations

Modulation of vascular endothelial gene expression by physical training in patients with chronic heart failure

Testa, M., Ennezat, P. V., Vikstrom, K. L., Demopoulos, L., Gentilucci, M., Loperfido, F., Fanelli, R., Kitsis, R. N., Leinwand, L. A. & LeJemtel, T. H., Oct 7 2000, In : Italian Heart Journal. 1, 6, p. 426-430 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

Bueno, O. F., De Windt, L. J., Tymitz, K. M., Witt, S. A., Kimball, T. R., Klevitsky, R., Hewett, T. E., Jones, S. P., Lefer, D. J., Peng, C. F., Kitsis, R. N. & Molkentin, J. D., Dec 1 2000, In : EMBO Journal. 19, 23, p. 6341-6350 10 p.

Research output: Contribution to journalArticle

582 Scopus citations