• 4064 Citations
  • 31 h-Index
19992020

Research output per year

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Publications

2020

HHLA2 is expressed in pancreatic and ampullary cancers and increased expression is associated with better post-surgical prognosis

Boor, P. P. C., Sideras, K., Biermann, K., Hosein Aziz, M., Levink, I. J. M., Mancham, S., Erler, N. S., Tang, X., van Eijck, C. H., Bruno, M. J., Sprengers, D., Zang, X. & Kwekkeboom, J., Apr 14 2020, In : British Journal of Cancer. 122, 8, p. 1211-1218 8 p.

Research output: Contribution to journalArticle

Over-Expression and Prognostic Significance of HHLA2, a New Immune Checkpoint Molecule, in Human Clear Cell Renal Cell Carcinoma

Zhang, Z., Liu, J., Zhang, C., Li, F., Li, L., Wang, D., Chand, D., Guan, F., Zang, X. & Zhang, Y., May 19 2020, In : Frontiers in Cell and Developmental Biology. 8, 280.

Research output: Contribution to journalArticle

Open Access
2019

Blockade of CTLA-4 and Tim-3 pathways induces fetal loss with altered cytokine profiles by decidual CD4 + T cells

Wang, S., Chen, C., Li, M., Qian, J., Sun, F., Li, Y., Yu, M., Wang, M., Zang, X., Zhu, R., Li, D. & Du, M., Jan 1 2019, In : Cell Death and Disease. 10, 1, 15.

Research output: Contribution to journalArticle

1 Scopus citations

Cell–cell contact with proinflammatory macrophages enhances the immunotherapeutic effect of mesenchymal stem cells in two abortion models

Li, Y., Zhang, D., Xu, L., Dong, L., Zheng, J., Lin, Y., Huang, J., Zhang, Y., Tao, Y., Zang, X., Li, D. & Du, M., Dec 1 2019, In : Cellular and Molecular Immunology. 16, 12, p. 908-920 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Corrigendum: HDAC1 Silence Promotes Neuroprotective Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in a Mouse Model of Traumatic Brain Injury via PI3K/AKT Pathway (Frontiers in Cellular Neuroscience, (2019), 12, 10.3389/fncel.2018.00498)

Xu, L., Xing, Q., Huang, T., Zhou, J., Liu, T., Cui, Y., Cheng, T., Wang, Y., Zhou, X., Yang, B., Yang, G. L., Zhang, J., Zang, X., Ma, S. & Guan, F., Sep 9 2019, In : Frontiers in Cellular Neuroscience. 13, 408.

Research output: Contribution to journalComment/debate

Open Access

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality

Saha, A., Taylor, P. A., Lees, C. J., Panoskaltsis-Mortari, A., Osborn, M. J., Feser, C. J., Thangavelu, G., Melchinger, W., Refaeli, Y., Hill, G. R., Munn, D. H., Murphy, W. J., Serody, J. S., Maillard, I., Kreymborg, K., van den Brink, M., Dong, C., Huang, S., Zang, X., Allison, J. P. & 2 others, Zeiser, R. & Blazar, B. R., 2019, In : JCI Insight. 4, 19, e127716.

Research output: Contribution to journalArticle

Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/β-catenin pathway

Cui, Y., Zhang, L., Wang, W., Ma, S., Liu, H., Zang, X., Zhang, Y. & Guan, F., Oct 1 2019, In : Molecular and Cellular Biochemistry. 460, 1-2, p. 93-103 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

HDAC1 silence promotes neuroprotective effects of human umbilical cord-derived mesenchymal stem cells in a mouse model of traumatic brain injury via PI3K/AKT pathway

Xu, L., Xing, Q., Huang, T., Zhou, J., Liu, T., Cui, Y., Cheng, T., Wang, Y., Zhou, X., Yang, B., Yang, G. L., Zhang, J., Zang, X., Ma, S. & Guan, F., Jan 4 2019, In : Frontiers in Cellular Neuroscience. 12, 498.

Research output: Contribution to journalArticle

10 Scopus citations

Histone deacetylases inhibitor MS-275 suppresses human esophageal squamous cell carcinoma cell growth and progression via the PI3K/Akt/mTOR pathway

Ma, S., Liu, T., Xu, L., Wang, Y., Zhou, J., Huang, T., Li, P., Liu, H., Zhang, Y., Zhou, X., Cui, Y., Zang, X., Wang, Y. & Guan, F., Jan 1 2019, In : Journal of Cellular Physiology. 234, 12, p. 22400-22410 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Identification of chimeric RNAs in human infant brains and their implications in neural differentiation

Tang, Y., Ma, S., Wang, X., Xing, Q., Huang, T., Liu, H., Li, Q., Zhang, Y., Zhang, K., Yao, M., Yang, G. L., Li, H., Zang, X., Yang, B. & Guan, F., Jun 2019, In : International Journal of Biochemistry and Cell Biology. 111, p. 19-26 8 p.

Research output: Contribution to journalArticle

Immune checkpoint B7x (B7-H4/B7S1/VTCN1) is over expressed in spontaneous canine bladder cancer: the first report and its implications in a preclinical model

Chand, D., Dhawan, D., Sankin, A., Ren, X., Lin, J., Schoenberg, M., Knapp, D. W. & Zang, X., Jan 1 2019, In : Bladder Cancer. 5, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies

Wang, H., Kaur, G., Sankin, A. I., Chen, F., Guan, F. & Zang, X., Jun 11 2019, In : Journal of Hematology and Oncology. 12, 1, 59.

Research output: Contribution to journalReview article

Open Access
12 Scopus citations

PAK kinase inhibition has therapeutic activity in novel preclinical models of adult T-Cell leukemia/lymphoma

Chung, E. Y., Mai, Y., Shah, U. A., Wei, Y., Ishida, E., Kataoka, K., Ren, X., Pradhan, K., Bartholdy, B., Wei, X., Zou, Y., Zhang, J., Ogawa, S., Steidl, U., Zang, X., Verma, A., Janakiram, M. & Ye, B. H., Jun 15 2019, In : Clinical Cancer Research. 25, 12, p. 3589-3601 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade

Rauch, D. A., Conlon, K. C., Janakiram, M., Brammer, J. E., Harding, J. C., Ye, B. H., Zang, X., Ren, X., Olson, S., Cheng, X., Miljkovic, M. D., Sundaramoorthi, H., Joseph, A., Skidmore, Z. L., Griffith, O., Griffith, M., Waldmann, T. A. & Ratner, L., Oct 24 2019, In : Blood. 134, 17, p. 1406-1414 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structures of Immune Checkpoints: An Overview on the CD28-B7 Family

Liu, W. & Zang, X., Jan 1 2019, In : Advances in experimental medicine and biology. 1172, p. 63-78 16 p.

Research output: Contribution to journalReview article

1 Scopus citations

The appropriate frequency and function of decidual Tim-3+CTLA-4+CD8+ T cells are important in maintaining normal pregnancy

Wang, S., Sun, F., Li, M., Qian, J., Chen, C., Wang, M., Zang, X., Li, D., Yu, M. & Du, M., Jun 1 2019, In : Cell Death and Disease. 10, 6, 407.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

The B7x Immune Checkpoint Pathway: From Discovery to Clinical Trial

John, P., Wei, Y., Liu, W., Du, M., Guan, F. & Zang, X., Nov 2019, In : Trends in Pharmacological Sciences. 40, 11, p. 883-896 14 p.

Research output: Contribution to journalReview article

The TRIM protein Mitsugumin 53 enhances survival and therapeutic efficacy of stem cells in murine traumatic brain injury

Guan, F., Huang, T., Wang, X., Xing, Q., Gumpper, K., Li, P., Song, J., Tan, T., Yang, G. L., Zang, X., Zhang, J., Wang, Y., Yang, Y., Liu, Y., Zhang, Y., Yang, B., Ma, J. & Ma, S., Nov 28 2019, In : Stem Cell Research and Therapy. 10, 1, 352.

Research output: Contribution to journalArticle

Open Access

Tumor Cholesterol Up, T Cells Down

Picarda, E., Ren, X. & Zang, X., Jul 2 2019, In : Cell metabolism. 30, 1, p. 12-13 2 p.

Research output: Contribution to journalShort survey

1 Scopus citations
2018
4 Scopus citations

An Immunoscore Using PD-L1, CD68, and Tumor-infiltrating Lymphocytes (TILs) to Predict Response to Neoadjuvant Chemotherapy in Invasive Breast Cancer

McLemore, L. E., Janakiram, M., Albanese, J., Shapiro, N., Lo, Y., Zang, X. & Fineberg, S., Oct 1 2018, In : Applied Immunohistochemistry and Molecular Morphology. 26, 9, p. 611-619 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

NF-κB RelA renders tumor-associated macrophages resistant to and capable of directly suppressing CD8+ T cells for tumor promotion

Li, L., Han, L., Sun, F., Zhou, J., Ohaegbulam, K. C., Tang, X., Zang, X., Steinbrecher, K. A., Qu, Z. & Xiao, G., Jun 3 2018, In : OncoImmunology. 7, 6, e1435250.

Research output: Contribution to journalArticle

4 Scopus citations

PD-L1 expression is a prognostic factor in subgroups of gastric cancer patients stratified according to their levels of CD8 and FOXP3 immune markers

Ying, L., Yan, F., Meng, Q., Yu, L., Yuan, X., Gantier, M. P., Williams, B. R. G., Chan, D. W., Shi, L., Tu, Y., Ni, P., Wang, X., Chen, W., Zang, X., Xu, D. & Hu, Y., Jun 3 2018, In : OncoImmunology. 7, 6, e1433520.

Research output: Contribution to journalArticle

10 Scopus citations

Wide expression and significance of alternative immune checkpoint molecules, B7x and HHLA2, in PD-L1–negative human lung cancers

Cheng, H., Borczuk, A., Janakiram, M., Ren, X., Lin, J., Assal, A., Halmos, B., Perez-Soler, R. & Zang, X., Apr 15 2018, In : Clinical Cancer Research. 24, 8, p. 1954-1964 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2017
25 Scopus citations

HHLA2, a new immune checkpoint member of the B7 family, is widely expressed in human lung cancer and associated with EGFR mutational status

Cheng, H., Janakiram, M., Borczuk, A., Lin, J., Qiu, W., Liu, H., Chinai, J. M., Halmos, B., Perez-Soler, R. & Zang, X., Feb 1 2017, In : Clinical Cancer Research. 23, 3, p. 825-832 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

The third group of the B7-CD28 immune checkpoint family: HHLA2, TMIGD2, B7x, and B7-H3

Janakiram, M., Shah, U. A., Liu, W., Zhao, A., Schoenberg, M. P. & Zang, X., Mar 1 2017, In : Immunological Reviews. 276, 1, p. 26-39 14 p.

Research output: Contribution to journalReview article

56 Scopus citations

Tumor-expressed immune checkpoint B7x promotes cancer progression and antigen-specific CD8 T cell exhaustion and suppressive innate immune cells

Ohaegbulam, K. C., Liu, W., Jeon, H., Almo, S. C. & Zang, X., Jan 1 2017, In : Oncotarget. 8, 47, p. 82740-82753 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

B7-H4(B7x)-mediated cross-talk between glioma-initiating cells and macrophages via the IL6/JAK/STAT3 pathway lead to poor prognosis in glioma patients

Yao, Y., Ye, H., Qi, Z., Mo, L., Yue, Q., Baral, A., Hoon, D. S. B., Vera, J. C., Heiss, J. D., Chen, C. C., Hua, W., Zhang, J., Jin, K., Wang, Y., Mao, Y., Zang, X. & Zhou, L., Jun 1 2016, In : Clinical Cancer Research. 22, 11, p. 2778-2790 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

Clinical outcome of various regimens of gonadotropin-releasing hormone analogues after conservative surgery in patients with endometriosis

Liu, W., Chen, C., Shi, J., Zang, X. X. & Zhao, A. M., Oct 30 2016, In : International Journal of Clinical and Experimental Medicine. 9, 10, p. 19935-19943 9 p., IJCEM0027833.

Research output: Contribution to journalArticle

Co-stimulate or Co-inhibit Regulatory T Cells, Which Side to Go?

Liu, W., Almo, S. C. & Zang, X., Nov 16 2016, In : Immunological Investigations. 45, 8, p. 813-831 19 p.

Research output: Contribution to journalReview article

15 Scopus citations

HHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival

Koirala, P., Roth, M. E., Gill, J., Chinai, J. M., Ewart, M. R., Piperdi, S., Geller, D. S., Hoang, B. H., Fatakhova, Y. V., Ghorpade, M., Zang, X. & Gorlick, R., Aug 17 2016, In : Scientific Reports. 6, 31154.

Research output: Contribution to journalArticle

29 Scopus citations

Immune checkpoint blockade in human cancer therapy: Lung cancer and hematologic malignancies

Janakiram, M., Pareek, V., Cheng, H., Narasimhulu, D. M. & Zang, X., Jun 1 2016, In : Immunotherapy. 8, 7, p. 809-819 11 p.

Research output: Contribution to journalReview article

29 Scopus citations

Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma

Koirala, P., Roth, M. E., Gill, J., Piperdi, S., Chinai, J. M., Geller, D. S., Hoang, B. H., Park, A., Fremed, M. A., Zang, X. & Gorlick, R., Jul 26 2016, In : Scientific Reports. 6, 30093.

Research output: Contribution to journalArticle

78 Scopus citations

Molecular pathways: Targeting B7-H3 (CD276) for human cancer immunotherapy

Picarda, E., Ohaegbulam, K. C. & Zang, X., Jul 15 2016, In : Clinical Cancer Research. 22, 14, p. 3425-3431 7 p.

Research output: Contribution to journalArticle

95 Scopus citations
3 Scopus citations

The expression of B7-H3 and B7-H4 in human gallbladder carcinoma and their clinical implications

Liu, C. L., Zang, X. X., Huang, H., Zhang, H., Wang, C., Kong, Y. L. & Zhang, H. Y., Nov 1 2016, In : European review for medical and pharmacological sciences. 20, 21, p. 4466-4473 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Tumor infiltrating lymphocytes as a prognostic and predictive biomarker in breast cancer

Janakiram, M., Khan, H., Fineberg, S. A., Zang, X. & Sparano, J. A., Jan 1 2016, Molecular Pathology of Breast Cancer. Springer International Publishing, p. 167-186 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2015

B7x/B7-H4 modulates the adaptive immune response and ameliorates renal injury in antibody-mediated nephritis

Pawar, R. D., Goilav, B., Xia, Y., Herlitz, L., Doerner, J., Chalmers, S., Ghosh, K., Zang, X. & Putterman, C., Feb 1 2015, In : Clinical and Experimental Immunology. 179, 2, p. 329-343 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Emerging targets in cancer immunotherapy: Beyond CTLA-4 and PD-1

Assal, A., Kaner, J., Pendurti, G. & Zang, X., Nov 2015, In : Immunotherapy. 7, 11, p. 1169-1186 18 p.

Research output: Contribution to journalReview article

27 Scopus citations

Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein

Janakiram, M., Chinai, J. M., Fineberg, S., Fiser, A., Montagna, C., Medavarapu, R., Castano, E., Jeon, H., Ohaegbulam, K. C., Zhao, R., Zhao, A., Almo, S. C., Sparano, J. A. & Zang, X., May 15 2015, In : Clinical Cancer Research. 21, 10, p. 2359-2366 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 families

Janakiram, M., Chinai, J. M., Zhao, A., Sparano, J. A. & Zang, X., Aug 3 2015, In : OncoImmunology. 4, 8

Research output: Contribution to journalArticle

23 Scopus citations

Human cancer immunotherapy with antibodies to the PD-1 and PD-L1 pathway

Ohaegbulam, K. C., Assal, A., Lazar-Molnar, E., Yao, Y. & Zang, X., Jan 1 2015, In : Trends in Molecular Medicine. 21, 1, p. 24-33 10 p.

Research output: Contribution to journalReview article

251 Scopus citations

New immunotherapies targeting the PD-1 pathway

Chinai, J. M., Janakiram, M., Chen, F., Chen, W., Kaplan, M. & Zang, X., Sep 12 2015, In : Trends in Pharmacological Sciences. 36, 9, p. 587-595 9 p.

Research output: Contribution to journalReview article

83 Scopus citations

Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of RB1 and enhances humoral immunity in old age

Zhao, H., Bauzon, F., Bi, E., Yu, J. J., Fu, H., Lu, Z., Cui, J., Jeon, H., Zang, X., Ye, B. H. & Zhu, L., Feb 27 2015, In : Journal of Biological Chemistry. 290, 9, p. 5797-5809 13 p.

Research output: Contribution to journalArticle

7 Scopus citations
2014

Structure and cancer immunotherapy of the B7 family member B7x

Jeon, H., Vigdorovich, V., Garrett-Thomson, S. C., Janakiram, M., Ramagopal, U. A., Abadi, Y. M., Lee, J. S., Scandiuzzi, L., Ohaegbulam, K. C., Chinai, J. M., Zhao, R., Yao, Y., Mao, Y., Sparano, J. A., Almo, S. C. & Zang, X., Jan 1 2014, In : Cell Reports. 9, 3, p. 1089-1098 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Tissue-Expressed B7-H1 Critically Controls Intestinal Inflammation

Scandiuzzi, L., Ghosh, K., Hofmeyer, K. A., Abadi, Y. M., Lázár-Molnár, E., Lin, E. Y., Liu, Q., Jeon, H., Almo, S. C., Chen, L., Nathenson, S. G. & Zang, X., Feb 14 2014, In : Cell Reports. 6, 4, p. 625-632 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2013

B7x and myeloid-derived suppressor cells in the tumor microenvironment a tale of two cities

Jeon, H., Ohaegbulam, K. C., Abadi, Y. M. & Zang, X., Sep 4 2013, In : OncoImmunology. 2, 7, e24744.

Research output: Contribution to journalArticle

16 Scopus citations