• 4114 Citations
  • 31 h-Index
19992020

Research output per year

If you made any changes in Pure these will be visible here soon.

Publications

2013

B7x and myeloid-derived suppressor cells in the tumor microenvironment a tale of two cities

Jeon, H., Ohaegbulam, K. C., Abadi, Y. M. & Zang, X., Sep 4 2013, In : OncoImmunology. 2, 7, e24744.

Research output: Contribution to journalArticle

17 Scopus citations

Curcumin improves the therapeutic efficacy of Listeriaat-Mage-b vaccine in correlation with improved T-cell responses in blood of a triple-negative breast cancer model 4T1

Singh, M., Ramos, I., Asafu-Adjei, D., Quispe-Tintaya, W., Chandra, D., Jahangir, A., Zang, X., Aggarwal, B. B. & Gravekamp, C., Aug 2013, In : Cancer Medicine. 2, 4, p. 571-582 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function

Zhao, R., Chinai, J. M., Buhl, S., Scandiuzzi, L., Ray, A., Jeon, H., Ohaegbulam, K. C., Ghosh, K., Zhao, A., Scharff, M. D. & Zang, X., Jun 11 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 24, p. 9879-9884 6 p.

Research output: Contribution to journalArticle

67 Scopus citations

Host B7x promotes pulmonary metastasis of breast cancer

Abadi, Y. M., Jeon, H., Ohaegbulam, K. C., Scandiuzzi, L., Ghosh, K., Hofmeyer, K. A., Lee, J. S., Ray, A., Gravekamp, C. & Zang, X., Apr 1 2013, In : Journal of Immunology. 190, 7, p. 3806-3814 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Structure and t cell inhibition properties of b7 family member, B7-H3

Vigdorovich, V., Ramagopal, U. A., Lázár-Molnár, E., Sylvestre, E., Lee, J. S., Hofmeyer, K. A., Zang, X., Nathenson, S. G. & Almo, S. C., May 7 2013, In : Structure. 21, 5, p. 707-717 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
2012

B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells

Lee, J. S., Scandiuzzi, L., Ray, A., Wei, J., Hofmeyer, K. A., Abadi, Y. M., Loke, P., Lin, J., Yuan, J., Serreze, D. V., Allison, J. P. & Zang, X., Oct 15 2012, In : Journal of Immunology. 189, 8, p. 4165-4174 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

T cell coinhibition and immunotherapy in human breast cancer.

Janakiram, M., Abadi, Y. M., Sparano, J. A. & Zang, X., Oct 2012, In : Discovery medicine. 14, 77, p. 229-236 8 p.

Research output: Contribution to journalReview article

28 Scopus citations

Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection

Hofmeyer, K. A., Scandiuzzi, L., Ghosh, K., Pirofski, L. A. & Zang, X., Sep 15 2012, In : Journal of Immunology. 189, 6, p. 3054-3063 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

T cell coinhibition in prostate cancer: New immune evasion pathways and emerging therapeutics

Barach, Y. S., Lee, J. S. & Zang, X., Jan 1 2011, In : Trends in Molecular Medicine. 17, 1, p. 47-55 9 p.

Research output: Contribution to journalReview article

29 Scopus citations

T cell costimulation and coinhibition: genetics and disease.

Scandiuzzi, L., Ghosh, K. & Zang, X., Aug 2011, In : Discovery Medicine. 12, 63, p. 119-128 10 p.

Research output: Contribution to journalReview article

14 Scopus citations

The PD-1/PD-L1 (B7-H1) pathway in chronic infection-induced cytotoxic T lymphocyte exhaustion

Hofmeyer, K. A., Jeon, H. & Zang, X., Nov 24 2011, In : Journal of Biomedicine and Biotechnology. 2011, 451694.

Research output: Contribution to journalReview article

73 Scopus citations

Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity

Wei, J., Loke, P., Zang, X. & Allison, J. P., Aug 1 2011, In : Journal of Experimental Medicine. 208, 18, p. 1683-1694 12 p.

Research output: Contribution to journalArticle

39 Scopus citations
2010

Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis

Scandiuzzi, L., Beghdadi, W., Daugas, E., Åbrink, M., Tiwari, N., Brochetta, C., Claver, J., Arouche, N., Zang, X., Pretolani, M., Monteiro, R. C., Pejler, G. & Blank, U., Jul 1 2010, In : Journal of Immunology. 185, 1, p. 624-633 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas

Zang, X., Sullivan, P. S., Soslow, R. A., Waitz, R., Reuter, V. E., Wilton, A., Thaler, H. T., Arul, M., Slovin, S. F., Wei, J., Spriggs, D. R., Dupont, J. & Allison, J. P., Aug 1 2010, In : Modern Pathology. 23, 8, p. 1104-1112 9 p.

Research output: Contribution to journalArticle

123 Scopus citations
2008

Serum-soluble B7x is elevated in renal cell carcinoma patients and is associated with advanced stage

Thompson, R. H., Zang, X., Lohse, C. M., Leibovich, B. C., Slovin, S. F., Reuter, V. E., Cheville, J. C., Blute, M. L., Russo, P., Kwon, E. D. & Allison, J. P., Aug 1 2008, In : Cancer research. 68, 15, p. 6054-6058 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

The contrasting role of B7-H3

Hofmeyer, K. A., Ray, A. & Zang, X., Jul 29 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 30, p. 10277-10278 2 p.

Research output: Contribution to journalComment/debate

74 Scopus citations
2007

Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection

Loke, PN., Gallagher, I., Nair, M. G., Zang, X., Brombacher, F., Mohrs, M., Allison, J. P. & Allen, J. E., Sep 15 2007, In : Journal of Immunology. 179, 6, p. 3926-3936 11 p.

Research output: Contribution to journalArticle

Open Access
199 Scopus citations

B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome

Zang, X., Thompson, R. H., Al-Ahmadie, H. A., Serio, A. M., Reuter, V. E., Eastham, J. A., Scardino, P. T., Sharma, P. & Allison, J. P., Dec 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19458-19463 6 p.

Research output: Contribution to journalArticle

240 Scopus citations

T Cell Immunoglobulin Mucin-3 Crystal Structure Reveals a Galectin-9-Independent Ligand-Binding Surface

Cao, E., Zang, X., Ramagopal, U. A., Mukhopadhaya, A., Fedorov, A., Fedorov, E., Zencheck, W. D., Lary, J. W., Cole, J. L., Deng, H., Xiao, H., DiLorenzo, T. P., Allison, J. P., Nathenson, S. G. & Almo, S. C., Mar 23 2007, In : Immunity. 26, 3, p. 311-321 11 p.

Research output: Contribution to journalArticle

114 Scopus citations

The B7 family and cancer therapy: Costimulation and coinhibition

Zang, X. & Allison, J. P., Sep 15 2007, In : Clinical Cancer Research. 13, 18, p. 5271-5279 9 p.

Research output: Contribution to journalReview article

248 Scopus citations
2006

A genetic library screen for signaling proteins that interact with phosphorylated T cell costimulatory receptors

Zang, X., Loke, P., Kim, J., Wojnoonski, K., Kusdra, L. & Allison, J. P., Dec 1 2006, In : Genomics. 88, 6, p. 841-845 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

To be or not to be B7

Zang, X. & Allison, J. P., Oct 2 2006, In : Journal of Clinical Investigation. 116, 10, p. 2590-2593 4 p.

Research output: Contribution to journalReview article

14 Scopus citations
2005

Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection

Loke, P., Zang, X., Hsuan, L., Waitz, R., Locksley, R. M., Allen, J. E. & Allison, J. P., Jul 12 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 28, p. 9872-9877 6 p.

Research output: Contribution to journalArticle

19 Scopus citations
2003

B7x: A widely expressed B7 family member that inhibits T cell activation

Zang, X., Loke, PN., Kim, J., Murphy, K., Waitz, R. & Allison, J. P., Sep 2 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 18, p. 10388-10392 5 p.

Research output: Contribution to journalArticle

273 Scopus citations

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

Watanabe, N., Gavrieli, M., Sedy, J. R., Yang, J., Fallarino, F., Loftin, S. K., Hurchla, M. A., Zimmerman, N., Sim, J., Zang, X., Murphy, T. L., Russell, J. H., Allison, J. P. & Murphy, K. M., Jul 1 2003, In : Nature Immunology. 4, 7, p. 670-679 10 p.

Research output: Contribution to journalArticle

544 Scopus citations
2002

Cloning and characterisation of mmc-1, a microfilarial-specific gene, from Brugia pahangi

Emes, R., Thompson, F., Moore, J., Zang, X. & Devaney, E., Feb 28 2002, In : International Journal for Parasitology. 32, 4, p. 415-424 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Homologues of human macrophage migration inhibitory factor from a parasitic nematode: Gene cloning, protein activity, and crystal structure

Zang, X., Taylor, P., Wang, J. M., Meyer, D. J., Scott, A. L., Walkinshaw, M. D. & Maizels, R. M., Nov 15 2002, In : Journal of Biological Chemistry. 277, 46, p. 44261-44267 7 p.

Research output: Contribution to journalArticle

86 Scopus citations
2001

A Brugia malayi homolog of macrophage migration inhibitory factor reveals an important link between macrophages and eosinophil recruitment during nematode infection

Falcone, F. H., Loke, P., Zang, X., MacDonald, A. S., Maizels, R. M. & Allen, J. E., Nov 1 2001, In : Journal of Immunology. 167, 9, p. 5348-5354 7 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations

Immune evasion genes from filarial nematodes

Maizels, R. M., Gomez-Escobar, N., Gregory, W. F., Murray, J. & Zang, X., Jun 23 2001, In : International Journal for Parasitology. 31, 9, p. 889-898 10 p.

Research output: Contribution to journalArticle

131 Scopus citations

Serine proteinase inhibitors from nematodes and the arms race between host and pathogen

Zang, X. & Maizels, R. M., Mar 1 2001, In : Trends in Biochemical Sciences. 26, 3, p. 191-197 7 p.

Research output: Contribution to journalReview article

111 Scopus citations
2000

The serpin secreted by Brugia malayi microfilariae, Bm-SPN-2, elicits strong, but short-lived, immune responses in mice and humans

Zang, X., Atmadja, A. K., Gray, P., Allen, J. E., Gray, C. A., Lawrence, R. A., Yazdanbakhsh, M. & Maizels, R. M., Nov 1 2000, In : Journal of Immunology. 165, 9, p. 5161-5169 9 p.

Research output: Contribution to journalArticle

Open Access
57 Scopus citations
1999

A novel serpin expressed by blood-borne microfilariae of the parasitic nematode Brugia malayi inhibits human neutrophil serine proteinases

Zang, X., Yazdanbakhsh, M., Jiang, H., Kanost, M. R. & Maizels, R. M., Aug 15 1999, In : Blood. 94, 4, p. 1418-1428 11 p.

Research output: Contribution to journalArticle

92 Scopus citations

Vaccination against helminth parasites - The ultimate challenge for vaccinologists?

Maizels, R. M., Holland, M. J., Falcone, F. H., Zang, X. X. & Yazdanbakhsh, M., Nov 9 1999, In : Immunological Reviews. 171, p. 125-147 23 p.

Research output: Contribution to journalReview article

69 Scopus citations