Projects per year
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Dive into the research topics where Matthew D. Scharff is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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A combined computational and experimental approach to the evolution and role of the DNA sequence environment in targeting mutations to antibody V regions
MacCarthy, T. & Scharff, M. D.
National Institute of Allergy and Infectious Diseases
3/1/18 → 2/28/22
Project: Research project
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Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)
Chu, E., Chu, E., Scharff, M. D., Goldman, I. D. & Eagle, H.
12/31/89 → 6/30/22
Project: Research project
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CORE--ANALYTICAL ULTRASTRUCTURE CENTER
Bases, R., Kadish, A., Wiernik, P., Orr, G., Bloom, B., Shapiro, L., Lilly, F., Chase, J., Atkinson, P., Maio, J., Reid, L., Levine, W., Nathenson, S., Fant, J., Warner, J., Peisach, J., Horwitz, M., Krauter, K., Makman, M., Blumenfeld, O., Schulman, L., Klinger, H., Rajan, T., Wadler, S., Chance, M., Buhl, S., Desai, K., Pollard, J. W., Sparano, J. A., Hurwitz, J., Duran-Reynals, M., Serrano, L., Alderman, M., Shin, S., West, M., Birshstein, B., Marians, K., Eagle, H., Russel, R., Grills, G., Pickering, K., Mahmood, R., Keller, S. M., Herbst, L., Seither, R., Condeelis, J. S., Edelmann, W., Kucherlapati, R., Gupta, R., Depinho, R., Dutcher, J., Diamond, B., Gaertner, D. J., Keller, S. M., Pollard, J. W., Kucherlapati, R., Gupta, R., Depinho, R., Dutcher, J., Diamond, B., Gaertner, D. J., Herbst, L. H., Goel, S., Scharff, M. D., Scharff, M. D., Scharff, M. D., Band Horwitz, S., Rubin, C. S., Schildkraut, C. L., Band Horwitz, S., Rubin, C. S., Schildkraut, C. L., Maitra, U., Satir, B. H., Cannizzaro, L. A., Cannizzaro, L. A., Childs, G. J., Childs, G. J., Skoultchi, A. I., Rohan, T. E., Porcelli, S. A., Montagna, C., Keller, S. M., Greally, J. M., Stanley, P., Beck, A. P., Steidl, U. G., Strickler, H., Rapkin, B. D. & Sparano, J. A.
1/1/01 → 6/30/22
Project: Research project
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Mismatch repair in V region mutation and isotype switching
National Institute of Allergy and Infectious Diseases
8/11/14 → 7/31/19
Project: Research project
Publications
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A Bayesian model based computational analysis of the relationship between bisulfite accessible single-stranded DNA in chromatin and somatic hypermutation of immunoglobulin genes
Yu, G., Wu, Y., Duan, Z., Tang, C., Xing, H., Scharff, M. D. & MacCarthy, T., Sep 2021, In: PLoS Computational Biology. 17, 9, e1009323.Research output: Contribution to journal › Article › peer-review
Open Access -
Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course
Bagnara, D., Tang, C., Brown, J. R., Kasar, S., Fernandes, S., Colombo, M., Vergani, S., Mazzarello, A. N., Ghiotto, F., Bruno, S., Morabito, F., Rai, K. R., Kolitz, J. E., Barrientos, J. C., Allen, S. L., Fais, F., Scharff, M. D., MacCarthy, T. & Chiorazzi, N., May 25 2021, In: Frontiers in Oncology. 11, 640731.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes
Duan, Z., Baughn, L. B., Wang, X., Zhang, Y., Gupta, V., MacCarthy, T., Scharff, M. D. & Yu, G., Jul 20 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 29, e2104013118.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions
Yu, G., Zhang, Y., Gupta, V., Zhang, J., MacCarthy, T., Duan, Z. & Scharff, M. D., Dec 14 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 50, e2114743118.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes
Tang, C., Bagnara, D., Chiorazzi, N., Scharff, M. D. & MacCarthy, T., Apr 30 2020, In: Frontiers in immunology. 11, 788.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations