Projects per year
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- 3 Similar Profiles
Antibodies
Medicine & Life Sciences
Immunoglobulins
Medicine & Life Sciences
Monoclonal Antibodies
Medicine & Life Sciences
Cryptococcus neoformans
Medicine & Life Sciences
Mutation
Medicine & Life Sciences
Hybridomas
Medicine & Life Sciences
Immunoglobulin Genes
Medicine & Life Sciences
Immunoglobulin G
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 1977 2023
A combined computational and experimental approach to the evolution and role of the DNA sequence environment in targeting mutations to antibody V regions
3/1/18 → 2/28/23
Project: Research project › Research Project
Mutation
Antibodies
Genes
Databases
Immunoglobulin Variable Region
CANCER RESEARCH CENTER
Brewer, C. F., Bases, R., Kadish, A., Wiernik, P., Orr, G., Bloom, B., Shapiro, L., Lilly, F., Chase, J., Atkinson, P., Maio, J., Reid, L., Levine, W., Nathenson, S., Fant, J., Warner, J., Peisach, J., Horwitz, M., Krauter, K., Makman, M., Blumenfeld, O., Schulman, L., Klinger, H., Rajan, T., Wadler, S., Chance, M., Buhl, S., Desai, K., Pollard, J. W., Brenowitz, M. D., Stanley, P., Skoultchi, A. I., Sparano, J. A., Hurwitz, J., Duran-Reynals, M., Serrano, L., Alderman, M., Shin, S., West, M., Birshstein, B., Marians, K., Eagle, H., Russel, R., Grills, G., Pickering, K., Mahmood, R., Keller, S. M., Herbst, L., Seither, R., Satir, B. H., Rubin, C. S., Scharff, M. D., Maitra, U., Band Horwitz, S., Schildkraut, C. L., Ho, G. Y. F., Cannizzaro, L. A., Childs, G. J., Augenlicht, L. H., Almo, S. C., Greally, J. M., Angeletti, R. H., Porcelli, S. A., Morrow, B. E., Condeelis, J. S., Montagna, C., Edelmann, W., Kim, M., Rohan, T. E., Goldman, I. D., Kucherlapati, R., Gupta, R., Depinho, R., Dutcher, J., Diamond, B., Gaertner, D. J., Keller, S. M., Pollard, J. W., Kucherlapati, R., Gupta, R., Depinho, R., Dutcher, J., Diamond, B., Gaertner, D. J. & Keller, S. M.
6/1/77 → 6/30/19
Project: Research project › Center Core Grants
Research Personnel
Organized Financing
Neoplasms
Research
Medical Oncology
Northeast Biodefense Center
Scharff, M. D., Palacios, G. F., Basler, C., Alaedini, A., Fries, B., Briese, T., Rice, C., [No Value], C. R., Chave, K. J., Bliska, J., Brady, S., Rose, J. K., Garcia-Sastre, A., Gulcicek, E., Perlin, D., Moscona, A., Palese, P., Lipkin, W., Califano, A., Buck, J., Belfort, M., Pei-Yong, S., Crystal, R., Severinov, K., Sturman, L., Bernard, K., Galan, J., MacKow, E. R., Egan, C., Kielian, M., Casadevall, A., Levy, D., Palacios, G. F., [No Value], C. R., Lipkin, W., Rose, J. K. & MacKow, E. R.
9/4/03 → 2/28/15
Project: Research project › Specialized Center--Cooperative Agreements
Chikungunya virus
Prostaglandins A
Anthrax
Dengue Virus
Passive Immunization
Mismatch Repair in V region mutation and isotype switch
7/1/03 → 7/31/14
Project: Research project › Research Project
DNA Mismatch Repair
Immunoglobulin Class Switching
Mutation
B-Lymphocytes
Antibodies
Mismatch repair in V region mutation and isotype switching
7/1/03 → 7/31/18
Project: Research project › Research Project
Immunoglobulin Class Switching
DNA Mismatch Repair
Mutation
Immunoglobulin Genes
Genetic Recombination
Publications 1960 2018
Human immunodeficiency virus tat protein aids V region somatic hypermutation in human B cells
Wang, X., Duan, Z., Yu, G., Fan, M. & Scharff, M. D., Mar 1 2018, In : mBio. 9, 2, e02315-17.Research output: Contribution to journal › Article
tat Gene Products
Human Immunodeficiency Virus Proteins
B-Lymphocytes
HIV
Virus Diseases
Error-Prone Mismatch and Base Excision DNA Repair in Somatic Hypermutation
Wang, S., Chahwan, R., Wei, L. & Scharff, M. D., Apr 27 2016, Molecular Immunology. Elsevier Inc., Vol. 2. p. 126-133 8 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
DNA Repair
Antibodies
V(D)J Recombination
Genetic Recombination
B-Lymphocytes
Overlapping hotspots in CDRs are critical sites for V region diversification
Wei, L., Chahwan, R., Wang, S., Wang, X., Pham, P. T., Goodman, M. F., Bergman, A., Scharff, M. D. & MacCarthy, T., Feb 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 7, p. E728-E737Research output: Contribution to journal › Article
Mutation
B-Lymphocytes
Immunoglobulin Variable Region
High-Throughput Nucleotide Sequencing
Mutation Rate
A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation
Wang, X., Fan, M., Kalis, S., Wei, L. & Scharff, M. D., Jun 13 2014, In : Nature Communications. 5, 4137.Research output: Contribution to journal › Article
Immunoglobulin Heavy Chains
Single-Stranded DNA
Transcription
deoxyribonucleic acid
activation
Detection and measurement of staphylococcal enterotoxin-like K (SEl-K) secretion by Staphylococcus aureus clinical isolates
Aguilar, J. L., Varshney, A. K., Wang, X., Stanford, L., Scharff, M. & Fries, B. C., 2014, In : Journal of Clinical Microbiology. 52, 7, p. 2536-2543 8 p.Research output: Contribution to journal › Article
Enterotoxins
Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus
Enzyme-Linked Immunosorbent Assay
Genes