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Matthew D. Scharff, M.D.

  • 13015 Citations
  • 61 h-Index
1960 …2023

Research output per year

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Grants

A combined computational and experimental approach to the evolution and role of the DNA sequence environment in targeting mutations to antibody V regions

Scharff, M. D.

National Institutes of Health

3/1/18 → 2/28/23

Project: Research project

    • CANCER RESEARCH CENTER

    Brewer, C. F., Bases, R., Kadish, A., Wiernik, P., Orr, G., Bloom, B., Shapiro, L., Lilly, F., Chase, J., Atkinson, P., Maio, J., Reid, L., Levine, W., Nathenson, S., Fant, J., Warner, J., Peisach, J., Horwitz, M., Krauter, K., Makman, M., Blumenfeld, O., Schulman, L., Klinger, H., Rajan, T., Wadler, S., Chance, M., Buhl, S., Desai, K., Pollard, J. W., Brenowitz, M. D., Stanley, P., Skoultchi, A. I., Sparano, J. A., Hurwitz, J., Duran-Reynals, M., Serrano, L., Alderman, M., Shin, S., West, M., Birshstein, B., Marians, K., Eagle, H., Russel, R., Grills, G., Pickering, K., Mahmood, R., Keller, S. M., Herbst, L., Seither, R., Satir, B. H., Rubin, C. S., Scharff, M. D., Maitra, U., Band Horwitz, S., Schildkraut, C. L., Ho, G. Y. F., Cannizzaro, L. A., Childs, G. J., Augenlicht, L. H., Almo, S. C., Greally, J. M., Angeletti, R. H., Porcelli, S. A., Morrow, B. E., Condeelis, J. S., Montagna, C., Edelmann, W., Kim, M., Rohan, T. E., Goldman, I. D., Kucherlapati, R., Gupta, R., Depinho, R., Dutcher, J., Diamond, B., Gaertner, D. J., Keller, S. M., Pollard, J. W., Kucherlapati, R., Gupta, R., Depinho, R., Dutcher, J., Diamond, B., Gaertner, D. J., Keller, S. M., Xue, X. (., Blanchard, J. S., Beck, A. P., Rapkin, B. D., Strickler, H., Goel, S., Bresnick, A. R., Steidl, U. G., Schramm, V. L. & Condeelis, J. S.

    National Institutes of Health

    6/1/77 → 6/30/22

    Project: Research project

    • Northeast Biodefense Center

    Scharff, M. D., Palacios, G. F., Basler, C., Alaedini, A., Fries, B., Briese, T., Rice, C., [No Value], C. R., Chave, K. J., Bliska, J., Brady, S., Rose, J. K., Garcia-Sastre, A., Gulcicek, E., Perlin, D., Moscona, A., Palese, P., Lipkin, W., Califano, A., Buck, J., Belfort, M., Pei-Yong, S., Crystal, R., Severinov, K., Sturman, L., Bernard, K., Galan, J., MacKow, E. R., Egan, C., Kielian, M., Casadevall, A., Levy, D., Palacios, G. F., [No Value], C. R., Lipkin, W., Rose, J. K. & MacKow, E. R.

    National Institutes of Health

    9/4/03 → 2/28/15

    Project: Research project

    • Mismatch Repair in V region mutation and isotype switch

    Scharff, M. D.

    National Institutes of Health

    7/1/03 → 7/31/14

    Project: Research project

    • Mismatch repair in V region mutation and isotype switching

    Scharff, M. D.

    National Institutes of Health

    7/1/03 → 7/31/19

    Project: Research project

    • Publications

    Human immunodeficiency virus tat protein aids V region somatic hypermutation in human B cells

    Wang, X., Duan, Z., Yu, G., Fan, M. & Scharff, M. D., Mar 1 2018, In : mBio. 9, 2, e02315-17.

    Research output: Contribution to journal › Article

    • Error-Prone Mismatch and Base Excision DNA Repair in Somatic Hypermutation

    Wang, S., Chahwan, R., Wei, L. & Scharff, M. D., Apr 27 2016, Molecular Immunology. Elsevier Inc., Vol. 2. p. 126-133 8 p.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

    • Overlapping hotspots in CDRs are critical sites for V region diversification

    Wei, L., Chahwan, R., Wang, S., Wang, X., Pham, P. T., Goodman, M. F., Bergman, A., Scharff, M. D. & MacCarthy, T., Feb 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 7, p. E728-E737

    Research output: Contribution to journal › Article

    • 23 Scopus citations

    A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation

    Wang, X., Fan, M., Kalis, S., Wei, L. & Scharff, M. D., Jun 13 2014, In : Nature communications. 5, 4137.

    Research output: Contribution to journal › Article

    • 18 Scopus citations

    Detection and measurement of staphylococcal enterotoxin-like K (SEl-K) secretion by Staphylococcus aureus clinical isolates

    Aguilar, J. L., Varshney, A. K., Wang, X., Stanford, L., Scharff, M. & Fries, B. C., Jul 2014, In : Journal of Clinical Microbiology. 52, 7, p. 2536-2543 8 p.

    Research output: Contribution to journal › Article

    • 14 Scopus citations