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Matthew D. Scharff, M.D.

  • 13220 Citations
  • 62 h-Index
1960 …2020

Research output per year

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Grants

A combined computational and experimental approach to the evolution and role of the DNA sequence environment in targeting mutations to antibody V regions

Scharff, M. D.

National Institute of Allergy and Infectious Diseases

3/1/18 → 12/31/18

Project: Research project

    • Mismatch repair in V region mutation and isotype switching

    Scharff, M. D.

    National Institute of Allergy and Infectious Diseases

    8/1/15 → 8/31/15

    Project: Research project

    • Northeast Biodefense Center

    Scharff, M. D., Palacios, G. F., Basler, C., Alaedini, A., Fries, B., Briese, T., Rice, C., [No Value], C. R., Chave, K. J., Bliska, J., Brady, S., Rose, J. K., Garcia-Sastre, A., Gulcicek, E., Perlin, D., Moscona, A., Palese, P., Lipkin, W., Califano, A., Buck, J., Belfort, M., Pei-Yong, S., Crystal, R., Severinov, K., Sturman, L., Bernard, K., Galan, J., MacKow, E. R., Egan, C., Casadevall, A., Levy, D., Palacios, G. F., [No Value], C. R., Lipkin, W., Rose, J. K. & MacKow, E. R.

    National Institute of Allergy and Infectious Diseases

    3/1/08 → 2/28/09

    Project: Research project

    • Mismatch Repair in V region mutation and isotype switch

    Scharff, M. D.

    National Cancer Institute

    7/1/03 → 6/30/04

    Project: Research project

    • The Production of More Effective Monoclonal Antibodies

    Scharff, M. D.

    National Institute of Allergy and Infectious Diseases

    9/1/02 → 8/31/03

    Project: Research project

    • Publications

    AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes

    Tang, C., Bagnara, D., Chiorazzi, N., Scharff, M. D. & MacCarthy, T., Apr 30 2020, In : Frontiers in immunology. 11, 788.

    Research output: Contribution to journal › Article

    Open Access

    • CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation

    Bartholdy, B. A., Wang, X., Yan, X. J., Pascual, M., Fan, M., Barrientos, J., Allen, S. L., Martinez-Climent, J. A., Rai, K. R., Chiorazzi, N., Scharff, M. D. & Roa, S., Mar 10 2020, In : Blood Advances. 4, 5, p. 893-906 14 p.

    Research output: Contribution to journal › Article

    Open Access

    • Human immunodeficiency virus tat protein aids V region somatic hypermutation in human B cells

    Wang, X., Duan, Z., Yu, G., Fan, M. & Scharff, M. D., Mar 1 2018, In : mBio. 9, 2, e02315-17.

    Research output: Contribution to journal › Article

    • Error-Prone Mismatch and Base Excision DNA Repair in Somatic Hypermutation

    Wang, S., Chahwan, R., Wei, L. & Scharff, M. D., Apr 27 2016, Molecular Immunology. Elsevier Inc., Vol. 2. p. 126-133 8 p.

    Research output: Chapter in Book/Report/Conference proceeding › Chapter

    • Overlapping hotspots in CDRs are critical sites for V region diversification

    Wei, L., Chahwan, R., Wang, S., Wang, X., Pham, P. T., Goodman, M. F., Bergman, A., Scharff, M. D. & MacCarthy, T., Feb 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 7, p. E728-E737

    Research output: Contribution to journal › Article

    • 26 Scopus citations