Projects per year
Fingerprint Dive into the research topics where Matthew D. Scharff is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 4 Similar Profiles
Antibodies
Medicine & Life Sciences
Immunoglobulins
Medicine & Life Sciences
Monoclonal Antibodies
Medicine & Life Sciences
Cryptococcus neoformans
Medicine & Life Sciences
Hybridomas
Medicine & Life Sciences
Immunoglobulin Genes
Medicine & Life Sciences
Mutation
Medicine & Life Sciences
Immunoglobulin G
Medicine & Life Sciences
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 1977 2023
A combined computational and experimental approach to the evolution and role of the DNA sequence environment in targeting mutations to antibody V regions
3/1/18 → 2/28/23
Project: Research project
Mutation
Antibodies
Genes
Databases
Immunoglobulin Variable Region
Northeast Biodefense Center
Scharff, M. D., Palacios, G. F., Basler, C., Alaedini, A., Fries, B., Briese, T., Rice, C., [No Value], C. R., Chave, K. J., Bliska, J., Brady, S., Rose, J. K., Garcia-Sastre, A., Gulcicek, E., Perlin, D., Moscona, A., Palese, P., Lipkin, W., Califano, A., Buck, J., Belfort, M., Pei-Yong, S., Crystal, R., Severinov, K., Sturman, L., Bernard, K., Galan, J., MacKow, E. R., Egan, C., Kielian, M., Casadevall, A., Levy, D., Palacios, G. F., [No Value], C. R., Lipkin, W., Rose, J. K. & MacKow, E. R.
9/4/03 → 2/28/15
Project: Research project
Chikungunya virus
Prostaglandins A
Anthrax
Dengue Virus
Passive Immunization
Immunoglobulin Class Switching
DNA Mismatch Repair
Mutation
Immunoglobulin Genes
Genetic Recombination
DNA Mismatch Repair
Immunoglobulin Class Switching
Mutation
B-Lymphocytes
Antibodies
Bioterrorism
Monoclonal Antibodies
Hybridomas
Mutation
Immunoglobulin Class Switching
Publications 1960 2018
Human immunodeficiency virus tat protein aids V region somatic hypermutation in human B cells
Wang, X., Duan, Z., Yu, G., Fan, M. & Scharff, M. D., Mar 1 2018, In : mBio. 9, 2, e02315-17.Research output: Contribution to journal › Article
tat Gene Products
Human Immunodeficiency Virus Proteins
B-Lymphocytes
HIV
Virus Diseases
Error-Prone Mismatch and Base Excision DNA Repair in Somatic Hypermutation
Wang, S., Chahwan, R., Wei, L. & Scharff, M. D., Apr 27 2016, Molecular Immunology. Elsevier Inc., Vol. 2. p. 126-133 8 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
DNA Repair
Antibodies
V(D)J Recombination
Genetic Recombination
B-Lymphocytes
23
Citations
(Scopus)
Overlapping hotspots in CDRs are critical sites for V region diversification
Wei, L., Chahwan, R., Wang, S., Wang, X., Pham, P. T., Goodman, M. F., Bergman, A., Scharff, M. D. & MacCarthy, T., Feb 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 7, p. E728-E737Research output: Contribution to journal › Article
Mutation
B-Lymphocytes
Immunoglobulin Variable Region
High-Throughput Nucleotide Sequencing
Mutation Rate
18
Citations
(Scopus)
A source of the single-stranded DNA substrate for activation-induced deaminase during somatic hypermutation
Wang, X., Fan, M., Kalis, S., Wei, L. & Scharff, M. D., Jun 13 2014, In : Nature Communications. 5, 4137.Research output: Contribution to journal › Article
Immunoglobulin Heavy Chains
Single-Stranded DNA
Transcription
deoxyribonucleic acid
activation
14
Citations
(Scopus)
Detection and measurement of staphylococcal enterotoxin-like K (SEl-K) secretion by Staphylococcus aureus clinical isolates
Aguilar, J. L., Varshney, A. K., Wang, X., Stanford, L., Scharff, M. D. & Fries, B. C., 2014, In : Journal of Clinical Microbiology. 52, 7, p. 2536-2543 8 p.Research output: Contribution to journal › Article
Enterotoxins
Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus
Enzyme-Linked Immunosorbent Assay
Genes