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David C. Spray, Ph.D.

  • 22669 Citations
  • 83 h-Index
1972 …2023
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  • 4 Similar Profiles
Gap Junctions Medicine & Life Sciences
Connexins Medicine & Life Sciences
Connexin 43 Medicine & Life Sciences
Astrocytes Medicine & Life Sciences
Neurons Medicine & Life Sciences
Gene Expression Medicine & Life Sciences
Genes Medicine & Life Sciences
Calcium Signaling Medicine & Life Sciences

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Grants 1977 2023

Structural, Molecular and Functional Specialization in Osteocyte Mechanosensing

Spray, D. C.

National Institutes of Health

7/11/18 → 4/30/23

Project: Research project › Research Project

Osteocytes
Integrins
T-Type Calcium Channels
Purinergic P2X7 Receptors
Pharmacology

The Astrocyte Nexus: Cx43 Protein Interactions

Spray, D. C. & Scemes, E.

National Institutes of Health

8/1/15 → 7/31/20

Project: Research project › Research Project

Connexin 43
Astrocytes
Connexins
Proteins
Gap Junctions

Structural, Molecular, and Functional Specialization in Osteocyte Mechanosensing

Spray, D. C., Weinbaum, S. & Schaffler, M.

National Institutes of Health

9/6/10 → 8/31/16

Project: Research project › Research Project

Osteocytes
Bone and Bones
Theoretical Models
Anabolic Agents
Bioengineering

Luminescence Imaging: Molecules, Cells and Tissues

Spray, D. C.

National Institutes of Health

5/15/06 → 12/31/09

Project: Research project › Biomedical Research Support Shared Instrumentation Grants

Luminescence
Luminescent Proteins
Connexins
Astrocytes
Group Processes

Neuronal Gap Junctions: Cx36 Gating, Binding &Function

Spray, D. C.

National Institutes of Health

2/1/02 → 1/31/08

Project: Research project › Research Project

Electrical Synapses
Connexins
Gap Junctions
Neurons
Macromolecular Substances

Publications 1972 2018

Concentrative transport of antifolates mediated by the proton-coupled folate transporter (slc46a1); Augmentation by a hepes buffer

Zhao, R., Najmi, M., Aluri, S., Spray, D. C. & Goldman, I. D., Mar 1 2018, In : Molecular Pharmacology. 93, 3, p. 208-215 8 p.

Research output: Contribution to journal › Article

Proton-Coupled Folate Transporter
Folic Acid Antagonists
Buffers
HEPES
Tumor Microenvironment

Adrenergic Receptors on Astrocytes Modulate Gap Junctions

Scmes, E., Stout, R. F. & Spray, D. C., Jan 1 2017, Noradrenergic Signaling and Astroglia. Elsevier Inc., p. 127-144 18 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Connexins
Gap Junctions
Second Messenger Systems
Astrocytes
Adrenergic Receptors

Cysteine residues in the cytoplasmic carboxy terminus of connexins dictate gap junction plaque stability

Stout, R. F. & Spray, D. C., Oct 15 2017, In : Molecular Biology of the Cell. 28, 21, p. 2757-2764 8 p.

Research output: Contribution to journal › Article

Connexins
Gap Junctions
Cysteine
Reducing Agents
Confocal Microscopy
3 Citations

Functional genomic fabrics are remodeled in a mouse model of Chagasic cardiomyopathy and restored following cell therapy

Iacobas, D. A., Iacobas, S., Tanowitz, H. B., Campos de Carvalho, A. & Spray, D. C., Jan 1 2017, (Accepted/In press) In : Microbes and Infection.

Research output: Contribution to journal › Article

Cell- and Tissue-Based Therapy
Cardiomyopathies
Muscle Contraction
Myocardium
Trypanosoma cruzi
10 Citations

Gap junctions, pannexins and pain

Spray, D. C. & Hanani, M., 2017, (Accepted/In press) In : Neuroscience Letters.

Research output: Contribution to journal › Article

Gap Junctions
Pain
Neuroglia
Sensory Ganglia
Migraine with Aura