• 24133 Citations
  • 88 h-Index
1972 …2020

Research output per year

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Publications

2020

Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels

McCutcheon, S., Majeska, R. J., Spray, D. C., Schaffler, M. B. & Vazquez, M., May 1 2020, In : Journal of Bone and Mineral Research. 35, 5, p. 966-977 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Author Correction: Stress gates an astrocytic energy reservoir to impair synaptic plasticity (Nature Communications, (2020), 11, 1, (2014), 10.1038/s41467-020-15778-9)

Murphy-Royal, C., Johnston, A. D., Boyce, A. K. J., Diaz-Castro, B., Institoris, A., Peringod, G., Zhang, O., Stout, R. F., Spray, D. C., Thompson, R. J., Khakh, B. S., Bains, J. S. & Gordon, G. R., Dec 1 2020, In : Nature communications. 11, 1, 3064.

Research output: Contribution to journalComment/debate

Open Access

Cellular environment remodels the genomic fabrics of functional pathways in astrocytes

Iacobas, D. A., Iacobas, S., Stout, R. F. & Spray, D. C., May 2020, In : Genes. 11, 5, 520.

Research output: Contribution to journalArticle

Open Access

Emerging importance of satellite glia in nervous system function and dysfunction

Hanani, M. & Spray, D. C., 2020, (Accepted/In press) In : Nature Reviews Neuroscience.

Research output: Contribution to journalReview article

Open Access

Stress gates an astrocytic energy reservoir to impair synaptic plasticity

Murphy-Royal, C., Johnston, A. D., Boyce, A. K. J., Diaz-Castro, B., Institoris, A., Peringod, G., Zhang, O., Stout, R. F., Spray, D. C., Thompson, R. J., Khakh, B. S., Bains, J. S. & Gordon, G. R., Dec 1 2020, In : Nature communications. 11, 1, 2014.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Trypanosoma cruzi Promotes Transcriptomic Remodeling of the JAK/STAT Signaling and Cell Cycle Pathways in Myoblasts

Nisimura, L. M., Coelho, L. L., de Melo, T. G., Vieira, P. D. C., Victorino, P. H., Garzoni, L. R., Spray, D. C., Iacobas, D. A., Iacobas, S., Tanowitz, H. B. & Adesse, D., Jun 17 2020, In : Frontiers in Cellular and Infection Microbiology. 10, 255.

Research output: Contribution to journalArticle

Open Access
2019

Correction: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model (Arthritis Research and Therapy (2014) 16 (508) DOI: 10.1186/s13075-014-0508-y)

Leong, D. J., Choudhury, M., Hanstein, R., Hirsh, D. M., Kim, S. J., Majeska, R. J., Schaffler, M. B., Hardin, J. A., Spray, D. C., Goldring, M. B., Cobelli, N. J. & Sun, H. B., Jan 3 2019, In : Arthritis Research and Therapy. 21, 1, 1.

Research output: Contribution to journalComment/debate

Gap junction mediated signaling between satellite glia and neurons in trigeminal ganglia

Spray, D. C., Iglesias, R., Shraer, N., Suadicani, S. O., Belzer, V., Hanstein, R. & Hanani, M., May 2019, In : Glia. 67, 5, p. 791-801 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Gap junctions, pannexins and pain

Spray, D. C. & Hanani, M., Mar 16 2019, In : Neuroscience Letters. 695, p. 46-52 7 p.

Research output: Contribution to journalReview article

13 Scopus citations

Tubulin-Dependent Transport of Connexin-36 Potentiates the Size and Strength of Electrical Synapses

Brown, C. A., Del Corsso, C., Zoidl, C., Donaldson, L. W., Spray, D. C. & Zoidl, G., Sep 25 2019, In : Cells. 8, 10

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018
1 Scopus citations

Functional genomic fabrics are remodeled in a mouse model of Chagasic cardiomyopathy and restored following cell therapy

Iacobas, D. A., Iacobas, S., Tanowitz, H. B., Campos de Carvalho, A. & Spray, D. C., Mar 2018, In : Microbes and Infection. 20, 3, p. 185-195 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Adrenergic Receptors on Astrocytes Modulate Gap Junctions

Scmes, E., Stout, R. F. & Spray, D. C., Jan 1 2017, Noradrenergic Signaling and Astroglia. Elsevier Inc., p. 127-144 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Cysteine residues in the cytoplasmic carboxy terminus of connexins dictate gap junction plaque stability

Stout, R. F. & Spray, D. C., Oct 15 2017, In : Molecular biology of the cell. 28, 21, p. 2757-2764 8 p.

Research output: Contribution to journalArticle

Osteocyte calcium signals encode strain magnitude and loading frequency in vivo

Lewis, K. J., Frikha-Benayed, D., Louie, J., Stephen, S., Spray, D. C., Thi, M. M., Seref-Ferlengez, Z., Majeska, R. J., Weinbaum, S. & Schaffler, M. B., Oct 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 44, p. 11775-11780 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Potential role for a specialized β3 integrin-based structure on osteocyte processes in bone mechanosensation

Cabahug-Zuckerman, P., Stout, R. F., Majeska, R. J., Thi, M. M., Spray, D. C., Weinbaum, S. & Schaffler, M. B., Jan 1 2017, (Accepted/In press) In : Journal of Orthopaedic Research.

Research output: Contribution to journalArticle

13 Scopus citations
2016

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals

Zhu, Y., Gao, Y., Tao, C., Shao, M., Zhao, S., Huang, W., Yao, T., Johnson, J. A., Liu, T., Cypess, A. M., Gupta, O., Holland, W. L., Gupta, R. K., Spray, D. C., Tanowitz, H. B., Cao, L., Lynes, M. D., Tseng, Y. H., Elmquist, J. K., Williams, K. W. & 2 others, Lin, H. V. & Scherer, P. E., Sep 13 2016, In : Cell metabolism. 24, 3, p. 420-433 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain

Kim, Y. S., Anderson, M., Park, K., Zheng, Q., Agarwal, A., Gong, C., Saijilafu, Young, L. A., He, S., LaVinka, P. C., Zhou, F., Bergles, D., Hanani, M., Guan, Y., Spray, D. C. & Dong, X., Sep 7 2016, In : Neuron. 91, 5, p. 1085-1096 12 p.

Research output: Contribution to journalArticle

75 Scopus citations

Effect of mesenchymal stem cells and mouse embryonic fibroblasts on the development of preimplantation mouse embryos

Jasmin, Peters, V. M., Spray, D. C. & Mendez-Otero, R., Apr 1 2016, In : In Vitro Cellular and Developmental Biology - Animal. 52, 4, p. 497-506 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria

Freeman, B. D., Martins, Y. C., Akide-Ndunge, O. B., Bruno, F. P., Wang, H., Tanowitz, H. B., Spray, D. C. & Desruisseaux, M. S., Mar 1 2016, In : PLoS Pathogens. 12, 3, e1005477.

Research output: Contribution to journalArticle

8 Scopus citations

FRAP for the study of gap junction nexus macromolecular organization

Stout, R. F. & Spray, D. C., Aug 5 2016, Gap Junction Channels and Hemichannels. CRC Press, p. 63-91 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Gap junctions and electric synapses

Dermietzel, R. & Spray, D. C., Jan 1 2016, Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, p. 511-546 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Glial pannexin1 contributes to tactile hypersensitivity in a mouse model of orofacial pain

Hanstein, R., Hanani, M., Scemes, E. & Spray, D. C., Dec 2 2016, In : Scientific reports. 6, 38266.

Research output: Contribution to journalArticle

14 Scopus citations

P2X7R-Panx1 complex impairs bone mechanosignaling under high glucose levels associated with type-1 diabetes

Seref-Ferlengez, Z., Maung, S., Schaffler, M. B., Spray, D. C., Suadicani, S. O. & Thi, M. M., May 1 2016, In : PloS one. 11, 5, e0155107.

Research output: Contribution to journalArticle

28 Scopus citations

Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes

Cheung, W. Y., Fritton, J. C., Morgan, S. A., Seref-Ferlengez, Z., Basta-Pljakic, J., Thi, M. M., Suadicani, S. O., Spray, D. C., Majeska, R. J. & Schaffler, M. B., Apr 1 2016, In : Journal of Bone and Mineral Research. 31, 4, p. 890-899 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes

He, Z., Leong, D. J., Zhuo, Z., Majeska, R. J., Cardoso, L., Spray, D. C., Goldring, M. B., Cobelli, N. J. & Sun, H. B., May 1 2016, In : Osteoarthritis and Cartilage. 24, 5, p. 892-901 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Structural and functional consequences of connexin 36 (Cx36) interaction with calmodulin

Siu, R. C. F., Smirnova, E., Brown, C. A., Zoidl, C., Spray, D. C., Donaldson, L. W. & Zoidl, G., Nov 18 2016, In : Frontiers in Molecular Neuroscience. 9, NOV2016, 120.

Research output: Contribution to journalArticle

7 Scopus citations

The speed of swelling kinetics modulates cell volume regulation and calcium signaling in astrocytes: A different point of view on the role of aquaporins

Mola, M. G., Sparaneo, A., Gargano, C. D., Spray, D. C., Svelto, M., Frigeri, A., Scemes, E. & Nicchia, G. P., Jan 1 2016, In : Glia. 64, 1, p. 139-154 16 p.

Research output: Contribution to journalArticle

45 Scopus citations
2015

Connexin type and fluorescent protein fusion tag determine structural stability of gap junction plaques

Stout, R. F., Snapp, E. L. & Spray, D. C., Sep 25 2015, In : Journal of Biological Chemistry. 290, 39, p. 23497-23514 18 p.

Research output: Contribution to journalArticle

12 Scopus citations

Developments in the management of Chagas cardiomyopathy

Tanowitz, H. B., Machado, F. S., Spray, D. C., Friedman, J. M., Weiss, O. S., Lora, J. N., Nagajyothi, J., Moraes, D. N., Garg, N. J., Nunes, M. C. P. & Ribeiro, A. L. P., Dec 2 2015, In : Expert Review of Cardiovascular Therapy. 13, 12, p. 1393-1409 17 p.

Research output: Contribution to journalArticle

30 Scopus citations

The Einstein-Brazil fogarty: A decade of synergy

Nosanchuk, J. D., Nosanchuk, M. D., Rodrigues, M. L., Nimrichter, L., Campos de Carvalho, A. C., Weiss, L. M., Spray, D. C. & Tanowitz, H. B., Oct 1 2015, In : Brazilian Journal of Microbiology. 46, 4, p. 945-955 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

Adipocytes in both brown and white adipose tissue of adult mice are functionally connected via gap junctions: Implications for Chagas disease

Burke, S., Nagajyothi, F., Thi, M. M., Hanani, M., Scherer, P. E., Tanowitz, H. B. & Spray, D. C., Nov 1 2014, In : Microbes and Infection. 16, 11, p. 893-901 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Connexins modulate autophagosome biogenesis

Bejarano, E., Yuste, A., Patel, B., Randy, R. F., Spray, D. C. & Cuervo, A. M., Jan 1 2014, In : Nature Cell Biology. 16, 5, p. 401-414 14 p.

Research output: Contribution to journalArticle

68 Scopus citations

Gap junctional communication in health and disease

Zoidl, G. & Spray, D. C., Jan 1 2014, In : Frontiers in Physiology. 5, Nov, 442.

Research output: Contribution to journalEditorial

1 Scopus citations

Gap Junctions in the Nervous System

Spray, D. C., Scemes, E. & Dermietzel, R., Jan 1 2014, Encyclopedia of the Neurological Sciences. Elsevier Inc., p. 402-408 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model

Leong, D. J., Choudhury, M., Hanstein, R., Hirsh, D. M., Kim, J. J., Majeska, R. J., Schaffler, M. B., Hardin, J. A., Spray, D. C., Goldring, M. B., Cobelli, N. J. & Sun, H. B., Dec 17 2014, In : Arthritis Research and Therapy. 16, 1, 508.

Research output: Contribution to journalArticle

42 Scopus citations

Human liver cell trafficking mutants: Characterization and whole exome sequencing

Yuan, F., Snapp, E. L., Novikoff, P. M., Suadicani, S. O., Spray, D. C., Potvin, B., Wolkoff, A. W. & Stanley, P., Jan 23 2014, In : PloS one. 9, 1, e87043.

Research output: Contribution to journalArticle

Inhibitors of the 5-lipoxygenase pathway activate pannexin1 channels in macrophages via the thromboxane receptor

da Silva-Souza, H. A., de Lira, M. N., Patel, N. K., Spray, D. C., Persechini, P. M. & Scemes, E., Sep 15 2014, In : American Journal of Physiology - Cell Physiology. 307, 6, p. C571-C579

Research output: Contribution to journalArticle

6 Scopus citations

Molecular imaging, biodistribution and efficacy of mesenchymal bone marrow cell therapy in a mouse model of Chagas disease

Jasmin, Jelicks, L. A., Tanowitz, H. B., Peters, V. M., Mendez-Otero, R., Campos de Carvalho, A. C. & Spray, D. C., Nov 1 2014, In : Microbes and Infection. 16, 11, p. 923-935 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pannexin 1 channels play essential roles in urothelial mechanotransduction and intercellular signaling

Negoro, H., Urban-Maldonado, M., Liou, L. S., Spray, D. C., Thi, M. M. & Suadicani, S. O., Aug 29 2014, In : PloS one. 9, 8, e106269.

Research output: Contribution to journalArticle

25 Scopus citations

Satellite glial cells as a target for chronic pain therapy

Hanani, M. & Spray, D. C., Mar 1 2014, Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention. Springer New York, p. 473-492 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1

Ebong, E. E., Lopez-Quintero, S. V., Rizzo, V., Spray, D. C. & Tarbell, J. M., Mar 2014, In : Integrative Biology (United Kingdom). 6, 3, p. 338-347 10 p.

Research output: Contribution to journalArticle

65 Scopus citations

Structural order in Pannexin 1 cytoplasmic domains

Spagnol, G., Sorgen, P. L. & Spray, D. C., Jan 1 2014, In : Channels. 8, 2, p. 157-166 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2013

Disruption of Calcium Homeostasis in Cardiomyocytes Underlies Cardiac Structural and Functional Changes in Severe Sepsis

Celes, M. R. N., Malvestio, L. M., Suadicani, S. O., Prado, C. M., Figueiredo, M. J., Campos, E. C., Freitas, A. C. S., Spray, D. C., Tanowitz, H. B., da Silva, J. S. & Rossi, M. A., Jul 23 2013, In : PloS one. 8, 7, e68809.

Research output: Contribution to journalArticle

22 Scopus citations

Gap junctions, electric synapses

Dermietzel, R. & Spray, D. C., Nov 1 2013, Neuroscience in the 21st Century: From Basic to Clinical. Springer New York, p. 439-473 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gap junctions and Bystander effects: Good Samaritans and executioners

Spray, D. C., Hanstein, R., Lopez-Quintero, S. V., Stout, R. F., Suadicani, S. O. & Thi, M. M., Jan 1 2013, In : Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 2, 1, p. 1-15 15 p.

Research output: Contribution to journalReview article

29 Scopus citations

High glucose attenuates shear-induced changes in endothelial hydraulic conductivity by degrading the glycocalyx

Lopez-Quintero, S. V., Cancel, L. M., Pierides, A., Antonetti, D., Spray, D. C. & Tarbell, J. M., Nov 18 2013, In : PloS one. 8, 11, e78954.

Research output: Contribution to journalArticle

24 Scopus citations

Identification of a functional prostanoid-like receptor in the protozoan parasite, Trypanosoma cruzi

Mukherjee, S., Sadekar, N., Ashton, A. W., Huang, H., Spray, D. C., Lisanti, M. P., MacHado, F. S., Weiss, L. M. & Tanowitz, H. B., Apr 1 2013, In : Parasitology Research. 112, 4, p. 1417-1425 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interaction of the glycocalyx with the actin cytoskeleton

Thi, M. M., Ebong, E. E., Spray, D. C. & Suadicani, S. O., Apr 2 2013, The Cytoskeleton: Imaging, Isolation, and Interaction. p. 43-62 20 p. (Neuromethods; vol. 79).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations