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1972 …2023
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Publications 1972 2019

2019

Correction: Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model (Arthritis Research and Therapy (2014) 16 (508) DOI: 10.1186/s13075-014-0508-y)

Leong, D. J., Choudhury, M., Hanstein, R., Hirsh, D. M., Kim, S. J., Majeska, R. J., Schaffler, M. B., Hardin, J. A., Spray, D. C., Goldring, M. B., Cobelli, N. J. & Sun, H. H., Jan 3 2019, In : Arthritis Research and Therapy. 21, 1, 1791.

Research output: Contribution to journalComment/debate

Ficus
Polyphenols
Tea
Osteoarthritis
Arthritis
1 Citation (Scopus)

Gap junction mediated signaling between satellite glia and neurons in trigeminal ganglia

Spray, D. C., Iglesias, R., Shraer, N., Suadicani, S. O., Belzer, V., Hanstein, R. & Hanani, M., Jan 1 2019, In : GLIA.

Research output: Contribution to journalArticle

Trigeminal Ganglion
Gap Junctions
Neuroglia
Neurons
Sensory Ganglia
Connexins
Nervous System Diseases
2018
Proton-Coupled Folate Transporter
Folic Acid Antagonists
Buffers
HEPES
Tumor Microenvironment
2017
2 Citations (Scopus)

Adrenergic Receptors on Astrocytes Modulate Gap Junctions

Scmes, E., Stout, R. F. & Spray, D. C., Jan 1 2017, Noradrenergic Signaling and Astroglia. Elsevier Inc., p. 127-144 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Connexins
Gap Junctions
Second Messenger Systems
Astrocytes
Adrenergic Receptors

Cysteine residues in the cytoplasmic carboxy terminus of connexins dictate gap junction plaque stability

Stout, R. F. & Spray, D. C., Oct 15 2017, In : Molecular Biology of the Cell. 28, 21, p. 2757-2764 8 p.

Research output: Contribution to journalArticle

Connexins
Gap Junctions
Cysteine
Reducing Agents
Confocal Microscopy
5 Citations (Scopus)

Functional genomic fabrics are remodeled in a mouse model of Chagasic cardiomyopathy and restored following cell therapy

Iacobas, D. A., Iacobas, S., Tanowitz, H. B., Campos de Carvalho, A. & Spray, D. C., Jan 1 2017, (Accepted/In press) In : Microbes and Infection.

Research output: Contribution to journalArticle

Cell- and Tissue-Based Therapy
Cardiomyopathies
Muscle Contraction
Myocardium
Trypanosoma cruzi
12 Citations (Scopus)

Gap junctions, pannexins and pain

Spray, D. C. & Hanani, M., 2017, (Accepted/In press) In : Neuroscience Letters.

Research output: Contribution to journalArticle

Gap Junctions
Pain
Neuroglia
Sensory Ganglia
Migraine with Aura
17 Citations (Scopus)

Osteocyte calcium signals encode strain magnitude and loading frequency in vivo

Lewis, K. J., Frikha-Benayed, D., Louie, J., Stephen, S., Spray, D. C., Thi, M. M., Seref-Ferlengez, Z., Majeska, R. J., Weinbaum, S. & Schaffler, M. B., Oct 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 44, p. 11775-11780 6 p.

Research output: Contribution to journalArticle

Osteocytes
Calcium
Bone and Bones
Multiphoton Fluorescence Microscopy
Metatarsal Bones
8 Citations (Scopus)

Potential role for a specialized β3 integrin-based structure on osteocyte processes in bone mechanosensation

Cabahug-Zuckerman, P., Stout, R. F., Majeska, R. J., Thi, M. M., Spray, D. C., Weinbaum, S. & Schaffler, M. B., Jan 1 2017, (Accepted/In press) In : Journal of Orthopaedic Research.

Research output: Contribution to journalArticle

Osteocytes
Integrins
Bone and Bones
Microscopy
Adenosine Triphosphate
2016
28 Citations (Scopus)

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals

Zhu, Y., Gao, Y., Tao, C., Shao, M., Zhao, S., Huang, W., Yao, T., Johnson, J. A., Liu, T., Cypess, A. M., Gupta, O., Holland, W. L., Gupta, R. K., Spray, D. C., Tanowitz, H. B., Cao, L., Lynes, M. D., Tseng, Y. H., Elmquist, J. K., Williams, K. W. & 2 others, Lin, H. V. & Scherer, P. E., Sep 13 2016, In : Cell Metabolism. 24, 3, p. 420-433 14 p.

Research output: Contribution to journalArticle

White Adipose Tissue
Connexin 43
Adipose Tissue
Pro-Opiomelanocortin
Glycyrrhetinic Acid
63 Citations (Scopus)

Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain

Kim, Y. S., Anderson, M., Park, K., Zheng, Q., Agarwal, A., Gong, C., Saijilafu, Young, L. A., He, S., LaVinka, P. C., Zhou, F., Bergles, D., Hanani, M., Guan, Y., Spray, D. C. & Dong, X., Sep 7 2016, In : Neuron. 91, 5, p. 1085-1096 12 p.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Diagnosis-Related Groups
Chronic Pain
Neurons
Gap Junctions
7 Citations (Scopus)

Effect of mesenchymal stem cells and mouse embryonic fibroblasts on the development of preimplantation mouse embryos

Jasmin, Peters, V. M., Spray, D. C. & Mendez-Otero, R., Jan 7 2016, (Accepted/In press) In : In Vitro Cellular and Developmental Biology - Plant. p. 1-10 10 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Embryonic Development
Fibroblasts
Coculture Techniques
Embryonic Structures
7 Citations (Scopus)

Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria

Freeman, B. D., Martins, Y. C., Akide-Ndunge, O. B., Bruno, F. P., Wang, H., Tanowitz, H. B., Spray, D. C. & Desruisseaux, M. S., Mar 1 2016, In : PLoS Pathogens. 12, 3, e1005477.

Research output: Contribution to journalArticle

Cerebral Malaria
Endothelin-1
Theoretical Models
Brain
Memory Disorders
1 Citation (Scopus)

FRAP for the study of gap junction nexus macromolecular organization

Stout, R. F. & Spray, D. C., Aug 5 2016, Gap Junction Channels and Hemichannels. CRC Press, p. 63-91 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gap Junctions
Nexus

Gap junctions and electric synapses

Dermietzel, R. & Spray, D. C., Jan 1 2016, Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, p. 511-546 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

gap junctions
Gap Junctions
synapse
Synapses
cells
12 Citations (Scopus)

Glial pannexin1 contributes to tactile hypersensitivity in a mouse model of orofacial pain

Hanstein, R., Hanani, M., Scemes, E. & Spray, D. C., Dec 2 2016, In : Scientific Reports. 6, 38266.

Research output: Contribution to journalArticle

Facial Pain
Touch
Neuroglia
Hypersensitivity
Trigeminal Ganglion
22 Citations (Scopus)

P2X7R-Panx1 complex impairs bone mechanosignaling under high glucose levels associated with type-1 diabetes

Seref-Ferlengez, Z., Maung, S., Schaffler, M. B., Spray, D. C., Suadicani, S. O. & Thi, M. M., May 1 2016, In : PLoS One. 11, 5, e0155107.

Research output: Contribution to journalArticle

insulin-dependent diabetes mellitus
Medical problems
Type 1 Diabetes Mellitus
Bone
Osteocytes
17 Citations (Scopus)

Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes

Cheung, W. Y., Fritton, J. C., Morgan, S. A., Seref-Ferlengez, Z., Basta-Pljakic, J., Thi, M. M., Suadicani, S. O., Spray, D. C., Majeska, R. J. & Schaffler, M. B., 2016, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Purinergic P2X7 Receptors
Osteocytes
Bone and Bones
Apoptosis
Adenosine Triphosphate
5 Citations (Scopus)

Structural and functional consequences of connexin 36 (Cx36) interaction with calmodulin

Siu, R. C. F., Smirnova, E., Brown, C. A., Zoidl, C., Spray, D. C., Donaldson, L. W. & Zoidl, G., Nov 18 2016, In : Frontiers in Molecular Neuroscience. 9, NOV2016, 120.

Research output: Contribution to journalArticle

Calmodulin
Calcium-Calmodulin-Dependent Protein Kinases
Electrical Synapses
Calcium
connexin 36
41 Citations (Scopus)

The speed of swelling kinetics modulates cell volume regulation and calcium signaling in astrocytes: A different point of view on the role of aquaporins

Mola, M. G., Sparaneo, A., Gargano, C. D., Spray, D. C., Svelto, M., Frigeri, A., Scemes, E. & Nicchia, G. P., Jan 1 2016, In : GLIA. 64, 1, p. 139-154 16 p.

Research output: Contribution to journalArticle

Aquaporins
Calcium Signaling
Cell Size
Astrocytes
TRPV Cation Channels
2015
12 Citations (Scopus)

Connexin type and fluorescent protein fusion tag determine structural stability of gap junction plaques

Stout, R. F., Snapp, E. L. & Spray, D. C., Sep 25 2015, In : Journal of Biological Chemistry. 290, 39, p. 23497-23514 18 p.

Research output: Contribution to journalArticle

Connexins
Gap Junctions
Fusion reactions
Connexin 43
Proteins
27 Citations (Scopus)

Developments in the management of Chagas cardiomyopathy

Tanowitz, H. B., Machado, F. S., Spray, D. C., Friedman, J. M., Weiss, O. S., Lora, J. N., Nagajyothi, J., Moraes, D. N., Garg, N. J., Nunes, M. C. P. & Ribeiro, A. L. P., Dec 2 2015, In : Expert Review of Cardiovascular Therapy. 13, 12, p. 1393-1409 17 p.

Research output: Contribution to journalArticle

Chagas Cardiomyopathy
Cardiac Arrhythmias
Nifurtimox
Vaccines
Heart Failure
18 Citations (Scopus)
Matrix Metalloproteinase 13
Matrix Metalloproteinase 1
Trans-Activators
Calcium Signaling
Cilia
1 Citation (Scopus)

The Einstein-Brazil fogarty: A decade of synergy

Nosanchuk, J. D., Nosanchuk, M. D., Rodrigues, M. L., Nimrichter, L., Campos de Carvalho, A. C., Weiss, L. M., Spray, D. C. & Tanowitz, H. B., Oct 1 2015, In : Brazilian Journal of Microbiology. 46, 4, p. 945-955 11 p.

Research output: Contribution to journalArticle

Brazil
Students
Communicable Diseases
Medicine
Education
2014
9 Citations (Scopus)

Adipocytes in both brown and white adipose tissue of adult mice are functionally connected via gap junctions: Implications for Chagas disease

Burke, S., Nagajyothi, F., Thi, M. M., Hanani, M., Scherer, P. E., Tanowitz, H. B. & Spray, D. C., Nov 1 2014, In : Microbes and Infection. 16, 11, p. 893-901 9 p.

Research output: Contribution to journalArticle

White Adipose Tissue
White Adipocytes
Brown Adipose Tissue
Chagas Disease
Gap Junctions
62 Citations (Scopus)

Connexins modulate autophagosome biogenesis

Bejarano, E., Yuste, A., Patel, B., Randy, R. F., Spray, D. C. & Cuervo, A. M., 2014, In : Nature Cell Biology. 16, 5, p. 401-414 14 p.

Research output: Contribution to journalArticle

Connexins
Autophagy
Cell Membrane
Starvation
Gap Junctions
1 Citation (Scopus)

Gap junctional communication in health and disease

Zoidl, G. & Spray, D. C., 2014, In : Frontiers in Physiology. 5, Nov, 442.

Research output: Contribution to journalArticle

Health Communication
Connexins
Cytoskeleton
Regeneration
Epilepsy

Gap Junctions in the Nervous System

Spray, D. C., Scemes, E. & Dermietzel, R., Jan 1 2014, Encyclopedia of the Neurological Sciences. Elsevier Inc., p. 402-408 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Connexins
Gap Junctions
Nervous System
Electrical Synapses
Charcot-Marie-Tooth Disease
35 Citations (Scopus)

Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumatic osteoarthritis model

Leong, D. J., Choudhury, M., Hanstein, R., Hirsh, D. M., Kim, S. J., Majeska, R. J., Schaffler, M. B., Hardin, J. A., Spray, D. C., Goldring, M. B., Cobelli, N. J. & Sun, H. H., 2014, In : Arthritis Research and Therapy. 16, 6, p. 508 1 p.

Research output: Contribution to journalArticle

Polyphenols
Tea
Osteoarthritis
Anti-Inflammatory Agents
Articular Cartilage

Human liver cell trafficking mutants: Characterization and whole exome sequencing

Yuan, F., Snapp, E. L., Novikoff, P. M., Suadicani, S. O., Spray, D. C., Potvin, B., Wolkoff, A. W. & Stanley, P., Jan 23 2014, In : PLoS One. 9, 1, e87043.

Research output: Contribution to journalArticle

Exome
Transferrin
Liver
hepatocytes
mutants
6 Citations (Scopus)

Inhibitors of the 5-lipoxygenase pathway activate pannexin1 channels in macrophages via the thromboxane receptor

da Silva-Souza, H. A., de Lira, M. N., Patel, N. K., Spray, D. C., Persechini, P. M. & Scemes, E., Sep 15 2014, In : American Journal of Physiology - Cell Physiology. 307, 6, p. C571-C579

Research output: Contribution to journalArticle

Thromboxane Receptors
Lipoxygenase Inhibitors
Macrophages
Adenosine Triphosphate
Coloring Agents
17 Citations (Scopus)

Molecular imaging, biodistribution and efficacy of mesenchymal bone marrow cell therapy in a mouse model of Chagas disease

Jasmin, Jelicks, L. A., Tanowitz, H. B., Peters, V. M., Mendez-Otero, R., Campos de Carvalho, A. C. & Spray, D. C., Nov 1 2014, In : Microbes and Infection. 16, 11, p. 923-935 13 p.

Research output: Contribution to journalArticle

Molecular Imaging
Chagas Disease
Cell- and Tissue-Based Therapy
Mesenchymal Stromal Cells
Bone Marrow Cells
23 Citations (Scopus)

Pannexin 1 channels play essential roles in urothelial mechanotransduction and intercellular signaling

Negoro, H., Urban-Maldonado, M., Liou, L. S., Spray, D. C., Thi, M. M. & Suadicani, S. O., Aug 29 2014, In : PLoS One. 9, 8, e106269.

Research output: Contribution to journalArticle

bladder
Adenosine Triphosphate
Mefloquine
Urinary Bladder
cells

Satellite glial cells as a target for chronic pain therapy

Hanani, M. & Spray, D. C., Mar 1 2014, Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention. Springer New York, p. 473-492 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Neuroglia
Chronic Pain
Gap Junctions
Sensory Receptor Cells
Ganglia
59 Citations (Scopus)

Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1

Ebong, E. E., Lopez-Quintero, S. V., Rizzo, V., Spray, D. C. & Tarbell, J. M., Mar 2014, In : Integrative Biology (United Kingdom). 6, 3, p. 338-347 10 p.

Research output: Contribution to journalArticle

Glypicans
Syndecan-1
Heparitin Sulfate
Endothelial cells
Glycocalyx
6 Citations (Scopus)

Structural order in Pannexin 1 cytoplasmic domains

Spagnol, G., Sorgen, P. L. & Spray, D. C., 2014, In : Channels. 8, 2, p. 157-166 10 p.

Research output: Contribution to journalArticle

Connexins
Caspases
Membranes
Oligomerization
Neurology
2013
20 Citations (Scopus)

Disruption of Calcium Homeostasis in Cardiomyocytes Underlies Cardiac Structural and Functional Changes in Severe Sepsis

Celes, M. R. N., Malvestio, L. M., Suadicani, S. O., Prado, C. M., Figueiredo, M. J., Campos, E. C., Freitas, A. C. S., Spray, D. C., Tanowitz, H. B., da Silva, J. S. & Rossi, M. A., Jul 23 2013, In : PLoS One. 8, 7, e68809.

Research output: Contribution to journalArticle

calpain
Calpain
Cardiac Myocytes
Dystrophin
Actins

Gap junctions, electric synapses

Dermietzel, R. & Spray, D. C., Nov 1 2013, Neuroscience in the 21st Century: From Basic to Clinical. Springer New York, p. 439-473 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gap Junctions
Synapses
Neurons
Neurotransmitter Agents
Brain
23 Citations (Scopus)

Gap junctions and Bystander effects: Good Samaritans and executioners

Spray, D. C., Hanstein, R., Lopez-Quintero, S. V., Stout, R. F., Suadicani, S. O. & Thi, M. M., Jan 2013, In : Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 2, 1, p. 1-15 15 p.

Research output: Contribution to journalArticle

Bystander Effect
Gap Junctions
Radiation Injuries
Poisons
Cell- and Tissue-Based Therapy
20 Citations (Scopus)

High glucose attenuates shear-induced changes in endothelial hydraulic conductivity by degrading the glycocalyx

Lopez-Quintero, S. V., Cancel, L. M., Pierides, A., Antonetti, D., Spray, D. C. & Tarbell, J. M., Nov 18 2013, In : PLoS One. 8, 11, e78954.

Research output: Contribution to journalArticle

Glycocalyx
Hydraulic conductivity
Medical problems
hydraulic conductivity
shear stress
6 Citations (Scopus)

Identification of a functional prostanoid-like receptor in the protozoan parasite, Trypanosoma cruzi

Mukherjee, S., Sadekar, N., Ashton, A. W., Huang, H., Spray, D. C., Lisanti, M. P., MacHado, F. S., Weiss, L. M. & Tanowitz, H. B., Apr 2013, In : Parasitology Research. 112, 4, p. 1417-1425 9 p.

Research output: Contribution to journalArticle

thromboxanes
Trypanosoma cruzi
prostaglandins
Prostaglandins
Protozoa
1 Citation (Scopus)

Interaction of the glycocalyx with the actin cytoskeleton

Thi, M. M., Ebong, E. E., Spray, D. C. & Suadicani, S. O., 2013, Neuromethods. Vol. 79. p. 43-62 20 p. (Neuromethods; vol. 79).

Research output: Chapter in Book/Report/Conference proceedingChapter

Glycocalyx
Actin Cytoskeleton
Actins
Confocal microscopy
Nerve Tissue
17 Citations (Scopus)

Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process

Wu, D., Schaffler, M. B., Weinbaum, S. & Spray, D. C., Jul 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 29, p. 12096-12101 6 p.

Research output: Contribution to journalArticle

Osteocytes
Bone and Bones
Apyrase
Purinergic P2 Receptors
Gap Junctions
51 Citations (Scopus)
Osteocytes
Integrins
Adenosine Triphosphate
Autocrine Communication
Cell Body
37 Citations (Scopus)

Promises and pitfalls of a Pannexin1 transgenic mouse line

Hanstein, R., Negoro, H., Patel, N. K., Charollais, A., Meda, P., Spray, D. C., Suadicani, S. O. & Scemes, E., 2013, In : Frontiers in Pharmacology. 4 MAY, Article 61.

Research output: Contribution to journalArticle

Knockout Mice
Transgenic Mice
Messenger RNA
Alleles
RNA
15 Citations (Scopus)

Transcriptome profiling of hippocampal CA1 after early-life seizure-induced preconditioning may elucidate new genetic therapies for epilepsy

Friedman, L. K., Mancuso, J., Patel, A., Kudur, V., Leheste, J. R., Iacobas, S., Botta, J., Iacobas, D. A. & Spray, D. C., Jul 2013, In : European Journal of Neuroscience. 38, 1, p. 2139-2152 14 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Genetic Therapy
Epilepsy
Seizures
Genes
2012
17 Citations (Scopus)

Altered Regulation of Akt Signaling with Murine Cerebral Malaria, Effects on Long-Term Neuro-Cognitive Function, Restoration with Lithium Treatment

Dai, M., Freeman, B., Shikani, H. J., Bruno, F. P., Collado, J. E., Macias, R., Reznik, S. E., Davies, P., Spray, D. C., Tanowitz, H. B., Weiss, L. M. & Desruisseaux, M. S., Oct 17 2012, In : PLoS One. 7, 10, e44117.

Research output: Contribution to journalArticle

Cerebral Malaria
lithium
Lithium
cognition
Cognition
95 Citations (Scopus)

ATP signaling is deficient in cultured pannexin1-null mouse astrocytes

Suadicani, S. O., Iglesias, R., Wang, J., Dahl, G., Spray, D. C. & Scemes, E., Jul 2012, In : GLIA. 60, 7, p. 1106-1116 11 p.

Research output: Contribution to journalArticle

Astrocytes
Connexins
Adenosine Triphosphate
Vertebrates
Paracrine Communication
81 Citations (Scopus)

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

Bejarano, E., Girao, H., Yuste, A., Patel, B., Marques, C., Spray, D. C., Pereira, P. & Cuervo, A. M., Jun 1 2012, In : Molecular Biology of the Cell. 23, 11, p. 2156-2169 14 p.

Research output: Contribution to journalArticle

Connexins
Autophagy
Ubiquitin
Gap Junctions
Cell Membrane