David C. Spray, Ph.D.

Grants

Projects per year 1984 1984 1985 1989 1990 1991 1995 2001 2002 2006 2010 2015 2018 2020 2023

• 1 Active
• 42 Finished

Projects per year

Search results

• Active

  Structural, Molecular and Functional Specialization in Osteocyte Mechanosensing

  Schaffler, M. M. B., Spray, D. D. C., Schaffler, M. B. & Spray, D. C.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  7/11/18 → 4/30/23

  Project: Research project

  • Osteocytes 100%
  • Integrins 15%
  • T-Type Calcium Channels 12%
  • Purinergic P2X7 Receptors 11%
  • Surface Plasmon Resonance 9%
• Finished

  AQP4 isoforms and brain edema

  Spray, D. C.

  5/1/20 → 10/31/21

  Project: Research project

  • brain 100%
  • homeostasis 52%
  • water 39%
  • blood 35%
  • distribution 23%

• AQP4 isoforms and brain edema

  Spray, D. C., Frigeri, A., Nicchia, G. & Scemes, E.

  National Institute of Neurological Disorders and Stroke

  5/1/20 → 10/31/21

  Project: Research project

  • brain 100%
  • homeostasis 48%
  • water 36%
  • blood 31%
  • distribution 21%

• Structural, Molecular and Functional Specialization in Osteocyte Mechanosensing

  Spray, D. C.

  7/11/18 → 4/30/22

  Project: Research project

  • Osteocytes 100%
  • Integrins 12%
  • T-Type Calcium Channels 10%
  • Purinergic P2X7 Receptors 9%
  • Pharmacology 8%

• The Astrocyte Nexus: Cx43 Protein Interactions

  Spray, D. C., Scemes, E. & Spray, D. C.

  National Institute of Neurological Disorders and Stroke

  8/1/15 → 7/31/21

  Project: Research project

  • Nexus 100%
  • Connexin 43 82%
  • Connexins 73%
  • Astrocytes 70%
  • Gap Junctions 28%

• The Astrocyte Nexus: Cx43 Protein Interactions

  Scemes, E., Spray, D. C. & Spray, D. C.

  8/1/15 → 7/31/21

  Project: Research project

  • Astrocytes 100%
  • Connexins 94%
  • Nexus 61%
  • Gap Junctions 37%
  • Protein Binding 21%

• Structural, Molecular, and Functional Specialization in Osteocyte Mechanosensing

  Weinbaum, S., Schaffler, M. B. & Spray, D. C.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  9/6/10 → 8/31/16

  Project: Research project

  • Osteocytes 100%
  • Cell Body 16%
  • Bone and Bones 16%
  • Theoretical Models 9%
  • Anabolic Agents 7%

• Structural, Molecular, and Functional Specialization in Osteocyte Mechanosensing

  Weinbaum, S., Schaffler, M., Spray, D. C., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  9/6/10 → 8/31/16

  Project: Research project

  • Osteocytes 100%
  • Cell Body 15%
  • Bone and Bones 15%
  • Theoretical Models 8%
  • Anabolic Agents 7%

• Luminescence Imaging: Molecules, Cells and Tissues

  Spray, D. C., Spray, D. C. & Rose, S. A.

  5/15/06 → 12/31/09

  Project: Research project

  • luminescence 100%
  • luminescent proteins 63%
  • connexins 57%
  • image analysis 49%
  • astrocytes 48%

• Luminescence Imaging: Molecules, Cells and Tissues

  Spray, D. C. & Spray, D. C.

  National Center for Research Resources

  5/15/06 → 12/31/09

  Project: Research project

  • luminescence 100%
  • luminescent proteins 73%
  • connexins 67%
  • image analysis 57%
  • astrocytes 56%

• LUMINESCENCE IMAGING: MOLECULES, CELLS AND TISSUES

  Spray, D. C.

  National Center for Research Resources

  5/15/06 → 5/14/07

  Project: Research project

• Neuronal Gap Junctions: Cx36 Gating, Binding &Function

  Spray, D. C. & Rose, S. A.

  2/1/02 → 1/31/08

  Project: Research project

  • Connexins 100%
  • Gap Junctions 91%
  • connexin 36 67%
  • Electrical Synapses 62%
  • Nexus 56%

• Neuronal Gap Junctions: Cx36 Gating, Binding &Function

  Spray, D. C. & Spray, D. C.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  2/1/02 → 1/31/04

  Project: Research project

  • Electrical Synapses 100%
  • Connexins 87%
  • Gap Junctions 80%
  • connexin 36 58%
  • Nexus 49%

• The Astrocyte Nexus: CX43-Protein Interactions

  Spray, D. C. & Spray, D. C.

  National Institute of Neurological Disorders and Stroke

  12/15/01 → 3/31/13

  Project: Research project

  • Nexus 100%
  • Connexin 43 91%
  • Gap Junctions 79%
  • Astrocytes 68%
  • Proteins 25%

• The Astrocyte Nexus: CX 43-Protein Interactions

  Spray, D. C. & Rose, S. A.

  12/15/01 → 3/31/13

  Project: Research project

  • Connexin 43 100%
  • Gap Junctions 78%
  • Nexus 77%
  • Astrocytes 50%
  • Proteins 25%

• Optimized Microarray Analysis of Neural Differentiation

  Spray, D. C.

  National Institute of Neurological Disorders and Stroke

  9/27/01 → 7/31/03

  Project: Research project

  • microarray technology 100%
  • gene expression 73%
  • connexins 24%
  • gap junctions 22%
  • DNA microarrays 18%

• Optimized Microarray Analysis of Neural Differentiation

  Spray, D. C.

  9/27/01 → 7/31/03

  Project: Research project

  • gene expression 100%
  • microarray technology 51%
  • connexins 34%
  • gap junctions 30%
  • DNA microarrays 25%

• GAP JUNCTIONS AND SCHWANN CELLS

  Spray, D. C.

  National Institute of Neurological Disorders and Stroke

  2/1/97 → 3/31/03

  Project: Research project

  • Schwann Cells 100%
  • Gap Junctions 94%
  • Connexins 80%
  • Myelin Proteins 31%
  • Transgenic Mice 20%

• GAP JUNCTIONS AND SCHWANN CELLS

  Spray, D. C.

  2/5/96 → 3/31/03

  Project: Research project

• THE IMPACT OF HYPOXIA ON DEVELOPMENT AND REMODELING OF CARDIC INTERCALATED DISK

  Behar, K. L. & Spray, D. C.

  National Institute of Child Health and Human Development

  10/1/95 → 7/31/10

  Project: Research project

  • Gap Junctions 100%
  • Hypoxia 63%
  • Connexin 43 42%
  • Hypercapnia 30%
  • Cell Death 19%

• GAP JUNCTIONS AND SCHWANN CELLS

  Spray, D. C.

  National Institute of Neurological Disorders and Stroke

  10/1/95 → 9/30/98

  Project: Research project

  • Schwann Cells 100%
  • Gap Junctions 87%
  • Connexins 60%
  • Remyelination 25%
  • Wounds and Injuries 23%

• CORE--CONFOCAL MICROSCOPY

  Spray, D. C.

  National Institute of Neurological Disorders and Stroke

  10/1/95 → 9/30/98

  Project: Research project

  • confocal microscopy 100%
  • connexins 96%
  • microscopes 64%
  • calcium 63%
  • Schwann cells 45%

• Hypoxia in Development;Injury and Adaptation Mechanisms

  Haddad, G. G., Boron, W. F., Iacobas, D. A., Kashgarian, M., Lister, G., Siegel, N. J., Spray, D. C., Behar, K. L., Gaudio, K. M., Haddad, G. G. & Haddad, G. G.

  2/10/95 → 7/31/11

  Project: Research project

  • Hypoxia 100%
  • Cardiac Myocytes 39%
  • Neuroglia 37%
  • Epithelium 32%
  • Wounds and Injuries 30%

• LENS GAP JUNCTIONS: IDENTITY AND PROPERTIES

  Spray, D. C.

  2/1/91 → 9/29/03

  Project: Research project

  • Lenses 100%
  • Crystallins 78%
  • Gap Junctions 69%
  • Connexins 37%
  • Liposomes 29%

• LENS GAP JUNCTIONS--IDENTITY AND PROPERTIES

  Spray, D. C.

  National Eye Institute

  2/1/91 → 1/31/97

  Project: Research project

  • Gap Junctions 100%
  • gap junctions 98%
  • Crystallins 97%
  • Lens 91%
  • Lenses 82%

• Liver Cell Membrane Protein-Expression and Function

  Wolkoff, A. W., Wolkoff, A. W., Cohen, D. C., Novifoff, P., Novikoff, P., Rojkind, M., Spray, D. C. & Stockert, R. J.

  National Institute of Diabetes and Digestive and Kidney Diseases

  5/15/90 → 5/31/13

  Project: Research project

  • Membrane Proteins 100%
  • Research Personnel 85%
  • Connexins 82%
  • connexin 32 67%
  • Liver 64%

• PATTERN FORMATION, GAP JUNCTIONS, AND COUPLING

  Spray, D. C.

  1/1/90 → 1/1/90

  Project: Research project

  • Gap Junctions 100%
  • Embryonic Structures 53%
  • Membrane Potentials 42%
  • Teratogens 30%
  • Amphibians 26%

• DIGITAL FLUORESCENCE IMAGING SYSTEM

  Spray, D. C.

  1/1/90 → 6/13/90

  Project: Research project

  • Ions 100%
  • Coloring Agents 99%
  • Gap Junctions 92%
  • Membrane Potentials 78%
  • Cardiac Myocytes 74%

• CARDIAC GAP JUNCTIONS--CONTROL OF EXPRESSION &FUNCTION

  Spray, D. C. & Fishman, G.

  12/31/89 → 3/31/01

  Project: Research project

  • Gap Junctions 100%
  • Connexins 21%
  • Messenger RNA 19%
  • Allergy and Immunology 18%
  • Membrane Proteins 14%

• BIOPHYSICS OF GAP JUNCTION CHANNELS

  Spray, D. C.

  12/31/89 → 11/30/95

  Project: Research project

  • Gap Junctions 100%
  • Connexins 65%
  • Biophysics 23%
  • Organized Financing 20%
  • Electrophysiology 19%

• Expression, Processing &Function of Liver Gap Junctions

  Spray, D. C.

  National Institute of Diabetes and Digestive and Kidney Diseases

  10/1/89 → 9/30/02

  Project: Research project

  • Gap Junctions 100%
  • Connexins 59%
  • Nexus 45%
  • Liver 37%
  • Hepatocytes 26%

• DIGITAL FLUORESCENCE IMAGING SYSTEM

  Spray, D. C.

  National Center for Research Resources

  6/14/89 → 6/13/90

  Project: Research project

  • Optical Imaging 100%
  • Coloring Agents 56%
  • Gap Junctions 52%
  • Membrane Potentials 44%
  • Cardiac Myocytes 42%

• CARDIAC GAP JUNCTIONS--CONTROL OF EXPRESSION AND FUNCTIO

  Fishman, G. I., Fishman, G. I. & Spray, D. C.

  National Heart, Lung, and Blood Institute

  7/1/88 → 3/31/01

  Project: Research project

  • Gap Junctions 100%
  • Connexins 38%
  • Phosphorylation 19%
  • Connexin 43 19%
  • Messenger RNA 14%

• HEPATITIS CIRRHOSIS CENTER

  Shafritz, D. A., Aisen, P., Arias, I. M., Bhargava, M. M., Burk, R. D., Chowdhury, J. R., Collins, J. C., Condeelis, J. S., Czaja, M. J., Das, K. M., Eder, H. A., Fajan, N. T. V., Gatmaitan, Z., Glaser, J. H., Goldfischer, S., Gupta, R. K., Levine, W. G., Lieberman, H. M., Listowsky, I., Mitchel, Y. B., Novikoff, P. M., Peisach, J., Rauch, H., Reid, L. M., Rifici, V. A., Rogler, C. E., Rosenstreich, D. L., Seifter, S., Sninsky, J. J., Spray, D. C., Stanley, R. E., Sternlieb, I., Stockert, R. J., Wolkoff, A. W. & Zern, M. A.

  6/1/86 → 5/31/89

  Project: Research project

  • Liver 100%
  • Cell Culture Techniques 29%
  • Collagen 29%
  • Medicine 28%
  • Biliary Atresia 25%

• REGULATION OF GAP JUNCTIONS IN HEPATOCYTES

  Spray, D. C.

  National Institute of Diabetes and Digestive and Kidney Diseases

  10/1/85 → 9/30/87

  Project: Research project

• PATTERN FORMATION, GAP JUNCTIONS, AND COUPLING

  Spray, D. C.

  National Institute of Neurological Disorders and Stroke

  8/1/85 → 7/31/87

  Project: Research project

  • Gap Junctions 100%
  • Embryonic Structures 53%
  • Membrane Potentials 42%
  • Teratogens 30%
  • Blastomeres 29%

• NEURONAL DEVELOPMENT INTERACTION AND ORGANIZATION

  Bennett, M. V. L., Bargiello, T. A., Ginzberg, R., Hall, D. H., Hall, L. M., Hertzberg, E. L., Kessler, J. A., Saez, J., Spray, D. C., Verselis, V., White, R. & Bennett, M. V. L.

  National Institute of Neurological Disorders and Stroke

  4/1/85 → 6/30/97

  Project: Research project

  • Gap Junctions 100%
  • Connexins 66%
  • Organizations 36%
  • Gangliosidoses 22%
  • Myeloma Proteins 18%

• BIOPHYSICS OF GAP JUNCTION CHANNELS

  Spray, D. C.

  National Institute of Neurological Disorders and Stroke

  12/1/84 → 11/30/95

  Project: Research project

  • Biophysics 100%
  • Gap Junctions 90%
  • Connexins 78%
  • Organized Financing 16%
  • Cell Line 12%

• PROPERTIES OF GAP JUNCTIONS IN VARIOUS TISSUES

  Spray, D. C.

  National Institute of Neurological Disorders and Stroke

  10/1/84 → 9/30/93

  Project: Research project

  • Gap Junctions 100%
  • Connexins 60%
  • Immunologic Techniques 17%
  • Myometrium 14%
  • Retinal Pigment Epithelium 13%

• NA+ CHANNELS AND EXCITABILITY IN HYPOXIA

  Spray, D. C., Iacobas, D. A., Siegel, N., Boron, W. F., Siegel, N., Lister, G., Gaudio, K., Behar, K., Boron, W. F., Kashgarian, M., Haddad, G., Boron, W. F., Gaudio, K., Behar, K., Boron, W. F., Kashgarian, M. & Haddad, G.

  1/1/01 → 7/31/11

  Project: Research project

  • Neurons 100%
  • Hypoxia 56%
  • ONC-107 46%
  • indium arsenide 29%
  • Microelectrodes 20%

• PROPERTIES OF GAP JUNCTIONS IN VARIOUS TISSUES

  Spray, D. C., White, R. O. Y., Saez, J., Hall, L., Ginzberg, R., Kessler, J., Bargiello, T., Bennett, M. V. L., Hertzberg, E., Verselis, V., White, R. O. Y., Hertzberg, E., Verselis, V., Bargiello, T. A., Spray, D. C., Bargiello, T. A., Spray, D. C., Bennett, M. V. L. & Hall, D. H.

  1/1/01 → 6/30/02

  Project: Research project

  • Gap Junctions 100%
  • Connexins 72%
  • Retinal Pigment Epithelium 16%
  • Melanocytes 16%
  • Proteins 16%

• CONTROL OF VESICULAR TRAFFICKING IN THE HEPATOCYTE

  Wolkoff, A. W., Novikoff, P., Rojkind, M., Cohen, D., Stockert, R., Novifoff, P., Spray, D. C. & Wolkoff, A. W.

  1/1/01 → 5/31/13

  Project: Research project

• STRUCTURAL STUDIES OF LIGANDIN AND GSH TRANSFERASES

  Burk, R. D., Sninsky, J., Listowsky, I., Novikoff, P., Bhargava, M., Glaser, J., Reid, L., Sternlieb, I., Levine, W., Eder, H., Peisach, J., Lieberman, H., Rifici, V., Mitchel, Y., Zern, M., Arias, I., Stockert, R., Aisen, P., Goldfischer, S., Collins, J., Rogler, C., Shafritz, D., Wolkoff, A. W., Spray, D. C., Stanley, E. R., Gatmaitan, Z., Fajan, T., Condeelis, J., Rauch, H., Seifter, S. A. M., Gupta, R., Das, K., Roy-Chowdhury, J., Rosenstreich, D. L., Czaja, M. J., Stanley, E. R., Fajan, T., Seifter, S. A. M., Stanley, E. R. & Condeelis, J. S.

  1/1/01 → 12/31/89

  Project: Research project

  • liver 100%
  • hepatocytes 43%
  • collagen 42%
  • shea 40%
  • research support 32%