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1972 …2020

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2020

Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels

McCutcheon, S., Majeska, R. J., Spray, D. C., Schaffler, M. B. & Vazquez, M., May 1 2020, In : Journal of Bone and Mineral Research. 35, 5, p. 966-977 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cellular environment remodels the genomic fabrics of functional pathways in astrocytes

Iacobas, D. A., Iacobas, S., Stout, R. F. & Spray, D. C., May 2020, In : Genes. 11, 5, 520.

Research output: Contribution to journalArticle

Open Access

Stress gates an astrocytic energy reservoir to impair synaptic plasticity

Murphy-Royal, C., Johnston, A. D., Boyce, A. K. J., Diaz-Castro, B., Institoris, A., Peringod, G., Zhang, O., Stout, R. F., Spray, D. C., Thompson, R. J., Khakh, B. S., Bains, J. S. & Gordon, G. R., Dec 1 2020, In : Nature communications. 11, 1, 2014.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Trypanosoma cruzi Promotes Transcriptomic Remodeling of the JAK/STAT Signaling and Cell Cycle Pathways in Myoblasts

Nisimura, L. M., Coelho, L. L., de Melo, T. G., Vieira, P. D. C., Victorino, P. H., Garzoni, L. R., Spray, D. C., Iacobas, D. A., Iacobas, S., Tanowitz, H. B. & Adesse, D., Jun 17 2020, In : Frontiers in Cellular and Infection Microbiology. 10, 255.

Research output: Contribution to journalArticle

Open Access
2019

Gap junction mediated signaling between satellite glia and neurons in trigeminal ganglia

Spray, D. C., Iglesias, R., Shraer, N., Suadicani, S. O., Belzer, V., Hanstein, R. & Hanani, M., May 2019, In : Glia. 67, 5, p. 791-801 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Tubulin-Dependent Transport of Connexin-36 Potentiates the Size and Strength of Electrical Synapses

Brown, C. A., Del Corsso, C., Zoidl, C., Donaldson, L. W., Spray, D. C. & Zoidl, G., Sep 25 2019, In : Cells. 8, 10

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018
1 Scopus citations

Functional genomic fabrics are remodeled in a mouse model of Chagasic cardiomyopathy and restored following cell therapy

Iacobas, D. A., Iacobas, S., Tanowitz, H. B., Campos de Carvalho, A. & Spray, D. C., Mar 2018, In : Microbes and Infection. 20, 3, p. 185-195 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2017

Cysteine residues in the cytoplasmic carboxy terminus of connexins dictate gap junction plaque stability

Stout, R. F. & Spray, D. C., Oct 15 2017, In : Molecular biology of the cell. 28, 21, p. 2757-2764 8 p.

Research output: Contribution to journalArticle

Osteocyte calcium signals encode strain magnitude and loading frequency in vivo

Lewis, K. J., Frikha-Benayed, D., Louie, J., Stephen, S., Spray, D. C., Thi, M. M., Seref-Ferlengez, Z., Majeska, R. J., Weinbaum, S. & Schaffler, M. B., Oct 31 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 44, p. 11775-11780 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Potential role for a specialized β3 integrin-based structure on osteocyte processes in bone mechanosensation

Cabahug-Zuckerman, P., Stout, R. F., Majeska, R. J., Thi, M. M., Spray, D. C., Weinbaum, S. & Schaffler, M. B., Jan 1 2017, (Accepted/In press) In : Journal of Orthopaedic Research.

Research output: Contribution to journalArticle

13 Scopus citations
2016

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals

Zhu, Y., Gao, Y., Tao, C., Shao, M., Zhao, S., Huang, W., Yao, T., Johnson, J. A., Liu, T., Cypess, A. M., Gupta, O., Holland, W. L., Gupta, R. K., Spray, D. C., Tanowitz, H. B., Cao, L., Lynes, M. D., Tseng, Y. H., Elmquist, J. K., Williams, K. W. & 2 others, Lin, H. V. & Scherer, P. E., Sep 13 2016, In : Cell metabolism. 24, 3, p. 420-433 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain

Kim, Y. S., Anderson, M., Park, K., Zheng, Q., Agarwal, A., Gong, C., Saijilafu, Young, L. A., He, S., LaVinka, P. C., Zhou, F., Bergles, D., Hanani, M., Guan, Y., Spray, D. C. & Dong, X., Sep 7 2016, In : Neuron. 91, 5, p. 1085-1096 12 p.

Research output: Contribution to journalArticle

75 Scopus citations

Effect of mesenchymal stem cells and mouse embryonic fibroblasts on the development of preimplantation mouse embryos

Jasmin, Peters, V. M., Spray, D. C. & Mendez-Otero, R., Apr 1 2016, In : In Vitro Cellular and Developmental Biology - Animal. 52, 4, p. 497-506 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria

Freeman, B. D., Martins, Y. C., Akide-Ndunge, O. B., Bruno, F. P., Wang, H., Tanowitz, H. B., Spray, D. C. & Desruisseaux, M. S., Mar 1 2016, In : PLoS Pathogens. 12, 3, e1005477.

Research output: Contribution to journalArticle

8 Scopus citations

Glial pannexin1 contributes to tactile hypersensitivity in a mouse model of orofacial pain

Hanstein, R., Hanani, M., Scemes, E. & Spray, D. C., Dec 2 2016, In : Scientific reports. 6, 38266.

Research output: Contribution to journalArticle

14 Scopus citations

P2X7R-Panx1 complex impairs bone mechanosignaling under high glucose levels associated with type-1 diabetes

Seref-Ferlengez, Z., Maung, S., Schaffler, M. B., Spray, D. C., Suadicani, S. O. & Thi, M. M., May 1 2016, In : PloS one. 11, 5, e0155107.

Research output: Contribution to journalArticle

28 Scopus citations

Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes

Cheung, W. Y., Fritton, J. C., Morgan, S. A., Seref-Ferlengez, Z., Basta-Pljakic, J., Thi, M. M., Suadicani, S. O., Spray, D. C., Majeska, R. J. & Schaffler, M. B., Apr 1 2016, In : Journal of Bone and Mineral Research. 31, 4, p. 890-899 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes

He, Z., Leong, D. J., Zhuo, Z., Majeska, R. J., Cardoso, L., Spray, D. C., Goldring, M. B., Cobelli, N. J. & Sun, H. B., May 1 2016, In : Osteoarthritis and Cartilage. 24, 5, p. 892-901 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Structural and functional consequences of connexin 36 (Cx36) interaction with calmodulin

Siu, R. C. F., Smirnova, E., Brown, C. A., Zoidl, C., Spray, D. C., Donaldson, L. W. & Zoidl, G., Nov 18 2016, In : Frontiers in Molecular Neuroscience. 9, NOV2016, 120.

Research output: Contribution to journalArticle

7 Scopus citations

The speed of swelling kinetics modulates cell volume regulation and calcium signaling in astrocytes: A different point of view on the role of aquaporins

Mola, M. G., Sparaneo, A., Gargano, C. D., Spray, D. C., Svelto, M., Frigeri, A., Scemes, E. & Nicchia, G. P., Jan 1 2016, In : Glia. 64, 1, p. 139-154 16 p.

Research output: Contribution to journalArticle

45 Scopus citations
2015

Connexin type and fluorescent protein fusion tag determine structural stability of gap junction plaques

Stout, R. F., Snapp, E. L. & Spray, D. C., Sep 25 2015, In : Journal of Biological Chemistry. 290, 39, p. 23497-23514 18 p.

Research output: Contribution to journalArticle

12 Scopus citations

Developments in the management of Chagas cardiomyopathy

Tanowitz, H. B., Machado, F. S., Spray, D. C., Friedman, J. M., Weiss, O. S., Lora, J. N., Nagajyothi, J., Moraes, D. N., Garg, N. J., Nunes, M. C. P. & Ribeiro, A. L. P., Dec 2 2015, In : Expert Review of Cardiovascular Therapy. 13, 12, p. 1393-1409 17 p.

Research output: Contribution to journalArticle

30 Scopus citations

The Einstein-Brazil fogarty: A decade of synergy

Nosanchuk, J. D., Nosanchuk, M. D., Rodrigues, M. L., Nimrichter, L., Campos de Carvalho, A. C., Weiss, L. M., Spray, D. C. & Tanowitz, H. B., Oct 1 2015, In : Brazilian Journal of Microbiology. 46, 4, p. 945-955 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2014

Adipocytes in both brown and white adipose tissue of adult mice are functionally connected via gap junctions: Implications for Chagas disease

Burke, S., Nagajyothi, F., Thi, M. M., Hanani, M., Scherer, P. E., Tanowitz, H. B. & Spray, D. C., Nov 1 2014, In : Microbes and Infection. 16, 11, p. 893-901 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Connexins modulate autophagosome biogenesis

Bejarano, E., Yuste, A., Patel, B., Randy, R. F., Spray, D. C. & Cuervo, A. M., Jan 1 2014, In : Nature Cell Biology. 16, 5, p. 401-414 14 p.

Research output: Contribution to journalArticle

68 Scopus citations

Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse posttraumatic osteoarthritis model

Leong, D. J., Choudhury, M., Hanstein, R., Hirsh, D. M., Kim, J. J., Majeska, R. J., Schaffler, M. B., Hardin, J. A., Spray, D. C., Goldring, M. B., Cobelli, N. J. & Sun, H. B., Dec 17 2014, In : Arthritis Research and Therapy. 16, 1, 508.

Research output: Contribution to journalArticle

42 Scopus citations

Human liver cell trafficking mutants: Characterization and whole exome sequencing

Yuan, F., Snapp, E. L., Novikoff, P. M., Suadicani, S. O., Spray, D. C., Potvin, B., Wolkoff, A. W. & Stanley, P., Jan 23 2014, In : PloS one. 9, 1, e87043.

Research output: Contribution to journalArticle

Inhibitors of the 5-lipoxygenase pathway activate pannexin1 channels in macrophages via the thromboxane receptor

da Silva-Souza, H. A., de Lira, M. N., Patel, N. K., Spray, D. C., Persechini, P. M. & Scemes, E., Sep 15 2014, In : American Journal of Physiology - Cell Physiology. 307, 6, p. C571-C579

Research output: Contribution to journalArticle

6 Scopus citations

Molecular imaging, biodistribution and efficacy of mesenchymal bone marrow cell therapy in a mouse model of Chagas disease

Jasmin, Jelicks, L. A., Tanowitz, H. B., Peters, V. M., Mendez-Otero, R., Campos de Carvalho, A. C. & Spray, D. C., Nov 1 2014, In : Microbes and Infection. 16, 11, p. 923-935 13 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pannexin 1 channels play essential roles in urothelial mechanotransduction and intercellular signaling

Negoro, H., Urban-Maldonado, M., Liou, L. S., Spray, D. C., Thi, M. M. & Suadicani, S. O., Aug 29 2014, In : PloS one. 9, 8, e106269.

Research output: Contribution to journalArticle

25 Scopus citations

Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1

Ebong, E. E., Lopez-Quintero, S. V., Rizzo, V., Spray, D. C. & Tarbell, J. M., Mar 2014, In : Integrative Biology (United Kingdom). 6, 3, p. 338-347 10 p.

Research output: Contribution to journalArticle

65 Scopus citations

Structural order in Pannexin 1 cytoplasmic domains

Spagnol, G., Sorgen, P. L. & Spray, D. C., Jan 1 2014, In : Channels. 8, 2, p. 157-166 10 p.

Research output: Contribution to journalArticle

6 Scopus citations
2013

Disruption of Calcium Homeostasis in Cardiomyocytes Underlies Cardiac Structural and Functional Changes in Severe Sepsis

Celes, M. R. N., Malvestio, L. M., Suadicani, S. O., Prado, C. M., Figueiredo, M. J., Campos, E. C., Freitas, A. C. S., Spray, D. C., Tanowitz, H. B., da Silva, J. S. & Rossi, M. A., Jul 23 2013, In : PloS one. 8, 7, e68809.

Research output: Contribution to journalArticle

22 Scopus citations

High glucose attenuates shear-induced changes in endothelial hydraulic conductivity by degrading the glycocalyx

Lopez-Quintero, S. V., Cancel, L. M., Pierides, A., Antonetti, D., Spray, D. C. & Tarbell, J. M., Nov 18 2013, In : PloS one. 8, 11, e78954.

Research output: Contribution to journalArticle

24 Scopus citations

Identification of a functional prostanoid-like receptor in the protozoan parasite, Trypanosoma cruzi

Mukherjee, S., Sadekar, N., Ashton, A. W., Huang, H., Spray, D. C., Lisanti, M. P., MacHado, F. S., Weiss, L. M. & Tanowitz, H. B., Apr 1 2013, In : Parasitology Research. 112, 4, p. 1417-1425 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Matrix-dependent adhesion mediates network responses to physiological stimulation of the osteocyte cell process

Wu, D., Schaffler, M. B., Weinbaum, S. & Spray, D. C., Jul 16 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 29, p. 12096-12101 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
64 Scopus citations

Promises and pitfalls of a Pannexin1 transgenic mouse line

Hanstein, R., Negoro, H., Patel, N. K., Charollais, A., Meda, P., Spray, D. C., Suadicani, S. O. & Scemes, E., Aug 20 2013, In : Frontiers in Pharmacology. 4 MAY, Article 61.

Research output: Contribution to journalArticle

39 Scopus citations

Transcriptome profiling of hippocampal CA1 after early-life seizure-induced preconditioning may elucidate new genetic therapies for epilepsy

Friedman, L. K., Mancuso, J., Patel, A., Kudur, V., Leheste, J. R., Iacobas, S., Botta, J., Iacobas, D. A. & Spray, D. C., Jul 1 2013, In : European Journal of Neuroscience. 38, 1, p. 2139-2152 14 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012

Altered Regulation of Akt Signaling with Murine Cerebral Malaria, Effects on Long-Term Neuro-Cognitive Function, Restoration with Lithium Treatment

Dai, M., Freeman, B., Shikani, H. J., Bruno, F. P., Collado, J. E., Macias, R., Reznik, S. E., Davies, P., Spray, D. C., Tanowitz, H. B., Weiss, L. M. & Desruisseaux, M. S., Oct 17 2012, In : PloS one. 7, 10, e44117.

Research output: Contribution to journalArticle

18 Scopus citations

ATP signaling is deficient in cultured pannexin1-null mouse astrocytes

Suadicani, S. O., Iglesias, R., Wang, J., Dahl, G., Spray, D. C. & Scemes, E., Jul 1 2012, In : Glia. 60, 7, p. 1106-1116 11 p.

Research output: Contribution to journalArticle

98 Scopus citations

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

Bejarano, E., Girao, H., Yuste, A., Patel, B., Marques, C., Spray, D. C., Pereira, P. & Cuervo, A. M., Jun 1 2012, In : Molecular biology of the cell. 23, 11, p. 2156-2169 14 p.

Research output: Contribution to journalArticle

85 Scopus citations

Calmodulin dependent protein kinase increases conductance at gap junctions formed by the neuronal gap junction protein connexin36

Del Corsso, C., Iglesias, R., Zoidl, G., Dermietzel, R. & Spray, D. C., Dec 3 2012, In : Brain Research. 1487, p. 69-77 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Connexin43 and Pannexin1 channels in osteoblasts: Who is the "hemichannel"?

Thi, M. M., Islam, S., Suadicani, S. O. & Spray, D. C., Jul 1 2012, In : Journal of Membrane Biology. 245, 7, p. 401-409 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Functional and Transcriptomic Recovery of Infarcted Mouse Myocardium Treated with Bone Marrow Mononuclear Cells

Lachtermacher, S., Esporcatte, B. L. B., da Silva de Azevedo Fortes, F., Rocha, N. N., Montalvão, F., Costa, P. C., Belem, L., Rabischoffisky, A., Neto, H. C. C. F., Vasconcellos, R., Iacobas, D. A., Iacobas, S., Spray, D. C., Thomas, N. M., Goldenberg, R. C. S. & de Carvalho, A. C. C., Mar 1 2012, In : Stem Cell Reviews and Reports. 8, 1, p. 251-261 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Mesenchymal Bone Marrow Cell Therapy in a Mouse Model of Chagas Disease. Where Do the Cells Go?

Jasmin, Jelicks, L. A., Koba, W., Tanowitz, H. B., Mendez-Otero, R., Campos de Carvalho, A. C. & Spray, D. C., Dec 1 2012, In : PLoS Neglected Tropical Diseases. 6, 12, e1971.

Research output: Contribution to journalArticle

33 Scopus citations

Pannexin1-mediated ATP release provides signal transmission between Neuro2A cells

Iglesias, R. M. & Spray, D. C., Jun 1 2012, In : Neurochemical Research. 37, 6, p. 1355-1363 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

The connexin43-dependent transcriptome during brain development: Importance of genetic background

Iacobas, S., Iacobas, D. A., Spray, D. C. & Scemes, E., Dec 3 2012, In : Brain Research. 1487, p. 131-139 9 p.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Imaging the endothelial glycocalyx in vitro by rapid freezing/freeze substitution transmission electron microscopy

Ebong, E. E., MacAluso, F. P., Spray, D. C. & Tarbell, J. M., Aug 1 2011, In : Arteriosclerosis, thrombosis, and vascular biology. 31, 8, p. 1908-1915 8 p.

Research output: Contribution to journalArticle

109 Scopus citations