Biochemistry

Projects

Projects per year 1979 1989 1997 2004 2008 2009 2010 2014 2016 2017 2019 2023

• 11 Active
• 242 Finished

Projects per year

Search results

• Research project

  MECHANISM OF FLAVOPROTEIN REDUCTASES

  Blanchard, J. S. & Blanchard, J. S.

  National Institute of General Medical Sciences

  4/1/85 → 1/31/04

  Project: Research project

  • flavoproteins 100%
  • principal investigators 88%
  • flavins 62%
  • disulfides 52%
  • NADH peroxidase 43%

• Metabolomic Analysis of Redox control in Mycobacterium tuberculosis persisters

  Jacobs, W. R., Kurland, I. J., Wu, P., Rose, S. A. & Rose, S. A.

  6/1/10 → 1/31/13

  Project: Research project

  • Mycobacterium tuberculosis 100%
  • Extensively Drug-Resistant Tuberculosis 25%
  • Citric Acid Cycle 21%
  • Metabolome 19%
  • Pandemics 18%

• MECHANISMS OF AMINOGLYCOSIDE RESISTANCE

  Blanchard, J. S.

  3/1/00 → 9/1/00

  Project: Research project

  • Aminoglycoside 100%
  • Resistance 47%
  • Aminoglycoside Antibiotic Agent 41%
  • Occurrence in Nature 24%
  • Semisynthetic Derivative 22%

• Structural biology of wobble-specific tRNA deaminases

  Kim, J.

  National Institutes of Health

  2/1/06 → 6/30/08

  Project: Research project

  • adenosine deaminase 100%
  • structural biology 98%
  • codons 72%
  • inosine 47%
  • infrastructure 41%

• Mechanistic and functional analysis of the proteasome activator Blm10

  Schmidt, M.

  National Institutes of Health

  5/1/09 → 2/28/14

  Project: Research project

  • Proteasome Endopeptidase Complex 100%
  • Mitochondrial Dynamics 19%
  • Proteins 6%
  • Phosphotransferases 5%
  • ATP dependent 26S protease 5%

• Protein Dynamics in Enzymatic Catalysis

  Callender, R., Dyer, R. B., Schwartz, S., Schramm, V. L. & Callender, R.

  5/1/04 → 4/30/20

  Project: Research project

  • Protein 100%
  • Catalysis 77%
  • Proton Transfer 43%
  • Chemistry 42%
  • Schwartz Hydrozirconation 39%

• Ricin-Mechanism, Transition State and Inhibitor Design

  Schramm, V. L. & Schramm, V. L.

  National Cancer Institute

  9/15/97 → 7/31/12

  Project: Research project

  • Ricin 100%
  • Transition State 59%
  • Transition State Structure 32%
  • Lethal 15%
  • Solvolysis 14%

• Novel Strategies for the Discovery of Microbial Metabolic Pathways

  Gerlt, J., Almo, S. C. & Jacobson, M.

  6/15/16 → 4/30/21

  Project: Research project

  • Solute 100%
  • Metabolic 79%
  • Ligand 74%
  • Protein 70%
  • Enzyme Activity 40%

• TRANSITION STATE ANALYSIS OF ENZYMATIC REACTIONS

  Schramm, V. L., Rose, S. A., Rose, S. A. & Schramm, V. L.

  12/31/89 → 7/31/21

  Project: Research project

  • Transition State Structure 100%
  • Purine 79%
  • Purine Nucleoside 61%
  • Inosine 59%
  • Transition State 51%

• Transition State Analysis of Enzymatic Reactions

  Schramm, V. L. & Schramm, V. L.

  National Institute of General Medical Sciences

  8/1/89 → 7/31/21

  Project: Research project

  • Enzymatic Reaction 100%
  • Transition State 85%
  • Transition State Structure 61%
  • Purine Nucleoside 47%
  • Kinetic Isotope Effect 25%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M., Bresnick, A. R. & Backer, J. M.

  National Institute of General Medical Sciences

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 55%
  • Neoplasm Metastasis 53%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• The dynamic mechanism of nuclear transport visualized at the atomic scale

  Cowburn, D., Rout, M. P. & Cowburn, D.

  National Institute of General Medical Sciences

  3/1/16 → 7/31/21

  Project: Research project

  • porosity 100%
  • macromolecules 66%
  • Cell Nucleus Active Transport 57%
  • Cell Nucleus 50%
  • Heart Diseases 39%

• Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

  Almo, S. C., Goel, S., Goldman, I. D., Chu, E., Goldman, I. D., Hogue-Angeletti, R., Scharff, M. D. & Eagle, H.

  National Cancer Institute

  6/1/85 → 6/30/22

  Project: Research project

  • neoplasms 100%
  • research programs 93%
  • biological hazards 50%
  • synthesis 37%
  • Organized Financing 33%

• Lectimers: Glycan-anchored scaffold libraries for targeting carbohydrate-binding

  Levy, M. & Levy, M.

  National Cancer Institute

  9/20/13 → 8/31/17

  Project: Research project

  • Nucleic Acid 100%
  • Carbohydrate 65%
  • Protein 65%
  • Ligand 34%
  • Peptide 22%

• GROWTH FACTORS OF THE KIDNEY

  Hatcher, V. B.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/30/87 → 8/31/91

  Project: Research project

  • Intercellular Signaling Peptides and Proteins 100%
  • Kidney 79%
  • heparin-sepharose 17%
  • Agarose Chromatography 16%
  • Ion Exchange 16%

• CENTER FOR STRUCTURAL GENOMICS

  Bonanno, J. B. & Burley, S.

  9/30/00 → 6/30/07

  Project: Research project

  • Genomics 100%
  • Proteins 59%
  • Crystallography 53%
  • Crystallization 29%
  • Internet 23%

• Time-resolved small angle X-ray scattering

  Brenowitz, M. D., Pollack, L., Steven, C., Altman, R. B., Doniach, S. & Herschlag, D.

  1/1/01 → 3/31/20

  Project: Research project

  • folding 100%
  • x ray scattering 36%
  • scattering 16%
  • probes 13%
  • characterization 12%

• Structural Genomics of Membrane Proteins

  Girvin, M. E., Gouaux, J., Szyperski, T. A., Mcdermott, A., Gerstein, M. B., Shapiro, L., Inouye, M., Gouaux, J. E., Zhou, M., MacKinnon, R., Rost, B., Hunt, J. F., Wang, D., Hendrickson, W. A., Szyperski, T. A. & Hendrickson, W. A.

  7/1/05 → 6/30/11

  Project: Research project

  • structural genomics 100%
  • membrane proteins 95%
  • protein structure 90%
  • structural biology 51%
  • crystallography 25%

• Allosteric inhibitors targeting oncogenic BRAF V600E dimers

  Gavathiotis, E.

  12/1/19 → 11/30/21

  Project: Research project

  • ponatinib 100%
  • Thyroid Neoplasms 48%
  • Melanoma 40%
  • Colorectal Neoplasms 38%
  • Dimerization 27%

• MECHANISMS OF COOPERATIVE PROTEIN-DNA INTERACTIONS

  Brenowitz, M. D.

  1/1/90 → 3/31/94

  Project: Research project

  • DNA 100%
  • Thermodynamics 48%
  • phage repressor proteins 37%
  • Cyclic AMP Receptor Protein 30%
  • Personal Autonomy 25%

• Targeting Cancer Cells with Functionalized Nanoparticle Libraries

  Levy, M.

  8/12/11 → 7/31/14

  Project: Research project

  • systematic evolution of ligands by exponential enrichment 100%
  • nanoparticles 88%
  • neoplasm cells 55%
  • neoplasms 46%
  • engineering 27%

• Fluorescent probes for quantitation of secretory protein levels in single cells

  Levy, M. & Snapp, E. L.

  National Cancer Institute

  9/24/12 → 8/31/13

  Project: Research project

  • Fluorescent Dyes 100%
  • Proteins 47%
  • Technology 35%
  • Secretory Pathway 28%
  • Bacterial Toxins 20%

• Analysis of Biomolecular Associations

  Brenowitz, M. D.

  4/1/02 → 3/31/03

  Project: Research project

  • ligands 100%
  • proteomics 97%
  • drug design 82%
  • surface plasmon resonance 78%
  • neurophysiology 68%

• Engineering Sortase Variants for Intracellular and Cell Surface Labeling

  Levy, M.

  9/30/09 → 8/31/15

  Project: Research project

  • Labeling 100%
  • Proteins 94%
  • Cells 49%

• EXPRESSION CONTROL OF YEAST GLUCOAMYLASE GENES

  Willis, I. M.

  5/1/92 → 4/30/97

  Project: Research project

  • glucan 1,4-alpha-glucosidase 100%
  • genes 76%
  • Saccharomyces cerevisiae 49%
  • gene expression 36%
  • clones 27%

• CORE RESEARCH--X-RAY OPTICS

  Bonanno, J. B.

  1/1/01 → 7/31/12

  Project: Research project

• Targeting BAX Oligomerization in Hematologic Disease

  Gavathiotis, E.

  8/9/10 → 7/31/14

  Project: Research project

  • Apoptosis 100%
  • Hematologic Diseases 84%
  • Cell Death 69%
  • Hematology 58%
  • alpha-Helical Protein Conformation 42%

• Immunotherapeutics Against Other Filovirus Threats

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  3/1/18 → 2/28/19

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 96%
  • Marburgvirus 72%
  • Monoclonal Antibodies 47%
  • Primates 30%

• CONFORMATIONS OF INSULIN &ITS RECEPTOR COMPLEXES

  Cowburn, D.

  12/31/89 → 8/31/93

  Project: Research project

  • Insulin Derivative 100%
  • Hormone 27%
  • Protein Secondary Structure 18%
  • Proton 18%
  • Solution Structure 14%

• Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

  Aman, J. M. & Lai, J. R.

  7/5/16 → 6/30/17

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 81%
  • Epitopes 37%
  • Ebolavirus 29%
  • Antibodies 27%

• Console and probe upgrade for 600 MHz NMR

  Cowburn, D.

  NIH Office of the Director

  7/1/14 → 6/30/15

  Project: Research project

  • structural biology 100%
  • probes (equipment) 98%
  • therapeutics 52%
  • neoplasms 51%
  • multiprotein complexes 48%

• PROTON-DETECTED HETERONUCLEAR NMR SPECTROSCOPY

  Cowburn, D.

  1/1/90 → 1/1/90

  Project: Research project

  • NMR Spectroscopy 100%
  • Probe 90%
  • Stable Isotope 81%
  • Two-Dimensional NMR 76%
  • Pharmacological Metabolism 57%

• 900 MHz NMR Spectrometer for Structural Biology

  Cowburn, D.

  7/1/02 → 6/30/08

  Project: Research project

  • structural biology 100%
  • spectrometers 74%
  • principal investigators 29%
  • nervous system diseases 22%
  • research institutions 21%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Serogroup 80%
  • Dengue 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%

• The dynamic mechanism of nuclear transport visualized at the atomic scale

  Cowburn, D.

  3/1/16 → 7/31/21

  Project: Research project

  • porosity 100%
  • macromolecules 86%
  • neoplasms 44%
  • nuclear magnetic resonance 43%
  • interactions 43%

• HMP 15N AND 13C NMR OF PROTEINS

  Cowburn, D. & Cowburn, D.

  12/31/89 → 1/1/90

  Project: Research project

  • Magnetic Resonance 100%
  • Protein 79%
  • Trypanothione 74%
  • Amide 68%
  • Oxytocin 64%

• Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

  Aman, J. M. & Lai, J. R.

  7/1/17 → 6/30/21

  Project: Research project

  • Ebolavirus 100%
  • Filoviridae 37%
  • Viruses 32%
  • Endosomes 27%
  • Bispecific Antibodies 23%

• Methods to Identify High-Affinity Antibodies that Target Tumor-Associated Glycans

  Lai, J. R.

  National Cancer Institute

  7/1/11 → 6/30/13

  Project: Research project

  • Neoplasm Antibodies 100%
  • Antibody Affinity 96%
  • Polysaccharides 88%
  • Antibodies 46%
  • Bacteriophages 28%

• Towards solution of the RNA folding problem

  Brenowitz, M. D.

  National Institute of General Medical Sciences

  5/1/09 → 2/28/15

  Project: Research project

  • RNA Folding 100%
  • RNA 45%
  • Kinetics 26%
  • Introns 23%
  • Riboswitch 18%

• RESONANCE RAMAN STUDIES OF ENZYMES

  Callender, R.

  12/31/89 → 7/31/03

  Project: Research project

  • NAD 100%
  • Raman Spectrum Analysis 31%
  • Enzymes 26%
  • DABA 24%
  • Oxidoreductases 22%

• Administrative Core.

  Callender, R.

  National Institute of General Medical Sciences

  8/15/14 → 4/30/19

  Project: Research project

  • travel 100%
  • management 55%
  • performance 52%
  • student 28%

• Structural biology of wobble-specific tRNA deaminases

  Kim, J.

  National Institute of General Medical Sciences

  2/1/06 → 5/31/08

  Project: Research project

  • adenosine deaminase 100%
  • structural biology 98%
  • codons 72%
  • inosine 47%
  • infrastructure 41%

• Structural Analysis of Multidrug Transport

  Girvin, M. E.

  National Institute of General Medical Sciences

  8/1/04 → 11/30/15

  Project: Research project

  • Pump 100%
  • Resistance 82%
  • Solution NMR 74%
  • Protein 62%
  • Drug 54%

• MOLECULAR BIOPHYSICS TRAINING GRANT

  Brenowitz, M. D., Chance, M., Rose, S. A. & Rose, S. A.

  7/1/95 → 6/30/10

  Project: Research project

  • trainee 100%
  • student 46%
  • training opportunities 33%
  • biochemistry 32%
  • physiology 29%

• Towards solution of the RNA folding problem

  Brenowitz, M. D. & Rose, S. A.

  5/1/09 → 2/28/15

  Project: Research project

  • RNA Folding 100%
  • RNA 63%
  • Kinetics 28%
  • Introns 25%
  • GIR1 ribozyme 24%

• 1989 GORDON CONFERENCE--ENZYMES COENZYMES &METABOLISM

  Schramm, V. L.

  12/31/89 → 6/14/90

  Project: Research project

  • Coenzyme 100%
  • Cofactor 56%
  • Metabolic 50%
  • Prosthetic Group 37%
  • Kinetic Isotope Effect 33%

• Old Drugs and New Strategies for Tumor Metastasis

  Bresnick, A. R.

  8/4/08 → 4/30/13

  Project: Research project

  • Neoplasm Metastasis 100%
  • Neoplasms 82%
  • Nonmuscle Myosin Type IIA 75%
  • Calcium-Binding Proteins 57%
  • Psychological Inhibition 56%

• Targeting Clostridioides difficile with microbiome-sparing, resistant-proof anti-toxins

  Schramm, V. L.

  National Institute of Allergy and Infectious Diseases

  4/1/21 → 3/31/22

  Project: Research project

  • Microbiota 100%
  • Gastrointestinal Microbiome 88%
  • Infections 85%
  • Anti-Bacterial Agents 73%
  • Microbial Drug Resistance 67%

• MECHANISM OF PEP CARBOXYKINASE AND PYRUVATE CARBOXYLASE

  Schramm, V. L. & Schramm, V. L.

  12/31/89 → 3/31/92

  Project: Research project

  • Pyruvate 100%
  • Metal 57%
  • Metal Ion 30%
  • Catalysis 20%
  • Transition State Structure 20%

• Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers

  Lai, J. R., Chandran, K., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  3/15/14 → 6/28/19

  Project: Research project

  • Antibodies 100%
  • Arenavirus 87%
  • Filoviridae 85%
  • Viral Hemorrhagic Fevers 43%
  • Monoclonal Antibodies 30%