Biochemistry

Projects

Projects per year 1979 1989 1997 2004 2008 2009 2010 2014 2015 2016 2017 2023

• 26 Active
• 196 Finished

Projects per year

Search results

• Active

  Structure-based design of broad flavivirus immunogens

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  9/24/21 → 8/31/22

  Project: Research project

  • Epitopes 100%
  • Flavivirus 91%
  • Zika Virus 82%
  • Serogroup 40%
  • Antibody-Dependent Enhancement 29%

• A whole body model of Pol III-related leukodystrophy

  Moir, R. D. & Willis, I. M.

  National Institute of Neurological Disorders and Stroke

  8/1/21 → 1/31/23

  Project: Research project

  • Phenotype 100%
  • Anodontia 81%
  • Genetic Suppression 77%
  • RNA Polymerase III 76%
  • Myopia 61%

• Eliciting and isolating neutralizing antibodies against Powassan virus

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  8/1/21 → 7/31/22

  Project: Research project

  • Tick-Borne Encephalitis Viruses 100%
  • Neutralizing Antibodies 43%
  • Nanoparticles 26%
  • Flavivirus 23%
  • Vaccines 18%

• Orbitrap Exploris 480 Basic System

  Sidoli, S.

  NIH Office of the Director

  5/15/21 → 5/14/22

  Project: Research project

  • Proteomics 100%
  • Microsporidia 20%
  • Research Personnel 18%
  • Myelodysplastic Syndromes 15%
  • Toxoplasma 15%

• Targeting Clostridioides difficile with microbiome-sparing, resistant-proof anti-toxins

  Schramm, V. L.

  National Institute of Allergy and Infectious Diseases

  4/1/21 → 3/31/22

  Project: Research project

  • Microbiota 100%
  • Gastrointestinal Microbiome 88%
  • Infections 85%
  • Anti-Bacterial Agents 73%
  • Microbial Drug Resistance 67%

• Regulation of Histone Chaperone Function by Glutamylation

  Shechter, D. & Shechter, D.

  National Institute of General Medical Sciences

  1/1/21 → 12/31/22

  Project: Research project

  • Histone Chaperones 100%
  • Histones 47%
  • Genome 21%
  • Chromatin Assembly and Disassembly 12%
  • Epigenomics 10%

• Regulation of Histone Chaperone Function by Glutamylation

  Shechter, D.

  1/1/20 → 12/31/21

  Project: Research project

  • Histones 100%
  • Histone Chaperones 94%
  • Chromatin Assembly and Disassembly 26%
  • Nucleoplasmins 13%
  • Chromatin 13%

• Allosteric inhibitors targeting oncogenic BRAF V600E dimers

  Gavathiotis, E.

  12/1/19 → 11/30/21

  Project: Research project

  • ponatinib 100%
  • Thyroid Neoplasms 48%
  • Melanoma 40%
  • Colorectal Neoplasms 38%
  • Dimerization 27%

• Novel Biologics Designed to Mobilize HIV-specific CTL for Sustained HIV Remission

  Almo, S. C. & Goldstein, H.

  National Institute of Allergy and Infectious Diseases

  4/5/19 → 3/31/22

  Project: Research project

  • Biological Products 100%
  • HIV 86%
  • T-Lymphocytes 61%
  • Cytokines 30%
  • Viremia 22%

• How MeCP2 discriminates epigenetic marks is still a mystery

  Brenowitz, M. D.

  National Institute of General Medical Sciences

  7/1/18 → 6/30/22

  Project: Research project

  • Chromatin 100%
  • Epigenomics 92%
  • Nucleotides 60%
  • Methyl-CpG-Binding Protein 2 57%
  • Rett Syndrome 51%

• How MeCP2 discriminates epigenetic marks is still a mystery

  Brenowitz, M. D.

  7/1/18 → 6/30/22

  Project: Research project

  • Chromatin 100%
  • Epigenomics 65%
  • Nucleotides 60%
  • Methyl-CpG-Binding Protein 2 57%
  • Rett Syndrome 51%

• Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction

  Charron, M. J., Fuloria, M. & Fuloria, M.

  3/1/18 → 2/28/22

  Project: Research project

  • T-Lymphocytes 100%
  • DNA Methylation 95%
  • Pediatric Obesity 69%
  • Growth 57%
  • Obesity 45%

• Impact of COVID-19 and Structural Racism on Maternal Mental Health and the Bronx MomBa Cohort

  Charron, M. J. & Fuloria, M.

  National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development

  3/1/18 → 9/30/22

  Project: Research project

  • Pediatric Obesity 100%
  • Fetal Growth Retardation 88%
  • T-Lymphocytes 74%
  • DNA Methylation 71%
  • Growth 42%

• Structural, functional, and mechanistic anlaysis of autoreactive CD8 T cells

  Almo, S. C. & DiLorenzo, T. P.

  National Institute of Allergy and Infectious Diseases

  2/8/18 → 1/31/22

  Project: Research project

  • T-Lymphocytes 100%
  • Alleles 65%
  • T-Cell Antigen Receptor 45%
  • Peptides 43%
  • Type 1 Diabetes Mellitus 40%

• PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE

  Meek, T., Schramm, V. L. & Tyler, P.

  National Institute of Allergy and Infectious Diseases

  9/25/17 → 8/31/22

  Project: Research project

  • Purine 100%
  • Hypoxanthine 22%
  • Parasitic 21%
  • Nucleotide 14%
  • Transition State 14%

• Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis

  Catz, S. D., Cherqui, S., Cuervo, A. M. & Gavathiotis, E.

  National Institute of Diabetes and Digestive and Kidney Diseases

  8/9/17 → 5/31/22

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Cystinosis 92%
  • Lysosomal Storage Diseases 66%
  • Cystine 33%
  • Cysteamine 12%

• Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis

  Cuervo, A. M. & Gavathiotis, E.

  8/9/17 → 5/31/22

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Cystinosis 92%
  • Cystine 33%
  • Cysteamine 12%
  • Kidney 6%

• Crosstalk to Histone Arginine Methylation

  Shechter, D.

  National Institute of General Medical Sciences

  9/1/14 → 8/31/22

  Project: Research project

  • histones 100%
  • methylation 97%
  • early development 95%
  • arginine 89%
  • Post Translational Protein Processing 38%

• Small Molecule Activators of Pro-apoptotic BAX for Cancer Therapy

  Gavathiotis, E. & Rose, S. A.

  7/1/14 → 5/31/22

  Project: Research project

  • Cell Death 100%
  • Apoptotic 80%
  • Antiapoptotic 66%
  • Molecule 48%
  • Pharmacological Property 27%

• Small Molecule Activators of Pro-apoptotic BAX for Cancer Therapy

  Gavathiotis, E.

  National Cancer Institute

  7/1/14 → 5/31/22

  Project: Research project

  • Cell Death 100%
  • Antiapoptotic 77%
  • Apoptotic 67%
  • Molecule 45%
  • Pharmacological Property 26%

• Autophagy in aging: testing geroscience in Alzheimer's disease

  Cuervo, A. M., Bravo Cordero, J. J., Macian-Juan, F., Gavathiotis, E., Santambrogio, L., Singh, R. & Cuervo, A. M.

  National Institute on Aging

  2/15/09 → 3/31/22

  Project: Research project

  • Autophagy 100%
  • autophagy 62%
  • Proteostasis 37%
  • Antigen Presentation 25%
  • Pharmaceutical Chemistry 24%

• Functional Consequences of Impaired Autophagy in Aging

  Santambrogio, L., Macian-Juan, F., Cuervo, A. M., Cuervo, A. M., Singh, R., Rose, S. A., Gavathiotis, E. & Bravo Cordero, J. J.

  2/15/09 → 3/31/22

  Project: Research project

  • autophagy 100%
  • cognition 24%
  • T-lymphocytes 19%
  • bookkeeping 18%
  • organisms 18%

• PROLINE RICH MOTIFS IN HIV NEF BINDING

  Xu, R.

  National Institutes of Health

  1/1/97 → …

  Project: Research project

  • src Homology Domains 100%
  • Proline 87%
  • Human Immunodeficiency Virus nef Gene Products 75%
  • nef Gene Products 65%
  • HIV 57%

• Transition State Analysis of Enzymatic Reactions

  Schramm, V. L.

  National Institute of General Medical Sciences

  8/1/90 → 7/31/22

  Project: Research project

  • Enzymatic Reaction 100%
  • Transition State 84%
  • Transition State Structure 54%
  • Purine Nucleoside 30%
  • Purine 18%

• FUNCTIONAL ANALYSIS OF ADIPOCYTE GLUCOSE TRANSPORTERS

  Charron, M. J.

  12/31/89 → …

  Project: Research project

• STRUCTURE OF THE DCCD BINDING SUBUNIT OF THE H+-ATPASE

  Girvin, M. E.

  8/15/87 → …

  Project: Research project