Biochemistry

Projects

Projects per year 1979 1989 1997 2004 2008 2009 2010 2014 2015 2016 2017 2023

• 26 Active
• 196 Finished

Projects per year

Search results

• Finished

  Allosteric inhibitors targeting oncogenic BRAF V600E dimers

  Gavathiotis, E.

  National Cancer Institute

  12/1/20 → 11/30/21

  Project: Research project

  • ponatinib 100%
  • Thyroid Neoplasms 48%
  • Melanoma 40%
  • Colorectal Neoplasms 38%
  • Dimerization 27%

• Novel Strategies for the Discovery of Microbial Metabolic Pathways

  Almo, S. C.

  5/1/20 → 4/30/21

  Project: Research project

  • Solute 100%
  • Metabolic 79%
  • Ligand 74%
  • Protein 70%
  • Enzyme Activity 40%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D. & Willis, I. M.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  3/1/19 → 2/29/20

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D. & Willis, I. M.

  3/1/19 → 2/28/21

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• An immunotherapeutic strategy for the induction and stabilization of remission in type 1 diabetes

  Almo, S. C. & DiLorenzo, T. P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/15/18 → 7/31/20

  Project: Research project

  • Remission Induction 100%
  • Type 1 Diabetes Mellitus 70%
  • T-Lymphocytes 57%
  • Antigens 29%
  • Immunological Synapses 27%

• PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE

  Schramm, V. L. & Schramm, V. L.

  9/25/17 → 8/31/21

  Project: Research project

  • Purine 100%
  • Hypoxanthine 20%
  • Parasitic 20%
  • Nucleotide 13%
  • Transition State 13%

• A Trojan Horse bispecific antibody strategy for broad filovirus therapeutics

  Chandran, K. & Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  7/14/17 → 6/30/20

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 78%
  • Monoclonal Antibodies 36%
  • Ebolavirus 28%
  • Sudan 18%

• A Trojan Horse bispecific antibody strategy for broad filovirus therapeutics

  Lai, J. R. & Chandran, K.

  7/14/17 → 6/30/21

  Project: Research project

  • Filoviridae 100%
  • Monoclonal Antibodies 33%
  • Bispecific Antibodies 27%
  • Ebolavirus 26%
  • Sudan 17%

• Function and Mechanism of Viperin, a radical SAM antiviral protein

  Almo, S. C. & Grove, T. L.

  National Institute of Allergy and Infectious Diseases

  6/26/17 → 5/31/19

  Project: Research project

  • Cytidine Triphosphate 100%
  • S-Adenosylmethionine 89%
  • Antiviral Agents 61%
  • Viruses 38%
  • Interferons 26%

• Function and Mechanism of Viperin, a radical SAM antiviral protein

  Almo, S. C.

  6/26/17 → 5/31/19

  Project: Research project

  • Cytidine Triphosphate 100%
  • S-Adenosylmethionine 74%
  • Antiviral Agents 61%
  • Viruses 38%
  • Interferons 26%

• Engineered, multispecific antibodies as broad anti-filovirus therapeutics

  Lai, J. R.

  6/1/17 → 5/31/21

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 43%
  • Monoclonal Antibodies 43%
  • Marburgvirus 25%
  • Viruses 18%

• Engineered, multispecific antibodies as broad anti-filovirus therapeutics

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  6/1/17 → 5/31/20

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 47%
  • Monoclonal Antibodies 46%
  • Antibodies 30%
  • Marburgvirus 27%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Serogroup 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%
  • Infections 50%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Dengue 94%
  • Serogroup 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%

• MAF1 Function and Metabolic Inefficiency

  Willis, I. M.

  National Institute of General Medical Sciences

  9/21/16 → 7/31/21

  Project: Research project

  • Energy Metabolism 100%
  • RNA 95%
  • Transfer RNA 90%
  • RNA Polymerase III 76%
  • Untranslated RNA 62%

• MAF1 Function and Metabolic Inefficiency

  Willis, I. M.

  9/21/16 → 7/31/21

  Project: Research project

  • Energy Metabolism 100%
  • RNA 95%
  • Transfer RNA 90%
  • RNA Polymerase III 76%
  • Untranslated RNA 62%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M. & Bresnick, A. R.

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 46%
  • Neoplasm Metastasis 44%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• Structural basis of allostery and mechanical properties of F-actin

  Almo, S. C.

  8/1/16 → 7/31/20

  Project: Research project

  • Actins 100%
  • Microfilament Proteins 66%
  • Protein Subunits 57%
  • Cryoelectron Microscopy 45%
  • Protein Binding 33%

• Structural basis of allostery and mechanical properties of F-actin

  Almo, S. C., Hanein, D. & Volkmann, N.

  National Institute of General Medical Sciences

  8/1/16 → 7/31/20

  Project: Research project

  • Actins 100%
  • Microfilament Proteins 71%
  • Protein Subunits 62%
  • Cryoelectron Microscopy 49%
  • Protein Binding 36%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M. & Bresnick, A. R.

  National Institute of General Medical Sciences

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 61%
  • Neoplasm Metastasis 59%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

  Lai, J. R.

  7/5/16 → 6/30/17

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 81%
  • Epitopes 37%
  • Ebolavirus 29%
  • Antibodies 27%

• Novel Strategies for Precision T-cell Therapies

  Almo, S. C.

  National Cancer Institute

  6/1/16 → 5/31/20

  Project: Research project

  • Immunological Synapses 100%
  • Cell- and Tissue-Based Therapy 75%
  • T-Lymphocytes 53%
  • Biological Products 37%
  • Peptides 18%

• Inhibitors of Maf1-dependent transcriptional repression

  Willis, I. M.

  National Institute of General Medical Sciences

  4/1/16 → 3/31/17

  Project: Research project

  • Anti-Obesity Agents 100%
  • Transfer RNA 76%
  • Obesity 72%
  • Genes 70%
  • Peptides 66%

• Inhibitors of Maf1-dependent transcriptional repression

  Willis, I. M.

  4/1/16 → 3/31/17

  Project: Research project

  • Anti-Obesity Agents 100%
  • Transfer RNA 76%
  • Obesity 72%
  • Genes 70%
  • Peptides 66%

• The dynamic mechanism of nuclear transport visualized at the atomic scale

  Cowburn, D.

  3/1/16 → 7/31/21

  Project: Research project

  • porosity 100%
  • macromolecules 86%
  • neoplasms 44%
  • nuclear magnetic resonance 43%
  • interactions 43%

• The dynamic mechanism of nuclear transport visualized at the atomic scale

  Cowburn, D.

  National Institute of General Medical Sciences

  3/1/16 → 7/31/20

  Project: Research project

  • porosity 100%
  • macromolecules 86%
  • neoplasms 44%
  • nuclear magnetic resonance 43%
  • interactions 43%

• Technologies for Mapping the Extracellular Interactome

  Almo, S. C.

  9/24/15 → 6/30/19

  Project: Research project

  • Membrane Proteins 100%
  • Proteins 88%
  • Technology 78%
  • Automation 74%
  • Proteome 62%

• Technologies for Mapping the Extracellular Interactome

  Almo, S. C.

  National Human Genome Research Institute

  9/24/15 → 6/30/19

  Project: Research project

  • Technology 100%
  • Membrane Proteins 70%
  • Proteins 62%
  • Automation 52%
  • Proteome 44%

• Chemoenzymatic methods for the detection of cell-surface glycans

  Wu, P.

  National Institutes of Health

  8/15/15 → 7/31/19

  Project: Research project

  • Polysaccharides 100%
  • Glycosylation 49%
  • Lectins 17%
  • Glycomics 12%
  • Lung Neoplasms 11%

• Chemoenzymatic methods for the detection of cellsurface glycans

  Wu, P.

  National Institute of General Medical Sciences

  8/15/15 → 7/31/20

  Project: Research project

  • Polysaccharides 100%
  • Glycosylation 48%
  • Lectins 16%
  • Lung Neoplasms 12%
  • Glycomics 11%

• 2015 Nucleosides, Nucleotides & Oligonucleotides Gordon Research Conference and Seminar

  Schramm, V. L.

  5/18/15 → 9/30/15

  Project: Research project

  • Nucleosides 100%
  • Oligonucleotides 98%
  • Congresses 93%
  • Nucleotides 76%
  • Synthetic Biology 43%

• Chemical tools for studying membrane protein glycosylation

  Ovryn, B. & Wu, P.

  National Institutes of Health

  4/15/15 → 3/31/19

  Project: Research project

  • Glycosylation 100%
  • Membrane Proteins 73%
  • Polysaccharides 60%
  • Glycoproteins 37%
  • Neoplasms 28%

• Chemical tools for studying membrane protein glycosylation

  Ovryn, B. & Wu, P.

  National Institute of General Medical Sciences

  4/15/15 → 3/31/19

  Project: Research project

  • Glycosylation 100%
  • Polysaccharides 64%
  • Membrane Proteins 61%
  • Glycoproteins 39%
  • Neoplasms 29%

• An integrated X-ray data collection system

  Almo, S. C.

  NIH Office of the Director

  4/1/15 → 3/31/16

  Project: Research project

  • biology 100%
  • medicine 53%
  • biochemistry 17%
  • immunity 16%
  • physiology 15%

• An integrated X-ray data collection system

  Almo, S. C.

  4/1/15 → 3/31/16

  Project: Research project

  • biology 100%
  • medicine 53%
  • biochemistry 17%
  • immunity 16%
  • physiology 15%

• Regulation of the Class IA PI 3-kinase PIK3CB

  Bresnick, A. R., Backer, J. M. & Bresnick, A. R.

  9/5/14 → 7/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • G-Protein-Coupled Receptors 36%
  • Neoplasms 18%
  • Growth 18%
  • Neoplasm Metastasis 13%

• Regulation of the Class IA PI 3-kinase PIK3CB

  Backer, J. M. & Bresnick, A. R.

  National Institute of General Medical Sciences

  9/5/14 → 7/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • G-Protein-Coupled Receptors 38%
  • Neoplasms 19%
  • Growth 19%
  • Neoplasm Metastasis 14%

• PRMT5-MEP50 Histone Arginine Methylation in Early Development

  Shechter, D.

  9/1/14 → 8/31/21

  Project: Research project

  • histones 100%
  • methylation 64%
  • protein arginine methyltransferases 23%
  • early development 19%
  • arginine 17%

• Console and probe upgrade for 600 MHz NMR

  Cowburn, D. & Rose, S. A.

  7/1/14 → 6/30/15

  Project: Research project

  • structural biology 100%
  • probes (equipment) 65%
  • therapeutics 52%
  • neoplasms 51%
  • multiprotein complexes 48%

• Orally available transition state inhibitors for triple negative breast cancer

  Isaacman, S. & Schramm, V. L.

  National Cancer Institute

  7/1/14 → 6/30/16

  Project: Research project

  • Triple Negative Breast Neoplasms 100%
  • 5'-methylthioadenosine phosphorylase 83%
  • Breast Neoplasms 30%
  • Neoplasms 26%
  • 5'-methylthioadenosine 20%

• Console and probe upgrade for 600 MHz NMR

  Cowburn, D.

  NIH Office of the Director

  7/1/14 → 6/30/15

  Project: Research project

  • structural biology 100%
  • probes (equipment) 98%
  • therapeutics 52%
  • neoplasms 51%
  • multiprotein complexes 48%

• Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers

  Lai, J. R., Chandran, K., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  3/15/14 → 6/28/19

  Project: Research project

  • Antibodies 100%
  • Arenavirus 87%
  • Filoviridae 85%
  • Viral Hemorrhagic Fevers 43%
  • Monoclonal Antibodies 30%

• Orally available transition state inhibitors for triple negative breast cancer

  Isaacman, S., Schramm, V. L., Rose, S. A. & Rose, S. A.

  1/1/14 → 6/30/16

  Project: Research project

  • 5'-methylthioadenosine phosphorylase 100%
  • Triple Negative Breast Neoplasms 85%
  • 5'-methylthioadenosine 25%
  • National Institutes of Health (U.S.) 14%
  • Neoplasms 13%

• Lectimers: Glycan-anchored scaffold libraries for targeting carbohydrate-binding

  Levy, M.

  9/20/13 → 8/31/17

  Project: Research project

  • Nucleic Acid 100%
  • Carbohydrate 65%
  • Protein 65%
  • Ligand 34%
  • Peptide 22%

• Lectimers: Glycan-anchored scaffold libraries for targeting carbohydrate-binding

  Levy, M.

  National Cancer Institute

  9/20/13 → 8/31/17

  Project: Research project

  • Nucleic Acid 100%
  • Carbohydrate 65%
  • Protein 65%
  • Ligand 34%
  • Peptide 22%

• Dissecting the roles of protein O-GlcNAcylation in Toxoplasma gondii

  Wu, P. & Kim, K.

  8/12/13 → 7/31/15

  Project: Research project

  • Toxoplasma gondii 100%
  • tachyzoites 68%
  • bradyzoites 56%
  • transferases 37%
  • life cycle (organisms) 31%

• Dissecting the roles of protein O-GlcNAcylation in Toxoplasma gondii

  Kim, K. & Wu, P.

  National Institute of Allergy and Infectious Diseases

  8/12/13 → 7/31/15

  Project: Research project

  • Toxoplasma gondii 100%
  • tachyzoites 75%
  • bradyzoites 63%
  • transferases 41%
  • life cycle (organisms) 35%

• Targeting CNS HIV reservoirs across the blood-brain barrier

  Levy, M. & Prasad, V. R.

  National Institute of Mental Health

  4/25/13 → 3/31/15

  Project: Research project

  • Blood-Brain Barrier 100%
  • HIV 59%
  • HIV-1 31%
  • Viral Proteins 29%
  • Nervous System Diseases 17%

• Targeting CNS HIV reservoirs across the blood-brain barrier

  Levy, M., Prasad, V. R., Rose, S. A. & Rose, S. A.

  4/25/13 → 3/31/15

  Project: Research project

  • Blood-Brain Barrier 100%
  • HIV 35%
  • HIV-1 29%
  • Viral Proteins 27%
  • Nervous System Diseases 16%

• Fluorescent probes for quantitation of secretory protein levels in single cells

  Snapp, E. L. & Levy, M.

  9/24/12 → 8/31/15

  Project: Research project

  • Proteins 100%
  • Technology 71%
  • Secretory Pathway 63%
  • Fluorescent Dyes 57%
  • Bacterial Toxins 37%