Biochemistry

Projects

Projects per year 1979 1989 1997 2008 2009 2010 2014 2016 2017 2023

• 10 Active
• 215 Finished

Projects per year

Search results

• Finished

  Eliciting and isolating neutralizing antibodies against Powassan virus

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  8/1/21 → 7/31/22

  Project: Research project

  • Tick-Borne Encephalitis Viruses 100%
  • Neutralizing Antibodies 43%
  • Nanoparticles 26%
  • Flavivirus 23%
  • Vaccines 18%

• Orbitrap Exploris 480 Basic System

  Sidoli, S.

  NIH Office of the Director

  5/15/21 → 5/14/22

  Project: Research project

  • Proteomics 100%
  • Microsporidia 20%
  • Research Personnel 18%
  • Myelodysplastic Syndromes 15%
  • Toxoplasma 15%

• Targeting Clostridioides difficile with microbiome-sparing, resistant-proof anti-toxins

  Schramm, V. L.

  National Institute of Allergy and Infectious Diseases

  4/1/21 → 3/31/22

  Project: Research project

  • Microbiota 100%
  • Gastrointestinal Microbiome 88%
  • Infections 85%
  • Anti-Bacterial Agents 73%
  • Microbial Drug Resistance 67%

• Novel Strategies for the Discovery of Microbial Metabolic Pathways

  Almo, S. C.

  5/1/20 → 4/30/21

  Project: Research project

  • Solute 100%
  • Metabolic 79%
  • Ligand 74%
  • Protein 70%
  • Enzyme Activity 40%

• Regulation of Histone Chaperone Function by Glutamylation

  Shechter, D.

  1/1/20 → 12/31/21

  Project: Research project

  • Histones 100%
  • Histone Chaperones 94%
  • Chromatin Assembly and Disassembly 26%
  • Nucleoplasmins 13%
  • Chromatin 13%

• Allosteric inhibitors targeting oncogenic BRAF V600E dimers

  Gavathiotis, E.

  12/1/19 → 11/30/21

  Project: Research project

  • ponatinib 100%
  • Thyroid Neoplasms 48%
  • Melanoma 40%
  • Colorectal Neoplasms 38%
  • Dimerization 27%

• Novel Biologics Designed to Mobilize HIV-specific CTL for Sustained HIV Remission

  Almo, S. C. & Goldstein, H.

  National Institute of Allergy and Infectious Diseases

  4/5/19 → 3/31/21

  Project: Research project

  • Biological Products 100%
  • HIV 98%
  • T-Lymphocytes 68%
  • Cytokines 34%
  • Viremia 24%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D. & Willis, I. M.

  3/1/19 → 2/28/21

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D., Willis, I. M. & Willis, I. M.

  National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development

  3/1/19 → 2/28/21

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• An immunotherapeutic strategy for the induction and stabilization of remission in type 1 diabetes

  Almo, S. C., DiLorenzo, T. P. & DiLorenzo, T. P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/15/18 → 7/31/21

  Project: Research project

  • Remission Induction 100%
  • Type 1 Diabetes Mellitus 71%
  • T-Lymphocytes 61%
  • Antigens 31%
  • Immunological Synapses 29%

• How MeCP2 discriminates epigenetic marks is still a mystery

  Brenowitz, M. D.

  7/1/18 → 6/30/22

  Project: Research project

  • Chromatin 100%
  • Epigenomics 65%
  • Nucleotides 60%
  • Methyl-CpG-Binding Protein 2 57%
  • Rett Syndrome 51%

• How MeCP2 discriminates epigenetic marks is still a mystery

  Brenowitz, M. D. & Brenowitz, M. D.

  National Institute of General Medical Sciences

  7/1/18 → 6/30/22

  Project: Research project

  • Chromatin 100%
  • Epigenomics 87%
  • Nucleotides 60%
  • Methyl-CpG-Binding Protein 2 57%
  • Rett Syndrome 51%

• Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction

  Charron, M. J., Fuloria, M. & Fuloria, M.

  3/1/18 → 2/28/22

  Project: Research project

  • T-Lymphocytes 100%
  • DNA Methylation 95%
  • Pediatric Obesity 69%
  • Growth 57%
  • Obesity 45%

• PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE

  Schramm, V. L. & Schramm, V. L.

  9/25/17 → 8/31/21

  Project: Research project

  • Purine 100%
  • Hypoxanthine 20%
  • Parasitic 20%
  • Nucleotide 13%
  • Transition State 13%

• PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE

  Meek, T., Schramm, V. L. & Tyler, P.

  National Institute of Allergy and Infectious Diseases

  9/25/17 → 8/31/19

  Project: Research project

  • Purine 100%
  • Hypoxanthine 21%
  • Parasitic 21%
  • Nucleotide 14%
  • Transition State 14%

• Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis

  Cuervo, A. M. & Gavathiotis, E.

  8/9/17 → 5/31/22

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Cystinosis 92%
  • Cystine 33%
  • Cysteamine 12%
  • Kidney 6%

• Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis

  Catz, S. D., Cherqui, S., Cuervo, A. M. & Gavathiotis, E.

  National Institute of Diabetes and Digestive and Kidney Diseases

  8/9/17 → 4/30/18

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Cystinosis 92%
  • Lysosomal Storage Diseases 43%
  • Cystine 33%
  • Cysteamine 12%

• A Trojan Horse bispecific antibody strategy for broad filovirus therapeutics

  Lai, J. R. & Chandran, K.

  7/14/17 → 6/30/21

  Project: Research project

  • Filoviridae 100%
  • Monoclonal Antibodies 33%
  • Bispecific Antibodies 27%
  • Ebolavirus 26%
  • Sudan 17%

• A Trojan Horse bispecific antibody strategy for broad filovirus therapeutics

  Chandran, K., Lai, J. R. & Chandran, K.

  National Institute of Allergy and Infectious Diseases

  7/14/17 → 6/30/22

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 59%
  • Monoclonal Antibodies 35%
  • Ebolavirus 27%
  • Sudan 18%

• Function and Mechanism of Viperin, a radical SAM antiviral protein

  Almo, S. C.

  6/26/17 → 5/31/19

  Project: Research project

  • Cytidine Triphosphate 100%
  • S-Adenosylmethionine 74%
  • Antiviral Agents 61%
  • Viruses 38%
  • Interferons 26%

• Function and Mechanism of Viperin, a radical SAM antiviral protein

  Almo, S. C., Grove, T. L. & Almo, S. C.

  National Institute of Allergy and Infectious Diseases

  6/26/17 → 5/31/19

  Project: Research project

  • Cytidine Triphosphate 100%
  • S-Adenosylmethionine 87%
  • Antiviral Agents 61%
  • Viruses 38%
  • Interferons 26%

• Engineered, multispecific antibodies as broad anti-filovirus therapeutics

  Lai, J. R.

  6/1/17 → 5/31/21

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 43%
  • Monoclonal Antibodies 43%
  • Marburgvirus 25%
  • Viruses 18%

• Engineered, multispecific antibodies as broad anti-filovirus therapeutics

  Lai, J. R. & Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  6/1/17 → 5/31/21

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 45%
  • Monoclonal Antibodies 45%
  • Marburgvirus 26%
  • Antibodies 22%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Serogroup 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%
  • Infections 50%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Serogroup 80%
  • Dengue 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%

• MAF1 Function and Metabolic Inefficiency

  Willis, I. M.

  9/21/16 → 7/31/21

  Project: Research project

  • Energy Metabolism 100%
  • RNA 95%
  • Transfer RNA 90%
  • RNA Polymerase III 76%
  • Untranslated RNA 62%

• MAF1 Function and Metabolic Inefficiency

  Willis, I. M. & Willis, I. M.

  National Institute of General Medical Sciences

  9/21/16 → 7/31/21

  Project: Research project

  • Energy Metabolism 100%
  • RNA 95%
  • Transfer RNA 90%
  • RNA Polymerase III 76%
  • Untranslated RNA 62%

• Structural basis of allostery and mechanical properties of F-actin

  Almo, S. C.

  8/1/16 → 7/31/20

  Project: Research project

  • Actins 100%
  • Microfilament Proteins 66%
  • Protein Subunits 57%
  • Cryoelectron Microscopy 45%
  • Protein Binding 33%

• Structural basis of allostery and mechanical properties of F-actin

  Almo, S. C., Almo, S. C. & Volkmann, N.

  National Institute of General Medical Sciences

  8/1/16 → 7/31/20

  Project: Research project

  • Actins 100%
  • Microfilament Proteins 71%
  • Protein Subunits 62%
  • Cryoelectron Microscopy 49%
  • Protein Binding 36%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M. & Bresnick, A. R.

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 46%
  • Neoplasm Metastasis 44%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M., Bresnick, A. R. & Backer, J. M.

  National Institute of General Medical Sciences

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 55%
  • Neoplasm Metastasis 53%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

  Lai, J. R.

  7/5/16 → 6/30/17

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 81%
  • Epitopes 37%
  • Ebolavirus 29%
  • Antibodies 27%

• Novel Strategies for the Discovery of Microbial Metabolic Pathways

  Gerlt, J., Almo, S. C. & Jacobson, M.

  National Institute of General Medical Sciences

  6/15/16 → 4/30/21

  Project: Research project

  • Carrier Proteins 100%
  • Ligands 90%
  • Solute 62%
  • Metabolic 49%
  • Ligand 46%

• Novel Strategies for Precision T-cell Therapies

  Almo, S. C. & Almo, S. C.

  National Cancer Institute

  6/1/16 → 5/31/21

  Project: Research project

  • Immunological Synapses 100%
  • Cell- and Tissue-Based Therapy 69%
  • T-Lymphocytes 54%
  • Biological Products 37%
  • Peptides 18%

• Inhibitors of Maf1-dependent transcriptional repression

  Willis, I. M.

  4/1/16 → 3/31/17

  Project: Research project

  • Anti-Obesity Agents 100%
  • Transfer RNA 76%
  • Obesity 72%
  • Genes 70%
  • Peptides 66%

• Inhibitors of Maf1-dependent transcriptional repression

  Willis, I. M.

  National Institute of General Medical Sciences

  4/1/16 → 3/31/17

  Project: Research project

  • Anti-Obesity Agents 100%
  • Transfer RNA 76%
  • Obesity 72%
  • Genes 70%
  • Peptides 66%

• The dynamic mechanism of nuclear transport visualized at the atomic scale

  Cowburn, D.

  3/1/16 → 7/31/21

  Project: Research project

  • porosity 100%
  • macromolecules 86%
  • neoplasms 44%
  • nuclear magnetic resonance 43%
  • interactions 43%

• The dynamic mechanism of nuclear transport visualized at the atomic scale

  Cowburn, D., Rout, M. P. & Cowburn, D.

  National Institute of General Medical Sciences

  3/1/16 → 7/31/21

  Project: Research project

  • porosity 100%
  • macromolecules 64%
  • proteins 39%
  • cargo 36%
  • routes 35%

• Technologies for Mapping the Extracellular Interactome

  Almo, S. C.

  9/24/15 → 6/30/19

  Project: Research project

  • Membrane Proteins 100%
  • Proteins 88%
  • Technology 78%
  • Automation 74%
  • Proteome 62%

• Technologies for Mapping the Extracellular Interactome

  Almo, S. C. & Almo, S. C.

  National Human Genome Research Institute

  9/24/15 → 6/30/19

  Project: Research project

  • Technology 100%
  • Membrane Proteins 72%
  • Proteins 64%
  • Automation 53%
  • Proteome 45%

• Chemoenzymatic methods for the detection of cell-surface glycans

  Wu, P.

  National Institutes of Health

  8/15/15 → 7/31/19

  Project: Research project

  • Polysaccharides 100%
  • Glycosylation 49%
  • Lectins 17%
  • Glycomics 12%
  • Lung Neoplasms 11%

• Chemoenzymatic methods for the detection of cellsurface glycans

  Wu, P.

  National Institute of General Medical Sciences

  8/15/15 → 7/31/20

  Project: Research project

  • Polysaccharides 100%
  • Glycosylation 48%
  • Lectins 16%
  • Lung Neoplasms 12%
  • Glycomics 11%

• 2015 Nucleosides, Nucleotides & Oligonucleotides Gordon Research Conference and Seminar

  Schramm, V. L.

  5/18/15 → 9/30/15

  Project: Research project

  • Nucleosides 100%
  • Oligonucleotides 98%
  • Congresses 93%
  • Nucleotides 76%
  • Synthetic Biology 43%

• Chemical tools for studying membrane protein glycosylation

  Ovryn, B. & Wu, P.

  National Institutes of Health

  4/15/15 → 3/31/19

  Project: Research project

  • Glycosylation 100%
  • Membrane Proteins 73%
  • Polysaccharides 60%
  • Glycoproteins 37%
  • Neoplasms 28%

• Chemical tools for studying membrane protein glycosylation

  Ovryn, B., Wu, P. & Wu, P.

  National Institute of General Medical Sciences

  4/15/15 → 3/31/19

  Project: Research project

  • Glycosylation 100%
  • Polysaccharides 64%
  • Membrane Proteins 61%
  • Glycoproteins 39%
  • Neoplasms 29%

• An integrated X-ray data collection system

  Almo, S. C.

  NIH Office of the Director

  4/1/15 → 3/31/16

  Project: Research project

  • biology 100%
  • medicine 53%
  • biochemistry 17%
  • immunity 16%
  • physiology 15%

• An integrated X-ray data collection system

  Almo, S. C.

  4/1/15 → 3/31/16

  Project: Research project

  • biology 100%
  • medicine 53%
  • biochemistry 17%
  • immunity 16%
  • physiology 15%

• Regulation of the Class IA PI 3-kinase PIK3CB

  Backer, J. M. & Bresnick, A. R.

  National Institute of General Medical Sciences

  9/5/14 → 7/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • G-Protein-Coupled Receptors 38%
  • Neoplasms 19%
  • Growth 19%
  • Neoplasm Metastasis 14%

• Regulation of the Class IA PI 3-kinase PIK3CB

  Bresnick, A. R., Backer, J. M. & Bresnick, A. R.

  9/5/14 → 7/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • G-Protein-Coupled Receptors 36%
  • Neoplasms 18%
  • Growth 18%
  • Neoplasm Metastasis 13%

• PRMT5-MEP50 Histone Arginine Methylation in Early Development

  Shechter, D.

  9/1/14 → 8/31/21

  Project: Research project

  • histones 100%
  • methylation 64%
  • protein arginine methyltransferases 23%
  • early development 19%
  • arginine 17%