Biochemistry

Projects

Projects per year 1979 1989 1995 1997 2003 2004 2008 2009 2010 2014 2016 2017 2023

• 21 Active
• 272 Finished

Projects per year

Search results

• Finished

  Structure-based design of broad flavivirus immunogens

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  9/24/21 → 8/31/22

  Project: Research project

  • Epitopes 100%
  • Flavivirus 91%
  • Zika Virus 82%
  • Serogroup 40%
  • Antibody-Dependent Enhancement 29%

• Eliciting and isolating neutralizing antibodies against Powassan virus

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  8/1/21 → 7/31/22

  Project: Research project

  • Tick-Borne Encephalitis Viruses 100%
  • Neutralizing Antibodies 43%
  • Nanoparticles 26%
  • Flavivirus 23%
  • Vaccines 18%

• Orbitrap Exploris 480 Basic System

  Sidoli, S.

  NIH Office of the Director

  5/15/21 → 5/14/22

  Project: Research project

  • Proteomics 100%
  • Microsporidia 20%
  • Research Personnel 18%
  • Myelodysplastic Syndromes 15%
  • Toxoplasma 15%

• Novel Strategies for the Discovery of Microbial Metabolic Pathways

  Almo, S. C.

  5/1/20 → 4/30/21

  Project: Research project

  • Solute 100%
  • Metabolic 79%
  • Ligand 74%
  • Protein 70%
  • Enzyme Activity 40%

• Core D - Chemical Biology and Therapeutics Innovation Core

  Gavathiotis, E.

  National Institute on Aging

  4/1/20 → 3/31/22

  Project: Research project

  • Autophagy 100%
  • Pharmaceutical Chemistry 81%
  • Lead 54%
  • Dementia 24%
  • Alzheimer Disease 23%

• Regulation of Histone Chaperone Function by Glutamylation

  Shechter, D.

  1/1/20 → 12/31/21

  Project: Research project

  • Histones 100%
  • Histone Chaperones 94%
  • Chromatin Assembly and Disassembly 26%
  • Nucleoplasmins 13%
  • Chromatin 13%

• Allosteric inhibitors targeting oncogenic BRAF V600E dimers

  Gavathiotis, E.

  12/1/19 → 11/30/21

  Project: Research project

  • ponatinib 100%
  • Thyroid Neoplasms 48%
  • Melanoma 40%
  • Colorectal Neoplasms 38%
  • Dimerization 27%

• Structural Biology

  Almo, S. S. C. & Almo, S. C.

  National Cancer Institute

  7/1/19 → 6/30/22

  Project: Research project

  • Proteomics 100%
  • Intellectual Property 41%
  • X-Rays 41%
  • Professional Competence 37%
  • Cryoelectron Microscopy 36%

• Chemical Synthesis

  Blanchard, J. S. & Blanchard, J. S.

  National Cancer Institute

  7/1/19 → 6/30/22

  Project: Research project

  • Chelating Agent 100%
  • Chemical Stability 96%
  • Pharmacological Effect 66%
  • Solubility 65%
  • Triazole 55%

• Cancer Research Career Enhancement and Related Activities (CRCE)

  Bresnick, A. A. R. & Bresnick, A. R.

  National Cancer Institute

  7/1/19 → 6/30/22

  Project: Research project

  • Neoplasms 100%
  • Education 57%
  • Medical Oncology 43%
  • Students 25%
  • Pediatrics 23%

• Experimental Therapeutics

  Schramm, V. L.

  National Cancer Institute

  7/1/19 → 6/30/21

  Project: Research project

  • Drug Development 100%
  • Computational Biology 99%
  • T-Lymphocytes 97%
  • Crystallography 76%
  • Genetic Epigenesis 75%

• Novel Biologics Designed to Mobilize HIV-specific CTL for Sustained HIV Remission

  Goldstein, H. & Almo, S. C.

  National Institute of Allergy and Infectious Diseases

  4/5/19 → 3/31/21

  Project: Research project

  • Biological Products 100%
  • HIV 81%
  • T-Lymphocytes 58%
  • Cytokines 29%
  • Viremia 21%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D. & Willis, I. M.

  3/1/19 → 2/28/21

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D., Willis, I. M. & Willis, I. M.

  National Institute of Child Health and Human Development

  3/1/19 → 2/28/21

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• An immunotherapeutic strategy for the induction and stabilization of remission in type 1 diabetes

  DiLorenzo, T. P., Almo, S. C. & DiLorenzo, T. P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/15/18 → 7/31/21

  Project: Research project

  • Remission Induction 100%
  • Type 1 Diabetes Mellitus 70%
  • T-Lymphocytes 55%
  • Antigens 28%
  • Immunological Synapses 26%

• How MeCP2 discriminates epigenetic marks is still a mystery

  Brenowitz, M. D. & Brenowitz, M. D.

  National Institute of General Medical Sciences

  7/1/18 → 6/30/22

  Project: Research project

  • Chromatin 100%
  • Epigenomics 93%
  • Nucleotides 60%
  • Methyl-CpG-Binding Protein 2 57%
  • Rett Syndrome 51%

• How MeCP2 discriminates epigenetic marks is still a mystery

  Brenowitz, M. D.

  7/1/18 → 6/30/22

  Project: Research project

  • Chromatin 100%
  • Epigenomics 65%
  • Nucleotides 60%
  • Methyl-CpG-Binding Protein 2 57%
  • Rett Syndrome 51%

• Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction

  Charron, M. J., Fuloria, M. & Fuloria, M.

  3/1/18 → 2/28/22

  Project: Research project

  • T-Lymphocytes 100%
  • DNA Methylation 95%
  • Pediatric Obesity 69%
  • Growth 57%
  • Obesity 45%

• Immunotherapeutics Against Other Filovirus Threats

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  3/1/18 → 2/28/19

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 96%
  • Marburgvirus 72%
  • Monoclonal Antibodies 47%
  • Primates 30%

• Capture and characterize transient catalytic intermediates by X-ray crystallography

  Rousseau, D. L. & Rousseau, D. L.

  National Institute of General Medical Sciences

  2/1/18 → 1/31/21

  Project: Research project

  • Holder 100%
  • X-Ray Crystallography 84%
  • Cytochrome 53%
  • Oxidase Reaction 30%
  • Time 29%

• PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE

  Schramm, V. L. & Schramm, V. L.

  9/25/17 → 8/31/21

  Project: Research project

  • Purine 100%
  • Hypoxanthine 20%
  • Parasitic 20%
  • Nucleotide 13%
  • Transition State 13%

• PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE

  Meek, T., Schramm, V. L. & Tyler, P.

  National Institute of Allergy and Infectious Diseases

  9/25/17 → 8/31/18

  Project: Research project

  • Purine 100%
  • Hypoxanthine 22%
  • Parasitic 21%
  • Nucleotide 14%
  • Transition State 14%

• Structures of time-resolved intermediates in cytochrome c oxidase obtained by serial femtosecond crystallography

  Rousseau, D. L., Yeh, S. & Rousseau, D. L.

  National Institute of General Medical Sciences

  9/15/17 → 8/31/21

  Project: Research project

  • Crystallography 100%
  • Cytochrome 94%
  • Proton 57%
  • Carbon Monoxide 45%
  • X-Ray Crystallography 29%

• Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis

  Cuervo, A. M. & Gavathiotis, E.

  8/9/17 → 5/31/22

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Cystinosis 92%
  • Cystine 33%
  • Cysteamine 12%
  • Kidney 6%

• A Trojan Horse bispecific antibody strategy for broad filovirus therapeutics

  Lai, J. R. & Chandran, K.

  7/14/17 → 6/30/21

  Project: Research project

  • Filoviridae 100%
  • Monoclonal Antibodies 33%
  • Bispecific Antibodies 27%
  • Ebolavirus 26%
  • Sudan 17%

• A Trojan Horse bispecific antibody strategy for broad filovirus therapeutics

  Chandran, K., Lai, J. R. & Chandran, K.

  National Institute of Allergy and Infectious Diseases

  7/14/17 → 6/30/22

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 82%
  • Monoclonal Antibodies 36%
  • Ebolavirus 28%
  • Sudan 19%

• Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

  Aman, J. M. & Lai, J. R.

  7/1/17 → 6/30/21

  Project: Research project

  • Ebolavirus 100%
  • Filoviridae 37%
  • Viruses 32%
  • Endosomes 27%
  • Bispecific Antibodies 23%

• Function and Mechanism of Viperin, a radical SAM antiviral protein

  Almo, S. C.

  6/26/17 → 5/31/19

  Project: Research project

  • Cytidine Triphosphate 100%
  • S-Adenosylmethionine 74%
  • Antiviral Agents 61%
  • Viruses 38%
  • Interferons 26%

• Function and Mechanism of Viperin, a radical SAM antiviral protein

  Almo, S. C., Grove, T. L. & Almo, S. C.

  National Institute of Allergy and Infectious Diseases

  6/26/17 → 5/31/19

  Project: Research project

  • Cytidine Triphosphate 100%
  • S-Adenosylmethionine 89%
  • Antiviral Agents 61%
  • Viruses 38%
  • Interferons 26%

• Engineered, multispecific antibodies as broad anti-filovirus therapeutics

  Lai, J. R.

  6/1/17 → 5/31/21

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 43%
  • Monoclonal Antibodies 43%
  • Marburgvirus 25%
  • Viruses 18%

• Engineered, multispecific antibodies as broad anti-filovirus therapeutics

  Lai, J. R. & Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  6/1/17 → 5/31/21

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 47%
  • Monoclonal Antibodies 46%
  • Antibodies 31%
  • Marburgvirus 27%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Dengue 94%
  • Serogroup 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Serogroup 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%
  • Infections 50%

• MAF1 Function and Metabolic Inefficiency

  Willis, I. M. & Willis, I. M.

  National Institute of General Medical Sciences

  9/21/16 → 7/31/21

  Project: Research project

  • Energy Metabolism 100%
  • RNA 95%
  • Transfer RNA 90%
  • RNA Polymerase III 76%
  • Untranslated RNA 62%

• MAF1 Function and Metabolic Inefficiency

  Willis, I. M.

  9/21/16 → 7/31/21

  Project: Research project

  • Energy Metabolism 100%
  • RNA 95%
  • Transfer RNA 90%
  • RNA Polymerase III 76%
  • Untranslated RNA 62%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M., Bresnick, A. R. & Backer, J. M.

  National Institute of General Medical Sciences

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 61%
  • Neoplasm Metastasis 59%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• Structural basis of allostery and mechanical properties of F-actin

  Almo, S. C.

  8/1/16 → 7/31/20

  Project: Research project

  • Actins 100%
  • Microfilament Proteins 66%
  • Protein Subunits 57%
  • Cryoelectron Microscopy 45%
  • Protein Binding 33%

• Structural basis of allostery and mechanical properties of F-actin

  Hanein, D., Almo, S. C. & Volkmann, N.

  National Institute of General Medical Sciences

  8/1/16 → 7/31/20

  Project: Research project

  • Actins 100%
  • Microfilament Proteins 73%
  • Protein Subunits 64%
  • Cryoelectron Microscopy 50%
  • Protein Binding 37%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M. & Bresnick, A. R.

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 46%
  • Neoplasm Metastasis 44%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

  Lai, J. R.

  7/5/16 → 6/30/17

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 81%
  • Epitopes 37%
  • Ebolavirus 29%
  • Antibodies 27%

• Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

  Aman, J. M. & Lai, J. R.

  7/5/16 → 6/30/17

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 81%
  • Epitopes 37%
  • Ebolavirus 29%
  • Antibodies 27%

• Protein/Structure Core

  Almo, S. C.

  National Institute of General Medical Sciences

  7/1/16 → 4/30/21

  Project: Research project

  • Proteins 100%
  • Oxygen 54%
  • Ligands 36%
  • Crystallization 30%
  • Carbohydrate Metabolism 29%

• Ligand Discovery Project

  Almo, S. C.

  National Institute of General Medical Sciences

  7/1/16 → 4/30/21

  Project: Research project

  • Carrier Proteins 100%
  • Ligands 83%
  • Metabolic Networks and Pathways 29%
  • Microbiota 29%
  • Gastrointestinal Microbiome 29%

• Novel Strategies for the Discovery of Microbial Metabolic Pathways

  Gerlt, J. A., Almo, S. C. & Jacobson, M. P.

  6/15/16 → 4/30/21

  Project: Research project

  • Solute 100%
  • Metabolic 79%
  • Ligand 74%
  • Protein 70%
  • Enzyme Activity 40%

• Novel Strategies for Precision T-cell Therapies

  Almo, S. C. & Almo, S. C.

  National Cancer Institute

  6/1/16 → 5/31/21

  Project: Research project

  • Immunological Synapses 100%
  • Cell- and Tissue-Based Therapy 76%
  • T-Lymphocytes 53%
  • Biological Products 37%
  • Peptides 18%

• Inhibitors of Maf1-dependent transcriptional repression

  Willis, I. M.

  4/1/16 → 3/31/17

  Project: Research project

  • Anti-Obesity Agents 100%
  • Transfer RNA 76%
  • Obesity 72%
  • Genes 70%
  • Peptides 66%

• Inhibitors of Maf1-dependent transcriptional repression

  Willis, I. M.

  National Institute of General Medical Sciences

  4/1/16 → 3/31/17

  Project: Research project

  • Anti-Obesity Agents 100%
  • Transfer RNA 76%
  • Obesity 72%
  • Genes 70%
  • Peptides 66%

• The dynamic mechanism of nuclear transport visualized at the atomic scale

  Cowburn, D.

  3/1/16 → 7/31/21

  Project: Research project

  • porosity 100%
  • macromolecules 86%
  • neoplasms 44%
  • nuclear magnetic resonance 43%
  • interactions 43%

• Tools for Exceptional Overexpression and Structural Stabilization of Membrane Proteins in Mammalian Cells

  Steinmetz, E. J., Gennerich, A. & Snapp, E. L.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  1/1/16 → 12/31/18

  Project: Research project

  • Crystallization 100%
  • Membrane Proteins 91%
  • Recombinant Proteins 54%
  • Technology 54%
  • Proteins 50%

• Technologies for Mapping the Extracellular Interactome

  Almo, S. C.

  9/24/15 → 6/30/19

  Project: Research project

  • Membrane Proteins 100%
  • Proteins 88%
  • Technology 78%
  • Automation 74%
  • Proteome 62%