Biochemistry

Projects

Projects per year 1979 2022

• 19 Active
• 183 Finished

Projects per year

Search results

• Active

  Regulation of Histone Chaperone Function by Glutamylation

  Shechter, D.

  1/1/21 → 12/31/21

  Project: Research project

  • Histones 100%
  • Histone Chaperones 94%
  • Chromatin Assembly and Disassembly 26%
  • Nucleoplasmins 13%
  • Chromatin 13%

• Allosteric inhibitors targeting oncogenic BRAF V600E dimers

  Gavathiotis, E.

  12/1/20 → 11/30/21

  Project: Research project

  • ponatinib 100%
  • Thyroid Neoplasms 48%
  • Melanoma 40%
  • Colorectal Neoplasms 38%
  • Dimerization 27%

• Regulation of Histone Chaperone Function by Glutamylation

  Shechter, D.

  National Institute of General Medical Sciences

  1/1/20 → 12/31/21

  Project: Research project

  • Histone Chaperones 100%
  • Histones 76%
  • Chromatin Assembly and Disassembly 20%
  • Nucleoplasmins 10%
  • Chromatin 10%

• Allosteric inhibitors targeting oncogenic BRAF V600E dimers

  Gavathiotis, E.

  National Cancer Institute

  12/1/19 → 11/30/21

  Project: Research project

  • ponatinib 100%
  • Thyroid Neoplasms 48%
  • Melanoma 40%
  • Colorectal Neoplasms 38%
  • Dimerization 27%

• How MeCP2 discriminates epigenetic marks is still a mystery

  Brenowitz, M. D.

  National Institute of General Medical Sciences

  7/1/18 → 6/30/22

  Project: Research project

  • Chromatin 100%
  • Epigenomics 90%
  • Nucleotides 60%
  • Methyl-CpG-Binding Protein 2 57%
  • Rett Syndrome 51%

• How MeCP2 discriminates epigenetic marks is still a mystery

  Brenowitz, M. D.

  7/1/18 → 6/30/22

  Project: Research project

  • Chromatin 100%
  • Epigenomics 65%
  • Nucleotides 60%
  • Methyl-CpG-Binding Protein 2 57%
  • Rett Syndrome 51%

• Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction

  Charron, M. J., Fuloria, M. & Fuloria, M.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  3/1/18 → 2/28/22

  Project: Research project

  • Pediatric Obesity 100%
  • Fetal Growth Retardation 95%
  • T-Lymphocytes 65%
  • DNA Methylation 62%
  • Growth 37%

• Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction

  Fuloria, M., Charron, M. J. & Fuloria, M.

  3/1/18 → 2/28/22

  Project: Research project

  • T-Lymphocytes 100%
  • DNA Methylation 95%
  • Pediatric Obesity 69%
  • Growth 57%
  • Obesity 45%

• PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE

  Schramm, V. L. & Schramm, V. L.

  National Institute of Allergy and Infectious Diseases

  9/25/17 → 8/31/21

  Project: Research project

  • Purine 100%
  • Hypoxanthine 21%
  • Parasitic 21%
  • Nucleotide 14%
  • Transition State 14%

• Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis

  Cuervo, A. M. & Gavathiotis, E.

  National Institute of Diabetes and Digestive and Kidney Diseases

  8/9/17 → 5/31/22

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Cystinosis 92%
  • Lysosomal Storage Diseases 63%
  • Cystine 33%
  • Cysteamine 12%

• Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis

  Gavathiotis, E. & Cuervo, A. M.

  8/9/17 → 5/31/22

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Cystinosis 92%
  • Cystine 33%
  • Cysteamine 12%
  • Kidney 6%

• PRMT5-MEP50 Histone Arginine Methylation in Early Development

  Shechter, D.

  National Institute of General Medical Sciences

  9/1/14 → 8/31/21

  Project: Research project

  • histones 100%
  • methylation 90%
  • early development 80%
  • arginine 75%
  • protein arginine methyltransferases 24%

• Small Molecule Activators of Pro-apoptotic BAX for Cancer Therapy

  Gavathiotis, E.

  7/1/14 → 5/31/22

  Project: Research project

  • Antiapoptotic 100%
  • Protein 96%
  • Resistance 58%
  • Venetoclax 50%
  • Cellular Property 38%

• Small Molecule Activators of Pro-apoptotic BAX for Cancer Therapy

  Gavathiotis, E. & Rose, S. A.

  National Cancer Institute

  7/1/14 → 5/31/22

  Project: Research project

  • Cell Death 100%
  • Apoptotic 71%
  • Antiapoptotic 64%
  • Molecule 41%
  • Pharmacological Property 23%

• Functional Consequences of Impaired Autophagy in Aging

  Santambrogio, L., Macian-Juan, F., Cuervo, A. M., Cuervo, A. M., Singh, R., Rose, S. A., Gavathiotis, E. & Bravo Cordero, J. J.

  National Institute on Aging

  2/15/09 → 3/31/22

  Project: Research project

  • Autophagy 100%
  • autophagy 71%
  • Antigen Presentation 28%
  • Pharmaceutical Chemistry 27%
  • Microautophagy 23%

• Autophagy in aging: testing geroscience in Alzheimer's disease

  Cuervo, A. M., Bravo Cordero, J. J., Macian-Juan, F., Gavathiotis, E., Santambrogio, L., Singh, R. & Cuervo, A. M.

  2/15/09 → 3/31/22

  Project: Research project

  • Autophagy 100%
  • Proteostasis 67%
  • Lymph 22%
  • Immune System 16%
  • Pharmaceutical Chemistry 14%

• PROLINE RICH MOTIFS IN HIV NEF BINDING

  Xu, R.

  National Institutes of Health

  1/1/97 → …

  Project: Research project

  • src Homology Domains 100%
  • Proline 87%
  • Human Immunodeficiency Virus nef Gene Products 75%
  • nef Gene Products 65%
  • HIV 57%

• FUNCTIONAL ANALYSIS OF ADIPOCYTE GLUCOSE TRANSPORTERS

  Charron, M. J.

  12/31/89 → …

  Project: Research project

• STRUCTURE OF THE DCCD BINDING SUBUNIT OF THE H+-ATPASE

  Girvin, M. E.

  8/15/87 → …

  Project: Research project

• Finished

  Novel Strategies for the Discovery of Microbial Metabolic Pathways

  Almo, S. C.

  5/1/20 → 4/30/21

  Project: Research project

  • Solute 100%
  • Metabolic 79%
  • Ligand 74%
  • Protein 70%
  • Enzyme Activity 40%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D. & Willis, I. M.

  3/1/19 → 2/29/20

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D. & Willis, I. M.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  3/1/19 → 2/28/21

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE

  Schramm, V. L. & Schramm, V. L.

  9/25/17 → 8/31/20

  Project: Research project

  • Purine 100%
  • Hypoxanthine 20%
  • Parasitic 20%
  • Nucleotide 13%
  • Transition State 13%

• A Trojan Horse bispecific antibody strategy for broad filovirus therapeutics

  Chandran, K. & Lai, J. R.

  7/14/17 → 6/30/20

  Project: Research project

  • Filoviridae 100%
  • Monoclonal Antibodies 33%
  • Bispecific Antibodies 27%
  • Ebolavirus 26%
  • Sudan 17%

• A Trojan Horse bispecific antibody strategy for broad filovirus therapeutics

  Lai, J. R. & Chandran, K.

  National Institute of Allergy and Infectious Diseases

  7/14/17 → 6/30/21

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 78%
  • Monoclonal Antibodies 36%
  • Ebolavirus 28%
  • Sudan 18%

• Function and Mechanism of Viperin, a radical SAM antiviral protein

  Almo, S. C.

  6/26/17 → 5/31/19

  Project: Research project

  • Cytidine Triphosphate 100%
  • S-Adenosylmethionine 74%
  • Antiviral Agents 61%
  • Viruses 38%
  • Interferons 26%

• Engineered, multispecific antibodies as broad anti-filovirus therapeutics

  Lai, J. R.

  6/1/17 → 5/31/20

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 43%
  • Monoclonal Antibodies 43%
  • Marburgvirus 25%
  • Viruses 18%

• Engineered, multispecific antibodies as broad anti-filovirus therapeutics

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  6/1/17 → 5/31/21

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 47%
  • Monoclonal Antibodies 46%
  • Antibodies 30%
  • Marburgvirus 27%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Serogroup 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%
  • Infections 50%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Dengue 94%
  • Serogroup 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%

• MAF1 Function and Metabolic Inefficiency

  Willis, I. M.

  National Institute of General Medical Sciences

  9/21/16 → 7/31/21

  Project: Research project

  • Energy Metabolism 100%
  • RNA 95%
  • Transfer RNA 90%
  • RNA Polymerase III 76%
  • Untranslated RNA 62%

• MAF1 Function and Metabolic Inefficiency

  Willis, I. M.

  9/21/16 → 7/31/21

  Project: Research project

  • Energy Metabolism 100%
  • RNA 95%
  • Transfer RNA 90%
  • RNA Polymerase III 76%
  • Untranslated RNA 62%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M. & Bresnick, A. R.

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 46%
  • Neoplasm Metastasis 44%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• Structural basis of allostery and mechanical properties of F-actin

  Almo, S. C.

  8/1/16 → 7/31/20

  Project: Research project

  • Actins 100%
  • Microfilament Proteins 66%
  • Protein Subunits 57%
  • Cryoelectron Microscopy 45%
  • Protein Binding 33%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M. & Bresnick, A. R.

  National Institute of General Medical Sciences

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 61%
  • Neoplasm Metastasis 59%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

  Lai, J. R.

  7/5/16 → 6/30/17

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 81%
  • Epitopes 37%
  • Ebolavirus 29%
  • Antibodies 27%

• Inhibitors of Maf1-dependent transcriptional repression

  Willis, I. M.

  National Institute of General Medical Sciences

  4/1/16 → 3/31/17

  Project: Research project

  • Anti-Obesity Agents 100%
  • Transfer RNA 76%
  • Obesity 72%
  • Genes 70%
  • Peptides 66%

• Inhibitors of Maf1-dependent transcriptional repression

  Willis, I. M.

  4/1/16 → 3/31/17

  Project: Research project

  • Anti-Obesity Agents 100%
  • Transfer RNA 76%
  • Obesity 72%
  • Genes 70%
  • Peptides 66%

• The dynamic mechanism of nuclear transport visualized at the atomic scale

  Cowburn, D.

  3/1/16 → 7/31/21

  Project: Research project

  • porosity 100%
  • macromolecules 86%
  • neoplasms 44%
  • nuclear magnetic resonance 43%
  • interactions 43%

• Technologies for Mapping the Extracellular Interactome

  Almo, S. C.

  9/24/15 → 6/30/19

  Project: Research project

  • Membrane Proteins 100%
  • Proteins 88%
  • Technology 78%
  • Automation 74%
  • Proteome 62%

• Chemoenzymatic methods for the detection of cell-surface glycans

  Wu, P.

  National Institutes of Health

  8/15/15 → 7/31/19

  Project: Research project

  • Polysaccharides 100%
  • Glycosylation 49%
  • Lectins 17%
  • Glycomics 12%
  • Lung Neoplasms 11%

• 2015 Nucleosides, Nucleotides & Oligonucleotides Gordon Research Conference and Seminar

  Schramm, V. L.

  5/18/15 → 9/30/15

  Project: Research project

  • Nucleosides 100%
  • Oligonucleotides 98%
  • Congresses 93%
  • Nucleotides 76%
  • Synthetic Biology 43%

• Chemical tools for studying membrane protein glycosylation

  Ovryn, B. & Wu, P.

  National Institutes of Health

  4/15/15 → 3/31/19

  Project: Research project

  • Glycosylation 100%
  • Membrane Proteins 73%
  • Polysaccharides 60%
  • Glycoproteins 37%
  • Neoplasms 28%

• An integrated X-ray data collection system

  Almo, S. C.

  4/1/15 → 3/31/16

  Project: Research project

  • biology 100%
  • medicine 53%
  • biochemistry 17%
  • immunity 16%
  • physiology 15%

• Regulation of the Class IA PI 3-kinase PIK3CB

  Bresnick, A. R., Backer, J. M. & Bresnick, A. R.

  National Institute of General Medical Sciences

  9/5/14 → 7/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • G-Protein-Coupled Receptors 38%
  • Neoplasms 19%
  • Growth 19%
  • Neoplasm Metastasis 14%

• Regulation of the Class IA PI 3-kinase PIK3CB

  Backer, J. M. & Bresnick, A. R.

  9/5/14 → 7/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • G-Protein-Coupled Receptors 36%
  • Neoplasms 18%
  • Growth 18%
  • Neoplasm Metastasis 13%

• Crosstalk to Histone Arginine Methylation

  Shechter, D.

  9/1/14 → 8/31/20

  Project: Research project

  • Post Translational Protein Processing 100%
  • Histones 99%
  • Chromatin 62%
  • Acetylation 37%
  • Arginine 32%

• Console and probe upgrade for 600 MHz NMR

  Cowburn, D. & Rose, S. A.

  7/1/14 → 6/30/15

  Project: Research project

  • structural biology 100%
  • probes (equipment) 65%
  • therapeutics 52%
  • neoplasms 51%
  • multiprotein complexes 48%

• Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers

  Lai, J. R., Chandran, K., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  3/15/14 → 6/28/19

  Project: Research project

  • Antibodies 100%
  • Arenavirus 87%
  • Filoviridae 85%
  • Viral Hemorrhagic Fevers 43%
  • Monoclonal Antibodies 30%

• Orally available transition state inhibitors for triple negative breast cancer

  Isaacman, S., Schramm, V. L., Rose, S. A. & Rose, S. A.

  1/1/14 → 6/30/16

  Project: Research project

  • 5'-methylthioadenosine phosphorylase 100%
  • Triple Negative Breast Neoplasms 85%
  • 5'-methylthioadenosine 25%
  • National Institutes of Health (U.S.) 14%
  • Neoplasms 13%