Biochemistry

Projects

Projects per year 1979 1989 1997 2008 2009 2010 2014 2016 2017 2023

• 24 Active
• 200 Finished

Projects per year

Search results

• Active

  Structure-based design of broad flavivirus immunogens

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  9/24/21 → 8/31/22

  Project: Research project

  • Epitopes 100%
  • Flavivirus 91%
  • Zika Virus 82%
  • Serogroup 40%
  • Antibody-Dependent Enhancement 29%

• A whole body model of Pol III-related leukodystrophy

  Moir, R. D. & Willis, I. M.

  National Institute of Neurological Disorders and Stroke

  8/1/21 → 1/31/23

  Project: Research project

  • Phenotype 100%
  • Anodontia 81%
  • Genetic Suppression 77%
  • RNA Polymerase III 76%
  • Myopia 61%

• Eliciting and isolating neutralizing antibodies against Powassan virus

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  8/1/21 → 7/31/22

  Project: Research project

  • Tick-Borne Encephalitis Viruses 100%
  • Neutralizing Antibodies 43%
  • Nanoparticles 26%
  • Flavivirus 23%
  • Vaccines 18%

• Orbitrap Exploris 480 Basic System

  Sidoli, S.

  NIH Office of the Director

  5/15/21 → 5/14/22

  Project: Research project

  • Proteomics 100%
  • Microsporidia 20%
  • Research Personnel 18%
  • Myelodysplastic Syndromes 15%
  • Toxoplasma 15%

• Regulation of Histone Chaperone Function by Glutamylation

  Shechter, D.

  National Institute of General Medical Sciences

  1/1/20 → 12/31/22

  Project: Research project

  • Histone Chaperones 100%
  • Histones 40%
  • Genome 23%
  • Epigenomics 18%
  • Chromatin Assembly and Disassembly 10%

• Allosteric inhibitors targeting oncogenic BRAF V600E dimers

  Gavathiotis, E.

  National Cancer Institute

  12/1/19 → 11/30/22

  Project: Research project

  • ponatinib 100%
  • Melanoma 63%
  • Thyroid Neoplasms 48%
  • Colorectal Neoplasms 38%
  • Neoplasms 31%

• How MeCP2 discriminates epigenetic marks is still a mystery

  Brenowitz, M. D.

  National Institute of General Medical Sciences

  7/1/18 → 6/30/22

  Project: Research project

  • Chromatin 100%
  • Epigenomics 93%
  • Nucleotides 60%
  • Methyl-CpG-Binding Protein 2 57%
  • Rett Syndrome 51%

• How MeCP2 discriminates epigenetic marks is still a mystery

  Brenowitz, M. D.

  7/1/18 → 6/30/22

  Project: Research project

  • Chromatin 100%
  • Epigenomics 65%
  • Nucleotides 60%
  • Methyl-CpG-Binding Protein 2 57%
  • Rett Syndrome 51%

• Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction

  Charron, M. J. & Fuloria, M.

  National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development

  3/1/18 → 2/28/23

  Project: Research project

  • Pediatric Obesity 100%
  • Fetal Growth Retardation 95%
  • T-Lymphocytes 57%
  • DNA Methylation 54%
  • Obesity 41%

• Structural, functional, and mechanistic anlaysis of autoreactive CD8 T cells

  Almo, S. C. & DiLorenzo, T. P.

  National Institute of Allergy and Infectious Diseases

  2/8/18 → 1/31/23

  Project: Research project

  • T-Lymphocytes 100%
  • Alleles 56%
  • T-Cell Antigen Receptor 39%
  • Type 1 Diabetes Mellitus 38%
  • Peptides 37%

• PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE

  Meek, T., Schramm, V. L. & Tyler, P.

  National Institute of Allergy and Infectious Diseases

  9/25/17 → 8/31/22

  Project: Research project

  • Purine 100%
  • Hypoxanthine 22%
  • Parasitic 21%
  • Nucleotide 14%
  • Transition State 14%

• Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis

  Cuervo, A. M. & Gavathiotis, E.

  8/9/17 → 5/31/22

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Cystinosis 92%
  • Cystine 33%
  • Cysteamine 12%
  • Kidney 6%

• Molecular and Cellular Mechanisms of the Lysosomal Storage Disease Cystinosis

  Catz, S. D., Cherqui, S., Cuervo, A. M. & Gavathiotis, E.

  National Institute of Diabetes and Digestive and Kidney Diseases

  8/9/17 → 5/31/22

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Cystinosis 92%
  • Lysosomal Storage Diseases 66%
  • Cystine 33%
  • Cysteamine 12%

• A "Trojan Horse" bispecific antibody strategy for broad filovirus therapeutics

  Chandran, K. & Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  7/14/17 → 6/30/22

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 82%
  • Monoclonal Antibodies 34%
  • Ebolavirus 30%
  • Sudan 16%

• The dynamic mechanism of nuclear transport visualized at the atomic scale

  Cowburn, D. & Rout, M.

  National Institute of General Medical Sciences

  3/1/16 → 7/31/22

  Project: Research project

  • porosity 100%
  • macromolecules 81%
  • Cell Nucleus Active Transport 47%
  • interactions 41%
  • Cell Nucleus 41%

• Crosstalk to Histone Arginine Methylation

  Shechter, D.

  National Institute of General Medical Sciences

  9/1/14 → 8/31/22

  Project: Research project

  • histones 100%
  • methylation 97%
  • early development 95%
  • arginine 89%
  • Post Translational Protein Processing 38%

• Small Molecule Activators of Pro-apoptotic BAX for Cancer Therapy

  Gavathiotis, E. & Rose, S. A.

  7/1/14 → 5/31/22

  Project: Research project

  • Cell Death 100%
  • Apoptotic 80%
  • Antiapoptotic 66%
  • Molecule 48%
  • Pharmacological Property 27%

• Small Molecule Activators of Pro-apoptotic BAX for Cancer Therapy

  Gavathiotis, E.

  National Cancer Institute

  7/1/14 → 5/31/22

  Project: Research project

  • Cell Death 100%
  • Antiapoptotic 83%
  • Apoptotic 66%
  • Molecule 51%
  • Protein 32%

• Autophagy in aging: testing geroscience in Alzheimer's disease

  Cuervo, A. M., Bravo Cordero, J. J., Macian-Juan, F., Gavathiotis, E., Santambrogio, L. & Singh, R.

  National Institute on Aging

  2/15/09 → 3/31/23

  Project: Research project

  • Autophagy 100%
  • Proteostasis 53%
  • autophagy 45%
  • Pharmaceutical Chemistry 23%
  • Alzheimer Disease 19%

• PROLINE RICH MOTIFS IN HIV NEF BINDING

  Xu, R.

  National Institutes of Health

  1/1/97 → …

  Project: Research project

  • src Homology Domains 100%
  • Proline 87%
  • Human Immunodeficiency Virus nef Gene Products 75%
  • nef Gene Products 65%
  • HIV 57%

• Transition State Analysis of Enzymatic Reactions

  Schramm, V. L.

  National Institute of General Medical Sciences

  8/1/90 → 7/31/22

  Project: Research project

  • Enzymatic Reaction 100%
  • Transition State 84%
  • Transition State Structure 53%
  • Purine Nucleoside 29%
  • Purine 17%

• Administrative Supplements to Existing NIH Grants and Cooperative Agreements (Parent Admin Supp Clinical Trial Optional)

  Almo, S. C., Goel, S., Goldman, I. D., Chu, E., Goldman, I. D., Scharff, M. D., Eagle, H., Seither, R., Bresnick, A. R., Condeelis, J. S., Herbst, L. H., Xue, X. N., Stein, D. T., Blanchard, J. S., Rohan, T. E., Porcelli, S. A., Edelmann, W., Morrow, B. E., Beck, A. P., Montagna, C., Steidl, U. G., Schramm, V. L., Strickler, H., Augenlicht, L. H., Rapkin, B. D. & Sparano, J. A.

  National Cancer Institute

  12/31/89 → 6/30/22

  Project: Research project

  • neoplasms 100%
  • research programs 67%
  • Neoplasms 49%
  • biological hazards 36%
  • Organized Financing 29%

• FUNCTIONAL ANALYSIS OF ADIPOCYTE GLUCOSE TRANSPORTERS

  Charron, M. J.

  12/31/89 → …

  Project: Research project

• STRUCTURE OF THE DCCD BINDING SUBUNIT OF THE H+-ATPASE

  Girvin, M. E.

  8/15/87 → …

  Project: Research project

• Finished

  Targeting Clostridioides difficile with microbiome-sparing, resistant-proof anti-toxins

  Schramm, V. L.

  National Institute of Allergy and Infectious Diseases

  4/1/21 → 3/31/22

  Project: Research project

  • Microbiota 100%
  • Gastrointestinal Microbiome 88%
  • Infections 85%
  • Anti-Bacterial Agents 73%
  • Microbial Drug Resistance 67%

• Novel Strategies for the Discovery of Microbial Metabolic Pathways

  Almo, S. C.

  5/1/20 → 4/30/21

  Project: Research project

  • Solute 100%
  • Metabolic 79%
  • Ligand 74%
  • Protein 70%
  • Enzyme Activity 40%

• Regulation of Histone Chaperone Function by Glutamylation

  Shechter, D.

  1/1/20 → 12/31/21

  Project: Research project

  • Histones 100%
  • Histone Chaperones 94%
  • Chromatin Assembly and Disassembly 26%
  • Nucleoplasmins 13%
  • Chromatin 13%

• Allosteric inhibitors targeting oncogenic BRAF V600E dimers

  Gavathiotis, E.

  12/1/19 → 11/30/21

  Project: Research project

  • ponatinib 100%
  • Thyroid Neoplasms 48%
  • Melanoma 40%
  • Colorectal Neoplasms 38%
  • Dimerization 27%

• Novel Biologics Designed to Mobilize HIV-specific CTL for Sustained HIV Remission

  Almo, S. C. & Goldstein, H.

  National Institute of Allergy and Infectious Diseases

  4/5/19 → 3/31/22

  Project: Research project

  • Biological Products 100%
  • HIV 81%
  • T-Lymphocytes 58%
  • Cytokines 29%
  • Viremia 21%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D. & Willis, I. M.

  3/1/19 → 2/28/21

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D. & Willis, I. M.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  3/1/19 → 2/28/21

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• An immunotherapeutic strategy for the induction and stabilization of remission in type 1 diabetes

  Almo, S. C. & DiLorenzo, T. P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/15/18 → 7/31/21

  Project: Research project

  • Remission Induction 100%
  • Type 1 Diabetes Mellitus 70%
  • T-Lymphocytes 57%
  • Antigens 29%
  • Immunological Synapses 27%

• Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction

  Charron, M. J., Fuloria, M. & Fuloria, M.

  3/1/18 → 2/28/22

  Project: Research project

  • T-Lymphocytes 100%
  • DNA Methylation 95%
  • Pediatric Obesity 69%
  • Growth 57%
  • Obesity 45%

• PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE

  Schramm, V. L. & Schramm, V. L.

  9/25/17 → 8/31/21

  Project: Research project

  • Purine 100%
  • Hypoxanthine 20%
  • Parasitic 20%
  • Nucleotide 13%
  • Transition State 13%

• A Trojan Horse bispecific antibody strategy for broad filovirus therapeutics

  Lai, J. R. & Chandran, K.

  7/14/17 → 6/30/21

  Project: Research project

  • Filoviridae 100%
  • Monoclonal Antibodies 33%
  • Bispecific Antibodies 27%
  • Ebolavirus 26%
  • Sudan 17%

• Function and Mechanism of Viperin, a radical SAM antiviral protein

  Almo, S. C.

  6/26/17 → 5/31/19

  Project: Research project

  • Cytidine Triphosphate 100%
  • S-Adenosylmethionine 74%
  • Antiviral Agents 61%
  • Viruses 38%
  • Interferons 26%

• Function and Mechanism of Viperin, a radical SAM antiviral protein

  Almo, S. C. & Grove, T. L.

  National Institute of Allergy and Infectious Diseases

  6/26/17 → 5/31/19

  Project: Research project

  • Cytidine Triphosphate 100%
  • S-Adenosylmethionine 89%
  • Antiviral Agents 61%
  • Viruses 38%
  • Interferons 26%

• Engineered, multispecific antibodies as broad anti-filovirus therapeutics

  Lai, J. R.

  6/1/17 → 5/31/21

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 43%
  • Monoclonal Antibodies 43%
  • Marburgvirus 25%
  • Viruses 18%

• Engineered, multispecific antibodies as broad anti-filovirus therapeutics

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  6/1/17 → 5/31/21

  Project: Research project

  • Filoviridae 100%
  • Ebolavirus 47%
  • Monoclonal Antibodies 46%
  • Antibodies 31%
  • Marburgvirus 27%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Dengue 94%
  • Serogroup 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%

• Engineered Dengue EDIIIs as Broad Immunogens

  Lai, J. R.

  1/1/17 → 12/31/18

  Project: Research project

  • Broadly Neutralizing Antibodies 100%
  • Serogroup 80%
  • Subunit Vaccines 64%
  • Glycoproteins 60%
  • Infections 50%

• MAF1 Function and Metabolic Inefficiency

  Willis, I. M.

  National Institute of General Medical Sciences

  9/21/16 → 7/31/21

  Project: Research project

  • Energy Metabolism 100%
  • RNA 95%
  • Transfer RNA 90%
  • RNA Polymerase III 76%
  • Untranslated RNA 62%

• MAF1 Function and Metabolic Inefficiency

  Willis, I. M.

  9/21/16 → 7/31/21

  Project: Research project

  • Energy Metabolism 100%
  • RNA 95%
  • Transfer RNA 90%
  • RNA Polymerase III 76%
  • Untranslated RNA 62%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M. & Bresnick, A. R.

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 46%
  • Neoplasm Metastasis 44%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• The Role of PI3Kbeta in Breast Cancer Metastasis

  Backer, J. M. & Bresnick, A. R.

  National Institute of General Medical Sciences

  8/1/16 → 7/31/21

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • Breast Neoplasms 61%
  • Neoplasm Metastasis 59%
  • G-Protein-Coupled Receptors 43%
  • Podosomes 43%

• Structural basis of allostery and mechanical properties of F-actin

  Almo, S. C.

  8/1/16 → 7/31/20

  Project: Research project

  • Actins 100%
  • Microfilament Proteins 66%
  • Protein Subunits 57%
  • Cryoelectron Microscopy 45%
  • Protein Binding 33%

• Structural basis of allostery and mechanical properties of F-actin

  Almo, S. C., Hanein, D. & Volkmann, N.

  National Institute of General Medical Sciences

  8/1/16 → 7/31/20

  Project: Research project

  • Actins 100%
  • Microfilament Proteins 71%
  • Protein Subunits 62%
  • Cryoelectron Microscopy 49%
  • Protein Binding 36%

• Broadly Protective Bispecific Antibodies for Treatment of Ebola Virus Disease

  Lai, J. R.

  7/5/16 → 6/30/17

  Project: Research project

  • Filoviridae 100%
  • Bispecific Antibodies 81%
  • Epitopes 37%
  • Ebolavirus 29%
  • Antibodies 27%

• Novel Strategies for the Discovery of Microbial Metabolic Pathways

  Gerlt, J., Almo, S. C. & Jacobson, M.

  National Institute of General Medical Sciences

  6/15/16 → 4/30/21

  Project: Research project

  • Carrier Proteins 100%
  • Ligands 90%
  • Solute 62%
  • Metabolic 49%
  • Ligand 46%

• Novel Strategies for Precision T-cell Therapies

  Almo, S. C.

  National Cancer Institute

  6/1/16 → 5/31/21

  Project: Research project

  • Immunological Synapses 100%
  • Cell- and Tissue-Based Therapy 76%
  • T-Lymphocytes 53%
  • Biological Products 37%
  • Peptides 18%