Biochemistry

Projects

Projects per year 1979 1989 1997 2008 2009 2010 2014 2016 2017 2023

• 15 Active
• 210 Finished

Projects per year

Search results

• Finished

  Orally available transition state inhibitors for triple negative breast cancer

  Isaacman, S. & Schramm, V. L.

  National Cancer Institute

  7/1/14 → 6/30/16

  Project: Research project

  • Triple Negative Breast Neoplasms 100%
  • 5'-methylthioadenosine phosphorylase 83%
  • Breast Neoplasms 30%
  • Neoplasms 26%
  • 5'-methylthioadenosine 20%

• Console and probe upgrade for 600 MHz NMR

  Cowburn, D.

  NIH Office of the Director

  7/1/14 → 6/30/15

  Project: Research project

  • structural biology 100%
  • probes (equipment) 98%
  • therapeutics 52%
  • neoplasms 51%
  • multiprotein complexes 48%

• Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers

  Lai, J. R., Chandran, K., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  3/15/14 → 6/28/19

  Project: Research project

  • Antibodies 100%
  • Arenavirus 87%
  • Filoviridae 85%
  • Viral Hemorrhagic Fevers 43%
  • Monoclonal Antibodies 30%

• Orally available transition state inhibitors for triple negative breast cancer

  Isaacman, S., Schramm, V. L., Rose, S. A. & Rose, S. A.

  1/1/14 → 6/30/16

  Project: Research project

  • 5'-methylthioadenosine phosphorylase 100%
  • Triple Negative Breast Neoplasms 85%
  • 5'-methylthioadenosine 25%
  • National Institutes of Health (U.S.) 14%
  • Neoplasms 13%

• Lectimers: Glycan-anchored scaffold libraries for targeting carbohydrate-binding

  Levy, M.

  9/20/13 → 8/31/17

  Project: Research project

  • Nucleic Acid 100%
  • Carbohydrate 65%
  • Protein 65%
  • Ligand 34%
  • Peptide 22%

• Lectimers: Glycan-anchored scaffold libraries for targeting carbohydrate-binding

  Levy, M. & Levy, M.

  National Cancer Institute

  9/20/13 → 8/31/17

  Project: Research project

  • Nucleic Acid 100%
  • Carbohydrate 65%
  • Protein 65%
  • Ligand 34%
  • Peptide 22%

• Dissecting the roles of protein O-GlcNAcylation in Toxoplasma gondii

  Wu, P. & Kim, K.

  8/12/13 → 7/31/15

  Project: Research project

  • Toxoplasma gondii 100%
  • tachyzoites 68%
  • bradyzoites 56%
  • transferases 37%
  • life cycle (organisms) 31%

• Dissecting the roles of protein O-GlcNAcylation in Toxoplasma gondii

  Kim, K. & Wu, P.

  National Institute of Allergy and Infectious Diseases

  8/12/13 → 7/31/15

  Project: Research project

  • Toxoplasma gondii 100%
  • tachyzoites 75%
  • bradyzoites 63%
  • transferases 41%
  • life cycle (organisms) 35%

• Targeting CNS HIV reservoirs across the blood-brain barrier

  Levy, M., Prasad, V. R., Rose, S. A. & Rose, S. A.

  4/25/13 → 3/31/15

  Project: Research project

  • Blood-Brain Barrier 100%
  • HIV 35%
  • HIV-1 29%
  • Viral Proteins 27%
  • Nervous System Diseases 16%

• Targeting CNS HIV reservoirs across the blood-brain barrier

  Levy, M. & Prasad, V. R.

  NATIONAL INSTITUTE OF MENTAL HEALTH, National Institute of Mental Health

  4/25/13 → 3/31/15

  Project: Research project

  • Blood-Brain Barrier 100%
  • HIV 59%
  • HIV-1 31%
  • Viral Proteins 29%
  • Nervous System Diseases 17%

• Fluorescent probes for quantitation of secretory protein levels in single cells

  Snapp, E. L. & Levy, M.

  9/24/12 → 8/31/15

  Project: Research project

  • Proteins 100%
  • Technology 71%
  • Secretory Pathway 63%
  • Fluorescent Dyes 57%
  • Bacterial Toxins 37%

• Fluorescent probes for quantitation of secretory protein levels in single cells

  Levy, M. & Snapp, E. L.

  National Cancer Institute

  9/24/12 → 8/31/13

  Project: Research project

  • Fluorescent Dyes 100%
  • Proteins 46%
  • Technology 34%
  • Secretory Pathway 24%
  • Bacterial Toxins 21%

• Targeting BAX Oligomerization in Hematologic Disease

  Gavathiotis, E.

  National Heart, Lung, and Blood Institute

  9/14/11 → 7/31/13

  Project: Research project

  • Hematologic Diseases 100%
  • Hematology 61%
  • Apoptosis 58%
  • Cell Death 57%
  • alpha-Helical Protein Conformation 44%

• Targeting Cancer Cells with Functionalized Nanoparticle Libraries

  Levy, M.

  8/12/11 → 7/31/14

  Project: Research project

  • systematic evolution of ligands by exponential enrichment 100%
  • nanoparticles 88%
  • neoplasm cells 55%
  • neoplasms 46%
  • engineering 27%

• Targeting Cancer Cells with Functionalized Nanoparticle Libraries

  Levy, M.

  National Cancer Institute

  8/12/11 → 7/31/13

  Project: Research project

  • systematic evolution of ligands by exponential enrichment 100%
  • nanoparticles 71%
  • neoplasm cells 55%
  • neoplasms 46%
  • methodology 16%

• Methods to Identify High-Affinity Antibodies that Target Tumor-Associated Glycans

  Lai, J. R., Rose, S. A. & Rose, S. A.

  7/1/11 → 6/30/14

  Project: Research project

  • Polysaccharides 100%
  • Antibodies 54%
  • Antibody Affinity 30%
  • Bacteriophages 24%
  • Neoplasms 21%

• Methods to Identify High-Affinity Antibodies that Target Tumor-Associated Glycans

  Lai, J. R.

  National Cancer Institute

  7/1/11 → 6/30/13

  Project: Research project

  • Neoplasm Antibodies 100%
  • Antibody Affinity 96%
  • Polysaccharides 88%
  • Antibodies 46%
  • Bacteriophages 28%

• Chemical tools for studying fucosylated glycans

  Wu, P.

  National Institutes of Health

  9/15/10 → 7/31/20

  Project: Research project

  • Fucoside 100%
  • Microarrays 22%
  • Lipid 13%
  • Guanidine 11%
  • Bilayer Membrane 11%

• In vivo imaging of X inactivation

  Greally, J. M., Levy, M. & Greally, J. M.

  National Institute on Drug Abuse

  9/15/10 → 5/31/16

  Project: Research project

  • inactivation 100%
  • image analysis 90%
  • epigenetics 55%
  • X chromosome 39%
  • histone code 28%

• In vivo imaging of X inactivation

  Greally, J. M., Levy, M., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  9/15/10 → 5/31/16

  Project: Research project

  • inactivation 100%
  • X chromosome 51%
  • image analysis 35%
  • epigenetics 35%
  • cells 27%

• Chemical tools for studying fucosylated glycans

  Wu, P. & Wu, P.

  National Institute of General Medical Sciences

  9/15/10 → 7/31/21

  Project: Research project

  • Fucoside 100%
  • Microarrays 22%
  • Lipid 13%
  • Guanidine 11%
  • Bilayer Membrane 11%

• The NYSGRC: A Large Scale Center for PSI:Biology

  Seidel, R. D., Fiser, A., Almo, S. C., Almo, S. C., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  9/1/10 → 6/30/16

  Project: Research project

  • Immune Evasion 100%
  • Fungal Proteins 99%
  • Bacterial Proteins 96%
  • Health 77%
  • Cell Biology 68%

• The NYSGRC: A Large Scale Center for PSI:Biology

  Almo, S. C. & Fiser, A.

  National Institute of General Medical Sciences

  9/1/10 → 6/30/16

  Project: Research project

  • Immune Evasion 100%
  • Fungal Proteins 99%
  • Bacterial Proteins 96%
  • Cell Biology 68%
  • Organizations 66%

• Targeting BAX Oligomerization in Hematologic Disease

  Gavathiotis, E.

  8/9/10 → 7/31/14

  Project: Research project

  • Apoptosis 100%
  • Hematologic Diseases 84%
  • Cell Death 69%
  • Hematology 58%
  • alpha-Helical Protein Conformation 42%

• Targeting Viral Envelope Glycoproteins with Synthetic Antibodies

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  7/1/10 → 6/30/15

  Project: Research project

  • Glycoproteins 100%
  • Antibodies 76%
  • Ebolavirus 23%
  • HIV-1 22%
  • Virus Internalization 21%

• Targeting Viral Envelope Glycoproteins with Synthetic Antibodies

  Lai, J. R., Rose, S. A. & Rose, S. A.

  7/1/10 → 6/30/15

  Project: Research project

  • Antibodies 100%
  • Viral Antibodies 29%
  • Ebolavirus 27%
  • HIV-1 26%
  • Virus Internalization 24%

• Metabolomic Analysis of Redox control in Mycobacterium tuberculosis persisters

  Jacobs Jr., W. R., Kurland, I. J. & Wu, P.

  National Institute of Allergy and Infectious Diseases

  6/1/10 → 1/31/13

  Project: Research project

  • Mycobacterium tuberculosis 100%
  • Metabolomics 78%
  • Oxidation-Reduction 71%
  • Extensively Drug-Resistant Tuberculosis 26%
  • Citric Acid Cycle 22%

• Metabolomic Analysis of Redox control in Mycobacterium tuberculosis persisters

  Jacobs, W. R., Kurland, I. J., Wu, P., Rose, S. A. & Rose, S. A.

  6/1/10 → 1/31/13

  Project: Research project

  • Mycobacterium tuberculosis 100%
  • Extensively Drug-Resistant Tuberculosis 25%
  • Citric Acid Cycle 21%
  • Metabolome 19%
  • Pandemics 18%

• COLLABORATIVE CENTER FOR AN ENZYME FUNCTION INITIATIVE

  Almo, S. C., Jacobson, M., Cronan, J. E., Gerlt, J. & Cronan, J. E.

  5/20/10 → 4/30/17

  Project: Research project

  • enzymes 100%
  • metabolomics 57%
  • genome 46%
  • structural biology 41%
  • amide hydrolases 40%

• Engineering Sortase Variants for Intracellular and Cell Surface Labeling

  Levy, M.

  9/30/09 → 8/31/15

  Project: Research project

  • Labeling 100%
  • Proteins 94%
  • Cells 49%

• Engineering Sortase Variants for Intracellular and Cell Surface Labeling

  Levy, M.

  National Institute of General Medical Sciences

  9/30/09 → 8/31/15

  Project: Research project

  • Labeling 100%
  • Proteins 94%
  • Cells 49%

• Applications of Click Chemistry in Glycobiology

  Wu, P.

  National Institute of General Medical Sciences

  6/19/09 → 5/31/12

  Project: Research project

  • Application 100%
  • Insulin Derivative 71%
  • Biopolymer 67%
  • Azide 63%
  • Alkyne 60%

• GLUT8 Overexpression in Cardioprotection

  Charron, M. J. & Rose, S. A.

  5/5/09 → 4/30/11

  Project: Research project

  • heart 100%
  • glucose transporters 84%
  • ischemia 53%
  • cardiovascular diseases 53%
  • cardiomyopathy 45%

• GLUT8 Overexpression in Cardioprotection

  Charron, M. J.

  National Heart, Lung, and Blood Institute

  5/5/09 → 4/30/10

  Project: Research project

  • heart 100%
  • glucose transporters 84%
  • ischemia 53%
  • cardiovascular diseases 53%
  • cardiomyopathy 45%

• Mechanistic and functional analysis of the proteasome activator Blm10

  Schmidt, M.

  National Institutes of Health

  5/1/09 → 2/28/14

  Project: Research project

  • Proteasome Endopeptidase Complex 100%
  • Mitochondrial Dynamics 19%
  • Proteins 6%
  • Phosphotransferases 5%
  • ATP dependent 26S protease 5%

• Towards solution of the RNA folding problem

  Brenowitz, M. D. & Rose, S. A.

  5/1/09 → 2/28/15

  Project: Research project

  • RNA Folding 100%
  • RNA 63%
  • Kinetics 28%
  • Introns 25%
  • GIR1 ribozyme 24%

• Towards solution of the RNA folding problem

  Brenowitz, M. D.

  National Institute of General Medical Sciences

  5/1/09 → 2/28/15

  Project: Research project

  • RNA Folding 100%
  • RNA 45%
  • Kinetics 29%
  • Introns 25%
  • Riboswitch 20%

• Mechanistic and functional analysis of the proteasome activator Blm10

  Schmidt, M.

  National Institute of General Medical Sciences

  5/1/09 → 2/28/14

  Project: Research project

  • Proteasome Endopeptidase Complex 100%
  • Mitochondrial Dynamics 20%
  • Proteins 7%
  • Phosphotransferases 6%
  • ATP dependent 26S protease 5%

• Transcriptional Repression by Maf1 in Yeast

  Willis, I. M. & Rose, S. A.

  3/1/09 → 2/28/14

  Project: Research project

  • Transfer RNA 100%
  • RNA Polymerase III 94%
  • Ribosomes 71%
  • Nuclear RNA 61%
  • Yeasts 55%

• Transcriptional Repression by Maf1 in Yeast

  Willis, I. M.

  National Institute of General Medical Sciences

  3/1/09 → 2/28/14

  Project: Research project

  • Transfer RNA 100%
  • RNA Polymerase III 94%
  • Ribosomes 71%
  • Yeasts 70%
  • Nuclear RNA 61%

• Functional Consequences of Impaired Autophagy in Aging

  Santambrogio, L., Macian-Juan, F., Cuervo, A. M., Cuervo, A. M., Singh, R., Rose, S. A., Gavathiotis, E. & Bravo Cordero, J. J.

  2/15/09 → 3/31/22

  Project: Research project

  • autophagy 100%
  • cognition 24%
  • T-lymphocytes 19%
  • bookkeeping 18%
  • organisms 18%

• DETECTING AND RESPONDING TO MISFOLDED PROTEIN BURDENS IN AGING CELLS

  Snapp, E. L. & Schmidt, M.

  National Institutes of Health

  9/15/08 → 8/31/10

  Project: Research project

  • Quality Control 100%
  • Cellular Senescence 90%
  • Proteins 37%
  • Heat-Shock Proteins 35%
  • Proteostasis Deficiencies 13%

• DETECTING AND RESPONDING TO MISFOLDED PROTEIN BURDENS IN AGING CELLS

  Schmidt, M., Snapp, E. L. & Snapp, E. L.

  National Institute on Aging

  9/15/08 → 8/31/09

  Project: Research project

  • Quality Control 100%
  • Cellular Senescence 90%
  • Proteins 37%
  • Heat-Shock Proteins 35%
  • Proteostasis Deficiencies 13%

• Transition State Analogues as Modulators of DNA Methylation

  Schramm, V. L., Rose, S. A. & Rose, S. A.

  9/11/08 → 4/30/20

  Project: Research project

  • 5'-methylthioadenosine phosphorylase 100%
  • DNA Methylation 46%
  • Neoplasms 39%
  • CpG Islands 34%
  • Methyltransferases 31%

• Methylthioadenosine Phosphorylase and AdoMet Synthetase in Cancer

  Schramm, V. L. & Schramm, V. L.

  National Cancer Institute

  9/11/08 → 4/30/20

  Project: Research project

  • DNA Methylation 100%
  • Transition State 88%
  • Human Metabolite 84%
  • 5'-methylthioadenosine phosphorylase 82%
  • Effective Dose 78%

• Old Drugs and New Strategies for Tumor Metastasis

  Bresnick, A. R.

  8/4/08 → 4/30/13

  Project: Research project

  • Neoplasm Metastasis 100%
  • Neoplasms 82%
  • Nonmuscle Myosin Type IIA 75%
  • Calcium-Binding Proteins 57%
  • Psychological Inhibition 56%

• Old Drugs and New Strategies for Tumor Metastasis

  Bresnick, A. R.

  National Cancer Institute

  8/4/08 → 4/30/13

  Project: Research project

  • Neoplasm Metastasis 100%
  • Pharmaceutical Preparations 59%
  • Neoplasms 56%
  • Nonmuscle Myosin Type IIA 56%
  • Calcium-Binding Proteins 42%

• Molecular Basis of Insulin Resistance

  Charron, M. J. & Rose, S. A.

  4/1/08 → 8/31/10

  Project: Research project

  • metabolic syndrome 100%
  • noninsulin-dependent diabetes mellitus 93%
  • metabolic diseases 62%
  • high fat diet 56%
  • insulin resistance 38%

• Molecular Basis of Insulin Resistance

  Charron, M. J.

  National Institute of Diabetes and Digestive and Kidney Diseases

  4/1/08 → 3/31/10

  Project: Research project

  • metabolic syndrome 100%
  • noninsulin-dependent diabetes mellitus 93%
  • insulin resistance 76%
  • metabolic diseases 62%
  • high fat diet 56%

• Principles of Protein Mimicry of DNA

  Brenowitz, M. D.

  National Institute of General Medical Sciences

  2/20/08 → 1/31/13

  Project: Research project

  • Molecular Mimicry 100%
  • Fluoroquinolones 38%
  • Proteins 30%
  • DNA Gyrase 19%
  • Anti-Bacterial Agents 13%