Biochemistry

Projects

Projects per year 1979 1989 1997 2004 2008 2009 2010 2014 2016 2017 2019 2023

• 18 Active
• 237 Finished

Projects per year

Search results

• Finished

  2015 Nucleosides, Nucleotides & Oligonucleotides Gordon Research Conference and Seminar

  Schramm, V. L.

  5/18/15 → 9/30/15

  Project: Research project

  • Nucleosides 100%
  • Oligonucleotides 98%
  • Congresses 93%
  • Nucleotides 76%
  • Synthetic Biology 43%

• Chemical tools for studying membrane protein glycosylation

  Ovryn, B. & Wu, P.

  National Institutes of Health

  4/15/15 → 3/31/19

  Project: Research project

  • Glycosylation 100%
  • Membrane Proteins 73%
  • Polysaccharides 60%
  • Glycoproteins 37%
  • Neoplasms 28%

• Chemical tools for studying membrane protein glycosylation

  Ovryn, B., Wu, P., Wu, P. & Ovryn, B.

  National Institute of General Medical Sciences

  4/15/15 → 3/31/19

  Project: Research project

  • Glycosylation 100%
  • Polysaccharides 64%
  • Membrane Proteins 61%
  • Glycoproteins 39%
  • Neoplasms 29%

• An integrated X-ray data collection system

  Almo, S. C.

  4/1/15 → 3/31/16

  Project: Research project

  • biology 100%
  • medicine 53%
  • biochemistry 17%
  • immunity 16%
  • physiology 15%

• An integrated X-ray data collection system

  Almo, S. C. & Almo, S. C.

  NIH Office of the Director

  4/1/15 → 3/31/16

  Project: Research project

  • biology 100%
  • medicine 53%
  • biochemistry 17%
  • immunity 16%
  • physiology 15%

• Regulation of the Class IA PI 3-kinase PIK3CB

  Bresnick, A. R., Backer, J. M. & Bresnick, A. R.

  9/5/14 → 7/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • G-Protein-Coupled Receptors 36%
  • Neoplasms 18%
  • Growth 18%
  • Neoplasm Metastasis 13%

• Regulation of the Class IA PI 3-kinase PIK3CB

  Backer, J. M., Bresnick, A. R. & Backer, J. M.

  National Institute of General Medical Sciences

  9/5/14 → 7/31/18

  Project: Research project

  • Phosphatidylinositol 3-Kinases 100%
  • G-Protein-Coupled Receptors 38%
  • Neoplasms 19%
  • Growth 19%
  • Neoplasm Metastasis 14%

• PRMT5-MEP50 Histone Arginine Methylation in Early Development

  Shechter, D.

  9/1/14 → 8/31/21

  Project: Research project

  • histones 100%
  • methylation 64%
  • protein arginine methyltransferases 23%
  • early development 19%
  • arginine 17%

• Protein architecture and Energy Landscape of Enzymes

  Callender, R.

  National Institute of General Medical Sciences

  8/15/14 → 4/30/19

  Project: Research project

  • energy 100%
  • enzymes 75%
  • phosphorylase 64%
  • nucleosides 60%
  • proteins 58%

• Administrative Core.

  Callender, R.

  National Institute of General Medical Sciences

  8/15/14 → 4/30/19

  Project: Research project

  • travel 100%
  • management 55%
  • performance 52%
  • student 28%

• Dynamics in enzymatic catalysis and transition state analogue binding.

  Schramm, V. L.

  National Institute of General Medical Sciences

  8/15/14 → 4/30/19

  Project: Research project

  • Nucleoside 100%
  • Catalysis 62%
  • Transition State 44%
  • Kinetic Isotope Effect 39%
  • Lactate 36%

• Console and probe upgrade for 600 MHz NMR

  Cowburn, D. & Rose, S. A.

  7/1/14 → 6/30/15

  Project: Research project

  • structural biology 100%
  • probes (equipment) 65%
  • therapeutics 52%
  • neoplasms 51%
  • multiprotein complexes 48%

• Small Molecule Activators of Pro-apoptotic BAX for Cancer Therapy

  Gavathiotis, E. & Rose, S. A.

  7/1/14 → 5/31/22

  Project: Research project

  • Cell Death 100%
  • Apoptotic 80%
  • Antiapoptotic 66%
  • Molecule 48%
  • Pharmacological Property 27%

• Orally available transition state inhibitors for triple negative breast cancer

  Isaacman, S. & Schramm, V. L.

  National Cancer Institute

  7/1/14 → 6/30/16

  Project: Research project

  • Triple Negative Breast Neoplasms 100%
  • 5'-methylthioadenosine phosphorylase 83%
  • Breast Neoplasms 30%
  • Neoplasms 26%
  • 5'-methylthioadenosine 20%

• Console and probe upgrade for 600 MHz NMR

  Cowburn, D.

  NIH Office of the Director

  7/1/14 → 6/30/15

  Project: Research project

  • structural biology 100%
  • probes (equipment) 98%
  • therapeutics 52%
  • neoplasms 51%
  • multiprotein complexes 48%

• Signaling, Motility and TEM Assays

  Bresnick, A. R.

  National Cancer Institute

  6/1/14 → 5/31/18

  Project: Research project

  • Stromal Cells 100%
  • Biosensing Techniques 80%
  • Transendothelial and Transepithelial Migration 44%
  • In Vitro Techniques 43%
  • Neoplasms 42%

• Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers

  Lai, J. R., Chandran, K., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  3/15/14 → 6/28/19

  Project: Research project

  • Antibodies 100%
  • Arenavirus 87%
  • Filoviridae 85%
  • Viral Hemorrhagic Fevers 43%
  • Monoclonal Antibodies 30%

• Consortium for Immunotherapeutics Against Viral Hemorrhagic Fevers

  Saphire, E. O., Chandran, K., Garry, R. F., Lai, J. R., Lai, J. R. & Zeitlin, L.

  3/15/14 → 6/28/19

  Project: Research project

  • Arenavirus 100%
  • Filoviridae 98%
  • Antibodies 97%
  • Monoclonal Antibodies 34%
  • Investigational New Drug Application 27%

• Orally available transition state inhibitors for triple negative breast cancer

  Isaacman, S., Schramm, V. L., Rose, S. A. & Rose, S. A.

  1/1/14 → 6/30/16

  Project: Research project

  • 5'-methylthioadenosine phosphorylase 100%
  • Triple Negative Breast Neoplasms 85%
  • 5'-methylthioadenosine 25%
  • National Institutes of Health (U.S.) 14%
  • Neoplasms 13%

• Lectimers: Glycan-anchored scaffold libraries for targeting carbohydrate-binding

  Levy, M.

  9/20/13 → 8/31/17

  Project: Research project

  • Nucleic Acid 100%
  • Carbohydrate 65%
  • Protein 65%
  • Ligand 34%
  • Peptide 22%

• Lectimers: Glycan-anchored scaffold libraries for targeting carbohydrate-binding

  Levy, M. & Levy, M.

  National Cancer Institute

  9/20/13 → 8/31/17

  Project: Research project

  • Nucleic Acid 100%
  • Carbohydrate 65%
  • Protein 65%
  • Ligand 34%
  • Peptide 22%

• Dissecting the roles of protein O-GlcNAcylation in Toxoplasma gondii

  Wu, P. & Kim, K.

  8/12/13 → 7/31/15

  Project: Research project

  • Toxoplasma gondii 100%
  • tachyzoites 68%
  • bradyzoites 56%
  • transferases 37%
  • life cycle (organisms) 31%

• Dissecting the roles of protein O-GlcNAcylation in Toxoplasma gondii

  Wu, P. & Kim, K.

  National Institute of Allergy and Infectious Diseases

  8/12/13 → 7/31/15

  Project: Research project

  • Toxoplasma gondii 100%
  • tachyzoites 75%
  • bradyzoites 63%
  • transferases 41%
  • life cycle (organisms) 35%

• Targeting CNS HIV reservoirs across the blood-brain barrier

  Levy, M., Prasad, V. R., Rose, S. A. & Rose, S. A.

  4/25/13 → 3/31/15

  Project: Research project

  • Blood-Brain Barrier 100%
  • HIV 35%
  • HIV-1 29%
  • Viral Proteins 27%
  • Nervous System Diseases 16%

• Targeting CNS HIV reservoirs across the blood-brain barrier

  Prasad, V. R. & Levy, M.

  NATIONAL INSTITUTE OF MENTAL HEALTH

  4/25/13 → 3/31/15

  Project: Research project

  • Blood-Brain Barrier 100%
  • HIV 59%
  • HIV-1 31%
  • Viral Proteins 29%
  • Nervous System Diseases 17%

• Fluorescent probes for quantitation of secretory protein levels in single cells

  Snapp, E. L. & Levy, M.

  9/24/12 → 8/31/15

  Project: Research project

  • Proteins 100%
  • Technology 71%
  • Secretory Pathway 63%
  • Fluorescent Dyes 57%
  • Bacterial Toxins 37%

• Fluorescent probes for quantitation of secretory protein levels in single cells

  Levy, M. & Snapp, E. L.

  National Cancer Institute

  9/24/12 → 8/31/13

  Project: Research project

  • Fluorescent Dyes 100%
  • Proteins 46%
  • Technology 34%
  • Secretory Pathway 24%
  • Bacterial Toxins 21%

• Targeting BAX Oligomerization in Hematologic Disease

  Gavathiotis, E.

  National Heart, Lung, and Blood Institute

  9/14/11 → 7/31/13

  Project: Research project

  • Hematologic Diseases 100%
  • Hematology 61%
  • Apoptosis 58%
  • Cell Death 57%
  • alpha-Helical Protein Conformation 44%

• Targeting Cancer Cells with Functionalized Nanoparticle Libraries

  Levy, M.

  8/12/11 → 7/31/14

  Project: Research project

  • systematic evolution of ligands by exponential enrichment 100%
  • nanoparticles 88%
  • neoplasm cells 55%
  • neoplasms 46%
  • engineering 27%

• Targeting Cancer Cells with Functionalized Nanoparticle Libraries

  Levy, M.

  National Cancer Institute

  8/12/11 → 7/31/13

  Project: Research project

  • systematic evolution of ligands by exponential enrichment 100%
  • nanoparticles 71%
  • neoplasm cells 55%
  • neoplasms 46%
  • methodology 16%

• Methods to Identify High-Affinity Antibodies that Target Tumor-Associated Glycans

  Lai, J. R., Rose, S. A. & Rose, S. A.

  7/1/11 → 6/30/14

  Project: Research project

  • Polysaccharides 100%
  • Antibodies 54%
  • Antibody Affinity 30%
  • Bacteriophages 24%
  • Neoplasms 21%

• Methods to Identify High-Affinity Antibodies that Target Tumor-Associated Glycans

  Lai, J. R.

  National Cancer Institute

  7/1/11 → 6/30/13

  Project: Research project

  • Neoplasm Antibodies 100%
  • Antibody Affinity 96%
  • Polysaccharides 88%
  • Antibodies 46%
  • Bacteriophages 28%

• Chemical tools for studying fucosylated glycans

  Wu, P.

  National Institutes of Health

  9/15/10 → 7/31/20

  Project: Research project

  • Fucoside 100%
  • Microarrays 22%
  • Lipid 13%
  • Guanidine 11%
  • Bilayer Membrane 11%

• In vivo imaging of X inactivation

  Greally, J. M., Levy, M. & Greally, J. M.

  National Institute on Drug Abuse

  9/15/10 → 5/31/16

  Project: Research project

  • inactivation 100%
  • image analysis 90%
  • epigenetics 52%
  • X chromosome 42%
  • histone code 26%

• In vivo imaging of X inactivation

  Greally, J. M., Levy, M., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  9/15/10 → 5/31/16

  Project: Research project

  • inactivation 100%
  • X chromosome 51%
  • image analysis 35%
  • epigenetics 35%
  • cells 27%

• Chemical Tools for Studying Fucosylated Glycans

  Wu, P. & Wu, P.

  National Institute of General Medical Sciences

  9/15/10 → 7/31/21

  Project: Research project

  • Fucoside 100%
  • Microarrays 22%
  • Lipid 13%
  • Guanidine 11%
  • Bilayer Membrane 11%

• The NYSGRC: A Large Scale Center for PSI:Biology

  Almo, S. C., Fiser, A., Seidel, R. D. & Almo, S. C.

  National Institute of General Medical Sciences

  9/1/10 → 6/30/16

  Project: Research project

  • Immune Evasion 100%
  • Fungal Proteins 99%
  • Bacterial Proteins 96%
  • Cell Biology 68%
  • Organizations 66%

• The NYSGRC: A Large Scale Center for PSI:Biology

  Seidel, R. D., Fiser, A., Almo, S. C., Almo, S. C., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A., Rose, S. A. & Rose, S. A.

  9/1/10 → 6/30/16

  Project: Research project

  • Immune Evasion 100%
  • Fungal Proteins 99%
  • Bacterial Proteins 96%
  • Health 77%
  • Cell Biology 68%

• Project 1

  Almo, S. C.

  National Institute of General Medical Sciences

  9/1/10 → 6/30/15

  Project: Research project

  • Immune Evasion 100%
  • Fungal Proteins 99%
  • Bacterial Proteins 96%
  • Cell Biology 68%
  • Organizations 66%

• Project 3

  Seidel, R. D.

  National Institute of General Medical Sciences

  9/1/10 → 6/30/15

  Project: Research project

  • Immune Evasion 100%
  • Fungal Proteins 99%
  • Bacterial Proteins 96%
  • Cell Biology 68%
  • Organizations 66%

• Targeting BAX Oligomerization in Hematologic Disease

  Gavathiotis, E.

  8/9/10 → 7/31/14

  Project: Research project

  • Apoptosis 100%
  • Hematologic Diseases 84%
  • Cell Death 69%
  • Hematology 58%
  • alpha-Helical Protein Conformation 42%

• Targeting Viral Envelope Glycoproteins with Synthetic Antibodies

  Lai, J. R.

  National Institute of Allergy and Infectious Diseases

  7/1/10 → 6/30/15

  Project: Research project

  • Glycoproteins 100%
  • Antibodies 76%
  • Ebolavirus 23%
  • HIV-1 22%
  • Virus Internalization 21%

• Targeting Viral Envelope Glycoproteins with Synthetic Antibodies

  Lai, J. R., Rose, S. A. & Rose, S. A.

  7/1/10 → 6/30/15

  Project: Research project

  • Antibodies 100%
  • Viral Antibodies 29%
  • Ebolavirus 27%
  • HIV-1 26%
  • Virus Internalization 24%

• Metabolomic Analysis of Redox control in Mycobacterium tuberculosis persisters

  Jacobs Jr., W. R., Kurland, I. J. & Wu, P.

  National Institute of Allergy and Infectious Diseases

  6/1/10 → 1/31/13

  Project: Research project

  • Mycobacterium tuberculosis 100%
  • Metabolomics 78%
  • Oxidation-Reduction 71%
  • Extensively Drug-Resistant Tuberculosis 26%
  • Citric Acid Cycle 22%

• Metabolomic Analysis of Redox control in Mycobacterium tuberculosis persisters

  Jacobs, W. R., Kurland, I. J., Wu, P., Rose, S. A. & Rose, S. A.

  6/1/10 → 1/31/13

  Project: Research project

  • Mycobacterium tuberculosis 100%
  • Extensively Drug-Resistant Tuberculosis 25%
  • Citric Acid Cycle 21%
  • Metabolome 19%
  • Pandemics 18%

• COLLABORATIVE CENTER FOR AN ENZYME FUNCTION INITIATIVE

  Almo, S. C., Jacobson, M., Cronan, J. E., Gerlt, J. & Cronan, J. E.

  5/20/10 → 4/30/17

  Project: Research project

  • enzymes 100%
  • metabolomics 57%
  • genome 46%
  • structural biology 41%
  • amide hydrolases 40%

• Core F: Structure

  Gerlt, J. A. & Almo, S. C.

  National Institute of General Medical Sciences

  5/20/10 → 4/30/16

  Project: Research project

  • crystallization 100%
  • ligand 87%
  • fold 61%
  • family 60%
  • aid 39%

• Core E: Protein

  Gerlt, J. A. & Almo, S. C.

  National Institute of General Medical Sciences

  5/20/10 → 4/30/16

  Project: Research project

  • Mass spectrometers 100%
  • Crystallization 57%
  • Proteins 48%
  • Chromatography 48%
  • Robots 33%

• COLLABORATIVE CENTER FOR AN ENZYME FUNCTION INITIATIVE

  Gerlt, J. A., Almo, S. C., Cronan, J. E., Jacobson, M. P. & Gerlt, J. A.

  5/20/10 → 4/30/17

  Project: Research project

  • enzymes 100%
  • metabolomics 57%
  • genome 46%
  • structural biology 41%
  • amide hydrolases 40%

• Engineering Sortase Variants for Intracellular and Cell Surface Labeling

  Levy, M.

  9/30/09 → 8/31/15

  Project: Research project

  • Labeling 100%
  • Proteins 94%
  • Cells 49%