• 10598 Citations
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1969 …2019

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2018

An Atypical Mechanism of Split Intein Molecular Recognition and Folding

Stevens, A. J., Sekar, G., Gramespacher, J. A., Cowburn, D. & Muir, T. W., Sep 19 2018, In : Journal of the American Chemical Society. 140, 37, p. 11791-11799 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Deciphering the “Fuzzy” Interaction of FG Nucleoporins and Transport Factors Using Small-Angle Neutron Scattering

Sparks, S., Temel, D. B., Rout, M. P. & Cowburn, D., Mar 6 2018, In : Structure. 26, 3, p. 477-484.e4

Research output: Contribution to journalArticle

7 Scopus citations
2017

A promiscuous split intein with expanded protein engineering applications

Stevens, A. J., Sekar, G., Shah, N. H., Mostafavi, A. Z., Cowburn, D. & Muir, T. W., Aug 8 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 32, p. 8538-8543 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Dynamic intramolecular regulation of the histone chaperone nucleoplasmin controls histone binding and release

Warren, C., Matsui, T., Karp, J. M., Onikubo, T., Cahill, S., Brenowitz, M., Cowburn, D., Girvin, M. E. & Shechter, D., Dec 1 2017, In : Nature Communications. 8, 1, 2215.

Research output: Contribution to journalArticle

9 Scopus citations

Effects of FGFR2 kinase activation loop dynamics on catalytic activity

Karp, J. M., Sparks, S. & Cowburn, D., Feb 2017, In : PLoS Computational Biology. 13, 2, e1005360.

Research output: Contribution to journalArticle

3 Scopus citations

Integrating NOE and RDC using sum-of-squares relaxation for protein structure determination

Khoo, Y., Singer, A. & Cowburn, D., Jun 14 2017, (Accepted/In press) In : Journal of Biomolecular NMR. p. 1-23 23 p.

Research output: Contribution to journalArticle

2 Scopus citations

Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex

Upla, P., Kim, S. J., Sampathkumar, P., Dutta, K., Cahill, S. M., Chemmama, I. E., Williams, R., Bonanno, J. B., Rice, W. J., Stokes, D. L., Cowburn, D., Almo, S. C., Sali, A., Rout, M. P. & Fernandez-Martinez, J., Mar 7 2017, In : Structure. 25, 3, p. 434-445 12 p.

Research output: Contribution to journalArticle

17 Scopus citations
2016

Anti-DNA antibody mediated catalysis is isotype dependent

Xia, Y., Eryilmaz, E., Zhang, Q., Cowburn, D. & Putterman, C., Jan 1 2016, In : Molecular Immunology. 69, p. 33-43 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

A peptide mimic blocks the cross-reaction of anti-DNA antibodies with glomerular antigens

Xia, Y., Eryilmaz, E., Der, E., Pawar, R. D., Guo, X., Cowburn, D. & Putterman, C., Mar 1 2016, In : Clinical and Experimental Immunology. 183, 3, p. 369-379 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Design of a Split Intein with Exceptional Protein Splicing Activity

Stevens, A. J., Brown, Z. Z., Shah, N. H., Sekar, G., Cowburn, D. & Muir, T. W., Mar 2 2016, In : Journal of the American Chemical Society. 138, 7, p. 2162-2165 4 p.

Research output: Contribution to journalArticle

50 Scopus citations

Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex

Raveh, B., Karp, J. M., Sparks, S., Dutta, K., Rout, M. P., Sali, A. & Cowburn, D., May 3 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 18, p. E2489-E2497

Research output: Contribution to journalArticle

37 Scopus citations
2015

Controlling lipid micelle stability using oligonucleotide headgroups

Wilner, S. E., Sparks, S. E., Cowburn, D., Girvin, M. E. & Levy, M., Feb 18 2015, In : Journal of the American Chemical Society. 137, 6, p. 2171-2174 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Correlation of chemical shifts predicted by molecular dynamics simulations for partially disordered proteins

Karp, J. M., Erylimaz, E. & Cowburn, D., Jan 2015, In : Journal of Biomolecular NMR. 61, 1, p. 35-45 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Identification of hydrophobic interfaces in protein-ligand complexes by selective saturation transfer NMR spectroscopy

Ferrage, F., Dutta, K. & Cowburn, D., Dec 9 2015, In : Molecules. 20, 12, p. 21992-21999 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

The molecular mechanism of nuclear transport revealed by atomic-scale measurements

Hough, L. E., Dutta, K., Sparks, S., Temel, D. B., Kamal, A., Tetenbaum-Novatt, J., Rout, M. P. & Cowburn, D., Sep 15 2015, In : eLife. 4, September, e10027.

Research output: Contribution to journalArticle

69 Scopus citations
2013

Cracking the molecular origin of intrinsic tyrosine kinase activity through analysis of pathogenic gain-of-function mutations

Chen, H., Huang, Z., Dutta, K., Blais, S., Neubert, T. A., Li, X., Cowburn, D., Traaseth, N. J. & Mohammadi, M., Jul 25 2013, In : Cell Reports. 4, 2, p. 376-384 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Extein residues play an intimate role in the rate-limiting step of protein trans -splicing

Shah, N. H., Eryilmaz, E., Cowburn, D. & Muir, T. W., Apr 17 2013, In : Journal of the American Chemical Society. 135, 15, p. 5839-5847 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Global structures of IgG isotypes expressing identical variable regions

Eryilmaz, E., Janda, A., Kim, J., Cordero, R. J. B., Cowburn, D. & Casadevall, A., Dec 31 2013, In : Molecular Immunology. 56, 4, p. 588-598 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Ligand-induced dynamic changes in extended PDZ domains from NHERF1

Bhattacharya, S., Ju, J. H., Orlova, N., Khajeh, J. A., Cowburn, D. & Bu, Z., Jul 24 2013, In : Journal of Molecular Biology. 425, 14, p. 2509-2528 20 p.

Research output: Contribution to journalArticle

22 Scopus citations

Naturally split inteins assemble through a "capture and collapse" mechanism

Shah, N. H., Eryilmaz, E., Cowburn, D. & Muir, T. W., Dec 11 2013, In : Journal of the American Chemical Society. 135, 49, p. 18673-18681 9 p.

Research output: Contribution to journalArticle

41 Scopus citations
2012
4 Scopus citations

Eigenvector synchronization, graph rigidity and the molecule problem

Cucuringu, M., Singer, A. & Cowburn, D., 2012, In : Information and Inference. 1, 1, p. 21-67 47 p.

Research output: Contribution to journalArticle

30 Scopus citations

Novel structures of self-associating stapled peptides

Bhattacharya, S., Zhang, H., Cowburn, D. & Debnath, A. K., May 2012, In : Biopolymers. 97, 5, p. 253-264 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

The alternatively spliced acid box region plays a key role in FGF receptor autoinhibition

Kalinina, J., Dutta, K., Ilghari, D., Beenken, A., Goetz, R., Eliseenkova, A. V., Cowburn, D. & Mohammadi, M., Jan 11 2012, In : Structure. 20, 1, p. 77-88 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Variable region identical immunoglobulins differing in isotype express different paratopes

Janda, A., Eryilmaz, E., Nakouzi, A., Cowburn, D. & Casadevall, A., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35409-35417 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
2011

Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain

Zhang, H., Curreli, F., Zhang, X., Bhattacharya, S., Waheed, A. A., Cooper, A., Cowburn, D., Freed, E. O. & Debnath, A. K., May 3 2011, In : Retrovirology. 8, 28.

Research output: Contribution to journalArticle

49 Scopus citations

Are zinc-finger domains of protein kinase C dynamic structures that unfold by lipid or redox activation?

Zhao, F., Ilbert, M., Varadan, R., Cremers, C. M., Hoyos, B., Acin-Perez, R., Vinogradov, V., Cowburn, D., Jakob, U. & Hammerling, U., Mar 1 2011, In : Antioxidants and Redox Signaling. 14, 5, p. 757-766 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2010

A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation

Bhattacharya, S., Dai, Z., Li, J., Baxter, S., Callaway, D. J. E., Cowburn, D. & Bu, Z., Mar 26 2010, In : Journal of Biological Chemistry. 285, 13, p. 9981-9994 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Branched intermediate formation stimulates peptide bond cleavage in protein splicing

Frutos, S., Goger, M., Giovani, B., Cowburn, D. & Muir, T. W., Jul 2010, In : Nature Chemical Biology. 6, 7, p. 527-533 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E

Tait, S., Dutta, K., Cowburn, D., Warwicker, J., Doig, A. J. & McCarthy, J. E. G., Oct 12 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 41, p. 17627-17632 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

On the measurement of 15N-{1H} nuclear Overhauser effects. 2. Effects of the saturation scheme and water signal suppression

Ferrage, F., Reichel, A., Battacharya, S., Cowburn, D. & Ghose, R., Dec 2010, In : Journal of Magnetic Resonance. 207, 2, p. 294-303 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Structural determination of biomolecular interfaces by nuclear magnetic resonance of proteins with reduced proton density

Ferrage, F., Dutta, K., Shekhtman, A. & Cowburn, D., May 2010, In : Journal of Biomolecular NMR. 47, 1, p. 41-54 14 p.

Research output: Contribution to journalArticle

8 Scopus citations
2009
51 Scopus citations

Optimized bacterial expression and purification of the c-Src catalytic domain for solution NMR studies

Piserchio, A., Ghose, R. & Cowburn, D., 2009, In : Journal of Biomolecular NMR. 44, 2, p. 87-93 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
2008

A Cell-penetrating Helical Peptide as a Potential HIV-1 Inhibitor

Zhang, H., Zhao, Q., Bhattacharya, S., Waheed, A. A., Tong, X., Hong, A., Heck, S., Curreli, F., Goger, M., Cowburn, D., Freed, E. O. & Debnath, A. K., May 2 2008, In : Journal of Molecular Biology. 378, 3, p. 565-580 16 p.

Research output: Contribution to journalArticle

161 Scopus citations

A Full-Length Group 1 Bacterial Sigma Factor Adopts a Compact Structure Incompatible with DNA Binding

Schwartz, E. C., Shekhtman, A., Dutta, K., Pratt, M. R., Cowburn, D., Darst, S. & Muir, T. W., Oct 20 2008, In : Chemistry and Biology. 15, 10, p. 1091-1103 13 p.

Research output: Contribution to journalArticle

41 Scopus citations

Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1

Xiong, X., Cui, P., Hossain, S., Xu, R., Warner, B., Guo, X., An, X., Debnath, A. K., Cowburn, D. & Kotula, L., May 1 2008, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1783, 5, p. 737-747 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

N-terminal cysteinyl proteins can be prepared using thrombin cleavage

Liu, D., Xu, R., Dutta, K. & Cowburn, D., Apr 2 2008, In : FEBS Letters. 582, 7, p. 1163-1167 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

On the measurement of 15N-{1H} nuclear Overhauser effects

Ferrage, F., Piserchio, A., Cowburn, D. & Ghose, R., Jun 1 2008, In : Journal of Magnetic Resonance. 192, 2, p. 302-313 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

Perspectives on NMR in drug discovery: A technique comes of age

Pellecchia, M., Bertini, I., Cowburn, D., Dalvit, C., Giralt, E., Jahnke, W., James, T. L., Homans, S. W., Kessler, H., Luchinat, C., Meyer, B., Oschkinat, H., Peng, J., Schwalbe, H. & Siegal, G., 2008, In : Nature Reviews Drug Discovery. 7, 9, p. 738-745 8 p.

Research output: Contribution to journalArticle

283 Scopus citations

Solution structure of a hydrocarbon stapled peptide inhibitor in complex with monomeric C-terminal domain of HIV-1 capsid

Bhattacharya, S., Zhang, H., Debnath, A. K. & Cowburn, D., Jun 13 2008, In : Journal of Biological Chemistry. 283, 24, p. 16274-16278 5 p.

Research output: Contribution to journalArticle

74 Scopus citations
2007

Joint composite-rotation adiabatic-sweep isotope filtration

Valentine, E. R., Ferrage, F., Massi, F., Cowburn, D. & Palmer, A. G., May 1 2007, In : Journal of Biomolecular NMR. 38, 1, p. 11-22 12 p.

Research output: Contribution to journalArticle

4 Scopus citations
2006

In-cell NMR for protein-protein interactions (STINT-NMR)

Burz, D. S., Dutta, K., Cowburn, D. & Shekhtman, A., Jun 1 2006, In : Nature Protocols. 1, 1, p. 146-152 7 p.

Research output: Contribution to journalArticle

62 Scopus citations

Mapping structural interactions using in-cell NMR spectroscopy (STINT-NMR)

Burz, D. S., Dutta, K., Cowburn, D. & Shekhtman, A., Feb 1 2006, In : Nature Methods. 3, 2, p. 91-93 3 p.

Research output: Contribution to journalArticle

128 Scopus citations

NMR determination that an extended BH3 motif of pro-apoptotic BID is specifically bound to BCL-XL

Ji, H., Shekhtman, A., Ghose, R., McDonnell, J. M. & Cowburn, D., Jul 2006, In : Magnetic Resonance in Chemistry. 44, 7 SPEC. ISS., p. S101-S107

Research output: Contribution to journalArticle

5 Scopus citations

NMR solution structure and backbone dynamics of domain III of the E protein of tick-borne Langat flavivirus suggests a potential site for molecular recognition

Mukherjee, M., Dutta, K., White, M. A., Cowburn, D. & Fox, R. O., Jun 2006, In : Protein Science. 15, 6, p. 1342-1355 14 p.

Research output: Contribution to journalArticle

18 Scopus citations

Protein backbone dynamics through 13C′-13C α cross-relaxation in NMR spectroscopy

Ferrage, F., Pelupessy, P., Cowburn, D. & Bodenhausen, G., Aug 30 2006, In : Journal of the American Chemical Society. 128, 34, p. 11072-11078 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Solution structure and folding characteristics of the C-terminal SH3 domain of c-Crk-II

Muralidharan, V., Dutta, K., Cho, J., Vila-Perello, M., Raleigh, D. P., Cowburn, D. & Muir, T. W., Jul 25 2006, In : Biochemistry. 45, 29, p. 8874-8884 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
2004

Segmental isotopic labeling for structural biological applications of NMR.

Cowburn, D., Shekhtman, A., Xu, R., Ottesen, J. J. & Muir, T. W., 2004, In : Methods in molecular biology (Clifton, N.J.). 278, p. 47-56 10 p.

Research output: Contribution to journalArticle

24 Scopus citations
125 Scopus citations