• 10598 Citations
  • 49 h-Index
1969 …2019

Research output per year

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Publications

2019

Phase separation in biology and disease—a symposium report

Cable, J., Brangwynne, C., Seydoux, G., Cowburn, D., Pappu, R. V., Castañeda, C. A., Berchowitz, L. E., Chen, Z., Jonikas, M., Dernburg, A., Mittag, T. & Fawzi, N. L., Sep 1 2019, In : Annals of the New York Academy of Sciences. 1452, 1, p. 3-11 9 p.

Research output: Contribution to journalComment/debate

3 Scopus citations
2018

An Atypical Mechanism of Split Intein Molecular Recognition and Folding

Stevens, A. J., Sekar, G., Gramespacher, J. A., Cowburn, D. & Muir, T. W., Sep 19 2018, In : Journal of the American Chemical Society. 140, 37, p. 11791-11799 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Deciphering the “Fuzzy” Interaction of FG Nucleoporins and Transport Factors Using Small-Angle Neutron Scattering

Sparks, S., Temel, D. B., Rout, M. P. & Cowburn, D., Mar 6 2018, In : Structure. 26, 3, p. 477-484.e4

Research output: Contribution to journalArticle

7 Scopus citations

Structure-Function in Antibodies to Double-Stranded DNA

Xia, Y., Eryilmaz, E., Cowburn, D. & Putterman, C., Jan 1 2018, Structural Biology in Immunology: Structure and Function of Novel Molecules of Immunologic Importance. Elsevier, p. 127-144 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Thermodynamic characterization of the multivalent interactions underlying rapid and selective translocation through the nuclear pore complex

Hayama, R., Sparks, S., Hecht, L. M., Dutta, K., Karp, J. M., Cabana, C. M., Rout, M. P., Cowburn, D. & Allewell, N. M., Mar 23 2018, In : Journal of Biological Chemistry. 293, 12, p. 4555-4563 9 p.

Research output: Contribution to journalReview article

15 Scopus citations
2017

A promiscuous split intein with expanded protein engineering applications

Stevens, A. J., Sekar, G., Shah, N. H., Mostafavi, A. Z., Cowburn, D. & Muir, T. W., Aug 8 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 32, p. 8538-8543 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Domain interactions of C-terminal Src Kinase determined through NMR spectroscopy with segmental isotope labeling

Liu, D., Yuan, Y., Xu, R. & Cowburn, D., Jan 1 2017, In : Protein and Cell. 8, 1, p. 67-71 5 p.

Research output: Contribution to journalLetter

3 Scopus citations

Dynamic intramolecular regulation of the histone chaperone nucleoplasmin controls histone binding and release

Warren, C., Matsui, T., Karp, J. M., Onikubo, T., Cahill, S., Brenowitz, M., Cowburn, D., Girvin, M. E. & Shechter, D., Dec 1 2017, In : Nature Communications. 8, 1, 2215.

Research output: Contribution to journalArticle

9 Scopus citations

Effects of FGFR2 kinase activation loop dynamics on catalytic activity

Karp, J. M., Sparks, S. & Cowburn, D., Feb 2017, In : PLoS Computational Biology. 13, 2, e1005360.

Research output: Contribution to journalArticle

3 Scopus citations

Integrating NOE and RDC using sum-of-squares relaxation for protein structure determination

Khoo, Y., Singer, A. & Cowburn, D., Jun 14 2017, (Accepted/In press) In : Journal of Biomolecular NMR. p. 1-23 23 p.

Research output: Contribution to journalArticle

2 Scopus citations

Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex

Upla, P., Kim, S. J., Sampathkumar, P., Dutta, K., Cahill, S. M., Chemmama, I. E., Williams, R., Bonanno, J. B., Rice, W. J., Stokes, D. L., Cowburn, D., Almo, S. C., Sali, A., Rout, M. P. & Fernandez-Martinez, J., Mar 7 2017, In : Structure. 25, 3, p. 434-445 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Segmental isotopic labeling of proteins for NMR study using intein technology

Liu, D. & Cowburn, D., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1495. p. 131-145 15 p. (Methods in Molecular Biology; vol. 1495).

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations
2016

Anti-DNA antibody mediated catalysis is isotype dependent

Xia, Y., Eryilmaz, E., Zhang, Q., Cowburn, D. & Putterman, C., Jan 1 2016, In : Molecular Immunology. 69, p. 33-43 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

A peptide mimic blocks the cross-reaction of anti-DNA antibodies with glomerular antigens

Xia, Y., Eryilmaz, E., Der, E., Pawar, R. D., Guo, X., Cowburn, D. & Putterman, C., Mar 1 2016, In : Clinical and Experimental Immunology. 183, 3, p. 369-379 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Design of a Split Intein with Exceptional Protein Splicing Activity

Stevens, A. J., Brown, Z. Z., Shah, N. H., Sekar, G., Cowburn, D. & Muir, T. W., Mar 2 2016, In : Journal of the American Chemical Society. 138, 7, p. 2162-2165 4 p.

Research output: Contribution to journalArticle

50 Scopus citations

Slide-and-exchange mechanism for rapid and selective transport through the nuclear pore complex

Raveh, B., Karp, J. M., Sparks, S., Dutta, K., Rout, M. P., Sali, A. & Cowburn, D., May 3 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 18, p. E2489-E2497

Research output: Contribution to journalArticle

37 Scopus citations
2015

Controlling lipid micelle stability using oligonucleotide headgroups

Wilner, S. E., Sparks, S. E., Cowburn, D., Girvin, M. E. & Levy, M., Feb 18 2015, In : Journal of the American Chemical Society. 137, 6, p. 2171-2174 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Correlation of chemical shifts predicted by molecular dynamics simulations for partially disordered proteins

Karp, J. M., Erylimaz, E. & Cowburn, D., Jan 2015, In : Journal of Biomolecular NMR. 61, 1, p. 35-45 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Identification of hydrophobic interfaces in protein-ligand complexes by selective saturation transfer NMR spectroscopy

Ferrage, F., Dutta, K. & Cowburn, D., Dec 9 2015, In : Molecules. 20, 12, p. 21992-21999 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

The molecular mechanism of nuclear transport revealed by atomic-scale measurements

Hough, L. E., Dutta, K., Sparks, S., Temel, D. B., Kamal, A., Tetenbaum-Novatt, J., Rout, M. P. & Cowburn, D., Sep 15 2015, In : eLife. 4, September, e10027.

Research output: Contribution to journalArticle

69 Scopus citations
2014

Structural and dynamical features of Inteins and implications on protein splicing

Eryilma, E., Shah, N. H., Muir, T. W. & Cowburn, D., 2014, In : Journal of Biological Chemistry. 289, 21, p. 14506-14511 6 p.

Research output: Contribution to journalReview article

37 Scopus citations

Structural and dynamical features of inteins and implications on protein splicing (Journal of Biological Chemistry (2014) 289 (14506-14511))

Eryilmaz, E., Shah, N. H., Muir, T. W. & Cowburn, D., Jul 11 2014, In : Journal of Biological Chemistry. 289, 28, 1 p.

Research output: Contribution to journalComment/debate

1 Scopus citations
2013

Cracking the molecular origin of intrinsic tyrosine kinase activity through analysis of pathogenic gain-of-function mutations

Chen, H., Huang, Z., Dutta, K., Blais, S., Neubert, T. A., Li, X., Cowburn, D., Traaseth, N. J. & Mohammadi, M., Jul 25 2013, In : Cell Reports. 4, 2, p. 376-384 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Extein residues play an intimate role in the rate-limiting step of protein trans -splicing

Shah, N. H., Eryilmaz, E., Cowburn, D. & Muir, T. W., Apr 17 2013, In : Journal of the American Chemical Society. 135, 15, p. 5839-5847 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Global structures of IgG isotypes expressing identical variable regions

Eryilmaz, E., Janda, A., Kim, J., Cordero, R. J. B., Cowburn, D. & Casadevall, A., Dec 31 2013, In : Molecular Immunology. 56, 4, p. 588-598 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Ligand-induced dynamic changes in extended PDZ domains from NHERF1

Bhattacharya, S., Ju, J. H., Orlova, N., Khajeh, J. A., Cowburn, D. & Bu, Z., Jul 24 2013, In : Journal of Molecular Biology. 425, 14, p. 2509-2528 20 p.

Research output: Contribution to journalArticle

22 Scopus citations

Naturally split inteins assemble through a "capture and collapse" mechanism

Shah, N. H., Eryilmaz, E., Cowburn, D. & Muir, T. W., Dec 11 2013, In : Journal of the American Chemical Society. 135, 49, p. 18673-18681 9 p.

Research output: Contribution to journalArticle

41 Scopus citations
2012
4 Scopus citations

Eigenvector synchronization, graph rigidity and the molecule problem

Cucuringu, M., Singer, A. & Cowburn, D., 2012, In : Information and Inference. 1, 1, p. 21-67 47 p.

Research output: Contribution to journalArticle

30 Scopus citations

Expression and purification of Src-family kinases for solution NMR studies

Piserchio, A., Cowburn, D. & Ghose, R., 2012, Protein NMR Techniques. p. 111-131 21 p. (Methods in Molecular Biology; vol. 831).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

In-Cell Protein NMR Spectroscopy

Burz, D. S., Cowburn, D., Dutta, K. & Shekhtman, A., Mar 21 2012, NMR of Biomolecules: Towards Mechanistic Systems Biology. Wiley-VCH, p. 478-494 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Novel structures of self-associating stapled peptides

Bhattacharya, S., Zhang, H., Cowburn, D. & Debnath, A. K., May 2012, In : Biopolymers. 97, 5, p. 253-264 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

The alternatively spliced acid box region plays a key role in FGF receptor autoinhibition

Kalinina, J., Dutta, K., Ilghari, D., Beenken, A., Goetz, R., Eliseenkova, A. V., Cowburn, D. & Mohammadi, M., Jan 11 2012, In : Structure. 20, 1, p. 77-88 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Variable region identical immunoglobulins differing in isotype express different paratopes

Janda, A., Eryilmaz, E., Nakouzi, A., Cowburn, D. & Casadevall, A., Oct 12 2012, In : Journal of Biological Chemistry. 287, 42, p. 35409-35417 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
2011

Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain

Zhang, H., Curreli, F., Zhang, X., Bhattacharya, S., Waheed, A. A., Cooper, A., Cowburn, D., Freed, E. O. & Debnath, A. K., May 3 2011, In : Retrovirology. 8, 28.

Research output: Contribution to journalArticle

49 Scopus citations

Are zinc-finger domains of protein kinase C dynamic structures that unfold by lipid or redox activation?

Zhao, F., Ilbert, M., Varadan, R., Cremers, C. M., Hoyos, B., Acin-Perez, R., Vinogradov, V., Cowburn, D., Jakob, U. & Hammerling, U., Mar 1 2011, In : Antioxidants and Redox Signaling. 14, 5, p. 757-766 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

Forward with fewer silos and more thought

Cowburn, D., Dec 1 2011, In : Nature Structural and Molecular Biology. 18, 12, 1 p.

Research output: Contribution to journalComment/debate

2010

A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation

Bhattacharya, S., Dai, Z., Li, J., Baxter, S., Callaway, D. J. E., Cowburn, D. & Bu, Z., Mar 26 2010, In : Journal of Biological Chemistry. 285, 13, p. 9981-9994 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Branched intermediate formation stimulates peptide bond cleavage in protein splicing

Frutos, S., Goger, M., Giovani, B., Cowburn, D. & Muir, T. W., Jul 2010, In : Nature Chemical Biology. 6, 7, p. 527-533 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E

Tait, S., Dutta, K., Cowburn, D., Warwicker, J., Doig, A. J. & McCarthy, J. E. G., Oct 12 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 41, p. 17627-17632 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Nuclear spin relaxation in isotropic and anisotropic media

Nicholas, M. P., Eryilmaz, E., Ferrage, F., Cowburn, D. & Ghose, R., Aug 1 2010, In : Progress in Nuclear Magnetic Resonance Spectroscopy. 57, 2, p. 111-158 48 p.

Research output: Contribution to journalReview article

30 Scopus citations

On the measurement of 15N-{1H} nuclear Overhauser effects. 2. Effects of the saturation scheme and water signal suppression

Ferrage, F., Reichel, A., Battacharya, S., Cowburn, D. & Ghose, R., Dec 2010, In : Journal of Magnetic Resonance. 207, 2, p. 294-303 10 p.

Research output: Contribution to journalArticle

34 Scopus citations

Structural determination of biomolecular interfaces by nuclear magnetic resonance of proteins with reduced proton density

Ferrage, F., Dutta, K., Shekhtman, A. & Cowburn, D., May 2010, In : Journal of Biomolecular NMR. 47, 1, p. 41-54 14 p.

Research output: Contribution to journalArticle

8 Scopus citations
2009
51 Scopus citations

Chapter 8 Segmental Isotopic Labeling of Proteins for Nuclear Magnetic Resonance

Liu, D., Xu, R. & Cowburn, D., 2009, Methods in Enzymology. Muir, T. & Abelson, J. (eds.). p. 151-175 25 p. (Methods in Enzymology; vol. 462).

Research output: Chapter in Book/Report/Conference proceedingChapter

32 Scopus citations

Optimized bacterial expression and purification of the c-Src catalytic domain for solution NMR studies

Piserchio, A., Ghose, R. & Cowburn, D., 2009, In : Journal of Biomolecular NMR. 44, 2, p. 87-93 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
2008

A Cell-penetrating Helical Peptide as a Potential HIV-1 Inhibitor

Zhang, H., Zhao, Q., Bhattacharya, S., Waheed, A. A., Tong, X., Hong, A., Heck, S., Curreli, F., Goger, M., Cowburn, D., Freed, E. O. & Debnath, A. K., May 2 2008, In : Journal of Molecular Biology. 378, 3, p. 565-580 16 p.

Research output: Contribution to journalArticle

161 Scopus citations

A Full-Length Group 1 Bacterial Sigma Factor Adopts a Compact Structure Incompatible with DNA Binding

Schwartz, E. C., Shekhtman, A., Dutta, K., Pratt, M. R., Cowburn, D., Darst, S. & Muir, T. W., Oct 20 2008, In : Chemistry and Biology. 15, 10, p. 1091-1103 13 p.

Research output: Contribution to journalArticle

41 Scopus citations