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David Cowburn, Ph.D.

  • 10171 Citations
  • 47 h-Index
1969 …2020
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Nuclear magnetic resonance Chemical Compounds
src Homology Domains Medicine & Life Sciences
Peptides Medicine & Life Sciences
Proteins Medicine & Life Sciences
Magnetic Resonance Spectroscopy Medicine & Life Sciences
Protons Medicine & Life Sciences
Chemical shift Chemical Compounds
Inteins Medicine & Life Sciences

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Grants 1976 2020

The dynamic mechanism of nuclear transport visualized at the atomic scale

Cowburn, D.

National Institutes of Health

3/1/16 → 1/31/20

Project: Research project

Macromolecules
Inosine Diphosphate
Intrinsically Disordered Proteins
Fluid dynamics
Phenylalanine

Console and probe upgrade for 600 MHz NMR

Cowburn, D.

National Institutes of Health

7/1/14 → 6/30/15

Project: Research project

Proteins
Research Personnel
Reproductive Health
Research
Antiviral Agents

EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION

Cowburn, D.

National Institutes of Health

9/15/02 → 6/30/07

Project: Research project

resources
convent
medical research
applicant
research facility

900 MHz NMR Spectrometer for Structural Biology

Cowburn, D.

National Institutes of Health

7/1/02 → 6/30/08

Project: Research project

Research Personnel
Muscle Neoplasms
Molecular Weight
Research
Physiological Phenomena

SIGNAL TRANSDUCTION PROBED BY CONSOLIDATED LIGANDS

Cowburn, D.

National Institutes of Health

1/1/97 → 12/31/01

Project: Research project

Signal transduction
Ligands
Binding Sites
Peptide Library
Proteins

Publications 1969 2019

Phase separation in biology and disease—a symposium report

Cable, J., Brangwynne, C., Seydoux, G., Cowburn, D., Pappu, R. V., Castañeda, C. A., Berchowitz, L. E., Chen, Z., Jonikas, M., Dernburg, A., Mittag, T. & Fawzi, N. L., Jan 1 2019, In : Annals of the New York Academy of Sciences.

Research output: Contribution to journal › Comment/debate

Phase separation
RNA
Proteins
Huntington Disease
Amyotrophic Lateral Sclerosis

An Atypical Mechanism of Split Intein Molecular Recognition and Folding

Stevens, A. J., Sekar, G., Gramespacher, J. A., Cowburn, D. & Muir, T. W., Sep 19 2018, In : Journal of the American Chemical Society. 140, 37, p. 11791-11799 9 p.

Research output: Contribution to journal › Article

Inteins
Molecular recognition
Proteins
Protein Splicing
Blueprints
6 Citations (Scopus)

Deciphering the "Fuzzy" Interaction of FG Nucleoporins and Transport Factors Using Small-Angle Neutron Scattering

Sparks, S., Temel, D. B., Rout, M. P. & Cowburn, D., Jan 1 2018, (Accepted/In press) In : Structure.

Research output: Contribution to journal › Article

Nuclear Pore Complex Proteins
Small Angle Scattering
Nuclear Pore
Neutrons
Phenylalanine
8 Citations (Scopus)

Thermodynamic characterization of the multivalent interactions underlying rapid and selective translocation through the nuclear pore complex

Hayama, R., Sparks, S., Hecht, L. M., Dutta, K., Karp, J. M., Cabana, C. M., Rout, M. P., Cowburn, D. & Allewell, N. M., Jan 1 2018, In : Journal of Biological Chemistry. 293, 12, p. 4555-4563 9 p.

Research output: Contribution to journal › Review article

Intrinsically Disordered Proteins
Nuclear Pore
Thermodynamics
phenylalanylglycine
Nuclear Pore Complex Proteins
16 Citations (Scopus)

A promiscuous split intein with expanded protein engineering applications

Stevens, A. J., Sekar, G., Shah, N. H., Mostafavi, A. Z., Cowburn, D. & Muir, T. W., Aug 8 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 32, p. 8538-8543 6 p.

Research output: Contribution to journal › Article

Inteins
Protein Engineering
Trans-Splicing
Protein Splicing
Cyclization