• 4266 Citations
  • 42 h-Index
1981 …2022
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Publications 1981 2019

  • 4266 Citations
  • 42 h-Index
  • 117 Article
  • 2 Chapter
2019
1 Citation (Scopus)
Lenses
Genes
Cell Nucleus
Crystallins
Alleles
6 Citations (Scopus)

Generation, transcriptome profiling, and functional validation of cone-rich human retinal organoids

Kim, S., Lowe, A., Dharmat, R., Lee, S., Owen, L. A., Wang, J., Shakoor, A., Li, Y., Morgan, D. J., Hejazi, A. A., Cvekl, A., DeAngelis, M. M., Jimmy Zhou, Z., Chen, R. & Liu, W., May 28 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 10824-10833 10 p.

Research output: Contribution to journalArticle

Organoids
Retinal Cone Photoreceptor Cells
Gene Expression Profiling
RNA Sequence Analysis
Vertebrate Photoreceptor Cells
1 Citation (Scopus)
Open Access
Crystalline Lens
Lenses
Chromatin
Transcription Factors
Nucleosomes
9 Citations (Scopus)

Proteome-transcriptome analysis and proteome remodeling in mouse lens epithelium and fibers

Zhao, Y., Wilmarth, P. A., Cheng, C., Limi, S., Fowler, V. M., Zheng, D., David, L. L. & Cvekl, A., Feb 1 2019, In : Experimental Eye Research. 179, p. 32-46 15 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Proteome
Lenses
Epithelium
Proteins

Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells

Ravichandran, M., Lei, R., Tang, Q., Zhao, Y., Lee, J., Ma, L., Chrysanthou, S., Lorton, B. M., Cvekl, A., Shechter, D., Zheng, D. & Dawlaty, M. M., Jan 1 2019, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

Open Access
Gene Regulatory Networks
Retinoids
Embryonic Stem Cells
Stem cells
Genes
2018
9 Citations (Scopus)
Spatio-Temporal Analysis
Lenses
Epithelial Cells
Epithelium
Lens Diseases
7 Citations (Scopus)

BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation

Brennan, L. A., McGreal-Estrada, R., Logan, C. M., Cvekl, A., Menko, A. S. & Kantorow, M., Sep 1 2018, In : Experimental Eye Research. 174, p. 173-184 12 p.

Research output: Contribution to journalArticle

Crystalline Lens
Golgi Apparatus
Endoplasmic Reticulum
Organelles
Lenses
2 Citations (Scopus)

Identification of Novel Gata3 Distal Enhancers Active in Mouse Embryonic Lens

Martynova, E., Bouchard, M., Musil, L. S. & Cvekl, A., Nov 1 2018, In : Developmental Dynamics. 247, 11, p. 1186-1198 13 p.

Research output: Contribution to journalArticle

Lenses
Transcription Factors
Binding Sites
Urogenital System
Chromatin Assembly and Disassembly

Promoter-enhancer looping and shadow enhancers of the mouse αA-crystallin locus

McGreal-Estrada, R. S., Wolf, L. V. & Cvekl, A., Jan 1 2018, In : Biology Open. 7, 12, bio036897.

Research output: Contribution to journalArticle

crystallins
Crystallins
Chromatin
chromatin
Lens
2 Citations (Scopus)

Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation

Diacou, R., Zhao, Y., Zheng, D., Cvekl, A. & Liu, W., Nov 27 2018, In : Cell Reports. 25, 9, p. 2510-2523.e4

Research output: Contribution to journalArticle

Catenins
Maintenance
Gene expression
Retina
Stem Cells
4 Citations (Scopus)

Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process

Limi, S., Senecal, A., Coleman, R. A., Lopez-Jones, M., Guo, P., Polumbo, C., Singer, R. H., Skoultchi, A. I. & Cvekl, A., Jan 1 2018, In : Journal of Biological Chemistry. 293, 34, p. 13176-13190 15 p.

Research output: Contribution to journalArticle

Lenses
Cell Differentiation
Fibers
Genes
Chromatin
2017
7 Citations (Scopus)

Evolutionary origins of Pax6 control of crystallin genes

Cvekl, A., Zhao, Y., Estrada, R. S., Xie, Q., Gu, X. & Zheng, D., 2017, In : Genome Biology and Evolution. 9, 8, p. 2075-2092 18 p.

Research output: Contribution to journalArticle

crystallins
Crystallins
gene
Genes
genes
13 Citations (Scopus)

N-myc regulates growth and fiber cell differentiation in lens development

Cavalheiro, G. R., Matos-Rodrigues, G. E., Zhao, Y., Gomes, A. L., Anand, D., Predes, D., de Lima, S., Abreu, J. G., Zheng, D., Lachke, S. A., Cvekl, A. & Martins, R. A. P., Sep 1 2017, In : Developmental Biology. 429, 1, p. 105-117 13 p.

Research output: Contribution to journalArticle

Lenses
Cell Differentiation
Growth
myc Genes
Morphogenesis
59 Citations (Scopus)

Programmed mitophagy is essential for the glycolytic switch during cell differentiation

Esteban-Martínez, L., Sierra-Filardi, E., Estrada, R. S., Salazar-Roa, M., Mariño, G., Seco, E., Durand, S., Enot, D., Graña, O., Malumbres, M., Cvekl, A., Cuervo, A. M., Kroemer, G. & Boya, P., Jun 14 2017, In : EMBO Journal. 36, 12, p. 1688-1706 19 p.

Research output: Contribution to journalArticle

Mitochondrial Degradation
Mitochondria
Retinal Ganglion Cells
Macrophages
Cell Differentiation
35 Citations (Scopus)

Signaling and Gene Regulatory Networks in Mammalian Lens Development

Cvekl, A. & Zhang, X., 2017, (Accepted/In press) In : Trends in Genetics.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Lenses
Crystallins
Clustered Regularly Interspaced Short Palindromic Repeats
Long Noncoding RNA
4 Citations (Scopus)
Retinal Pigment Epithelium
Cell Survival
Population
Chick Embryo
Prosencephalon
2016
14 Citations (Scopus)

Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation

He, S., Limi, S., Estrada, R. S., Xie, Q., Brennan, L. A., Kantorow, W. L., Kokavec, J., Majumdar, R., Hou, H., Edelmann, W., Liu, W., Ashery-Padan, R., Zavadil, J., Kantorow, M., Skoultchi, A. I., Stopka, T. & Cvekl, A., Jun 1 2016, In : Development (Cambridge). 143, 11, p. 1937-1947 11 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Lenses
Enzymes
Cell Differentiation
Gene Expression
22 Citations (Scopus)

Intercellular Adhesion-Dependent Cell Survival and ROCK-Regulated Actomyosin-Driven Forces Mediate Self-Formation of a Retinal Organoid

Lowe, A., Harris, R., Bhansali, P., Cvekl, A. & Liu, W., May 10 2016, In : Stem Cell Reports. 6, 5, p. 743-756 14 p.

Research output: Contribution to journalArticle

Organoids
Actomyosin
Stem cells
Monolayers
Cell Survival
11 Citations (Scopus)

Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers

Sun, J., Zhao, Y., Estrada, R. S., Cohen-Tayar, Y., Rockowitz, S., Wilczek, C., Ashery-Padan, R., Shechter, D., Zheng, D. & Cvekl, A., Sep 9 2016, In : Epigenetics and Chromatin. 9, 1, 37.

Research output: Contribution to journalArticle

Methylation
Lenses
Post Translational Protein Processing
Chromatin
Histones
17 Citations (Scopus)

Regulation of c-Maf and αA-Crystallin in ocular lens by fibroblast growth factor signaling

Xie, Q., Estrada, R. S., Harris, R., Gao, C. Y., Liu, W., Reneker, L. W., Musil, L. S. & Cvekl, A., Feb 19 2016, In : Journal of Biological Chemistry. 291, 8, p. 3947-3958 12 p.

Research output: Contribution to journalArticle

Crystalline Lens
Crystallins
Fibroblast Growth Factors
Lenses
Transcription Factor AP-1
6 Citations (Scopus)

Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals

Menuchin-Lasowski, Y., Oren-Giladi, P., Xie, Q., Ezra-Elia, R., Ofri, R., Peled-Hajaj, S., Farhy, C., Higashi, Y., Van de Putte, T., Kondoh, H., Huylebroeck, D., Cvekl, A. & Ashery-Padan, R., Aug 1 2016, In : Development (Cambridge). 143, 15, p. 2829-2841 13 p.

Research output: Contribution to journalArticle

Cell Lineage
Neuroglia
Mammals
Transcription Factors
Cell Count
11 Citations (Scopus)

Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract

Lyu, L., Whitcomb, E. A., Jiang, S., Chang, M. L., Gu, Y., Duncan, M. K., Cvekl, A., Wang, W. L., Limi, S., Reneker, L. W., Shang, F., Du, L. & Taylor, A., Mar 1 2016, In : FASEB Journal. 30, 3, p. 1087-1095 9 p.

Research output: Contribution to journalArticle

Unfolded Protein Response
Cataract
Lenses
Stabilization
Fibers
2015
12 Citations (Scopus)

Chromatin features, RNA polymerase II and the comparative expression of lens genes encoding crystallins, transcription factors, and autophagy mediators

Sun, J., Rockowitz, S., Chauss, D., Wang, P., Kantorow, M., Zheng, D. & Cvekl, A., Aug 28 2015, In : Molecular Vision. 21, p. 955-973 19 p.

Research output: Contribution to journalArticle

Crystallins
RNA Polymerase II
Autophagy
Lenses
Chromatin
46 Citations (Scopus)

Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development

Sun, J., Rockowitz, S., Xie, Q., Ashery-Padan, R., Zheng, D. & Cvekl, A., Jul 2 2015, In : Nucleic Acids Research. 43, 14, p. 6827-6846 20 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Prosencephalon
Lenses
DNA
Transcription Factors
14 Citations (Scopus)

Lens Biology and Biochemistry

Hejtmancik, J. F., Riazuddin, S. A., Estrada, R. S., Liu, W., Cvekl, A. & Shiels, A., 2015, In : Progress in Molecular Biology and Translational Science. 134, p. 169-201 33 p.

Research output: Contribution to journalArticle

Biochemistry
Lenses
Crystallins
Light
Organelles
15 Citations (Scopus)

Lens Development and Crystallin Gene Expression

Cvekl, A., Estrada, R. S. & Liu, W., 2015, In : Progress in Molecular Biology and Translational Science. 134, p. 129-167 39 p.

Research output: Contribution to journalArticle

Crystallins
Lenses
Gene Expression
Untranslated RNA
Crystalline Lens
28 Citations (Scopus)

PAX6: 25th anniversary and more to learn

Cvekl, A. & Callaerts, P., Nov 12 2015, (Accepted/In press) In : Experimental Eye Research.

Research output: Contribution to journalArticle

Anniversaries and Special Events
Technology
High-Throughput Nucleotide Sequencing
Forensic Anthropology
Ectoderm
2014
9 Citations (Scopus)

Gene regulation by PAX6: Structural-functional correlations of missense mutants and transcriptional control of Trpm3/miR-204

Xie, Q., Ung, D., Khafizov, K., Fiser, A. & Cvekl, A., Mar 6 2014, In : Molecular Vision. 20, p. 270-282 13 p.

Research output: Contribution to journalArticle

Mutation
Binding Sites
Genes
Missense Mutation
Regulator Genes

Lens-specific transcription factors and their roles in diagnosis and treatment of human congenital cataract

Cvekl, A., Friedman, I. B. & Semina, E. V., Mar 1 2014, Lens Epithelium and Posterior Capsular Opacification. Springer Japan, p. 105-130 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cataract
Lenses
Transcription Factors
Therapeutics
Ectoderm
14 Citations (Scopus)

Mammalian TBX1 preferentially binds and regulates downstream targets via a tandem T-site repeat

Castellanos, R., Xie, Q., Zheng, D., Cvekl, A. & Morrow, B. E., May 5 2014, In : PLoS One. 9, 5, e95151.

Research output: Contribution to journalArticle

tandem repeat sequences
consensus sequence
Consensus Sequence
DiGeorge Syndrome
Tandem Repeat Sequences
80 Citations (Scopus)

The cellular and molecular mechanisms of vertebrate lens development

Cvekl, A. & Ashery-Padan, R., Dec 1 2014, In : Development (Cambridge). 141, 23, p. 4432-4447 16 p.

Research output: Contribution to journalArticle

Lenses
Vertebrates
Crystalline Lens
Gene Regulatory Networks
Elasticity
2013
33 Citations (Scopus)

Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage

Braunger, B. M., Ohlmann, A., Koch, M., Tanimoto, N., Volz, C., Yang, Y., Bösl, M. R., Cvekl, A., Jägle, H., Seeliger, M. W. & Tamm, E. R., Feb 2013, In : Neurobiology of Disease. 50, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Endothelin-2
Catenins
Endothelin B Receptors
Light
Brain-Derived Neurotrophic Factor
42 Citations (Scopus)

Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation

Walcher, T., Xie, Q., Sun, J., Irmler, M., Beckers, J., Öztürk, T., Niessing, D., Stoykova, A., Cvekl, A., Ninkovic, J. & Götz, M., 2013, In : Development (Cambridge). 140, 5, p. 1123-1136 14 p.

Research output: Contribution to journalArticle

Neurogenesis
Prosencephalon
Dissection
Mutation
DNA
38 Citations (Scopus)

Histone posttranslational modifications and cell fate determination: Lens induction requires the lysine acetyltransferases CBP and p300

Wolf, L., Harrison, W., Huang, J., Xie, Q., Xiao, N., Sun, J., Kong, L., Lachke, S. A., Kuracha, M. R., Govindarajan, V., Brindle, P. K., Ashery-Padan, R., Beebe, D. C., Overbeek, P. A. & Cvekl, A., Dec 2013, In : Nucleic Acids Research. 41, 22, p. 10199-10214 16 p.

Research output: Contribution to journalArticle

Histone Code
Post Translational Protein Processing
Lenses
Histones
Aphakia
24 Citations (Scopus)

Identification and Characterization of FGF2-Dependent mRNA: microRNA Networks During Lens Fiber Cell Differentiation

Wolf, L., Gao, C. S., Gueta, K., Xie, Q., Chevallier, T., Podduturi, N. R., Sun, J., Conte, I., Zelenka, P. S., Ashery-Padan, R., Zavadil, J. & Cvekl, A., 2013, In : G3: Genes, Genomes, Genetics. 3, 12, p. 2239-2255 17 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
MicroRNAs
Lenses
Cell Differentiation
Messenger RNA

Lens differentiation from embryonic stem (ES) and induced pluripotent stem (iPS) cells

Cvekl, A., Yang, Y., Jing, Y. & Xie, Q., Jan 1 2013, Stem Cell Biology and Regenerative Medicine in Ophthalmology. Springer New York, p. 57-73 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Induced Pluripotent Stem Cells
Stem cells
Lenses
Cataract
Stem Cells
49 Citations (Scopus)

Pax6 Interactions with Chromatin and Identification of Its Novel Direct Target Genes in Lens and Forebrain

Xie, Q., Yang, Y., Huang, J., Ninkovic, J., Walcher, T., Wolf, L., Vitenzon, A., Zheng, D., Götz, M., Beebe, D. C., Zavadil, J. & Cvekl, A., Jan 14 2013, In : PLoS One. 8, 1, e54507.

Research output: Contribution to journalArticle

Prosencephalon
Lens
Lenses
Chromatin
chromatin
58 Citations (Scopus)

Pax6 Regulates Gene Expression in the Vertebrate Lens through miR-204

Shaham, O., Gueta, K., Mor, E., Oren-Giladi, P., Grinberg, D., Xie, Q., Cvekl, A., Shomron, N., Davis, N., Keydar-Prizant, M., Raviv, S., Pasmanik-Chor, M., Bell, R. E., Levy, C., Avellino, R., Banfi, S., Conte, I. & Ashery-Padan, R., 2013, In : PLoS Genetics. 9, 3, e1003357.

Research output: Contribution to journalArticle

Lens
Lenses
gene expression
Vertebrates
vertebrate
2012
1 Citation (Scopus)

Focus on Molecules: Brg1: A range of functions during eye development

He, S. & Cvekl, A., Oct 2012, In : Experimental Eye Research. 103, p. 117-118 2 p.

Research output: Contribution to journalArticle

DNA Helicases
Chromatin Assembly and Disassembly
Nuclear Proteins
Lenses
Retina
29 Citations (Scopus)

Spatial expression patterns of autophagy genes in the eye lens and induction of autophagy in lens cells

Brennan, L. A., Kantorow, W. L., Chauss, D., Estrada, R. S., He, S., Mattucci, L., Wei, J., Amer Riazuddin, S., Cvekl, A., Fielding Hejtmancik, J. & Kantorow, M., Jun 30 2012, In : Molecular Vision. 18, p. 1773-1786 14 p.

Research output: Contribution to journalArticle

Crystalline Lens
Autophagy
Lenses
Genes
Light
2011
46 Citations (Scopus)

The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops

Xie, Q. & Cvekl, A., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43259-43271 13 p.

Research output: Contribution to journalArticle

Morphogenesis
Lenses
Tissue
Crystallins
Gene Regulatory Networks
2010
38 Citations (Scopus)

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation

He, S., Pirity, M. K., Wang, W. L., Wolf, L., Chauhan, B. K., Cveklova, K., Tamm, E. R., Ashery-Padan, R., Metzger, D., Nakai, A., Chambon, P., Zavadil, J. & Cvekl, A., 2010, In : Epigenetics and Chromatin. 3, 1, 21.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Lenses
Cell Differentiation
Enzymes
Deoxyribonucleases
58 Citations (Scopus)

Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions

Yang, C., Yang, Y., Brennan, L., Bouhassira, E. E., Kantorow, M. & Cvekl, A., Sep 2010, In : FASEB Journal. 24, 9, p. 3274-3283 10 p.

Research output: Contribution to journalArticle

Stem cells
Lenses
Stem Cells
Cataract
Crystallins
56 Citations (Scopus)

Epigenetic regulatory mechanisms in vertebrate eye development and disease

Cvekl, A. & Mitton, K. P., Jul 2010, In : Heredity. 105, 1, p. 135-151 17 p.

Research output: Contribution to journalArticle

Eye Diseases
Epigenomics
Chromatin
Vertebrates
Untranslated RNA
25 Citations (Scopus)
Cytoplasmic and Nuclear Receptors
Lenses
Cell Differentiation
Apoptosis
Nuclear Receptor Coactivators
20 Citations (Scopus)

Perturbing the ubiquitin pathway reveals how mitosis is hijacked to denucleate and regulate cell proliferation and differentiation in Vivo

Caceres, A., Shang, F., Wawrousek, E., Liu, Q., Avidan, O., Cvekl, A., Yang, Y., Haririnia, A., Storaska, A., Fushman, D., Kuszak, J., Dudek, E., Smith, D. & Taylor, A., 2010, In : PLoS One. 5, 10, e13331.

Research output: Contribution to journalArticle

Cell proliferation
ubiquitin
Ubiquitin
Mitosis
cell differentiation
33 Citations (Scopus)

Retinoid signaling in inner ear development: A "Goldilocks" phenomenon

Frenz, D. A., Liu, W., Cvekl, A., Xie, Q., Wassef, L., Quadro, L., Niederreither, K., Maconochie, M. & Shanske, A., Dec 2010, In : American Journal of Medical Genetics, Part A. 152 A, 12, p. 2947-2961 15 p.

Research output: Contribution to journalArticle

Retinoids
Inner Ear
Tretinoin
Ear
Epithelium
76 Citations (Scopus)

The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin αA

Ninkovic, J., Pinto, L., Petricca, S., Lepier, A., Sun, J., Rieger, M. A., Schroeder, T., Cvekl, A., Favor, J. & Götz, M., Nov 18 2010, In : Neuron. 68, 4, p. 682-694 13 p.

Research output: Contribution to journalArticle

Crystallins
Olfactory Bulb
Transcription Factors
Interneurons
Neurons
16 Citations (Scopus)

Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog

Zhou, J., Liu, Y., Zhang, W., Popov, V. M., Wang, M., Pattabiraman, N., Suñé, C., Cvekl, A., Wu, K., Jiang, J., Wang, C. & Pestell, R. G., Dec 17 2010, In : Journal of Biological Chemistry. 285, 51, p. 40342-40350 9 p.

Research output: Contribution to journalArticle

Transcription
Elongation
Gene Expression
Genes
Binding Sites
2009

Gene sharing and evolution

Cvekl, A. & Zheng, D., Oct 1 2009, In : Human Genomics. 4, 1, p. 66-67 2 p.

Research output: Contribution to journalArticle

Genes