• 4444 Citations
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1981 …2019

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Article
2019

A distal enhancer that directs Otx2 expression in the retinal pigment epithelium and neuroretina

Bhansali, P., Cvekl, A. & Liu, W., Jan 1 2019, (Accepted/In press) In : Developmental Dynamics.

Research output: Contribution to journalArticle

Bidirectional analysis of cryba4-crybb1 nascent transcription and nuclear accumulation of crybb3 mrnas in lens fibers

Limi, S., Zhao, Y., Guo, P., Lopez-Jones, M., Zheng, D., Singer, R. H., Skoultchi, A. I. & Cvekl, A., Jan 1 2019, In : Investigative Ophthalmology and Visual Science. 60, 1, p. 234-244 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Generation, transcriptome profiling, and functional validation of cone-rich human retinal organoids

Kim, S., Lowe, A., Dharmat, R., Lee, S., Owen, L. A., Wang, J., Shakoor, A., Li, Y., Morgan, D. J., Hejazi, A. A., Cvekl, A., DeAngelis, M. M., Jimmy Zhou, Z., Chen, R. & Liu, W., May 28 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 166, 22, p. 10824-10833 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
Open Access
4 Scopus citations

Proteome-transcriptome analysis and proteome remodeling in mouse lens epithelium and fibers

Zhao, Y., Wilmarth, P. A., Cheng, C., Limi, S., Fowler, V. M., Zheng, D., David, L. L. & Cvekl, A., Feb 2019, In : Experimental Eye Research. 179, p. 32-46 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells

Ravichandran, M., Lei, R., Tang, Q., Zhao, Y., Lee, J., Ma, L., Chrysanthou, S., Lorton, B. M., Cvekl, A., Shechter, D., Zheng, D. & Dawlaty, M. M., Aug 20 2019, In : Cell Reports. 28, 8, p. 1993-2003.e5

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3

Martynova, E., Zhao, Y., Xie, Q., Zheng, D. & Cvekl, A., Dec 1 2019, In : Open Biology. 9, 12, 190220.

Research output: Contribution to journalArticle

Open Access
2018
10 Scopus citations

BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation

Brennan, L. A., McGreal-Estrada, R., Logan, C. M., Cvekl, A., Menko, A. S. & Kantorow, M., Sep 2018, In : Experimental Eye Research. 174, p. 173-184 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Identification of Novel Gata3 Distal Enhancers Active in Mouse Embryonic Lens

Martynova, E., Bouchard, M., Musil, L. S. & Cvekl, A., Nov 2018, In : Developmental Dynamics. 247, 11, p. 1186-1198 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Promoter-enhancer looping and shadow enhancers of the mouse αA-crystallin locus

McGreal-Estrada, R. S., Wolf, L. V. & Cvekl, A., 2018, In : Biology Open. 7, 12, bio036897.

Research output: Contribution to journalArticle

Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation

Diacou, R., Zhao, Y., Zheng, D., Cvekl, A. & Liu, W., Nov 27 2018, In : Cell Reports. 25, 9, p. 2510-2523.e4

Research output: Contribution to journalArticle

4 Scopus citations

Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process

Limi, S., Senecal, A., Coleman, R., Lopez-Jones, M., Guo, P., Polumbo, C., Singer, R. H., Skoultchi, A. I. & Cvekl, A., Aug 24 2018, In : Journal of Biological Chemistry. 293, 34, p. 13176-13190 15 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Evolutionary origins of Pax6 control of crystallin genes

Cvekl, A., Zhao, Y., McGreal, R., Xie, Q., Gu, X. & Zheng, D., Jan 1 2017, In : Genome Biology and Evolution. 9, 8, p. 2075-2092 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

N-myc regulates growth and fiber cell differentiation in lens development

Cavalheiro, G. R., Matos-Rodrigues, G. E., Zhao, Y., Gomes, A. L., Anand, D., Predes, D., de Lima, S., Abreu, J. G., Zheng, D., Lachke, S. A., Cvekl, A. & Martins, R. A. P., Sep 1 2017, In : Developmental Biology. 429, 1, p. 105-117 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Programmed mitophagy is essential for the glycolytic switch during cell differentiation

Esteban-Martínez, L., Sierra-Filardi, E., McGreal, R. S., Salazar-Roa, M., Mariño, G., Seco, E., Durand, S., Enot, D., Graña, O., Malumbres, M., Cvekl, A., Cuervo, A. M., Kroemer, G. & Boya, P., Jun 14 2017, In : EMBO Journal. 36, 12, p. 1688-1706 19 p.

Research output: Contribution to journalArticle

79 Scopus citations
4 Scopus citations
2016

Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation

He, S., Limi, S., McGreal, R. S., Xie, Q., Brennan, L. A., Kantorow, W. L., Kokavec, J., Majumdar, R., Hou, H., Edelmann, W., Liu, W., Ashery-Padan, R., Zavadil, J., Kantorow, M., Skoultchi, A. I., Stopka, T. & Cvekl, A., Jun 1 2016, In : Development (Cambridge). 143, 11, p. 1937-1947 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Intercellular Adhesion-Dependent Cell Survival and ROCK-Regulated Actomyosin-Driven Forces Mediate Self-Formation of a Retinal Organoid

Lowe, A., Harris, R., Bhansali, P., Cvekl, A. & Liu, W., May 10 2016, In : Stem Cell Reports. 6, 5, p. 743-756 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers

Sun, J., Zhao, Y., McGreal, R., Cohen-Tayar, Y., Rockowitz, S., Wilczek, C., Ashery-Padan, R., Shechter, D., Zheng, D. & Cvekl, A., Sep 9 2016, In : Epigenetics and Chromatin. 9, 1, 37.

Research output: Contribution to journalArticle

13 Scopus citations

Regulation of c-Maf and αA-Crystallin in ocular lens by fibroblast growth factor signaling

Xie, Q., Estrada, R. S., Harris, R., Gao, C. Y., Liu, W., Reneker, L. W., Musil, L. S. & Cvekl, A., Feb 19 2016, In : Journal of Biological Chemistry. 291, 8, p. 3947-3958 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals

Menuchin-Lasowski, Y., Oren-Giladi, P., Xie, Q., Ezra-Elia, R., Ofri, R., Peled-Hajaj, S., Farhy, C., Higashi, Y., Van de Putte, T., Kondoh, H., Huylebroeck, D., Cvekl, A. & Ashery-Padan, R., Aug 1 2016, In : Development (Cambridge). 143, 15, p. 2829-2841 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract

Lyu, L., Whitcomb, E. A., Jiang, S., Chang, M. L., Gu, Y., Duncan, M. K., Cvekl, A., Wang, W. L., Limi, S., Reneker, L. W., Shang, F., Du, L. & Taylor, A., Mar 2016, In : FASEB Journal. 30, 3, p. 1087-1095 9 p.

Research output: Contribution to journalArticle

12 Scopus citations
2015

Chromatin features, RNA polymerase II and the comparative expression of lens genes encoding crystallins, transcription factors, and autophagy mediators

Sun, J., Rockowitz, S., Chauss, D., Wang, P., Kantorow, M., Zheng, D. & Cvekl, A., Aug 28 2015, In : Molecular vision. 21, p. 955-973 19 p.

Research output: Contribution to journalArticle

12 Scopus citations

Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development

Sun, J., Rockowitz, S., Xie, Q., Ashery-Padan, R., Zheng, D. & Cvekl, A., Jul 2 2015, In : Nucleic acids research. 43, 14, p. 6827-6846 20 p.

Research output: Contribution to journalArticle

49 Scopus citations

PAX6: 25th anniversary and more to learn

Cvekl, A. & Callaerts, P., Nov 12 2015, (Accepted/In press) In : Experimental Eye Research.

Research output: Contribution to journalArticle

33 Scopus citations
2014

Gene regulation by PAX6: Structural-functional correlations of missense mutants and transcriptional control of Trpm3/miR-204

Xie, Q., Ung, D., Khafizov, K., Fiser, A. & Cvekl, A., Mar 6 2014, In : Molecular vision. 20, p. 270-282 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mammalian TBX1 preferentially binds and regulates downstream targets via a tandem T-site repeat

Castellanos, R., Xie, Q., Zheng, D., Cvekl, A. & Morrow, B. E., May 5 2014, In : PloS one. 9, 5, e95151.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage

Braunger, B. M., Ohlmann, A., Koch, M., Tanimoto, N., Volz, C., Yang, Y., Bösl, M. R., Cvekl, A., Jägle, H., Seeliger, M. W. & Tamm, E. R., Feb 1 2013, In : Neurobiology of Disease. 50, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation

Walcher, T., Xie, Q., Sun, J., Irmler, M., Beckers, J., Öztürk, T., Niessing, D., Stoykova, A., Cvekl, A., Ninkovic, J. & Götz, M., Feb 19 2013, In : Development (Cambridge). 140, 5, p. 1123-1136 14 p.

Research output: Contribution to journalArticle

42 Scopus citations

Histone posttranslational modifications and cell fate determination: Lens induction requires the lysine acetyltransferases CBP and p300

Wolf, L., Harrison, W., Huang, J., Xie, Q., Xiao, N., Sun, J., Kong, L., Lachke, S. A., Kuracha, M. R., Govindarajan, V., Brindle, P. K., Ashery-Padan, R., Beebe, D. C., Overbeek, P. A. & Cvekl, A., Dec 2013, In : Nucleic acids research. 41, 22, p. 10199-10214 16 p.

Research output: Contribution to journalArticle

39 Scopus citations

Identification and Characterization of FGF2-Dependent mRNA: microRNA Networks During Lens Fiber Cell Differentiation

Wolf, L., Gao, C. S., Gueta, K., Xie, Q., Chevallier, T., Podduturi, N. R., Sun, J., Conte, I., Zelenka, P. S., Ashery-Padan, R., Zavadil, J. & Cvekl, A., Dec 2013, In : G3: Genes, Genomes, Genetics. 3, 12, p. 2239-2255 17 p.

Research output: Contribution to journalArticle

25 Scopus citations

Pax6 Interactions with Chromatin and Identification of Its Novel Direct Target Genes in Lens and Forebrain

Xie, Q., Yang, Y., Huang, J., Ninkovic, J., Walcher, T., Wolf, L., Vitenzon, A., Zheng, D., Götz, M., Beebe, D. C., Zavadil, J. & Cvekl, A., Jan 14 2013, In : PloS one. 8, 1, e54507.

Research output: Contribution to journalArticle

51 Scopus citations

Pax6 Regulates Gene Expression in the Vertebrate Lens through miR-204

Shaham, O., Gueta, K., Mor, E., Oren-Giladi, P., Grinberg, D., Xie, Q., Cvekl, A., Shomron, N., Davis, N., Keydar-Prizant, M., Raviv, S., Pasmanik-Chor, M., Bell, R. E., Levy, C., Avellino, R., Banfi, S., Conte, I. & Ashery-Padan, R., 2013, In : PLoS genetics. 9, 3, e1003357.

Research output: Contribution to journalArticle

64 Scopus citations
2012

Spatial expression patterns of autophagy genes in the eye lens and induction of autophagy in lens cells

Brennan, L. A., Kantorow, W. L., Chauss, D., Mcgreal, R., He, S., Mattucci, L., Wei, J., Amer Riazuddin, S., Cvekl, A., Fielding Hejtmancik, J. & Kantorow, M., Jun 30 2012, In : Molecular vision. 18, p. 1773-1786 14 p.

Research output: Contribution to journalArticle

29 Scopus citations
2011

The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops

Xie, Q. & Cvekl, A., Dec 16 2011, In : Journal of Biological Chemistry. 286, 50, p. 43259-43271 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
2010

Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation

He, S., Pirity, M. K., Wang, W. L., Wolf, L., Chauhan, B. K., Cveklova, K., Tamm, E. R., Ashery-Padan, R., Metzger, D., Nakai, A., Chambon, P., Zavadil, J. & Cvekl, A., Dec 2 2010, In : Epigenetics and Chromatin. 3, 1, 21.

Research output: Contribution to journalArticle

40 Scopus citations

Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions

Yang, C., Yang, Y., Brennan, L., Bouhassira, E. E., Kantorow, M. & Cvekl, A., Sep 1 2010, In : FASEB Journal. 24, 9, p. 3274-3283 10 p.

Research output: Contribution to journalArticle

60 Scopus citations
25 Scopus citations

Perturbing the ubiquitin pathway reveals how mitosis is hijacked to denucleate and regulate cell proliferation and differentiation in Vivo

Caceres, A., Shang, F., Wawrousek, E., Liu, Q., Avidan, O., Cvekl, A., Yang, Y., Haririnia, A., Storaska, A., Fushman, D., Kuszak, J., Dudek, E., Smith, D. & Taylor, A., 2010, In : PloS one. 5, 10, e13331.

Research output: Contribution to journalArticle

20 Scopus citations

The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin αA

Ninkovic, J., Pinto, L., Petricca, S., Lepier, A., Sun, J., Rieger, M. A., Schroeder, T., Cvekl, A., Favor, J. & Götz, M., Nov 18 2010, In : Neuron. 68, 4, p. 682-694 13 p.

Research output: Contribution to journalArticle

79 Scopus citations

Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog

Zhou, J., Liu, Y., Zhang, W., Popov, V. M., Wang, M., Pattabiraman, N., Suñé, C., Cvekl, A., Wu, K., Jiang, J., Wang, C. & Pestell, R. G., Dec 17 2010, In : Journal of Biological Chemistry. 285, 51, p. 40342-40350 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2009

Identification of Pax6-dependent gene regulatory networks in the mouse lens

Wolf, L. V., Yang, Y., Wang, J., Xie, Q., Braunger, B., Tamm, E. R., Zavadil, J. & Cvekl, A., Jan 9 2009, In : PloS one. 4, 1, e4159.

Research output: Contribution to journalArticle

66 Scopus citations
2008

Cell autonomous roles for AP-2α in lens vesicle separation and maintenance of the lens epithelial cell phenotype

Pontoriero, G. F., Deschamps, P., Ashery-Padan, R., Wong, R., Yang, Y., Zavadil, J., Cvekl, A., Sullivan, S., Williams, T. & West-Mays, J. A., Mar 1 2008, In : Developmental Dynamics. 237, 3, p. 602-617 16 p.

Research output: Contribution to journalArticle

46 Scopus citations

Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis

Chen, Y., Doughman, Y. Q., Gu, S., Jarrell, A., Aota, S. I., Cvekl, A., Watanabe, M., Dunwoodie, S. L., Johnson, R. S., van Heyningen, V., Kleinjan, D. A., Beebe, D. C. & Yang, Y. C., Sep 2008, In : Development. 135, 17, p. 2939-2948 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Dual requirement for Pax6 in retinal progenitor cells

Oron-Karni, V., Farhy, C., Elgart, M., Marquardt, T., Remizova, L., Yaron, O., Xie, Q., Cvekl, A. & Ashery-Padan, R., Dec 1 2008, In : Development. 135, 24, p. 4037-4047 11 p.

Research output: Contribution to journalArticle

70 Scopus citations

Transcriptional regulation of mouse alpha A-crystallin gene in a 148kb Cryaa BAC and its derivates

Wolf, L., Yang, Y., Wawrousek, E. & Cvekl, A., Oct 21 2008, In : BMC Developmental Biology. 8, 88.

Research output: Contribution to journalArticle

16 Scopus citations
2007

Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth

Wu, K., Liu, M., Li, A., Donninger, H., Rao, M., Jiao, X., Lisanti, M. P., Cvekl, A., Birrer, M. & Pestell, R. G., Mar 1 2007, In : Molecular biology of the cell. 18, 3, p. 755-767 13 p.

Research output: Contribution to journalArticle

47 Scopus citations

Distinct Embryonic Expression and Localization of CBP and p300 Histone Acetyltransferases at the Mouse αA-Crystallin Locus in Lens

Yang, Y., Wolf, L. V. & Cvekl, A., Jun 15 2007, In : Journal of Molecular Biology. 369, 4, p. 917-926 10 p.

Research output: Contribution to journalArticle

16 Scopus citations

Rybp, a polycomb complex-associated protein, is required for mouse eye development

Pirity, M. K., Wang, W. L., Wolf, L. V., Tamm, E. R., Schreiber-Agus, N. & Cvekl, A., May 28 2007, In : BMC Developmental Biology. 7, 39.

Research output: Contribution to journalArticle

20 Scopus citations