• 4506 Citations
  • 43 h-Index
1981 …2019

Research output per year

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Publications

1981

Fluorescence study of the molecular conformation of human haemopexin

Kodiček, M., Cvekl, A. & Vodrá, Z., Dec 1981, In : International Journal of Biological Macromolecules. 3, 6, p. 397-398 2 p.

Research output: Contribution to journalLetter

1 Scopus citations
1988

The effect of divalent cations and core polymerase in the abortive initiation by escherichia coli dna-dependent rna polymerase using phosphonate dinucleotide primers

Cvekl, A., Horská, K., Šebesta, K., Rosenberg, I. & Holý, A., Jan 1 1988, In : Biocatalysis and Biotransformation. 1, 4, p. 275-281 7 p.

Research output: Contribution to journalArticle

2 Scopus citations
1989

Phosphonate analogues of dinucleotides as substrates for DNA-dependent RNA polymerase from Escherichia coli in primed abortive initiation reaction

Cvekl, A., Horská, K., Sěbesta, K., Rosenberg, I. & Holý, A., Feb 1989, In : International Journal of Biological Macromolecules. 11, 1, p. 33-38 6 p.

Research output: Contribution to journalArticle

2 Scopus citations
1990

Isolation and functional characterization of TIF-IB, a factor that confers promoter specificity to mouse RNA polymerase I

Schnapp, A., Clos, J., Hädelt, W., Schreck, R., Cvekl, A. & Grummt, I., Mar 25 1990, In : Nucleic acids research. 18, 6, p. 1385-1393 9 p.

Research output: Contribution to journalArticle

45 Scopus citations
1991

Protein-binding A + T-rich motifs flank the duck βA-globin enhancer

Cvekl, A., Horská, K., Vlček, Č. & P`ačes, V., Jul 22 1991, In : Gene. 103, 2, p. 253-257 5 p.

Research output: Contribution to journalArticle

9 Scopus citations
1992

Interactions between proteins bound to the duck βA-globin gene promoter and enhancer detected by the DNaseI footprinting

Cvekl, A. & Pačes, V., Jan 15 1992, In : Gene. 110, 2, p. 225-228 4 p.

Research output: Contribution to journalArticle

6 Scopus citations
1993

Functional elements DE2A, DE2B, and DE1A and the TATA box are required for activity of the chicken αA-crystallin gene in transfected lens epithelial cells

Klement, J. F., Cvekl, A. & Piatigorsky, J., Jan 1 1993, In : Journal of Biological Chemistry. 268, 9, p. 6777-6784 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Protein-DNA interactions of the mouse αA-crystallin control regions: Differences between expressing and non-expressing cells

Kantorow, M., Cvekl, A., Sax, C. M. & Piatigorsky, J., Mar 20 1993, In : Journal of Molecular Biology. 230, 2, p. 425-435 11 p.

Research output: Contribution to journalArticle

21 Scopus citations
1994

A complex array of positive and negative elements regulates the chicken αA-crystallin gene: Involvement of Pax-6, USF, CREB and/or CREM, and AP-1 proteins

Cvekl, A., Sax, C. M., Bresnick, E. H. & Piatigorsky, J., Nov 1994, In : Molecular and cellular biology. 14, 11, p. 7363-7376 14 p.

Research output: Contribution to journalArticle

Open Access
127 Scopus citations

Convergent evolution of crystallin gene regulation in squid and chicken: The AP-1/ARE connection

Tomarev, S. I., Duncan, M. K., Roth, H. J., Cvekl, A. & Piatigorsky, J., Aug 1994, In : Journal of Molecular Evolution. 39, 2, p. 134-143 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Identification of negative-acting and protein-binding elements in the mouse αA-crystallin -1556/-1165 region

Sax, C. M., Cvekl, A., Kantorow, M., Sommer, B., Chepelinsky, A. B. & Piatigorsky, J., Jul 8 1994, In : Gene. 144, 2, p. 163-169 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
1995

cDNA encoding a chicken protein (CRP1) with homology to hnRNP type A/B

Cvekl, A., McDermott, J. B. & Piatigorsky, J., Apr 4 1995, In : BBA - Gene Structure and Expression. 1261, 2, p. 290-292 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

Lens-specific activity of the mouse αA-crystallin promoter in the absence of a TATA box: Functional and protein binding analysis of the mouse (αA-crystallin PE1 region

Sax, C. M., Cvekl, A., Kantorow, M., Gopal-srivastava, R., Ilagan, J. G., Ambulos, N. P. & Piatigorsky, J., Feb 11 1995, In : Nucleic acids research. 23, 3, p. 442-451 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pax-6 and lens-specific transcription of the chicken δ1-crystallin gene

Cvekl, A., Sax, C. M., Li, X., Mcdermott, J. B. & Piatigorsky, J., May 9 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 10, p. 4681-4685 5 p.

Research output: Contribution to journalArticle

Open Access
93 Scopus citations

Pax-6 is essential for lens-specific expression of ζ-crystallin

Richardson, J., Cvekl, A. & Wistow, G., May 9 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 10, p. 4676-4680 5 p.

Research output: Contribution to journalArticle

Open Access
116 Scopus citations

Protein-induced bending or flexing at the 5′-end of the duck βA-globin promoter

Mátlová, R., Horská, K., Benes, V., Cvekl, A. & Sponar, J., Apr 24 1995, In : Gene. 156, 2, p. 277-281 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Sequence, initial functional analysis and protein-DNA binding sites of the mouse βB2-crystallin-encoding gene

Chambers, C., Cvekl, A., Sax, C. M. & Russell, P., Dec 12 1995, In : Gene. 166, 2, p. 287-292 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Transactivation of the human T-cell lymphotropic virus type 1 tax1- responsive 21-base-pair repeats requires holo-TFIID and TFIIA

Duvall, J. F., Kashanchi, F., Cvekl, A., Radonovich, M. F., Piras, G. & Brady, J. N., 1995, In : Journal of virology. 69, 8, p. 5077-5086 10 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Transcriptional regulation of the mouse αA-crystallin gene: Activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site

Cvekl, A., Kashanchi, F., Sax, C. M., Brady, J. N. & Piatigorsky, J., Feb 1995, In : Molecular and cellular biology. 15, 2, p. 653-660 8 p.

Research output: Contribution to journalArticle

Open Access
106 Scopus citations
1996

Developmental regulation of the chicken βB1-crystallin promoter

Duncan, M. K., Tomarev, S. I., Cvekl, A. & Piatigorsky, J., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3, p. S986

Research output: Contribution to journalArticle

Expression of the chicken and duck δ2-crystallin gene

Li, X., Cvekl, A. & Piatigorsky, J., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3, p. S902

Research output: Contribution to journalArticle

Lens development and crystallin gene expression: Many roles for Pax-6

Cvekl, A. & Piatigorsky, J., Aug 1996, In : BioEssays. 18, 8, p. 621-630 10 p.

Research output: Contribution to journalReview article

239 Scopus citations

Lens-specific expression of a chicken ßA3/A1-crystallin promoter fragment in transgenic mice

McDermott, J. B., Cvekl, A. & Piatigorsky, J., Apr 25 1996, In : Biochemical and Biophysical Research Communications. 221, 3, p. 559-564 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

PAX6, a "master gene" for eye development: Target genes and mechanism of action

Cvekl, A., Kashanchi, F., Epstein, J., Rauchman, M., Maas, R. & Piatigorsky, J., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3, p. S150

Research output: Contribution to journalArticle

1 Scopus citations

Pax-6 and αB-crystallin/small heat shock protein gene regulation in the murine lens. Interaction with the lens-specific regions, LSR1 and LSR2

Gopal-Srivastava, R., Cvekl, A. & Piatigorsky, J., Jan 1 1996, In : Journal of Biological Chemistry. 271, 38, p. 23029-23036 8 p.

Research output: Contribution to journalArticle

62 Scopus citations

Regulation of PAX-6 gene expression in the lens

Kantorow, M., Cvekl, A. & Piatigorsky, J., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3, p. S987

Research output: Contribution to journalArticle

Regulation of the murine αB-crystallin gene in lens

Gopal-Srivastava, R., Cvekl, A. & Piatigorsky, J., Feb 15 1996, In : Investigative Ophthalmology and Visual Science. 37, 3, p. S987

Research output: Contribution to journalArticle

1997

A complex enhancer of the chicken βA3/A1-crystallin gene depends on an AP-1-CRE element for activity

McDermott, J. B., Cvekl, A. & Piatigorsky, J., May 17 1997, In : Investigative Ophthalmology and Visual Science. 38, 5, p. 951-959 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Lens-preferred activity of chicken δ1- and δ2-crystallin enhancers in transgenic mice and evidence for retinoic acid-responsive regulation of the δ1-crystallin gene

Li, X., Cvekl, A., Bassnett, S. & Piatigorsky, J., Jul 18 1997, In : Developmental Genetics. 20, 3, p. 258-266 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Transcriptional regulation of the mouse αA-crystallin gene: Binding of USF to the -7/+5 region

Sax, C. M., Cvekl, A. & Piatigorsky, J., Feb 7 1997, In : Gene. 185, 2, p. 209-216 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
1998

Dual roles for Pax-6: A transcriptional repressor of lens fiber cell- specific β-crystallin genes

Duncan, M. K., Haynes, J. I., Cvekl, A. & Piatigorsky, J., Sep 1 1998, In : Molecular and cellular biology. 18, 9, p. 5579-5586 8 p.

Research output: Contribution to journalArticle

110 Scopus citations

Involvement of retinoic acid/retinoid receptors in the regulation of murine αB-crystallin/small heat shock protein gene expression in the lens

Gopal-Srivastava, R., Cvekl, A. & Piatigorsky, J., Jul 10 1998, In : Journal of Biological Chemistry. 273, 28, p. 17954-17961 8 p.

Research output: Contribution to journalArticle

55 Scopus citations
1999

Localization of the human homologue of the Drosophila dachshund gene (DACH) to chromosome 13q21

Kozmik, Z. & Cvekl, A., Jul 1 1999, In : Genomics. 59, 1, p. 110-111 2 p.

Research output: Contribution to journalArticle

7 Scopus citations

Molecular cloning and expression of the human and mouse homologues of the Drosophila dachshund gene

Kozmik, Z., Pfeffer, P., Kralova, J., Paces, J., Paces, V., Kalousova, A. & Cvekl, A., Oct 6 1999, In : Development Genes and Evolution. 209, 9, p. 537-545 9 p.

Research output: Contribution to journalArticle

55 Scopus citations

Pax-6 interactions with TATA-box-binding protein and retinoblastoma protein

Cvekl, A., Kashanchi, F., Brady, J. N. & Piatigorsky, J., 1999, In : Investigative Ophthalmology and Visual Science. 40, 7, p. 1343-1350 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Regulation of αA-crystallin gene expression: Lens specificity achieved through the differential placement of similar transcriptional control elements in mouse and chicken

Ilagan, J. G., Cvekl, A., Kantorow, M., Piatigorsky, J. & Sax, C. M., Jul 9 1999, In : Journal of Biological Chemistry. 274, 28, p. 19973-19978 6 p.

Research output: Contribution to journalArticle

27 Scopus citations
2000

Regulation of human myocilin/TIGR gene transcription in trabecular meshwork cells and astrocytes: Role of upstream stimulatory factor

Kirstein, L., Cvekl, A., Chauhan, B. K. & Tamm, E. R., Sep 2 2000, In : Genes to Cells. 5, 8, p. 661-676 16 p.

Research output: Contribution to journalArticle

35 Scopus citations

Truncated forms of Pax-6 disrupt lens morphology in transgenic mice

Duncan, M. K., Cvekl, A., Li, X. & Piatigorsky, J., Feb 15 2000, In : Investigative Ophthalmology and Visual Science. 41, 2, p. 464-473 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2001

Quantification of PAX6 and PAX6(5a) transcript levels in adult human lens, cornea, and monkey retina

Zhang, W., Cveklova, K., Opperman, B., Kantorow, M. & Cvekl, A., Dec 1 2001, In : Molecular vision. 7, p. 1-5 5 p.

Research output: Contribution to journalArticle

45 Scopus citations
2002

A comparative cDNA microarray analysis reveals a spectrum of genes regulated by Pax6 in mouse lens

Chauhan, B. K., Reed, N. A., Yang, Y., Čermák, L., Reneker, L., Duncan, M. K. & Cvekl, A., Dec 1 2002, In : Genes to Cells. 7, 12, p. 1267-1283 17 p.

Research output: Contribution to journalArticle

59 Scopus citations

Cataract- and lens-specific upregulation of ARK receptor tyrosine kinase in emory mouse cataract

Sheets, N. L., Chauhan, B. K., Wawrousek, E., Hejtmancik, J. F., Cvekl, A. & Kantorow, M., 2002, In : Investigative Ophthalmology and Visual Science. 43, 6, p. 1870-1875 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Identification of differentially expressed genes in mouse Pax6 heterozygous lenses

Chauhan, B. K., Zhang, W., Cveklova, K., Kantorow, M. & Cvekl, A., 2002, In : Investigative Ophthalmology and Visual Science. 43, 6, p. 1884-1890 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Identification of genes downstream of Pax6 in the mouse lens using cDNA microarrays

Chauhan, B. K., Reed, N. A., Zhang, W., Duncan, M. K., Kilimann, M. W. & Cvekl, A., Mar 29 2002, In : Journal of Biological Chemistry. 277, 13, p. 11539-11548 10 p.

Research output: Contribution to journalArticle

76 Scopus citations

Pax6 heterozygous eyes show defects in chamber angle differentiation that are associated with a wide spectrum of other anterior eye segment abnormalities

Baulmann, D. C., Ohlmann, A., Flügel-Koch, C., Goswami, S., Cvekl, A. & Tamm, E. R., Oct 1 2002, In : Mechanisms of Development. 118, 1-2, p. 3-17 15 p.

Research output: Contribution to journalArticle

119 Scopus citations

Structure of the retinal determination protein Dachshund reveals a DNA binding motif

Kim, S. S., Zhang, R. G., Braunstein, S. E., Joachimiak, A., Cvekl, A. & Hegde, R. S., Jun 24 2002, In : Structure. 10, 6, p. 787-795 9 p.

Research output: Contribution to journalArticle

58 Scopus citations
2003

DACH1 Inhibits Transforming Growth Factor-β Signaling through Binding Smad4

Wu, K., Yang, Y., Wang, C., Davoli, M. A., D'Amico, M., Li, A., Cveklova, K., Kozmik, Z., Lisanti, M. P., Russell, R. G., Cvekl, A. & Pestell, R. G., Dec 19 2003, In : Journal of Biological Chemistry. 278, 51, p. 51673-51684 12 p.

Research output: Contribution to journalArticle

104 Scopus citations

Spectrum and range of oxidative stress responses of human lens epithelial cells to H2O2 insult

Goswami, S., Sheets, N. L., Zavadil, J., Chauhan, B. K., Bottinger, E. P., Reddy, V. N., Kantorow, M. & Cvekl, A., May 1 2003, In : Investigative Ophthalmology and Visual Science. 44, 5, p. 2084-2093 10 p.

Research output: Contribution to journalArticle

69 Scopus citations
2004

Analysis of transcripts from 17p13.3 in medulloblastoma suggests ROX/MNT as a potential tumour suppressor gene

Cvekl, A., Zavadil, J., Birshtein, B. K., Grotzer, M. A. & Cvekl, A., Nov 1 2004, In : European Journal of Cancer. 40, 16, p. 2525-2532 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Anterior eye development and ocular mesenchyme: New insights from mouse models and human diseases

Cvekl, A. & Tamm, E. R., Apr 2004, In : BioEssays. 26, 4, p. 374-386 13 p.

Research output: Contribution to journalReview article

199 Scopus citations

Expression of the α4 integrin subunit gene promoter is modulated by the transcription factor Pax-6 in corneal epithelial cells

Zaniolo, K., Leclerc, S., Cvekl, A., Vallières, L., Bazin, R., Larouche, K. & Guérin, S. L., Jun 2004, In : Investigative Ophthalmology and Visual Science. 45, 6, p. 1692-1704 13 p.

Research output: Contribution to journalArticle

25 Scopus citations