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2019

PSC-RED and MNC-RED: Albumin-free and low-transferrin robust erythroid differentiation protocols to produce human enucleated red blood cells

Olivier, E. N., Zhang, S., Yan, Z., Suzuka, S. M., Roberts, K., Wang, K. & Bouhassira, E. E., Jul 2019, In : Experimental Hematology. 75, p. 31-52.e15

Research output: Contribution to journalArticle

2 Scopus citations

Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade

Rauch, D. A., Conlon, K. C., Janakiram, M., Brammer, J. E., Harding, J. C., Ye, B. H., Zang, X., Ren, X., Olson, S., Cheng, X., Miljkovic, M. D., Sundaramoorthi, H., Joseph, A., Skidmore, Z. L., Griffith, O., Griffith, M., Waldmann, T. A. & Ratner, L., Oct 24 2019, In : Blood. 134, 17, p. 1406-1414 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Runx1 promotes murine erythroid progenitor proliferation and inhibits differentiation by preventing Pu.1 downregulation

Willcockson, M. A., Taylor, S. J., Ghosh, S., Healton, S. E., Wheat, J. C., Wilson, T. J., Steidl, U. & Skoultchi, A. I., Sep 3 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 36, p. 17841-17847 7 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Stem cell mutations can be detected in myeloma patients years before onset of secondary leukemias

Sridharan, A., Schinke, C. D., Georgiev, G., da Silva Ferreira, M., Thiruthuvanathan, V., MacArthur, I., Bhagat, T. D., Choudhary, G. S., Aluri, S., Chen, J., Pradhan, K., Xia, Y., Panjikaran, M., Sims, G., Bhagat, C. K., Bender, R., Keeler, L., Graber, A., Heuck, C., Fletcher, F. A. & 10 others, Alapat, D., Weinhold, N., Johnson, S. K., Wickrema, A., Barlogie, B., Morgan, G. J., Shastri, A., Steidl, U., Will, B. & Verma, A., 2019, In : Blood Advances. 3, 23, p. 3962-3967 6 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Surface (S) Layer Proteins of Lactobacillus acidophilus Block Virus Infection via DC-SIGN Interaction

Acosta, M. P., Geoghegan, E. M., Lepenies, B., Ruzal, S., Kielian, M. & Martinez, M. G., Jan 1 2019, In : Frontiers in Microbiology. 10, MAR, 810.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

The alphavirus E2 membrane-proximal domain impacts capsid interaction and glycoprotein lattice formation

Byrd, E. A. & Kielian, M., Feb 1 2019, In : Journal of virology. 93, 4, e0188118.

Research output: Contribution to journalArticle

The ETS inhibitors YK-4-279 and TK-216 are novel antilymphoma agents

Spriano, F., Chung, E. Y. L., Gaudio, E., Tarantelli, C., Cascione, L., Napoli, S., Jessen, K., Carrassa, L., Priebe, V., Sartori, G., Graham, G., Selvanathan, S. P., Cavalli, A., Rinaldi, A., Kwee, I., Testoni, M., Genini, D., Ye, B. H., Zucca, E., Stathis, A. & 3 others, Lannutti, B., Toretsky, J. A. & Bertoni, F., Aug 15 2019, In : Clinical Cancer Research. 25, 16, p. 5167-5176 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

The good side of inflammation: Staphylococcus aureus proteins SpA and Sbi contribute to proper abscess formation and wound healing during skin and soft tissue infections

Gonzalez, C. D., Ledo, C., Cela, E., Stella, I., Xu, C., Ojeda, D. S., Frenette, P. S. & Gómez, M. I., Oct 1 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 10, p. 2657-2670 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

The splicing factor Sf3b1 regulates erythroid maturation and proliferation via TGFb signaling in zebrafish

De La Garza, A., Cameron, R. C., Gupta, V., Fraint, E., Nik, S. & Bowman, T. V., Jul 23 2019, In : Blood Advances. 3, 14, p. 2093-2104 12 p.

Research output: Contribution to journalArticle

Open Access

Transcriptional regulators CITED2 and PU.1 cooperate in maintaining hematopoietic stem cells

Mattes, K., Geugien, M., Korthuis, P. M., Brouwers-Vos, A. Z., Fehrmann, R. S. N., Todorova, T. I., Steidl, U., Vellenga, E. & Schepers, H., May 2019, In : Experimental Hematology. 73, p. 38-49.e7

Research output: Contribution to journalArticle

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies

Smith, M. A., Choudhary, G. S., Pellagatti, A., Choi, K., Bolanos, L. C., Bhagat, T. D., Gordon-Mitchell, S., Von Ahrens, D., Pradhan, K., Steeples, V., Kim, S., Steidl, U., Walter, M., Fraser, I. D. C., Kulkarni, A., Salomonis, N., Komurov, K., Boultwood, J., Verma, A. & Starczynowski, D. T., May 1 2019, In : Nature Cell Biology. 21, 5, p. 640-650 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ultra-High-Frequency Reprogramming of Individual Long-Term Hematopoietic Stem Cells Yields Low Somatic Variant Induced Pluripotent Stem Cells

Wang, K., Guzman, A. K., Yan, Z., Zhang, S., Hu, M. Y., Hamaneh, M. B., Yu, Y. K., Tolu, S., Zhang, J., Kanavy, H. E., Ye, K., Bartholdy, B. & Bouhassira, E. E., Mar 5 2019, In : Cell Reports. 26, 10, p. 2580-2592.e7

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

Maryanovich, M., Zahalka, A. H., Pierce, H., Pinho, S., Nakahara, F., Asada, N., Wei, Q., Wang, X., Ciero, P., Xu, J., Leftin, A. & Frenette, P. S., Jun 1 2018, In : Nature Medicine. 24, 6, p. 782-791 10 p.

Research output: Contribution to journalArticle

59 Scopus citations

A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche

Guarnerio, J., Mendez, L. M., Asada, N., Menon, A. V., Fung, J., Berry, K., Frenette, P. S., Ito, K. & Pandolfi, P. P., Dec 1 2018, In : Nature communications. 9, 1, 66.

Research output: Contribution to journalArticle

6 Scopus citations

Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells

Shastri, A., Choudhary, G., Teixeira, M., Gordon-Mitchell, S., Ramachandra, N., Bernard, L., Bhattacharyya, S., Lopez, R., Pradhan, K., Giricz, O., Ravipati, G., Wong, L. F., Cole, S., Bhagat, T. D., Feld, J., Dhar, Y., Bartenstein, M., Thiruthuvanathan, V. J., Wickrema, A., Hilda Ye, B. & 13 others, Frank, D. A., Pellagatti, A., Boultwood, J., Zhou, T., Kim, Y., Robert MacLeod, A., Epling-Burnette, P. K., Ye, M., McCoon, P., Woessner, R., Steidl, U., Will, B. & Verma, A., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5489-5504 16 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Dual inhibition of MDMX and MDM2 as a therapeutic strategy in leukemia

Carvajal, L. A., Ben Neriah, D., Senecal, A., Benard, L., Thiruthuvanathan, V., Yatsenko, T., Narayanagari, S. R., Wheat, J. C., Todorova, T. I., Mitchell, K., Kenworthy, C., Guerlavais, V., Annis, D. A., Bartholdy, B., Will, B., Anampa, J. D., Mantzaris, I., Aivado, M., Singer, R. H., Coleman, R. A. & 2 others, Verma, A. & Steidl, U., Apr 11 2018, In : Science Translational Medicine. 10, 436, aao3003.

Research output: Contribution to journalArticle

39 Scopus citations

Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD

Escudero, S., Zaganjor, E., Lee, S., Mill, C. P., Morgan, A. M., Crawford, E. B., Chen, J., Wales, T. E., Mourtada, R., Luccarelli, J., Bird, G. H., Steidl, U., Engen, J. R., Haigis, M. C., Opferman, J. T. & Walensky, L. D., Mar 1 2018, In : Molecular Cell. 69, 5, p. 729-743.e7

Research output: Contribution to journalArticle

11 Scopus citations

Engineered dengue virus domain III proteins elicit cross-neutralizing antibody responses in mice

Frei, J. C., Wirchnianski, A. S., Govero, J., Vergnolle, O., Dowd, K. A., Pierson, T. C., Kielian, M., Girvin, M. E., Diamond, M. S. & Lai, J. R., Sep 1 2018, In : Journal of virology. 92, 18, e01023.

Research output: Contribution to journalArticle

10 Scopus citations

Erratum to: Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level (Nature Medicine, (2018), 10.1038/s41591-018-0267-4)

Chen, J., Kao, Y. R., Sun, D., Todorova, T. I., Reynolds, D., Narayanagari, S-R., Montagna, C., Will, B., Verma, A. K. & Steidl, U. G., Jan 1 2018, (Accepted/In press) In : Nature Medicine.

Research output: Contribution to journalArticle

1 Scopus citations

Hematopoietic stem cell fate through metabolic control

Ito, K. & Ito, K., Aug 2018, In : Experimental Hematology. 64, p. 1-11 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Histone Variant MacroH2A1 Plays an Isoform-Specific Role in Suppressing Epithelial-Mesenchymal Transition

Hodge, D. Q., Cui, J., Gamble, M. J. & Guo, W., Dec 1 2018, In : Scientific Reports. 8, 1, 841.

Research output: Contribution to journalArticle

2 Scopus citations

Human immunodeficiency virus tat protein aids V region somatic hypermutation in human B cells

Wang, X., Duan, Z., Yu, G., Fan, M. & Scharff, M. D., Mar 1 2018, In : mBio. 9, 2, e02315-17.

Research output: Contribution to journalArticle

IL1RAP potentiates multiple oncogenic signaling pathways in AML

Mitchell, K., Barreyro, L., Todorova, T. I., Taylor, S. J., Antony-Debré, I., Narayanagari, S. R., Carvajal, L. A., Leite, J., Piperdi, Z., Pendurti, G., Mantzaris, I., Paietta, E., Verma, A., Gritsman, K. & Steidl, U., Jun 1 2018, In : Journal of Experimental Medicine. 215, 6, p. 1709-1727 19 p.

Research output: Contribution to journalArticle

11 Scopus citations

Inhibition of Delta-induced Notch signaling using fucose analogs

Schneider, M., Kumar, V., Nordstrøm, L. U., Feng, L., Takeuchi, H., Hao, H., Luca, V. C., Garcia, K. C., Stanley, P., Wu, P. & Haltiwanger, R. S., Jan 1 2018, In : Nature Chemical Biology. 14, 1, p. 65-71 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Inhibition of HIF1α Signaling: A Grand Slam for MDS Therapy?

Chen, J. & Steidl, U. G., Nov 1 2018, In : Cancer Discovery. 8, 11, p. 1355-1357 3 p.

Research output: Contribution to journalArticle

Insertion of Dengue E into lipid bilayers studied by neutron reflectivity and molecular dynamics simulations

Vanegas, J. M., Heinrich, F., Rogers, D. M., Carson, B. D., La Bauve, S., Vernon, B. C., Akgun, B., Satija, S., Zheng, A., Kielian, M., Rempe, S. B. & Kent, M. S., May 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 5, p. 1216-1230 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Lineage-Biased Hematopoietic Stem Cells Are Regulated by Distinct Niches

Pinho, S., Marchand, T., Yang, E., Wei, Q., Nerlov, C. & Frenette, P. S., Mar 12 2018, In : Developmental cell. 44, 5, p. 634-641.e4

Research output: Contribution to journalArticle

46 Scopus citations

Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis

Mao, S. P. H., Park, M., Cabrera, R. M., Christin, J. R., Karagiannis, G. S., Oktay, M. H., Zaiss, D. M. W., Abrams, S. I., Guo, W., Condeelis, J. S., Kenny, P. A. & Segall, J. E., Oct 26 2018, In : Breast Cancer Research. 20, 1, 131.

Research output: Contribution to journalArticle

3 Scopus citations

LSD1 inhibition exerts its antileukemic effect by recommissioning PU.1- and C/EBPa-dependent enhancers in AML

Cusan, M., Cai, S. F., Mohammad, H., Krivtsov, A., Chramiec, A., Loizou, E., Witkin, M. D., Smitheman, K. N., Tenen, D. G., Ye, M., Will, B., Steidl, U., Kruger, R. G., Levine, R. L., Rienhoff, H. Y., Koche, R. P. & Armstrong, S. A., Apr 12 2018, In : Blood. 131, 15, p. 1730-1742 13 p.

Research output: Contribution to journalArticle

25 Scopus citations

Mechanisms of establishment and functional significance of DNA demethylation during erythroid differentiation

Bartholdy, B., Lajugie, J., Yan, Z., Zhang, S., Mukhopadhyay, R., Greally, J. M., Suzuki, M. & Bouhassira, E. E., Aug 14 2018, In : Blood Advances. 2, 15, p. 1833-1852 20 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Membrane-potential compensation reveals mitochondrial volume expansion during HSC commitment

Bonora, M., Ito, K., Morganti, C., Pinton, P. & Ito, K., Dec 2018, In : Experimental Hematology. 68, p. 30-37.e1

Research output: Contribution to journalArticle

7 Scopus citations

MGAT1 and Complex N-Glycans Regulate ERK Signaling during Spermatogenesis

Biswas, B., Batista, F., Sundaram, S. & Stanley, P., Dec 1 2018, In : Scientific reports. 8, 1, 2022.

Research output: Contribution to journalArticle

8 Scopus citations

Multiple myeloma and its precursor disease among firefighters exposed to theworld trade center disaster

Landgren, O., Zeig-Owens, R., Giricz, O., Goldfarb, D., Murata, K., Thoren, K., Ramanathan, L., Hultcrantz, M., Dogan, A., Nwankwo, G., Steidl, U., Pradhan, K., Hall, C. B., Cohen, H. W., Jaber, N., Schwartz, T., Crowley, L., Crane, M., Irby, S., Webber, M. P. & 2 others, Verma, A. & Prezant, D. J., Jun 2018, In : JAMA Oncology. 4, 6, p. 821-827 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective

Zhao, X., Zhang, Y., Wilkins, K., Edelmann, W. & Usdin, K., Oct 2018, In : PLoS genetics. 14, 10, e1007719.

Research output: Contribution to journalArticle

6 Scopus citations

Neural regulation of bone and bone marrow

Maryanovich, M., Takeishi, S. & Frenette, P. S., Sep 1 2018, In : Cold Spring Harbor Perspectives in Medicine. 8, 9, a031344.

Research output: Contribution to journalArticle

11 Scopus citations

North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies

Shah, U. A., Chung, E. Y., Giricz, O., Pradhan, K., Kataoka, K., Gordon-Mitchel, S., Bhagat, T. D., Mai, Y., Wei, Y., Ishida, E., Choudhary, G. S., Joseph, A., Rice, R., Gitego, N., Parrish, C., Bartenstein, M., Goel, S., Mantzaris, I., Shastri, A., Derman, O. & 13 others, Binder, A. F., Gritsman, K., Kornblum, N., Braunschweig, I., Bhagat, C., Hall, J., Graber, A., Ratner, L., Wang, Y., Ogawa, S., Verma, A., Ye, B. H. & Janakiram, M., Oct 4 2018, In : Blood. 132, 14, p. 1507-1518 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Sox11 augments bcr signaling to drive mcl-like tumor development

Kuo, P. Y., Jatiani, S. S., Rahman, A. H., Edwards, D., Jiang, Z., Ahr, K., Perumal, D., Leshchenko, V. V., Brody, J., Shaknovich, R., Ye, B. H. & Parekh, S., May 17 2018, In : Blood. 131, 20, p. 2247-2255 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow

Xu, C., Gao, X., Wei, Q., Nakahara, F., Zimmerman, S. E., Mar, J. & Frenette, P. S., Dec 1 2018, In : Nature communications. 9, 1, 2449.

Research output: Contribution to journalArticle

31 Scopus citations

Thrombopoietin receptor-independent stimulation of hematopoietic stem cells by eltrombopag

Kao, Y. R., Chen, J., Narayanagari, S. R., Todorova, T. I., Aivalioti, M. M., Ferreira, M., Ramos, P. M., Pallaud, C., Mantzaris, I., Shastri, A., Bussel, J. B., Verma, A., Steidl, U. & Will, B., Sep 12 2018, In : Science translational medicine. 10, 458, eaas9563.

Research output: Contribution to journalArticle

9 Scopus citations

Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process

Limi, S., Senecal, A., Coleman, R., Lopez-Jones, M., Guo, P., Polumbo, C., Singer, R. H., Skoultchi, A. I. & Cvekl, A., Aug 24 2018, In : Journal of Biological Chemistry. 293, 34, p. 13176-13190 15 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Adrenergic nerves activate an angio-metabolic switch in prostate cancer

Zahalka, A. H., Arnal-Estapé, A., Maryanovich, M., Nakahara, F., Cruz, C. D., Finley, L. W. S. & Frenette, P. S., Oct 20 2017, In : Science. 358, 6361, p. 321-326 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways

Bhattacharyya, S., Pradhan, K., Campbell, N., Mazdo, J., Vasantkumar, A., Maqbool, S., Bhagat, T. D., Gupta, S., Suzuki, M., Yu, Y., Greally, J. M., Steidl, U., Bradner, J., Dawlaty, M., Godley, L., Maitra, A. & Verma, A., Nov 1 2017, In : Genome Research. 27, 11, p. 1830-1842 13 p.

Research output: Contribution to journalArticle

22 Scopus citations
15 Scopus citations

A myeloid tumor suppressor role for NOL3

Stanley, R. F., Piszczatowski, R. T., Bartholdy, B., Mitchell, K., McKimpson, W. M., Narayanagari, S., Walter, D., Todorova, T. I., Hirsch, C., Makishima, H., Will, B., McMahon, C., Gritsman, K., Maciejewski, J. P., Kitsis, R. N. & Steidl, U., Mar 6 2017, In : The Journal of experimental medicine. 214, 3, p. 753-771 19 p.

Research output: Contribution to journalArticle

2 Scopus citations

An alphavirus E2 membrane-proximal domain promotes envelope protein lateral interactions and virus budding

Byrd, E. A. & Kielian, M., Nov 1 2017, In : mBio. 8, 6, e01564-17.

Research output: Contribution to journalArticle

10 Scopus citations
53 Scopus citations

Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia

Reyna, D. E., Garner, T. P., Lopez, A., Kopp, F., Choudhary, G. S., Sridharan, A., Narayanagari, S. R., Mitchell, K., Dong, B., Bartholdy, B. A., Walensky, L. D., Verma, A., Steidl, U. & Gavathiotis, E., Oct 9 2017, In : Cancer Cell. 32, 4, p. 490-505.e10

Research output: Contribution to journalArticle

39 Scopus citations

Efficacy of ALK5 inhibition in myelofibrosis

Yue, L., Bartenstein, M., Zhao, W., Ho, W. T., Han, Y., Murdun, C., Mailloux, A. W., Zhang, L., Wang, X., Budhathoki, A., Pradhan, K., Rapaport, F., Wang, H., Shao, Z., Ren, X., Steidl, U., Levine, R. L., Zhao, Z. J., Verma, A. & Epling-Burnette, P. K., Apr 6 2017, In : JCI Insight. 2, 7, p. e90932

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Epigenetically aberrant stroma in MDS propagates disease via Wnt/β-catenin activation

Bhagat, T. D., Chen, S., Bartenstein, M., Barlowe, A. T., Von Ahrens, D., Choudhary, G. S., Tivnan, P., Amin, E., Marcondes, A. M., Sanders, M. A., Hoogenboezem, R. M., Kambhampati, S., Ramachandra, N., Mantzaris, I., Sukrithan, V., Laurence, R., Lopez, R., Bhagat, P., Giricz, O., Sohal, D. & 18 others, Wickrema, A., Yeung, C., Gritsman, K., Aplan, P., Hochedlinger, K., Yu, Y., Pradhan, K., Zhang, J., Greally, J. M., Mukherjee, S., Pellagatti, A., Boultwood, J., Will, B., Steidl, U., Raaijmakers, M. H. G. P., Deeg, H. J., Kharas, M. G. & Verma, A., Sep 15 2017, In : Cancer Research. 77, 18, p. 4846-4857 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells

Chen, C. C., Avdievich, E., Zhang, Y., Zhang, Y., Wei, K., Lee, K-R., Edelmann, W., Jasin, M. & LaRocque, J. R., Sep 1 2017, In : DNA Repair. 57, p. 98-106 9 p.

Research output: Contribution to journalArticle

3 Scopus citations