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2020

AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes

Tang, C., Bagnara, D., Chiorazzi, N., Scharff, M. D. & MacCarthy, T., Apr 30 2020, In : Frontiers in immunology. 11, 788.

Research output: Contribution to journalArticle

Open Access

CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation

Bartholdy, B. A., Wang, X., Yan, X. J., Pascual, M., Fan, M., Barrientos, J., Allen, S. L., Martinez-Climent, J. A., Rai, K. R., Chiorazzi, N., Scharff, M. D. & Roa, S., Mar 10 2020, In : Blood Advances. 4, 5, p. 893-906 14 p.

Research output: Contribution to journalArticle

Open Access

Clonal origin in normal adults of all blood lineages and circulating hematopoietic stem cells

Wang, K., Yan, Z., Zhang, S., Bartholdy, B., Eaves, C. J. & Bouhassira, E. E., Mar 2020, In : Experimental Hematology. 83, p. 25-34.e2

Research output: Contribution to journalArticle

Open Access

Dynamic Assembly and Disassembly of the Human DNA Polymerase δ Holoenzyme on the Genome In Vivo

Drosopoulos, W. C., Vierra, D. A., Kenworthy, C. A., Coleman, R. A. & Schildkraut, C. L., Feb 4 2020, In : Cell Reports. 30, 5, p. 1329-1341.e5

Research output: Contribution to journalArticle

Open Access

Epidemiology and survival trend of adult T-cell leukemia/lymphoma in the United States

Shah, U. A., Shah, N., Qiao, B., Acuna-Villaorduna, A., Pradhan, K., Adrianzen Herrera, D., Sica, R. A., Shastri, A., Mantzaris, I., Derman, O., Kornblum, N., Braunschweig, I., Ye, B. H., Verma, A. & Janakiram, M., Feb 1 2020, In : Cancer. 126, 3, p. 567-574 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Fueling clonal dominance through TRAFficking of NF-κB signaling

Ueda, K., Kumari, R. & Steidl, U., May 1 2020, In : Nature Immunology. 21, 5, p. 489-490 2 p.

Research output: Contribution to journalArticle

Linker histone h1.2 and h1.4 affect the neutrophil lineage determination

Sollberger, G., Streeck, R., Apel, F., Caffrey, B. E., Skoultchi, A. I. & Zychlinsky, A., May 2020, In : eLife. 9, p. 1-24 24 p., e52563.

Research output: Contribution to journalArticle

Open Access

Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling

Chitu, V., Biundo, F., Shlager, G. G. L., Park, E. S., Wang, P., Gulinello, M. E., Gokhan, Ş., Ketchum, H. C., Saha, K., DeTure, M. A., Dickson, D. W., Wszolek, Z. K., Zheng, D., Croxford, A. L., Becher, B., Sun, D., Mehler, M. F. & Stanley, E. R., Mar 3 2020, In : Cell Reports. 30, 9, p. 3004-3019.e5

Research output: Contribution to journalArticle

Open Access

Molecular structures and mechanisms of DNA break processing in mouse meiosis

Yamada, S., Hinch, A. G., Kamido, H., Zhang, Y., Edelmann, W. & Keeney, S., Jun 1 2020, In : Genes & development. 34, 11-12, p. 806-818 13 p.

Research output: Contribution to journalArticle

Open Access

Prp5-Spt8/Spt3 interaction mediates a reciprocal coupling between splicing and transcription

Shao, W., Ding, Z., Zheng, Z. Z., Shen, J. J., Shen, Y. X., Pu, J., Fan, Y. J., Query, C. C. & Xu, Y. Z., Jun 19 2020, In : Nucleic acids research. 48, 11, p. 5799-5813 15 p.

Research output: Contribution to journalArticle

Open Access

Single-molecule imaging of transcription dynamics in somatic stem cells

Wheat, J. C., Sella, Y., Willcockson, M., Skoultchi, A. I., Bergman, A., Singer, R. H. & Steidl, U., 2020, (Accepted/In press) In : Nature.

Research output: Contribution to journalArticle

Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression

Wei, Q., Nakahara, F., Asada, N., Zhang, D., Gao, X., Xu, C., Alfieri, A. A., Brodin, N. P., Zimmerman, S. E., Mar, J. C., Guha, C., Guo, W. & Frenette, P. S., 2020, (Accepted/In press) In : Developmental cell.

Research output: Contribution to journalArticle

Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer

Christin, J. R., Wang, C., Chung, C. Y., Liu, Y., Dravis, C., Tang, W., Oktay, M. H., Wahl, G. M. & Guo, W., Jun 9 2020, In : Cell Reports. 31, 10, 107742.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression

Zhang, C., Chen, Z., Yin, Q., Fu, X., Li, Y., Stopka, T., Skoultchi, A. I. & Zhang, Y., Feb 1 2020, In : Genes and Development. 34, 3, p. 166-178 13 p.

Research output: Contribution to journalArticle

Open Access

The Golgi Glycoprotein MGAT4D is an Intrinsic Protector of Testicular Germ Cells From Mild Heat Stress

Akintayo, A., Liang, M., Bartholdy, B., Batista, F., Aguilan, J., Prendergast, J., Sabrin, A., Sundaram, S. & Stanley, P., Dec 1 2020, In : Scientific reports. 10, 1, 2135.

Research output: Contribution to journalArticle

Open Access

Transgenic Rescue of Spermatogenesis in Males With Mgat1 Deleted in Germ Cells

Biswas, B., Batista, F., Akintayo, A., Aguilan, J. & Stanley, P., Apr 2 2020, In : Frontiers in Cell and Developmental Biology. 8, 212.

Research output: Contribution to journalArticle

Open Access
2019

Akt3-Mediated Protection Against Inflammatory Demyelinating Disease

DuBois, J. C., Ray, A. K., Gruber, R. C., Zhang, Y., Aflakpui, R., Macian-Juan, F. & Shafit-Zagardo, B., Jan 1 2019, In : Frontiers in immunology. 10, 1 p.

Research output: Contribution to journalArticle

Open Access

A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice

Varshney, S., Wei, H. X., Batista, F., Nauman, M., Sundaram, S., Siminovitch, K., Tanwar, A. & Stanley, P., Oct 7 2019, In : BMC Developmental Biology. 19, 1, 19.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Ascorbic acid–induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma

Shenoy, N., Bhagat, T. D., Cheville, J., Lohse, C., Bhattacharyya, S., Tischer, A., Machha, V., Gordon-Mitchell, S., Choudhary, G., Wong, L. F., Gross, L. A., Ressigue, E., Leibovich, B., Boorjian, S. A., Steidl, U., Wu, X., Pradhan, K., Gartrell, B., Agarwal, B., Pagliaro, L. & 8 others, Suzuki, M., Greally, J. M., Rakheja, D., Houston Thompson, R., Susztak, K., Witzig, T., Zou, Y. & Verma, A., Apr 1 2019, In : Journal of Clinical Investigation. 129, 4, p. 1612-1625 14 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Aurora kinase A inhibition: A mega-hit for myelofibrosis therapy?

Piszczatowski, R. T. & Steidl, U., Jan 1 2019, In : Clinical Cancer Research. 25, 16, p. 4868-4870 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cytokine-regulated phosphorylation and activation of TET2 by JAK2 in hematopoiesis

Jeong, J. J., Gu, X., Nie, J., Sundaravel, S., Liu, H., Kuo, W. L., Bhagat, T. D., Pradhan, K., Cao, J., Nischal, S., McGraw, K. L., Bhattacharyya, S., Bishop, M. R., Artz, A., Thirman, M. J., Moliterno, A., Ji, P., Levine, R. L., Godley, L. A., Steidl, U. & 6 others, Bieker, J. J., List, A. F., Saunthararajah, Y., He, C., Verma, A. & Wickrema, A., Jun 2019, In : Cancer discovery. 9, 6, p. 778-795 18 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Electron transport chain complex II sustains high mitochondrial membrane potential in hematopoietic stem and progenitor cells

Morganti, C., Bonora, M., Ito, K. & Ito, K., Oct 2019, In : Stem Cell Research. 40, 101573.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita

Nachmani, D., Bothmer, A. H., Grisendi, S., Mele, A., Bothmer, D., Lee, J. D., Monteleone, E., Cheng, K., Zhang, Y., Bester, A. C., Guzzetti, A., Mitchell, C. A., Mendez, L. M., Pozdnyakova, O., Sportoletti, P., Martelli, M. P., Vulliamy, T. J., Safra, M., Schwartz, S., Luzzatto, L. & 8 others, Bluteau, O., Soulier, J., Darnell, R. B., Falini, B., Dokal, I., Ito, K., Clohessy, J. G. & Pandolfi, P. P., Oct 1 2019, In : Nature Genetics. 51, 10, p. 1518-1529 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging

Acuna-Villaorduna, A., Gonzalez-Lugo, J., Ye, B. H., Adrianzen Herrera, D. A., Sica, R. A., Shah, U., Shah, N., Kornblum, N., Braunschweig, I., Derman, O., Mantzaris, I., Shastri, A., Wang, Y., Verma, A., Zalta, B. & Janakiram, M., Nov 10 2019, In : Leukemia and Lymphoma. 60, 13, p. 3272-3276 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Histone 1 Mutations Drive Lymphomagenesis By Inducing Primitive Stem Cell Functions and Epigenetic Instructions through Profound 3D Re-Organization of the B-Cell Genome

Yusufova, N., Teater, M. R., Soshnev, A., Kloetgen, A., Osunsade, A., Conway, J., Doane, A., Skoultchi, A., Tsirigos, A., David, Y., Allis, C. D., Cesarman, E. & Melnick, A., Nov 13 2019, In : Blood. 134, 1, 1 p.

Research output: Contribution to journalArticle

HIV portends a poor prognosis in myelodysplastic syndromes

Kaner, J. D., Thibaud, S., Jasra, S., Wang, Y., Janakiram, M., Sharma, A., Sridharan, A., Elias, H., Polineni, R., Assal, A., Weiss, L., Braunschweig, I., Steidl, U., Pradhan, K., Shastri, A., Chaitowitz, M., Zingman, B., Will, B., Mantzaris, I. & Verma, A., Dec 6 2019, In : Leukemia and Lymphoma. 60, 14, p. 3529-3535 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Homozygous hydroxymethylbilane synthase knock-in mice provide pathogenic insights into the severe neurological impairments present in human homozygous dominant acute intermittent porphyria

Yasuda, M., Gan, L., Chen, B., Yu, C., Zhang, J., Gama-Sosa, M. A., Pollak, D. D., Berger, S., Phillips, J. D., Edelmann, W. & Desnick, R. J., Jun 1 2019, In : Human molecular genetics. 28, 11, p. 1755-1767 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins

Quiroz, J. A., Malonis, R. J., Thackray, L. B., Cohen, C. A., Pallesen, J., Jangra, R. K., Brown, R. S., Hofmann, D., Holtsberg, F. W., Shulenin, S., Nyakatura, E. K., Durnell, L. A., Rayannavar, V., Daily, J. P., Ward, A. B., Javad Aman, M., Dye, J. M., Chandran, K., Diamond, M. S., Kielian, M. & 1 others, Lai, J. R., Jan 1 2019, In : PLoS pathogens. 15, 11, e1008061.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
1 Scopus citations

ISWI ATPase SMARCA5 regulates differentiation of thymocytes undergoing β-selection

Zikmund, T., Kokavec, J., Turkova, T., Savvulidi, F., Paszekova, H., Vodenkova, S., Sedlacek, R., Skoultchi, A. I. & Stopka, T., Jun 15 2019, In : Journal of Immunology. 202, 12, p. 3434-3446 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

Bhagat, T. D., Von Ahgrens, D., Dawlaty, M., Zou, Y., Baddour, J., Achreja, A., Zhao, H., Yang, L., Patel, B., Kwak, C., Choudhary, G. S., Gordon-Mitchell, S., Alluri, S., Bhattacharyya, S., Sahu, S., Yu, Y., Bartenstein, M., Giricz, O., Suzuki, M., Sohal, D. & 12 others, Gupta, S., Guerrero, P., Batra, S., Goggins, M., Steidl, U., Greally, J., Agarwal, B., Pradhan, K., Banerjee, D., Nagrath, D., Maitra, A. & Verma, A., Oct 2019, In : eLife. 8, e50663.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Maea expressed by macrophages, but not erythroblasts, maintains postnatal murine bone marrow erythroblastic islands

Wei, Q., Boulais, P. E., Zhang, D., Pinho, S., Tanaka, M. & Frenette, P. S., Jan 1 2019, In : Blood. 133, 11, p. 1222-1232 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Mechanism of tetherin inhibition of alphavirus release

Wan, J. J., Ooi, Y. S. & Kielian, M., Jan 1 2019, In : Journal of virology. 93, 7, e02165.

Research output: Contribution to journalArticle

MicroRNA-22 promotes megakaryocyte differentiation through repression of its target, GFI1

Weiss, C. N. & Ito, K., Jan 8 2019, In : Blood Advances. 3, 1, p. 33-46 14 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Misidentification of MLL3 and other mutations in cancer due to highly homologous genomic regions

Bowler, T. G., Pradhan, K., Kong, Y., Bartenstein, M., Morrone, K. A., Shridharan, A., Kessel, R. M., Shastri, A., Giricz, O., Bhagat, T. D., Gordon-Mitchell, S., Rohanizadegan, M., Hooda, L., Datt, I., Przychodzen, B. P., Parmar, S., Maqbool, S., Maciejewski, J. P., Steidl, U., Greally, J. M. & 1 others, Verma, A., Jan 1 2019, In : Leukemia and Lymphoma.

Research output: Contribution to journalArticle

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging

Luo, H., Mu, W. C., Karki, R., Chiang, H. H., Mohrin, M., Shin, J. J., Ohkubo, R., Ito, K., Kanneganti, T. D. & Chen, D., Jan 22 2019, In : Cell Reports. 26, 4, p. 945-954.e4

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Mutation of the ATPase domain of mutS homolog-5 (MSH5) reveals a requirement for a functional MutSG complex for all crossovers in mammalian meiosis

Milano, C. R., Kim Holloway, J., Zhang, Y., Jin, B., Smith, C., Bergman, A., Edelmann, W. & Cohen, P. E., Jan 1 2019, In : G3: Genes, Genomes, Genetics. 9, 6, p. 1839-1850 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Nestin+NG2+ Cells Form a Reserve Stem Cell Population in the Mouse Prostate

Hanoun, M., Arnal-Estapé, A., Maryanovich, M., Zahalka, A. H., Bergren, S. K., Chua, C. W., Leftin, A., Brodin, P. N., Shen, M. M., Guha, C. & Frenette, P. S., Jun 11 2019, In : Stem Cell Reports. 12, 6, p. 1201-1211 11 p.

Research output: Contribution to journalArticle

Open Access

Non-catalytic Roles of Tet2 Are Essential to Regulate Hematopoietic Stem and Progenitor Cell Homeostasis

Ito, K., Lee, J., Chrysanthou, S., Zhao, Y., Josephs, K., Sato, H., Teruya-Feldstein, J., Zheng, D., Dawlaty, M. M. & Ito, K., Sep 3 2019, In : Cell Reports. 28, 10, p. 2480-2490.e4

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

PAK kinase inhibition has therapeutic activity in novel preclinical models of adult T-Cell leukemia/lymphoma

Chung, E. Y., Mai, Y., Shah, U. A., Wei, Y., Ishida, E., Kataoka, K., Ren, X., Pradhan, K., Bartholdy, B., Wei, X., Zou, Y., Zhang, J., Ogawa, S., Steidl, U., Zang, X., Verma, A., Janakiram, M. & Ye, B. H., Jun 15 2019, In : Clinical Cancer Research. 25, 12, p. 3589-3601 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Phase II study of the ALK5 inhibitor galunisertib in very low-, low-, and intermediate-risk myelodysplastic syndromes

Santini, V., Valcarcel, D., Platzbecker, U., Komrokji, R. S., Cleverly, A. L., Lahn, M. M., Janssen, J., Zhao, Y., Chiang, A., Giagounidis, A., Guba, S. C., Gueorguieva, I., Girvan, A. C., Da Silva Ferreira, M., Bhagat, T. D., Pradhan, K., Steidl, U., Sridharan, A., Will, B. & Verma, A., Dec 1 2019, In : Clinical Cancer Research. 25, 23, p. 6976-6985 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

PI3K alpha and delta promote hematopoietic stem cell activation

Hemmati, S., Sinclair, T., Tong, M., Bartholdy, B., Okabe, R. O., Ames, K., Ostrodka, L., Haque, T., Kaur, I., Mills, T. S., Agarwal, A., Pietras, E. M., Zhao, J. J., Roberts, T. M. & Gritsman, K., Jul 11 2019, In : JCI Insight. 4, 13, e125832.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Proteome-wide analysis of chaperone-mediated autophagy targeting motifs

Kirchner, P., Bourdenx, M., Madrigal-Matute, J., Tiano, S., Diaz, A., Bartholdy, B. A., Will, B. & Cuervo, A. M., May 1 2019, In : PLoS biology. 17, 5, p. e3000301

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

PSC-RED and MNC-RED: Albumin-free and low-transferrin robust erythroid differentiation protocols to produce human enucleated red blood cells

Olivier, E. N., Zhang, S., Yan, Z., Suzuka, S. M., Roberts, K., Wang, K. & Bouhassira, E. E., Jul 2019, In : Experimental Hematology. 75, p. 31-52.e15

Research output: Contribution to journalArticle

1 Scopus citations

Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade

Rauch, D. A., Conlon, K. C., Janakiram, M., Brammer, J. E., Harding, J. C., Ye, B. H., Zang, X., Ren, X., Olson, S., Cheng, X., Miljkovic, M. D., Sundaramoorthi, H., Joseph, A., Skidmore, Z. L., Griffith, O., Griffith, M., Waldmann, T. A. & Ratner, L., Oct 24 2019, In : Blood. 134, 17, p. 1406-1414 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Runx1 promotes murine erythroid progenitor proliferation and inhibits differentiation by preventing Pu.1 downregulation

Willcockson, M. A., Taylor, S. J., Ghosh, S., Healton, S. E., Wheat, J. C., Wilson, T. J., Steidl, U. & Skoultchi, A. I., Sep 3 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 36, p. 17841-17847 7 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations