Research Output

2020

AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes

Tang, C., Bagnara, D., Chiorazzi, N., Scharff, M. D. & MacCarthy, T., Apr 30 2020, In : Frontiers in immunology. 11, 788.

Research output: Contribution to journalArticle

Open Access

Are all splicing mutations the same?

Bowman, T. V. & Query, C. C., Mar 26 2020, In : Blood. 135, 13, p. 978-979 2 p.

Research output: Contribution to journalReview article

Open Access

CLL intraclonal fractions exhibit established and recently acquired patterns of DNA methylation

Bartholdy, B. A., Wang, X., Yan, X. J., Pascual, M., Fan, M., Barrientos, J., Allen, S. L., Martinez-Climent, J. A., Rai, K. R., Chiorazzi, N., Scharff, M. D. & Roa, S., Mar 10 2020, In : Blood Advances. 4, 5, p. 893-906 14 p.

Research output: Contribution to journalArticle

Open Access

Clonal origin in normal adults of all blood lineages and circulating hematopoietic stem cells

Wang, K., Yan, Z., Zhang, S., Bartholdy, B., Eaves, C. J. & Bouhassira, E. E., Mar 2020, In : Experimental Hematology. 83, p. 25-34.e2

Research output: Contribution to journalArticle

Open Access

Dynamic Assembly and Disassembly of the Human DNA Polymerase δ Holoenzyme on the Genome In Vivo

Drosopoulos, W. C., Vierra, D. A., Kenworthy, C. A., Coleman, R. A. & Schildkraut, C. L., Feb 4 2020, In : Cell Reports. 30, 5, p. 1329-1341.e5

Research output: Contribution to journalArticle

Open Access

Epidemiology and survival trend of adult T-cell leukemia/lymphoma in the United States

Shah, U. A., Shah, N., Qiao, B., Acuna-Villaorduna, A., Pradhan, K., Adrianzen Herrera, D., Sica, R. A., Shastri, A., Mantzaris, I., Derman, O., Kornblum, N., Braunschweig, I., Ye, B. H., Verma, A. & Janakiram, M., Feb 1 2020, In : Cancer. 126, 3, p. 567-574 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Fueling clonal dominance through TRAFficking of NF-κB signaling

Ueda, K., Kumari, R. & Steidl, U., May 1 2020, In : Nature Immunology. 21, 5, p. 489-490 2 p.

Research output: Contribution to journalArticle

H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction

Healton, S. E., Pinto, H. D., Mishra, L. N., Hamilton, G. A., Hamilton, G. A., Wheat, J. C., Swist-Rosowska, K., Shukeir, N., Dou, Y., Steidl, U., Jenuwein, T., Gamble, M. J., Gamble, M. J. & Skoultchi, A. I., Jun 23 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 25, p. 14251-14258 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hematopoietic Stem Cell Metabolism during Development and Aging

Nakamura-Ishizu, A., Ito, K. & Suda, T., Jul 20 2020, In : Developmental cell. 54, 2, p. 239-255 17 p.

Research output: Contribution to journalReview article

Open Access

Hemoglobin F mitigation of sickle cell complications decreases with aging

Tolu, S. S., Reyes-Gil, M., Ogu, U. O., Thomas, M., Bouhassira, E. E. & Minniti, C. P., May 1 2020, In : American Journal of Hematology. 95, 5, p. E122-E125

Research output: Contribution to journalLetter

Open Access
1 Scopus citations

Linker histone h1.2 and h1.4 affect the neutrophil lineage determination

Sollberger, G., Streeck, R., Apel, F., Caffrey, B. E., Skoultchi, A. I. & Zychlinsky, A., May 2020, In : eLife. 9, p. 1-24 24 p., e52563.

Research output: Contribution to journalArticle

Open Access

Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling

Chitu, V., Biundo, F., Shlager, G. G. L., Park, E. S., Wang, P., Gulinello, M. E., Gokhan, Ş., Ketchum, H. C., Saha, K., DeTure, M. A., Dickson, D. W., Wszolek, Z. K., Zheng, D., Croxford, A. L., Becher, B., Sun, D., Mehler, M. F. & Stanley, E. R., Mar 3 2020, In : Cell Reports. 30, 9, p. 3004-3019.e5

Research output: Contribution to journalArticle

Open Access

Molecular structures and mechanisms of DNA break processing in mouse meiosis

Yamada, S., Hinch, A. G., Kamido, H., Zhang, Y., Edelmann, W. & Keeney, S., Jun 1 2020, In : Genes and Development. 34, 11-12, p. 806-818 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

MS2-TRIBE Evaluates Both Protein-RNA Interactions and Nuclear Organization of Transcription by RNA Editing

Biswas, J., Rahman, R., Gupta, V., Rosbash, M. & Singer, R. H., Jul 24 2020, In : iScience. 23, 7, 101318.

Research output: Contribution to journalArticle

Open Access

Prp5-Spt8/Spt3 interaction mediates a reciprocal coupling between splicing and transcription

Shao, W., Ding, Z., Zheng, Z. Z., Shen, J. J., Shen, Y. X., Pu, J., Fan, Y. J., Query, C. C. & Xu, Y. Z., Jun 19 2020, In : Nucleic acids research. 48, 11, p. 5799-5813 15 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Single-molecule imaging of transcription dynamics in somatic stem cells

Wheat, J. C., Sella, Y., Willcockson, M., Skoultchi, A. I., Bergman, A., Singer, R. H. & Steidl, U., Jul 16 2020, In : Nature. 583, 7816, p. 431-436 6 p.

Research output: Contribution to journalArticle

Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression

Wei, Q., Nakahara, F., Asada, N., Zhang, D., Gao, X., Xu, C., Alfieri, A., Brodin, N. P., Zimmerman, S. E., Mar, J. C., Guha, C., Guo, W. & Frenette, P. S., Jun 8 2020, In : Developmental cell. 53, 5, p. 503-513.e5

Research output: Contribution to journalArticle

Stem Cell Determinant SOX9 Promotes Lineage Plasticity and Progression in Basal-like Breast Cancer

Christin, J. R., Wang, C., Chung, C. Y., Liu, Y., Dravis, C., Tang, W., Oktay, M. H., Wahl, G. M. & Guo, W., Jun 9 2020, In : Cell Reports. 31, 10, 107742.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression

Zhang, C., Chen, Z., Yin, Q., Fu, X., Li, Y., Stopka, T., Skoultchi, A. I. & Zhang, Y., Feb 1 2020, In : Genes and Development. 34, 3, p. 166-178 13 p.

Research output: Contribution to journalArticle

Open Access

The Golgi Glycoprotein MGAT4D is an Intrinsic Protector of Testicular Germ Cells From Mild Heat Stress

Akintayo, A., Liang, M., Bartholdy, B., Batista, F., Aguilan, J., Prendergast, J., Sabrin, A., Sundaram, S. & Stanley, P., Dec 1 2020, In : Scientific reports. 10, 1, 2135.

Research output: Contribution to journalArticle

Open Access

The thrombopoietin mimetic JNJ-26366821 increases megakaryopoiesis without affecting malignant myeloid proliferation

Adrianzen-Herrera, D., Choudhary, G., Gordon-Mitchell, S., Ramachandra, N., Bhagat, T. D., Zhang, H., Aluri, S., Shastri, A., Steidl, U. G., Will, B., Yang, W. L., Mahler, M., Eichenbaum, G., Guha, C. & Verma, A., 2020, (Accepted/In press) In : Leukemia and Lymphoma.

Research output: Contribution to journalArticle

Transgenic Rescue of Spermatogenesis in Males With Mgat1 Deleted in Germ Cells

Biswas, B., Batista, F., Akintayo, A., Aguilan, J. & Stanley, P., Apr 2 2020, In : Frontiers in Cell and Developmental Biology. 8, 212.

Research output: Contribution to journalArticle

Open Access
2019

Akt3-Mediated Protection Against Inflammatory Demyelinating Disease

DuBois, J. C., Ray, A. K., Gruber, R. C., Zhang, Y., Aflakpui, R., Macian-Juan, F. & Shafit-Zagardo, B., 2019, In : Frontiers in immunology. 10, 1 p., 1738.

Research output: Contribution to journalArticle

Open Access

A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice

Varshney, S., Wei, H. X., Batista, F., Nauman, M., Sundaram, S., Siminovitch, K., Tanwar, A. & Stanley, P., Oct 7 2019, In : BMC Developmental Biology. 19, 1, 19.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Ascorbic acid–induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma

Shenoy, N., Bhagat, T. D., Cheville, J., Lohse, C., Bhattacharyya, S., Tischer, A., Machha, V., Gordon-Mitchell, S., Choudhary, G., Wong, L. F., Gross, L. A., Ressigue, E., Leibovich, B., Boorjian, S. A., Steidl, U., Wu, X., Pradhan, K., Gartrell, B., Agarwal, B., Pagliaro, L. & 8 others, Suzuki, M., Greally, J. M., Rakheja, D., Houston Thompson, R., Susztak, K., Witzig, T., Zou, Y. & Verma, A., Apr 1 2019, In : Journal of Clinical Investigation. 129, 4, p. 1612-1625 14 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

A toolset to study functions of Cytosolic non-specific dipeptidase 2 (CNDP2) using Drosophila as a model organism

Andreyeva, E. N., Ogienko, A. A., Dubatolova, T. D., Oshchepkova, A. L., Kozhevnikova, E. N., Ivankin, A. V., Pavlova, G. A., Kopyl, S. A. & Pindyurin, A. V., Mar 18 2019, In : BMC genetics. 20, 31.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Aurora kinase A inhibition: A mega-hit for myelofibrosis therapy?

Piszczatowski, R. T. & Steidl, U., 2019, In : Clinical Cancer Research. 25, 16, p. 4868-4870 3 p.

Research output: Contribution to journalArticle

Author Correction: Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche (Nature Medicine, (2018), 24, 6, (782-791), 10.1038/s41591-018-0030-x)

Maryanovich, M., Zahalka, A. H., Pierce, H., Pinho, S., Nakahara, F., Asada, N., Wei, Q., Wang, X., Ciero, P., Xu, J., Leftin, A. & Frenette, P. S., Apr 1 2019, In : Nature Medicine. 25, 4, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Bidirectional analysis of cryba4-crybb1 nascent transcription and nuclear accumulation of crybb3 mrnas in lens fibers

Limi, S., Zhao, Y., Guo, P., Lopez-Jones, M., Zheng, D., Singer, R. H., Skoultchi, A. I. & Cvekl, A., Jan 1 2019, In : Investigative Ophthalmology and Visual Science. 60, 1, p. 234-244 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
2 Scopus citations

Cytokine-regulated phosphorylation and activation of TET2 by JAK2 in hematopoiesis

Jeong, J. J., Gu, X., Nie, J., Sundaravel, S., Liu, H., Kuo, W. L., Bhagat, T. D., Pradhan, K., Cao, J., Nischal, S., McGraw, K. L., Bhattacharyya, S., Bishop, M. R., Artz, A., Thirman, M. J., Moliterno, A., Ji, P., Levine, R. L., Godley, L. A., Steidl, U. & 6 others, Bieker, J. J., List, A. F., Saunthararajah, Y., He, C., Verma, A. & Wickrema, A., Jun 2019, In : Cancer discovery. 9, 6, p. 778-795 18 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Differentiation of Baboon (Papio anubis) Induced-Pluripotent Stem Cells into Enucleated Red Blood Cells

Olivier, E. N., Wang, K., Grossman, J., Mahmud, N. & Bouhassira, E. E., Oct 19 2019, In : Cells. 8, 10

Research output: Contribution to journalArticle

Open Access

Electron transport chain complex II sustains high mitochondrial membrane potential in hematopoietic stem and progenitor cells

Morganti, C., Bonora, M., Ito, K. & Ito, K., Oct 2019, In : Stem Cell Research. 40, 101573.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells

Nakahara, F., Borger, D. K., Wei, Q., Pinho, S., Maryanovich, M., Zahalka, A. H., Suzuki, M., Cruz, C. D., Wang, Z., Xu, C., Boulais, P. E., Ma’ayan, A., Greally, J. M. & Frenette, P. S., May 1 2019, In : Nature Cell Biology. 21, 5, p. 560-567 8 p.

Research output: Contribution to journalLetter

16 Scopus citations

Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita

Nachmani, D., Bothmer, A. H., Grisendi, S., Mele, A., Bothmer, D., Lee, J. D., Monteleone, E., Cheng, K., Zhang, Y., Bester, A. C., Guzzetti, A., Mitchell, C. A., Mendez, L. M., Pozdnyakova, O., Sportoletti, P., Martelli, M. P., Vulliamy, T. J., Safra, M., Schwartz, S., Luzzatto, L. & 8 others, Bluteau, O., Soulier, J., Darnell, R. B., Falini, B., Dokal, I., Ito, K., Clohessy, J. G. & Pandolfi, P. P., Oct 1 2019, In : Nature Genetics. 51, 10, p. 1518-1529 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

High prevalence of pulmonary findings in computed tomographies of HTLV-1-infected patients with and without adult-T cell leukemia/lymphoma–implications for staging

Acuna-Villaorduna, A., Gonzalez-Lugo, J., Ye, B. H., Adrianzen Herrera, D. A., Sica, R. A., Shah, U., Shah, N., Kornblum, N., Braunschweig, I., Derman, O., Mantzaris, I., Shastri, A., Wang, Y., Verma, A., Zalta, B. & Janakiram, M., Nov 10 2019, In : Leukemia and Lymphoma. 60, 13, p. 3272-3276 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Histone 1 Mutations Drive Lymphomagenesis By Inducing Primitive Stem Cell Functions and Epigenetic Instructions through Profound 3D Re-Organization of the B-Cell Genome

Yusufova, N., Teater, M. R., Soshnev, A., Kloetgen, A., Osunsade, A., Conway, J., Doane, A., Skoultchi, A., Tsirigos, A., David, Y., Allis, C. D., Cesarman, E. & Melnick, A., Nov 13 2019, In : Blood. 134, 1, 1 p.

Research output: Contribution to journalArticle

HIV portends a poor prognosis in myelodysplastic syndromes

Kaner, J. D., Thibaud, S., Jasra, S., Wang, Y., Janakiram, M., Sharma, A., Sridharan, A., Elias, H., Polineni, R., Assal, A., Weiss, L., Braunschweig, I., Steidl, U., Pradhan, K., Shastri, A., Chaitowitz, M., Zingman, B., Will, B., Mantzaris, I. & Verma, A., Dec 6 2019, In : Leukemia and Lymphoma. 60, 14, p. 3529-3535 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Homozygous hydroxymethylbilane synthase knock-in mice provide pathogenic insights into the severe neurological impairments present in human homozygous dominant acute intermittent porphyria

Yasuda, M., Gan, L., Chen, B., Yu, C., Zhang, J., Gama-Sosa, M. A., Pollak, D. D., Berger, S., Phillips, J. D., Edelmann, W. & Desnick, R. J., Jun 1 2019, In : Human molecular genetics. 28, 11, p. 1755-1767 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins

Quiroz, J. A., Malonis, R. J., Thackray, L. B., Cohen, C. A., Pallesen, J., Jangra, R. K., Brown, R. S., Hofmann, D., Holtsberg, F. W., Shulenin, S., Nyakatura, E. K., Durnell, L. A., Rayannavar, V., Daily, J. P., Ward, A. B., Javad Aman, M., Dye, J. M., Chandran, K., Diamond, M. S., Kielian, M. & 1 others, Lai, J. R., 2019, In : PLoS pathogens. 15, 11, e1008061.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2 Scopus citations

ISWI ATPase SMARCA5 regulates differentiation of thymocytes undergoing β-selection

Zikmund, T., Kokavec, J., Turkova, T., Savvulidi, F., Paszekova, H., Vodenkova, S., Sedlacek, R., Skoultchi, A. I. & Stopka, T., Jun 15 2019, In : Journal of Immunology. 202, 12, p. 3434-3446 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

Bhagat, T. D., Von Ahgrens, D., Dawlaty, M., Zou, Y., Baddour, J., Achreja, A., Zhao, H., Yang, L., Patel, B., Kwak, C., Choudhary, G. S., Gordon-Mitchell, S., Alluri, S., Bhattacharyya, S., Sahu, S., Yu, Y., Bartenstein, M., Giricz, O., Suzuki, M., Sohal, D. & 12 others, Gupta, S., Guerrero, P., Batra, S., Goggins, M., Steidl, U., Greally, J., Agarwal, B., Pradhan, K., Banerjee, D., Nagrath, D., Maitra, A. & Verma, A., Oct 2019, In : eLife. 8, e50663.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Maea expressed by macrophages, but not erythroblasts, maintains postnatal murine bone marrow erythroblastic islands

Wei, Q., Boulais, P. E., Zhang, D., Pinho, S., Tanaka, M. & Frenette, P. S., Jan 1 2019, In : Blood. 133, 11, p. 1222-1232 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mechanism of tetherin inhibition of alphavirus release

Wan, J. J., Ooi, Y. S. & Kielian, M., 2019, In : Journal of virology. 93, 7, e02165.

Research output: Contribution to journalArticle

Mechanisms and therapeutic prospects of thrombopoietin receptor agonists

Bussel, J., Kulasekararaj, A., Cooper, N., Verma, A., Steidl, U., Semple, J. W. & Will, B., Oct 2019, In : Seminars in hematology. 56, 4, p. 262-278 17 p.

Research output: Contribution to journalReview article

Metabolism as master of hematopoietic stem cell fate

Ito, K., Bonora, M. & Ito, K., Jan 22 2019, In : International journal of hematology. 109, 1, p. 18-27 10 p.

Research output: Contribution to journalReview article

5 Scopus citations

MicroRNA-22 promotes megakaryocyte differentiation through repression of its target, GFI1

Weiss, C. N. & Ito, K., Jan 8 2019, In : Blood Advances. 3, 1, p. 33-46 14 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations