• 13969 Citations
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1968 …2020

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2020

Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases

Zhang, D., Burdette, B. E., Wang, Z., Karn, K., Li, H. Y., Schramm, V. L., Tyler, P. C., Evans, G. B. & Wang, S., Feb 25 2020, In : Biochemistry. 59, 7, p. 831-835 5 p.

Research output: Contribution to journalArticle

2019

Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis

Joshi, S., Fedoseyenko, D., Mahanta, N., Ducati, R. G., Feng, M., Schramm, V. L. & Begley, T. P., Mar 14 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 363-366 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase

Harijan, R. K., Hoff, O., Ducati, R. G., Firestone, R. S., Hirsch, B. M., Evans, G. B., Schramm, V. L. & Tyler, P. C., Apr 11 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3286-3296 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Enzymatic Transition States and Drug Design

Schramm, V. L., Jan 1 2018, (Accepted/In press) In : Chemical Reviews.

Research output: Contribution to journalArticle

6 Scopus citations

Genetic resistance to purine nucleoside phosphorylase inhibition in plasmodium falciparum

Ducati, R. G., Namanja-Magliano, H. A., Harijan, R. K., Eduardo Fajardo, J., Fiser, A., Daily, J. P. & Schramm, V. L., Feb 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 9, p. 2114-2119 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inverse enzyme isotope effects in human purine nucleoside phosphorylase with heavy asparagine labels

Harijan, R. K., Zoi, I., Antoniou, D., Schwartz, S. D. & Schramm, V. L., Jul 3 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 27, p. E6209-E6216

Research output: Contribution to journalArticle

7 Scopus citations

Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase

Harris, L. D., Harijan, R. K., Ducati, R. G., Evans, G. B., Hirsch, B. M. & Schramm, V. L., Jan 19 2018, In : ACS Chemical Biology. 13, 1, p. 152-160 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Transition-State Analogues of Campylobacter jejuni 5′-Methylthioadenosine Nucleosidase

Ducati, R. G., Harijan, R. K., Cameron, S. A., Tyler, P. C., Evans, G. B. & Schramm, V. L., Nov 16 2018, In : ACS Chemical Biology. 13, 11, p. 3173-3183 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase

Harijan, R. K., Zoi, I., Antoniou, D., Schwartz, S. D. & Schramm, V. L., Jun 20 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 25, p. 6456-6461 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5′-Methylthioadenosine Phosphorylase

Firestone, R. S., Cameron, S. A., Karp, J. M., Arcus, V. L. & Schramm, V. L., Feb 17 2017, In : ACS Chemical Biology. 12, 2, p. 464-473 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Intracellular rebinding of transition-state analogues provides extended in vivo inhibition lifetimes on human purine nucleoside phosphorylase

Gebre, S. T., Cameron, S. A., Li, L., Babu, Y. S. & Schramm, V. L., Sep 22 2017, In : Journal of Biological Chemistry. 292, 38, p. 15907-15915 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Kinetic Isotope Effects and Transition State Structure for Human Phenylethanolamine N-Methyltransferase

Stratton, C. F., Poulin, M. B., Du, Q. & Schramm, V. L., Feb 17 2017, In : ACS Chemical Biology. 12, 2, p. 342-346 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Kinetic Isotope Effects and Transition State Structure for Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Plasmodium falciparum

Ducati, R. G., Firestone, R. S. & Schramm, V. L., Dec 5 2017, In : Biochemistry. 56, 48, p. 6368-6376 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Oligonucleotide transition state analogues of saporin L3

Mason, J. M., Yuan, H., Evans, G. B., Tyler, P. C., Du, Q. & Schramm, V. L., Feb 15 2017, In : European Journal of Medicinal Chemistry. 127, p. 793-809 17 p.

Research output: Contribution to journalArticle

1 Scopus citations

The transition-state structure for human MAT2A from isotope effects

Firestone, R. S. & Schramm, V. L., 2017, In : Journal of the American Chemical Society. 139, 39, p. 13754-13760 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Transition State Analogue Inhibitors of 5′-Deoxyadenosine/5′-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

Namanja-Magliano, H. A., Evans, G. B., Harijan, R. K., Tyler, P. C. & Schramm, V. L., Sep 26 2017, In : Biochemistry. 56, 38, p. 5090-5098 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase

Moggré, G. J., Poulin, M. B., Tyler, P. C., Schramm, V. L. & Parker, E. J., Oct 20 2017, In : ACS Chemical Biology. 12, 10, p. 2662-2670 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Continuous fluorescence assays for reactions involving adenine

Firestone, R. S., Cameron, S. A., Tyler, P. C., Ducati, R. G., Spitz, A. Z. & Schramm, V. L., Jan 1 2016, In : Analytical Chemistry. 88, 23, p. 11860-11867 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Human DNMT1 transition state structure

Du, Q., Wang, Z. & Schramm, V. L., Mar 15 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 11, p. 2916-2921 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

Hydride Transfer in DHFR by Transition Path Sampling, Kinetic Isotope Effects, and Heavy Enzyme Studies

Wang, Z., Antoniou, D., Schwartz, S. D. & Schramm, V. L., Jan 19 2016, In : Biochemistry. 55, 1, p. 157-166 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics

Zoi, I., Suarez, J., Antoniou, D., Cameron, S. A., Schramm, V. L. & Schwartz, S. D., Mar 16 2016, In : Journal of the American Chemical Society. 138, 10, p. 3403-3409 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Nucleosome binding alters the substrate bonding environment of histone H3 lysine 36 methyltransferase NSD2

Poulin, M. B., Schneck, J. L., Matico, R. E., Hou, W., McDevitt, P. J., Holbert, M. & Schramm, V. L., Jun 1 2016, In : Journal of the American Chemical Society. 138, 21, p. 6699-6702 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36

Poulin, M. B., Schneck, J. L., Matico, R. E., McDevitt, P. J., Huddleston, M. J., Hou, W., Johnson, N. W., Thrall, S. H., Meek, T. D. & Schramm, V. L., Feb 2 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 5, p. 1197-1201 5 p.

Research output: Contribution to journalArticle

29 Scopus citations

Transition State Structure and Inhibition of Rv0091, a 5′-Deoxyadenosine/5′-methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

Namanja-Magliano, H. A., Stratton, C. F. & Schramm, V. L., Jun 17 2016, In : ACS Chemical Biology. 11, 6, p. 1669-1676 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Transition State Structure of RNA Depurination by Saporin L3

Yuan, H., Stratton, C. F. & Schramm, V. L., May 20 2016, In : ACS Chemical Biology. 11, 5, p. 1383-1390 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Triple Isotope Effects Support Concerted Hydride and Proton Transfer and Promoting Vibrations in Human Heart Lactate Dehydrogenase

Wang, Z., Chang, E. P. & Schramm, V. L., Nov 16 2016, In : Journal of the American Chemical Society. 138, 45, p. 15004-15010 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
2015

Active site and remote contributions to catalysis in methylthioadenosine nucleosidases

Thomas, K., Cameron, S. A., Almo, S. C., Burgos, E. S., Gulab, S. A. & Schramm, V. L., Apr 21 2015, In : Biochemistry. 54, 15, p. 2520-2529 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Binding Isotope Effects for para-Aminobenzoic Acid with Dihydropteroate Synthase from Staphylococcus aureus and Plasmodium falciparum

Stratton, C. F., Namanja-Magliano, H. A., Cameron, S. A. & Schramm, V. L., Oct 16 2015, In : ACS Chemical Biology. 10, 10, p. 2182-2186 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Chemoenzymatic Synthesis of 36S Isotopologues of Methionine and S-Adenosyl-L-methionine

Poulin, M. B., Du, Q. & Schramm, V. L., May 15 2015, In : Journal of Organic Chemistry. 80, 10, p. 5344-5347 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Enzyme homologues have distinct reaction paths through their transition states

Zoi, I., Motley, M. W., Antoniou, D., Schramm, V. L. & Schwartz, S. D., Mar 5 2015, In : Journal of Physical Chemistry B. 119, 9, p. 3662-3668 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis

Freitas, E. O., Nico, D., Alves-Silva, M. V., Morrot, A., Clinch, K., Evans, G. B., Tyler, P. C., Schramm, V. L. & Palatnik-de-Sousa, C. B., Dec 23 2015, In : PLoS neglected tropical diseases. 9, 12, e0004297.

Research output: Contribution to journalArticle

9 Scopus citations

Immucillins impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis multiplication In Vitro

Freitas, E. O., Nico, D., Guan, R., Meyer-Fernandes, J. R., Clinch, K., Evans, G. B., Tyler, P. C., Schramm, V. L. & Palatnik-de-Sousa, C. B., Apr 24 2015, In : PloS one. 10, 4, e0124183.

Research output: Contribution to journalArticle

8 Scopus citations
16 Scopus citations

New Antibiotic Candidates against Helicobacter pylori

Wang, S., Cameron, S. A., Clinch, K., Evans, G. B., Wu, Z., Schramm, V. L. & Tyler, P. C., Nov 18 2015, In : Journal of the American Chemical Society. 137, 45, p. 14275-14280 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Soapwort Saporin L3 Expression in Yeast, Mutagenesis, and RNA Substrate Specificity

Yuan, H., Du, Q., Sturm, M. B. & Schramm, V. L., Jul 28 2015, In : Biochemistry. 54, 29, p. 4565-4574 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

The immucillins: Design, synthesis and application of transition-state analogues

Evans, G. B., Schramm, V. L. & Tyler, P. C., 2015, In : Current Medicinal Chemistry. 22, 34, p. 3897-3909 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

The synthesis of possible transition state analogue inhibitors of thymidine phosphorylase

Evans, G. B., Gainsford, G. J., Schramm, V. L. & Tyler, P. C., Jan 8 2015, In : Tetrahedron Letters. 56, 2, p. 406-409 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Tight binding enantiomers of pre-clinical drug candidates

Evans, G. B., Cameron, S. A., Luxenburger, A., Guan, R., Suarez, J., Thomas, K., Schramm, V. L. & Tyler, P. C., Sep 1 2015, In : Bioorganic and Medicinal Chemistry. 23, 17, p. 5326-5333 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Transition states and transition state analogue interactions with enzymes

Schramm, V. L., Apr 21 2015, In : Accounts of Chemical Research. 48, 4, p. 1032-1039 8 p.

Research output: Contribution to journalArticle

32 Scopus citations
2014

Catalytic site cooperativity in dimeric methylthioadenosine nucleosidase

Wang, S., Thomas, K. & Schramm, V. L., Mar 11 2014, In : Biochemistry. 53, 9, p. 1527-1535 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inhibition and structure of toxoplasma gondii purine nucleoside phosphorylase

Donaldson, T. M., Cassera, M. B., Ho, M. C., Zhan, C., Merino, E. F., Evans, G. B., Tyler, P. C., Almo, S. C., Schramm, V. L. & Kim, K., May 2014, In : Eukaryotic Cell. 13, 5, p. 572-579 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Protein mass-modulated effects in the catalytic mechanism of dihydrofolate reductase: Beyond promoting vibrations

Wang, Z., Singh, P., Czekster, C. M., Kohen, A. & Schramm, V. L., Jun 11 2014, In : Journal of the American Chemical Society. 136, 23, p. 8333-8341 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Structural and biochemical characterization of Chlamydia trachomatis hypothetical protein CT263 supports that menaquinone synthesis occurs through the futalosine pathway

Barta, M. L., Thomas, K., Yuan, H., Lovell, S., Battaile, K. P., Schramm, V. L. & Hefty, P. S., Nov 14 2014, In : Journal of Biological Chemistry. 289, 46, p. 32214-32229 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Transition-state analysis of 2-O acetyl-ADP-ribose hydrolysis by human macrodomain 1

Hirsch, B. M., Burgos, E. S. & Schramm, V. L., Oct 17 2014, In : ACS Chemical Biology. 9, 10, p. 2255-2262 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2013

Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

Clinch, K., Crump, D. R., Evans, G. B., Hazleton, K. Z., Mason, J. M., Schramm, V. L. & Tyler, P. C., Sep 1 2013, In : Bioorganic and Medicinal Chemistry. 21, 17, p. 5629-5646 18 p.

Research output: Contribution to journalArticle

19 Scopus citations

Catalytic site conformations in human PNP by 19F-NMR and crystallography

Suarez, J., Haapalainen, A. M., Cahill, S. M., Ho, M. C., Yan, F., Almo, S. C. & Schramm, V. L., Feb 21 2013, In : Chemistry and Biology. 20, 2, p. 212-222 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Conformational freedom in tight binding enzymatic transition-state analogues

Motley, M. W., Schramm, V. L. & Schwartz, S. D., Aug 22 2013, In : Journal of Physical Chemistry B. 117, 33, p. 9591-9597 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Recycling nicotinamide. the transition-state structure of human nicotinamide phosphoribosyltransferase

Burgos, E. S., Vetticatt, M. J. & Schramm, V. L., Mar 6 2013, In : Journal of the American Chemical Society. 135, 9, p. 3485-3493 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Salmonella enterica MTAN at 1.36 Å resolution: A structure-based design of tailored transition state analogs

Haapalainen, A. M., Thomas, K., Tyler, P. C., Evans, G. B., Almo, S. C. & Schramm, V. L., Jun 4 2013, In : Structure. 21, 6, p. 963-974 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Thermodynamic analysis of transition-state features in picomolar inhibitors of human 5′-methylthioadenosine phosphorylase

Guan, R., Tyler, P. C., Evans, G. B. & Schramm, V. L., Nov 19 2013, In : Biochemistry. 52, 46, p. 8313-8322 10 p.

Research output: Contribution to journalArticle

2 Scopus citations