Projects per year
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Targeting Clostridioides difficile with microbiome-sparing, resistant-proof anti-toxins
Schramm, V. V. L. & Schramm, V. L.
National Institute of Allergy and Infectious Diseases
4/1/21 → 3/31/23
Project: Research project
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Transition State Analysis of Enzymatic Reactions
Schramm, V. L. & Schramm, V. L.
National Institute of General Medical Sciences
8/1/89 → 7/31/23
Project: Research project
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Antigen specific strategies for treatment of HIV+ cancer patients in the Montefiore/Einstein Cancer Center Catchment Area (Immuno/microenvironment)
Almo, S. C., Hogue-Angeletti, R., Augenlicht, L. H., Condeelis, J. S., Desai, K., Edelmann, W., Goldman, I. D., Greally, J. M., Herbst, L. H., Keller, S. M., Kim, M. Y., Mahmood, R., Montagna, C., Morrow, B. E., Pollard, J. W., Porcelli, S. A., Rohan, T. E., Scharff, M. D., Seither, R., Skoultchi, A. I., Sparano, J. A., Stanley, P. M., Chu, E. E., Bresnick, A. A. R., Skoultchi, A. A. I., Beck, A. A. P., Beck, A. P., Morrow, B. B. E., Blanchard, J. S., Bresnick, A. R., Morrow, B. E., Diamond, B. B., Rapkin, B. B. D., Chu, E., Montagna, C., Stein, D. D. T., Gaertner, D. D. J., Chu, E. E., Ho, G. G. Y., Goel, S., Strickler, H., Goldman, I. I. D., Pollard, J. J. W., Condeelis, J. J. S., Dutcher, J. J. P., Greally, J. M., Blanchard, J. S., Sparano, J. J. A., Desai, K. K., Herbst, L. L. H., Augenlicht, L. H., Cannizzaro, L. A., Scharff, M. M. D., Brenowitz, M. D., Kim, M. M. Y., Stanley, P., Mahmood, R. R., Gupta, R. R. K., Rapkin, B. D., Depinho, R. R. A., Angeletti, R. R. H., Kucherlapati, R. R. S., Goel, S. S., Schramm, V. L., Sparano, J. A., Steidl, U. G., Stein, D. T., Almo, S. S. C., Keller, S. S. M., Strickler, H. D., Almo, S. S., Porcelli, S. S. A., Rohan, T. E., Steidl, U. U. G., Edelmann, W. W., Xue, X. X. N., Xue, X. N., Alderman, M. H., Atkinson, P. H., Bases, R. E., Birshstein, B. K., Bloom, B. R., Blumenfeld, O. O., Brenowitz, M. D., Brewer, F. C., Buhl, S., Cannizzaro, L. A., Chance, M. R., Chase, J. W., Childs, G. J., Depinho, R., Depinho, R. A., Diamond, B. A., Diamond, B., Duran-reynals, M. L., Dutcher, J. P., Eagle, H., Fant, J., Gaertner, D. J., Grills, G., Gupta, R. K., Ho, G. Y., Band Horwitz, S., Horwitz, M. S., Hurwitz, J., Kadish, A. S., Klinger, H. P., Krauter, K. S., Kucherlapati, R. S., Levine, W. G., Lilly, F., Maio, J. J., Maitra, U., Makman, M. H., Marians, K. J., Nathenson, S. G., Orr, G. A., Peisach, J., Pickering, K., Rajan, T. V., Reid, L. M., Rubin, C. S., Russel, R., Satir, B. H., Schildkraut, C. L., Schulman, L. H., Serrano, L. J., Shapiro, L., Shin, S., Wadler, S. H., Warner, J. R., West, M. & Wiernik, P. H.
6/1/85 → 6/30/23
Project: Research project
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PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE
Schramm, V. L. & Schramm, V. L.
9/25/17 → 8/31/21
Project: Research project
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Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an SNi Mechanism and Ion Pair Transition State
Paparella, A. S., Cahill, S. M., Aboulache, B. L. & Schramm, V. L., Sep 16 2022, In: ACS Chemical Biology. 17, 9, p. 2507-2518 12 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Inhibition and Mechanism of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase
Minnow, Y. V. T., Suthagar, K., Clinch, K., Ducati, R. G., Ghosh, A., Buckler, J. N., Harijan, R. K., Cahill, S. M., Tyler, P. C. & Schramm, V. L., Dec 16 2022, In: ACS Chemical Biology. 17, 12, p. 3407-3419 13 p.Research output: Contribution to journal › Article › peer-review
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Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine-Guanine Phosphoribosyltransferases
Glockzin, K., Kostomiris, D., Minnow, Y. V. T., Suthagar, K., Clinch, K., Gai, S., Buckler, J. N., Schramm, V. L., Tyler, P. C., Meek, T. D. & Katzfuss, A., Oct 4 2022, In: Biochemistry. 61, 19, p. 2088-2105 18 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1
Lamiable-Oulaidi, F., Harijan, R. K., Shaffer, K. J., Crump, D. R., Sun, Y., Du, Q., Gulab, S. A., Khan, A. A., Luxenburger, A., Woolhouse, A. D., Sidoli, S., Tyler, P. C. & Schramm, V. L., Apr 14 2022, In: Journal of Medicinal Chemistry. 65, 7, p. 5462-5494 33 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues
Gai, S., Suthagar, K., Shaffer, K. J., Jiao, W., Minnow, Y. V. T., Glockzin, K., Maatouk, S. W., Katzfuss, A., Meek, T. D., Schramm, V. L. & Tyler, P. C., Nov 15 2022, In: Bioorganic and Medicinal Chemistry. 74, 117038.Research output: Contribution to journal › Article › peer-review