• 13307 Citations
  • 63 h-Index
1968 …2022
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  • 4 Similar Profiles
Purine-Nucleoside Phosphorylase Medicine & Life Sciences
Isotopes Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Kinetics Chemical Compounds
AMP nucleosidase Medicine & Life Sciences
N-Glycosyl Hydrolases Chemical Compounds
Catalytic Domain Medicine & Life Sciences
Substrates Chemical Compounds

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Grants 1979 2022

African Trypanosomiasis
Trypanosoma brucei brucei
Chagas Disease
Plasmodium falciparum
Malaria
Ligases
DNA Methylation
Neoplasms
Growth
Head and Neck Neoplasms

Protein Dynamics in Enzymatic Catalysis

Callender, R., Dyer, R. B., Schwartz, S. & Schramm, V. L.

National Institutes of Health

5/1/044/30/19

Project: Research project

Catalysis
Proteins
Enzymes
Purine-Nucleoside Phosphorylase
Tetrahydrofolate Dehydrogenase
Isotopes
Enzymes
Purine-Nucleoside Phosphorylase
Inosine
Hydrolases
Nucleosides
Oligonucleotides
Nucleotides
Research
Synthetic Biology

Publications 1968 2019

  • 13307 Citations
  • 63 h-Index
  • 349 Article
  • 6 Chapter
  • 3 Review article

Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis

Joshi, S., Fedoseyenko, D., Mahanta, N., Ducati, R. G., Feng, M., Schramm, V. L. & Begley, T. P., Mar 14 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 363-366 4 p.

Research output: Contribution to journalArticle

Vitamin K 2
Biosynthesis
Pylorus
Anti-Bacterial Agents
Enzymes

Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase

Harijan, R. K., Hoff, O., Ducati, R. G., Firestone, R. S., Hirsch, B. M., Evans, G. B., Schramm, V. L. & Tyler, P. C., Apr 11 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3286-3296 11 p.

Research output: Contribution to journalArticle

adenosylhomocysteine nucleosidase
Helicobacter pylori
Vitamin K 2
S-Adenosylmethionine
Catalytic Domain

Enzymatic Transition States and Drug Design

Schramm, V. L., Jan 1 2018, (Accepted/In press) In : Chemical Reviews.

Research output: Contribution to journalArticle

Computational chemistry
Quantum chemistry
Isotopes
Pharmaceutical Preparations
Kinetics
4 Citations (Scopus)

Genetic resistance to purine nucleoside phosphorylase inhibition in plasmodium falciparum

Ducati, R. G., Namanja-Magliano, H. A., Harijan, R. K., Eduardo Fajardo, J., Fiser, A., Daily, J. P. & Schramm, V. L., Feb 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 9, p. 2114-2119 6 p.

Research output: Contribution to journalArticle

Purine-Nucleoside Phosphorylase
Plasmodium falciparum
Antimalarials
Gene Amplification
Starvation
4 Citations (Scopus)

Immucillins in Infectious Diseases

Evans, G. B., Tyler, P. C. & Schramm, V. L., Feb 9 2018, In : ACS Infectious Diseases. 4, 2, p. 107-117 11 p.

Research output: Contribution to journalReview article

Communicable Diseases
Nucleic Acid Precursors
Helicobacter pylori
Purine-Nucleoside Phosphorylase
Vitamin K 2