Projects per year
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- 4 Similar Profiles
Purine-Nucleoside Phosphorylase
Medicine & Life Sciences
Isotopes
Medicine & Life Sciences
Enzymes
Medicine & Life Sciences
Kinetics
Chemical Compounds
AMP nucleosidase
Medicine & Life Sciences
N-Glycosyl Hydrolases
Chemical Compounds
Catalytic Domain
Medicine & Life Sciences
Substrates
Chemical Compounds
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Grants 1979 2022
PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE
9/25/17 → 8/31/22
Project: Research project
African Trypanosomiasis
Trypanosoma brucei brucei
Chagas Disease
Plasmodium falciparum
Malaria
Transition State Analogues as Modulators of DNA Methylation
9/11/08 → 4/30/19
Project: Research project
Ligases
DNA Methylation
Neoplasms
Growth
Head and Neck Neoplasms
Protein Dynamics in Enzymatic Catalysis
Callender, R., Dyer, R. B., Schwartz, S. & Schramm, V. L.
5/1/04 → 4/30/19
Project: Research project
Catalysis
Proteins
Enzymes
Purine-Nucleoside Phosphorylase
Tetrahydrofolate Dehydrogenase
Isotopes
Enzymes
Purine-Nucleoside Phosphorylase
Inosine
Hydrolases
2015 Nucleosides, Nucleotides & Oligonucleotides Gordon Research Conference and Seminar
5/18/15 → 9/30/15
Project: Research project
Nucleosides
Oligonucleotides
Nucleotides
Research
Synthetic Biology
Publications 1968 2019
Antibacterial Strategy against H. pylori: Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis
Joshi, S., Fedoseyenko, D., Mahanta, N., Ducati, R. G., Feng, M., Schramm, V. L. & Begley, T. P., Mar 14 2019, In : ACS Medicinal Chemistry Letters. 10, 3, p. 363-366 4 p.Research output: Contribution to journal › Article
Vitamin K 2
Biosynthesis
Pylorus
Anti-Bacterial Agents
Enzymes
Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase
Harijan, R. K., Hoff, O., Ducati, R. G., Firestone, R. S., Hirsch, B. M., Evans, G. B., Schramm, V. L. & Tyler, P. C., Apr 11 2019, In : Journal of Medicinal Chemistry. 62, 7, p. 3286-3296 11 p.Research output: Contribution to journal › Article
adenosylhomocysteine nucleosidase
Helicobacter pylori
Vitamin K 2
S-Adenosylmethionine
Catalytic Domain
Enzymatic Transition States and Drug Design
Schramm, V. L., Jan 1 2018, (Accepted/In press) In : Chemical Reviews.Research output: Contribution to journal › Article
Computational chemistry
Quantum chemistry
Isotopes
Pharmaceutical Preparations
Kinetics
4
Citations
(Scopus)
Genetic resistance to purine nucleoside phosphorylase inhibition in plasmodium falciparum
Ducati, R. G., Namanja-Magliano, H. A., Harijan, R. K., Eduardo Fajardo, J., Fiser, A., Daily, J. P. & Schramm, V. L., Feb 27 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 9, p. 2114-2119 6 p.Research output: Contribution to journal › Article
Purine-Nucleoside Phosphorylase
Plasmodium falciparum
Antimalarials
Gene Amplification
Starvation
4
Citations
(Scopus)
Immucillins in Infectious Diseases
Evans, G. B., Tyler, P. C. & Schramm, V. L., Feb 9 2018, In : ACS Infectious Diseases. 4, 2, p. 107-117 11 p.Research output: Contribution to journal › Review article
Communicable Diseases
Nucleic Acid Precursors
Helicobacter pylori
Purine-Nucleoside Phosphorylase
Vitamin K 2