• 3878 Citations
  • 34 h-Index
1989 …2019

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2019

Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase

Winters, M., DuHadaway, J. B., Pham, K. N., Lewis-Ballester, A., Badir, S., Wai, J., Sheikh, E., Yeh, S. R., Prendergast, G. C., Muller, A. J. & Malachowski, W. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 455-464 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Snapshot of an oxygen intermediate in the catalytic reaction of cytochrome c oxidase

Ishigami, I., Lewis, A., Echelmeier, A., Brehm, G., Zatsepin, N. A., Grant, T. D., Coe, J. D., Lisova, S., Nelson, G., Zhang, S., Dobson, Z. F., Boutet, S., Sierra, R. G., Batyuk, A., Fromme, P., Fromme, R., Spence, J. C. H., Ros, A., Yeh, S. R. & Rousseau, D. L., Feb 26 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3572-3577 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Structural Basis of Inhibitor Selectivity in Human Indoleamine 2,3-Dioxygenase 1 and Tryptophan Dioxygenase

Pham, K. N., Lewis-Ballester, A. & Yeh, S. R., Nov 27 2019, In : Journal of the American Chemical Society. 141, 47, p. 18771-18779 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Inhibition Mechanisms of Human Indoleamine 2,3 Dioxygenase 1

Lewis-Ballester, A., Karkashon, S., Batabyal, D., Poulos, T. L. & Yeh, S-R., Apr 5 2018, (Accepted/In press) In : Journal of the American Chemical Society.

Research output: Contribution to journalArticle

11 Scopus citations

Mapping the Binding Trajectory of a Suicide Inhibitor in Human Indoleamine 2,3-Dioxygenase 1

Pham, K. N. & Yeh, S. R., Nov 7 2018, In : Journal of the American Chemical Society. 140, 44, p. 14538-14541 4 p.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature

Ishigami, I., Zatsepin, N. A., Hikita, M., Conrad, C. E., Nelson, G., Coe, J. D., Basu, S., Grant, T. D., Seaberg, M. H., Sierra, R. G., Hunter, M. S., Fromme, P., Fromme, R., Yeh, S-R. & Rousseau, D. L., Jul 25 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. 8011-8016 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mycobacterium tuberculosis universal stress protein Rv2623 interacts with the putative ATP binding cassette (APC) transporter Rv1747 to regulate mycobacterial growth

Glass, L. N., Swapna, G., Chavadi, S. S., Tufariello, J. A. M., Mi, K., Drumm, J. E., Lam, T. K. T., Zhu, G., Zhan, C., Vilchéze, C., Arcos, J., Chen, Y., Bi, L., Mehta, S., Porcelli, S. A., Almo, S. C., Yeh, S. R., Jacobs, W. R., Torrelles, J. B. & Chan, J., Jul 2017, In : PLoS pathogens. 13, 7, e1006515.

Research output: Contribution to journalArticle

14 Scopus citations

Reaction intermediates in the heme degradation reaction by HutZ from: Vibrio cholerae

Uchida, T., Sekine, Y., Dojun, N., Lewis-Ballester, A., Ishigami, I., Matsui, T., Yeh, S. R. & Ishimori, K., Jan 1 2017, In : Dalton Transactions. 46, 25, p. 8104-8109 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase

Lewis-Ballester, A., Pham, K. N., Batabyal, D., Karkashon, S., Bonanno, J. B., Poulos, T. L. & Yeh, S-R., Dec 1 2017, In : Nature Communications. 8, 1, 1693.

Research output: Contribution to journalArticle

44 Scopus citations
2016

A Comparative Analysis of the Effector Role of Redox Partner Binding in Bacterial P450s

Batabyal, D., Lewis-Ballester, A., Yeh, S. R. & Poulos, T. L., Nov 29 2016, In : Biochemistry. 55, 47, p. 6517-6523 7 p.

Research output: Contribution to journalArticle

8 Scopus citations

Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase

Lewis-Ballester, A., Forouhar, F., Kim, S. M., Lew, S., Wang, Y., Karkashon, S., Seetharaman, J., Batabyal, D., Chiang, B. Y., Hussain, M., Correia, M. A., Yeh, S. R. & Tong, L., Oct 20 2016, In : Scientific reports. 6, 35169.

Research output: Contribution to journalArticle

34 Scopus citations

O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1

Malachowski, W. P., Winters, M., DuHadaway, J. B., Lewis-Ballester, A., Badir, S., Wai, J., Rahman, M., Sheikh, E., LaLonde, J. M., Yeh, S. R., Prendergast, G. C. & Muller, A. J., Jan 27 2016, In : European Journal of Medicinal Chemistry. 108, p. 564-576 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

Structural Study of a Flexible Active Site Loop in Human Indoleamine 2,3-Dioxygenase and Its Functional Implications

Álvarez, L., Lewis-Ballester, A., Roitberg, A., Estrin, D. A., Yeh, S-R., Marti, M. A. & Capece, L., May 17 2016, In : Biochemistry. 55, 19, p. 2785-2793 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Three-dimensional-printed gas dynamic virtual nozzles for x-ray laser sample delivery

Nelson, G., Kirian, R. A., Weierstall, U., Zatsepin, N. A., Faragó, T., Baumbach, T., Wilde, F., Niesler, F. B. P., Zimmer, B., Ishigami, I., Hikita, M., Bajt, S., Yeh, S-R., Rousseau, D. L., Chapman, H. N., Spence, J. C. H. & Heymann, M., May 30 2016, In : Optics Express. 24, 11, p. 11515-11530 16 p.

Research output: Contribution to journalArticle

35 Scopus citations
2015

Heme Stabilization of α-Synuclein Oligomers during Amyloid Fibril Formation

Hayden, E. Y., Kaur, P., Williams, T. L., Matsui, H., Yeh, S. R. & Rousseau, D. L., Aug 4 2015, In : Biochemistry. 54, 30, p. 4599-4610 12 p.

Research output: Contribution to journalArticle

21 Scopus citations
4 Scopus citations

Spectroscopic and mutagenesis studies of human pgrmc1

Kaluka, D., Batabyal, D., Chiang, B. Y., Poulos, T. L. & Yeh, S. R., Mar 3 2015, In : Biochemistry. 54, 8, p. 1638-1647 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

The two transmembrane helices of CcoP are sufficient for assembly of the cbb3-type heme-copper oxygen reductase from Vibrio cholerae

Ahn, Y. O., Lee, H. J., Kaluka, D., Yeh, S. R., Rousseau, D. L., Ädelroth, P. & Gennis, R. B., Jul 13 2015, In : Biochimica et Biophysica Acta - Bioenergetics. 1847, 10, p. 1231-1239 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Conformational coupling between the active site and residues within the KC-channel of the Vibrio cholerae cbb3-type (C-family) oxygen reductase

Ahn, Y. O., Mahinthichaichan, P., Lee, H. J., Ouyang, H., Kaluka, D., Yeh, S. R., Arjona, D., Rousseau, D. L., Tajkhorshid, E., Ädelroth, P. & Gennis, R. B., Oct 21 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 42, p. E4419-E4428

Research output: Contribution to journalArticle

8 Scopus citations
2013

Catalytic intermediates of inducible nitric-oxide synthase stabilized by the W188H mutation

Sabat, J., Egawa, T., Lu, C., Stuehr, D. J., Gerfen, G. J., Rousseau, D. L. & Yeh, S. R., Mar 1 2013, In : Journal of Biological Chemistry. 288, 9, p. 6095-6106 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Redox-Controlled Proton Gating in Bovine Cytochrome c Oxidase

Egawa, T., Yeh, S. R. & Rousseau, D. L., May 16 2013, In : PloS one. 8, 5, e63669.

Research output: Contribution to journalArticle

25 Scopus citations

Regulatory role of Glu546 in flavin mononucleotide - Heme electron transfer in human inducible nitric oxide synthase

Li, W., Chen, L., Lu, C., Elmore, B. O., Astashkin, A. V., Rousseau, D. L., Yeh, S. R. & Feng, C., May 6 2013, In : Inorganic Chemistry. 52, 9, p. 4795-4801 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2012

An unconventional hexacoordinated flavohemoglobin from Mycobacterium tuberculosis

Gupta, S., Pawaria, S., Lu, C., Hade, M. D., Singh, C., Yeh, S. R. & Dikshit, K. L., May 11 2012, In : Journal of Biological Chemistry. 287, 20, p. 16435-16446 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Complete reaction mechanism of indoleamine 2,3-dioxygenase as revealed by QM/MM simulations

Capece, L., Lewis-Ballester, A., Yeh, S. R., Estrin, D. A. & Marti, M. A., Feb 2 2012, In : Journal of Physical Chemistry B. 116, 4, p. 1401-1413 13 p.

Research output: Contribution to journalArticle

51 Scopus citations

The rate-limiting step in O 2 reduction by cytochrome ba 3 from Thermus thermophilus

Egawa, T., Chen, Y., Fee, J. A., Yeh, S. R. & Rousseau, D. L., Apr 1 2012, In : Biochimica et Biophysica Acta - Bioenergetics. 1817, 4, p. 666-671 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Two tyrosyl radicals stabilize high oxidation states in cytochrome c oxidase for efficient energy conservation and proton translocation

Yu, M. A., Egawa, T., Shinzawa-Itoh, K., Yoshikawa, S., Guallar, V., Yeh, S. R., Rousseau, D. L. & Gerfen, G. J., Mar 14 2012, In : Journal of the American Chemical Society. 134, 10, p. 4753-4761 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2011

Differential effects of glutamate-286 mutations in the aa3-type cytochrome c oxidase from Rhodobacter sphaeroides and the cytochrome bo 3 ubiquinol oxidase from Escherichia coli

Egawa, T., Ganesan, K., Lin, M. T., Yu, M. A., Hosler, J. P., Yeh, S. R., Rousseau, D. L. & Gennis, R. B., Oct 1 2011, In : Biochimica et Biophysica Acta - Bioenergetics. 1807, 10, p. 1342-1348 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Ferryl derivatives of human indoleamine 2,3-dioxygenase

Lu, C. & Yeh, S. R., Jun 17 2011, In : Journal of Biological Chemistry. 286, 24, p. 21220-21230 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ligand migration in human indoleamine-2,3 dioxygenase

Nienhaus, K., Nickel, E., Lu, C., Yeh, S. R. & Nienhaus, G. U., Mar 1 2011, In : IUBMB Life. 63, 3, p. 153-159 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Molecular basis for the substrate stereoselectivity in tryptophan dioxygenase

Capece, L., Lewis-Ballester, A., Marti, M. A., Estrin, D. A. & Yeh, S. R., Dec 20 2011, In : Biochemistry. 50, 50, p. 10910-10918 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Novel flavohemoglobins of mycobacteria

Gupta, S., Pawaria, S., Lu, C., Yeh, S. R. & Dikshit, K. L., May 1 2011, In : IUBMB Life. 63, 5, p. 337-345 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Radical formation in cytochrome c oxidase

Yu, M. A., Egawa, T., Shinzawa-Itoh, K., Yoshikawa, S., Yeh, S. R., Rousseau, D. L. & Gerfen, G. J., Oct 1 2011, In : Biochimica et Biophysica Acta - Bioenergetics. 1807, 10, p. 1295-1304 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Role of the distal hydrogen-bonding network in regulating oxygen affinity in the truncated hemoglobin III from campylobacter jejuni

Arroyo Mañez, P., Lu, C., Boechi, L., Martí, M. A., Shepherd, M., Wilson, J. L., Poole, R. K., Luque, F. J., Yeh, S. R. & Estrin, D. A., May 17 2011, In : Biochemistry. 50, 19, p. 3946-3956 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2010

Co-expression of ferrochelatase allows for complete heme incorporation into recombinant proteins produced in E. coli

Sudhamsu, J., Kabir, M., Airola, M. V., Patel, B. A., Yeh, S. R., Rousseau, D. L. & Crane, B. R., 2010, In : Protein Expression and Purification. 73, 1, p. 78-82 5 p.

Research output: Contribution to journalArticle

19 Scopus citations
14 Scopus citations

Modulation of the active site conformation by site-directed mutagenesis in cytochrome c oxidase from Paracoccus denitrificans

Ji, H., Das, T. K., Puustinen, A., Wikström, M., Yeh, S. R. & Rousseau, D. L., Mar 1 2010, In : Journal of Inorganic Biochemistry. 104, 3, p. 318-323 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Role of copper ion in regulating ligand binding in a myoglobin-based cytochrome c oxidase model

Lu, C., Zhao, X., Lu, Y., Rousseau, D. L. & Yeh, S. R., Feb 10 2010, In : Journal of the American Chemical Society. 132, 5, p. 1598-1605 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Spectroscopic studies of ligand and substrate binding to human indoleamine 2,3-dioxygenase

Lu, C., Lin, Y. & Yeh, S. R., Jun 22 2010, In : Biochemistry. 49, 24, p. 5028-5034 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Substrate stereo-specificity in tryptophan dioxygenase and indoleamine 2,3-dioxygenase

Capece, L., Arrar, M., Roitberg, A. E., Yeh, S. R., Marti, M. A. & Estrin, D. A., Nov 1 2010, In : Proteins: Structure, Function and Bioinformatics. 78, 14, p. 2961-2972 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

The first step of the dioxygenation reaction carried out by tryptophan dioxygenase and indoleamine 2,3-dioxygenase as revealed by quantum mechanical/molecular mechanical studies

Capece, L., Lewis-Ballester, A., Batabyal, D., Di Russo, N., Yeh, S. R., Estrin, D. A. & Marti, M. A., Aug 1 2010, In : Journal of Biological Inorganic Chemistry. 15, 6, p. 811-823 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

The single-domain globin from the pathogenic bacterium Campylobacter jejuni: Novel D-helix conformation, proximal hydrogen bonding that influences ligand binding, and peroxidase-like redox properties

Shepherd, M., Barynin, V., Lu, C., Bernhardt, P. V., Wu, G., Yeh, S. R., Egawa, T., Sedelnikova, S. E., Rice, D. W., Wilson, J. L. & Poole, R. K., Apr 23 2010, In : Journal of Biological Chemistry. 285, 17, p. 12747-12754 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
2009

Characterization of the proximal ligand in the P420 form of inducible nitric oxide synthase

Sabat, J., Stuehr, D. J., Yeh, S. R. & Rousseau, D. L., Sep 2 2009, In : Journal of the American Chemical Society. 131, 34, p. 12186-12192 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Communication between R481 and CuB in cytochrome bo3 ubiquinol oxidase from Escherichia coli

Egawa, T., Lin, M. T., Hosler, J. P., Gennis, R. B., Yeh, S. R. & Rousseau, D. L., Dec 29 2009, In : Biochemistry. 48, 51, p. 12113-12124 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Critical structural role of R481 in cytochrome c oxidase from Rhodobacter sphaeroides

Egawa, T., Lee, H. J., Gennis, R. B., Yeh, S. R. & Rousseau, D. L., Oct 1 2009, In : Biochimica et Biophysica Acta - Bioenergetics. 1787, 10, p. 1272-1275 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Design and evaluation of a passive alcove-based microfluidic mixer

Egawa, T., Durand, J. L., Hayden, E. Y., Rousseau, D. L. & Yeh, S. R., Feb 15 2009, In : Analytical Chemistry. 81, 4, p. 1622-1627 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Evidence for a ferryl intermediate in a heme-based dioxygenase

Lewis-Ballester, A., Batabyal, D., Egawa, T., Lu, C., Lin, Y., Marti, M. A., Capece, L., Estrin, D. A. & Yeh, S. R., Oct 13 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 41, p. 17371-17376 6 p.

Research output: Contribution to journalArticle

88 Scopus citations

Factors controlling the reactivity of hydrogen sulfide with hemeproteins

Pietri, R., Lewis, A., León, R. G., Casabona, G., Kiger, L., Yeh, S. R., Fernandez-Alberti, S., Marden, M. C., Cadilla, C. L. & López-Garriga, J., Jun 9 2009, In : Biochemistry. 48, 22, p. 4881-4894 14 p.

Research output: Contribution to journalArticle

73 Scopus citations

Identification of heme propionate vibrational modes in the resonance Raman spectra of cytochrome c oxidase

Egawa, T., Lee, H. J., Ji, H., Gennis, R. B., Yeh, S. R. & Rousseau, D. L., Nov 1 2009, In : Analytical Biochemistry. 394, 1, p. 141-143 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Inhibitory substrate binding site of human indoleamine 2,3-dioxygenase

Lu, C., Lin, Y. & Yeh, S. R., Sep 16 2009, In : Journal of the American Chemical Society. 131, 36, p. 12866-12867 2 p.

Research output: Contribution to journalArticle

64 Scopus citations

Ligand and substrate migration in human indoleamine 2,3-dioxygenase

Nickel, E., Nienhaus, K., Lu, C., Yeh, S. R. & Nienhaus, G. U., 2009, In : Journal of Biological Chemistry. 284, 46, p. 31548-31554 7 p.

Research output: Contribution to journalArticle

17 Scopus citations