• 3478 Citations
  • 31 h-Index
1989 …2021
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  • 5 Similar Profiles
Heme Medicine & Life Sciences
Indoleamine-Pyrrole 2,3,-Dioxygenase Chemical Compounds
Truncated Hemoglobins Chemical Compounds
Ligands Medicine & Life Sciences
Electron Transport Complex IV Chemical Compounds
Carbon Monoxide Chemical Compounds
Tryptophan Medicine & Life Sciences
Oxygen Medicine & Life Sciences

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Grants 2001 2021

Crystallography
Electron Transport Complex IV
Carbon Monoxide
Protons
Enzymes
Dioxygenases
Tryptophan
Neurodegenerative diseases
Kynurenine
Enzymes
Indoleamine-Pyrrole 2,3,-Dioxygenase
Dioxygenases
Heme
Protein Isoforms
Neoplasms

Structure Function Relationship in Hemeproteins

Yeh, S.

National Institutes of Health

12/1/015/31/06

Project: Research projectResearch Project

Hemeproteins
Hemoglobins
Heme
Peroxidases
Truncated Hemoglobins

Publications 1989 2019

  • 3478 Citations
  • 31 h-Index
  • 99 Article
  • 3 Chapter
  • 2 Conference contribution

CHAPTER 9: Structure, Function and Regulation of Human Heme-based Dioxygenases

Lewis-Ballester, A., Pham, K. N., Liao, M., Correia, M. A. & Yeh, S-R., Jan 1 2019, Dioxygen-dependent Heme Enzymes. Ikeda-Saito, M. & Raven, E. (eds.). 13 ed. Royal Society of Chemistry, p. 181-221 41 p. (RSC Metallobiology; vol. 2019-January, no. 13).

Research output: Chapter in Book/Report/Conference proceedingChapter

Dioxygenases
Indoleamine-Pyrrole 2,3,-Dioxygenase
Heme
Protons
Tryptophan

Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase

Winters, M., DuHadaway, J. B., Pham, K. N., Lewis-Ballester, A., Badir, S., Wai, J., Sheikh, E., Yeh, S-R., Prendergast, G. C., Muller, A. J. & Malachowski, W. P., Jan 15 2019, In : European Journal of Medicinal Chemistry. 162, p. 455-464 10 p.

Research output: Contribution to journalArticle

Hydroxylamines
Indoleamine-Pyrrole 2,3,-Dioxygenase
Dioxygenases
Tryptophan
Enzymes

Inhibition Mechanisms of Human Indoleamine 2,3 Dioxygenase 1

Lewis-Ballester, A., Karkashon, S., Batabyal, D., Poulos, T. L. & Yeh, S. R., Apr 5 2018, (Accepted/In press) In : Journal of the American Chemical Society.

Research output: Contribution to journalArticle

Ethanol
Dioxygenases
Binding Sites
Tryptophan
Tunnels

Mapping the Binding Trajectory of a Suicide Inhibitor in Human Indoleamine 2,3-Dioxygenase 1

Pham, K. N. & Yeh, S-R., Nov 7 2018, In : Journal of the American chemical society. 140, 44, p. 14538-14541 4 p.

Research output: Contribution to journalArticle

Suicide
Conformations
Trajectories
Enzymes
Heme
4 Citations

Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature

Ishigami, I., Zatsepin, N. A., Hikita, M., Conrad, C. E., Nelson, G., Coe, J. D., Basu, S., Grant, T. D., Seaberg, M. H., Sierra, R. G., Hunter, M. S., Fromme, P., Fromme, R., Yeh, S. R. & Rousseau, D. L., Jul 25 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 30, p. 8011-8016 6 p.

Research output: Contribution to journalArticle

X Ray Crystallography
Electron Transport Complex IV
Carbon Monoxide
Synchrotrons
Temperature