• 7324 Citations
  • 48 h-Index
1978 …2023
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Personal profile

Keywords

  • RZ Other systems of medicine
  • Microbiome
  • Health
  • orphan nuclear receptors
  • inflammatory bowel disease
  • colon cancer
  • probiotics

Fingerprint Dive into the research topics where Sridhar Mani is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 5 Similar Profiles
Neoplasms Medicine & Life Sciences
irinotecan Medicine & Life Sciences
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gemcitabine Medicine & Life Sciences
alvocidib Medicine & Life Sciences
Xenobiotics Medicine & Life Sciences
Pharmaceutical Preparations Medicine & Life Sciences

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Grants 1978 2023

Colitis
Colorectal Neoplasms
Toll-Like Receptor 4
Inflammation
Colonic Neoplasms
Halogenated Diphenyl Ethers
Dysbiosis
Tryptophan
Indoles
Phenotype
irinotecan
Glucuronidase
Pharmaceutical Preparations
Neoplasms
Pharmacology

6th International Conference on SBDS

Mani, S. & Liu, J. M.

National Institutes of Health

6/1/116/30/12

Project: Research project

Inborn Genetic Diseases
Bone Marrow
Hematopoiesis
Research Personnel
Medicine
Orphan Nuclear Receptors
Ketoconazole
Ligands
pregnane X receptor
Molecular Biology

Publications 1990 2019

  • 7324 Citations
  • 48 h-Index
  • 179 Article
  • 1 Chapter
  • 1 Review article
1 Citation (Scopus)

Belinostat, at Its Clinically Relevant Concentrations, Inhibits Rifampicin-Induced CYP3A4 and MDR1 Gene Expression

Abbott, K. L., Chaudhury, C. S., Chandran, A., Vishveshwara, S., Dvorak, Z., Jiskrova, E., Poulikova, K., Vyhlidalova, B., Mani, S. & Pondugula, S. R., Mar 1 2019, In : Molecular Pharmacology. 95, 3, p. 324-334 11 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Rifampin
Gene Expression
irinotecan
Combination Drug Therapy

Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells

Vyhlídalová, B., Poulíková, K., Bartoňková, I., Krasulová, K., Vančo, J., Trávníček, Z., Mani, S. & Dvořák, Z., Oct 1 2019, In : Toxicology Letters. 313, p. 66-76 11 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Cytochrome P-450 CYP1A1
Enzyme activity
Human Activities
Hepatocytes

Orbiting of Flagellated Bacteria within a Thin Fluid Film around Micrometer-Sized Particles

Araujo, G., Chen, W., Mani, S. & Tang, J. X., Jan 1 2019, In : Biophysical Journal.

Research output: Contribution to journalArticle

Agar
Escherichia coli
Bacteria
Enterobacter
Functional Laterality

Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation

Hudson, G., Flannigan, K. L., Venu, V. K. P., Alston, L., Sandall, C. F., MacDonald, J. A., Muruve, D. A., Chang, T. K. H., Mani, S. & Hirota, S. A., Jul 1 2019, In : The Journal of pharmacology and experimental therapeutics. 370, 1, p. 44-53 10 p.

Research output: Contribution to journalArticle

Open Access
Inflammasomes
Adenosine Triphosphate
Macrophages
Xenobiotics
Purinergic P2X Receptors
3 Citations (Scopus)

Methylindoles and methoxyindoles are agonists and antagonists of human aryl hydrocarbon receptor

Stepankova, M., Bartonkova, I., Jiskrova, E., Vrzal, R., Mani, S., Kortagere, S. & Dvorak, Z., Jun 1 2018, In : Molecular Pharmacology. 93, 6, p. 631-644 14 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Inhibitory Concentration 50
Cytochrome P-450 CYP1A1
Reporter Genes
indole