• 7788 Citations
  • 49 h-Index
1978 …2023
If you made any changes in Pure, your changes will be visible here soon.

Publications 1990 2019

  • 7788 Citations
  • 49 h-Index
  • 181 Article
  • 3 Review article
  • 1 Chapter
Filter
Article
2019
3 Citations (Scopus)

Belinostat, at Its Clinically Relevant Concentrations, Inhibits Rifampicin-Induced CYP3A4 and MDR1 Gene Expression

Abbott, K. L., Chaudhury, C. S., Chandran, A., Vishveshwara, S., Dvorak, Z., Jiskrova, E., Poulikova, K., Vyhlidalova, B., Mani, S. & Pondugula, S. R., Mar 1 2019, In : Molecular Pharmacology. 95, 3, p. 324-334 11 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Rifampin
Gene Expression
irinotecan
Combination Drug Therapy

Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells

Vyhlídalová, B., Poulíková, K., Bartoňková, I., Krasulová, K., Vančo, J., Trávníček, Z., Mani, S. & Dvořák, Z., Oct 1 2019, In : Toxicology Letters. 313, p. 66-76 11 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Cytochrome P-450 CYP1A1
Enzyme activity
Human Activities
Hepatocytes

Orbiting of Flagellated Bacteria within a Thin Fluid Film around Micrometer-Sized Particles

Araujo, G., Chen, W., Mani, S. & Tang, J. X., Jan 1 2019, In : Biophysical Journal.

Research output: Contribution to journalArticle

Agar
Escherichia coli
Bacteria
Enterobacter
Functional Laterality

Polybrominated diphenyl ethers and gut microbiome modulate metabolic syndrome-related aqueous metabolites in mice

Scoville, D. K., Li, C. Y., Wang, D., Dempsey, J. L., Raftery, D., Mani, S., Gu, H. & Cui, J. Y., Jan 1 2019, In : Drug Metabolism and Disposition. 47, 8, p. 928-940 13 p.

Research output: Contribution to journalArticle

Halogenated Diphenyl Ethers
Liver
Mannosyltransferases
Serum
Dysbiosis

Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation

Hudson, G., Flannigan, K. L., Venu, V. K. P., Alston, L., Sandall, C. F., MacDonald, J. A., Muruve, D. A., Chang, T. K. H., Mani, S. & Hirota, S. A., Jul 1 2019, In : The Journal of pharmacology and experimental therapeutics. 370, 1, p. 44-53 10 p.

Research output: Contribution to journalArticle

Open Access
Inflammasomes
Adenosine Triphosphate
Macrophages
Xenobiotics
Purinergic P2X Receptors

The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation

Venu, V. K. P., Saifeddine, M., Mihara, K., Tsai, Y. C., Nieves, K., Alston, L., Mani, S., McCoy, K. D., Hollenberg, M. D. & Hirota, S. A., Aug 1 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 317, 2, p. E350-E361

Research output: Contribution to journalArticle

Microbiota
Vasodilation
Endothelium
Ligands
Nitric Oxide Synthase Type III
2018
4 Citations (Scopus)

Methylindoles and methoxyindoles are agonists and antagonists of human aryl hydrocarbon receptor

Stepankova, M., Bartonkova, I., Jiskrova, E., Vrzal, R., Mani, S., Kortagere, S. & Dvorak, Z., Jun 1 2018, In : Molecular Pharmacology. 93, 6, p. 631-644 14 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Inhibitory Concentration 50
Cytochrome P-450 CYP1A1
Reporter Genes
indole
5 Citations (Scopus)

Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis

Huang, K., Mukherjee, S., Desmarais, V. M., Albanese, J. M., Rafti, E., Draghi, A., Maher, L. A., Khanna, K. M., Mani, S. & Matson, A. P., May 1 2018, In : Pediatric Research. 83, 5, p. 1031-1040 10 p.

Research output: Contribution to journalArticle

Necrotizing Enterocolitis
Toll-Like Receptor 4
Theoretical Models
Inflammation
Lithocholic Acid
2017
27 Citations (Scopus)

Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice

Luo, X., Yu, Z., Deng, C., Zhang, J., Ren, G., Sun, A., Mani, S., Wang, Z. & Dou, W., Dec 1 2017, In : Scientific Reports. 7, 1, 16374.

Research output: Contribution to journalArticle

Myeloid Differentiation Factor 88
Trinitrobenzenes
Inflammasomes
Toll-Like Receptor 4
Sulfonic Acids
10 Citations (Scopus)

Constitutive androstane receptor regulates the intestinal mucosal response to injury

Hudson, G. M., Flannigan, K. L., Erickson, S. L., Vicentini, F. A., Zamponi, A., Hirota, C. L., Alston, L., Altier, C., Ghosh, S., Rioux, K. P., Mani, S., Chang, T. K. & Hirota, S. A., 2017, In : British Journal of Pharmacology. 174, 12, p. 1857-1871 15 p.

Research output: Contribution to journalArticle

Wounds and Injuries
Xenobiotics
Ulcerative Colitis
Inflammatory Bowel Diseases
Crohn Disease
3 Citations (Scopus)

Microbiota and Breast Cancer

Mani, S., 2017, (Accepted/In press) In : Progress in Molecular Biology and Translational Science.

Research output: Contribution to journalArticle

Microbiota
Breast
Breast Neoplasms
Carcinogenesis
Bacteria
2016
21 Citations (Scopus)

C-glycosyl flavonoid orientin improves chemically induced inflammatory bowel disease in mice

Sun, A., Ren, G., Deng, C., Zhang, J., Luo, X., Wu, X., Mani, S., Dou, W. & Wang, Z., Mar 1 2016, In : Journal of Functional Foods. 21, p. 418-430 13 p.

Research output: Contribution to journalArticle

NF-kappa B
inflammatory bowel disease
mitogen-activated protein kinase
Inflammatory Bowel Diseases
Flavonoids
19 Citations (Scopus)

Pregnane x receptor activation attenuates inflammation-associated intestinal epithelial barrier dysfunction by inhibiting cytokine-induced myosin light-chain kinase expression and c-jun n-terminal kinase 1/2 activation

Garg, A., Zhao, A., Erickson, S. L., Mukherjee, S., Lau, A. J., Alston, L., Chang, T. K. H., Mani, S. & Hirota, S. A., Oct 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 359, 1, p. 91-101 11 p.

Research output: Contribution to journalArticle

Pregnanes
Myosin-Light-Chain Kinase
Phosphotransferases
Cytokines
Inflammation
8 Citations (Scopus)

Pregnane X receptor regulates pathogen-induced inflammation and host defense against an intracellular bacterial infection through toll-like receptor 4

Qiu, Z., Cervantes, J. L., Cicek, B. B., Mukherjee, S., Venkatesh, M., Maher, L. A., Salazar, J. C., Mani, S. & Khanna, K. M., Aug 23 2016, In : Scientific Reports. 6, 31936.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Listeria monocytogenes
Bacterial Infections
Listeriosis
Inflammation
2015
6 Citations (Scopus)

Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity

Pasquel, D., Doricakova, A., Li, H., Kortagere, S., Krasowski, M. D., Biswas, A., Walton, W. G., Redinbo, M. R., Dvorak, Z. & Mani, S., Nov 18 2015, (Accepted/In press) In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms.

Research output: Contribution to journalArticle

Acetylation
Lysine
DNA
Xenobiotics
Metabolism
824 Citations (Scopus)

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Vétizou, M., Pitt, J. M., Daillère, R., Lepage, P., Waldschmitt, N., Flament, C., Rusakiewicz, S., Routy, B., Roberti, M. P., Duong, C. P. M., Poirier-Colame, V., Roux, A., Becharef, S., Formenti, S., Golden, E., Cording, S., Eberl, G., Schlitzer, A., Ginhoux, F., Mani, S. & 18 others, Yamazaki, T., Jacquelot, N., Enot, D. P., Bérard, M., Nigou, J., Opolon, P., Eggermont, A., Woerther, P. L., Chachaty, E., Chaput, N., Robert, C., Mateus, C., Kroemer, G., Raoult, D., Boneca, I. G., Carbonnel, F., Chamaillard, M. & Zitvogel, L., Nov 27 2015, In : Science. 350, 6264, p. 1079-1084 6 p.

Research output: Contribution to journalArticle

Immunotherapy
Bacteroides
Adoptive Transfer
Antibodies
Polysaccharides
28 Citations (Scopus)

Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR

Pondugula, S. R., Flannery, P. C., Abbott, K. L., Coleman, E. S., Mani, S., Samuel, T. & Xie, W., Feb 3 2015, In : Toxicology Letters. 232, 3, p. 580-589 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
P-Glycoprotein
Gene expression
Gene Expression
Drug interactions
24 Citations (Scopus)

Hepatocellular shuttling and recirculation of sorafenib-glucuronide is dependent on Abcc2, Abcc3, and Oatp1a/1b

Vasilyeva, A., Durmus, S., Li, L., Wagenaar, E., Hu, S., Gibson, A. A., Panetta, J. C., Mani, S., Sparreboom, A., Baker, S. D. & Schinkel, A. H., Jul 1 2015, In : Cancer Research. 75, 13, p. 2729-2736 8 p.

Research output: Contribution to journalArticle

Glucuronides
Hepatocytes
Liver
Clinical Pharmacology
Xenobiotics
2 Citations (Scopus)

Microbial control of intestinal innate immunity

Brave, M., Lukin, D. J. & Mani, S., 2015, In : Oncotarget. 6, 24, p. 19962-19963 2 p.

Research output: Contribution to journalArticle

Innate Immunity
Intestines
Immunity
Gastrointestinal Microbiome
40 Citations (Scopus)

Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activations

Zhang, J., Ding, L., Wang, B., Ren, G., Sun, A., Deng, C., Wei, X., Mani, S., Wang, Z. & Dou, W., Jan 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 352, 2, p. 315-324 10 p., A9.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Xenobiotics
Colitis
Colon
Panax notoginseng
83 Citations (Scopus)

Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity

Wallace, B. D., Roberts, A. B., Pollet, R. M., Ingle, J. D., Biernat, K. A., Pellock, S. J., Venkatesh, M. K., Guthrie, L., O'Neal, S. K., Robinson, S. J., Dollinger, M., Figueroa, E., McShane, S. R., Cohen, R. D., Jin, J., Frye, S. V., Zamboni, W. C., Pepe-Ranney, C., Mani, S., Kelly, L. & 1 others, Redinbo, M. R., Jun 22 2015, In : Chemistry and Biology. 22, 9, p. 1238-1249 12 p.

Research output: Contribution to journalArticle

Microbiota
Glucuronidase
Drug-Related Side Effects and Adverse Reactions
Toxicity
irinotecan
20 Citations (Scopus)

The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis

Ren, G., Sun, A., Deng, C., Zhang, J., Wu, X., Wei, X., Mani, S., Dou, W. & Wang, Z., Sep 1 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 7, p. G517-G527

Research output: Contribution to journalArticle

Colitis
Anti-Inflammatory Agents
Dextran Sulfate
Toll-Like Receptor 4
Mitogen-Activated Protein Kinases
2014
60 Citations (Scopus)

Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation

Dou, W., Zhang, J., Ren, G., Ding, L., Sun, A., Deng, C., Wu, X., Wei, X., Mani, S. & Wang, Z., 2014, In : International Immunopharmacology. 23, 1, p. 170-178 9 p.

Research output: Contribution to journalArticle

Dextran Sulfate
NF-kappa B
Colitis
Mitogen-Activated Protein Kinases
Inflammatory Bowel Diseases
57 Citations (Scopus)

Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway

Zhang, J., Dou, W., Zhang, E., Sun, A., Ding, L., Wei, X., Chou, G., Mani, S. & Wang, Z., Jan 1 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 306, 1

Research output: Contribution to journalArticle

Dextran Sulfate
Toll-Like Receptor 4
Colitis
Paeonia
Interleukin-6
39 Citations (Scopus)

Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway

Dou, W., Zhang, J., Li, H., Kortagere, S., Sun, K., Ding, L., Ren, G., Wang, Z. & Mani, S., 2014, In : Journal of Nutritional Biochemistry. 25, 9, p. 923-933 11 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Xenobiotics
Ligands
Metabolism
Interleukin-6
201 Citations (Scopus)

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and toll-like receptor 4

Venkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A. P., Qiu, Z., Maher, L., Redinbo, M. R., Phillips, R. S., Fleet, J. C., Kortagere, S., Mukherjee, P., Fasano, A., Le Ven, J., Nicholson, J. K., Dumas, M. E., Khanna, K. M. & Mani, S., Aug 21 2014, In : Immunity. 41, 2, p. 296-310 15 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Xenobiotics
Indoles
Enterocytes
Toll-Like Receptors
23 Citations (Scopus)

Understanding and modulating mammalian-microbial communication for improved human health

Mani, S., Boelsterli, U. A. & Redinbo, M. R., 2014, In : Annual Review of Pharmacology and Toxicology. 54, p. 559-580 22 p.

Research output: Contribution to journalArticle

Bacteria
Microbiota
Communication
Health
Biotransformation
2013
68 Citations (Scopus)

Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-kB signaling pathway

Dou, W., Zhang, J., Zhang, E., Sun, A., Ding, L., Chou, G., Wang, Z. & Mani, S., Jun 2013, In : Journal of Pharmacology and Experimental Therapeutics. 345, 3, p. 473-482 10 p.

Research output: Contribution to journalArticle

Colitis
Transcription Factors
Colon
Xenobiotics
Flavonoids
1 Citation (Scopus)

Clinical outcome and prognostic markers for patients with gynecologic malignancies in phase 1 clinical trials: A single institution experience from 1999 to 2010

Hou, J. Y., Aparo, S., Ghalib, M., Chaudhary, I., Shah, U., Swami, U., Einstein, M., Goldberg, G. L., Mani, S. & Goel, S., Oct 2013, In : Gynecologic Oncology. 131, 1, p. 163-168 6 p.

Research output: Contribution to journalArticle

Clinical Trials, Phase I
Neoplasms
Albumins
Multivariate Analysis
Logistic Models
41 Citations (Scopus)

Methodologies to decipher the cell secretome

Mukherjee, P. & Mani, S., 2013, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1834, 11, p. 2226-2232 7 p.

Research output: Contribution to journalArticle

Proteins
Cell signaling
RNA Sequence Analysis
Extracellular Space
Proteome
58 Citations (Scopus)

Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity

Roberts, A. B., Wallace, B. D., Venkatesh, M. K., Mani, S. & Redinbo, M. R., Aug 2013, In : Molecular Pharmacology. 84, 2, p. 208-217 10 p.

Research output: Contribution to journalArticle

irinotecan
Glucuronidase
Escherichia coli
Pharmaceutical Preparations
23 Citations (Scopus)

Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR

Li, H., Redinbo, M. R., Venkatesh, M., Ekins, S., Chaudhry, A., Bloch, N., Negassa, A., Mukherjee, P., Kalpana, G. V. & Mani, S., May 10 2013, In : Journal of Biological Chemistry. 288, 19, p. 13655-13668 14 p.

Research output: Contribution to journalArticle

Ketoconazole
Xenobiotics
Cytoplasmic and Nuclear Receptors
Yeast
Yeasts
52 Citations (Scopus)

Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily

Smutny, T., Mani, S. & Pavek, P., Dec 2013, In : Current Drug Metabolism. 14, 10, p. 1059-1069 11 p.

Research output: Contribution to journalArticle

Post Translational Protein Processing
Cytochrome P-450 Enzyme System
Xenobiotics
Metabolism
Genes
54 Citations (Scopus)

Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response

Pondugula, S. R. & Mani, S., Jan 1 2013, In : Cancer Letters. 328, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Pregnanes
Xenobiotics
Neoplasms
Therapeutics
Pharmaceutical Preparations
87 Citations (Scopus)

Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling

Dou, W., Zhang, J., Sun, A., Zhang, E., Ding, L., Mukherjee, S., Wei, X., Chou, G., Wang, Z. T. & Mani, S., Aug 28 2013, In : British Journal of Nutrition. 110, 4, p. 599-608 10 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Colitis
Interleukin-6
Citrus paradisi
HT29 Cells
47 Citations (Scopus)

PXR antagonists and implication in drug metabolism

Mani, S., Dou, W. & Redinbo, M. R., Feb 2013, In : Drug Metabolism Reviews. 45, 1, p. 60-72 13 p.

Research output: Contribution to journalArticle

Pharmaceutical Preparations
Azoles
pregnane X receptor
Orphan Nuclear Receptors
Phenotype
4 Citations (Scopus)
Two-Hybrid System Techniques
Cytoplasmic and Nuclear Receptors
Ketoconazole
Hybrid systems
Yeast
Two-Hybrid System Techniques
Cytoplasmic and Nuclear Receptors
Hybrid systems
Yeast
Assays
39 Citations (Scopus)

Therapeutic targeting of CPT-11 induced diarrhea: a case for prophylaxis.

Swami, U., Goel, S. & Mani, S., Jun 2013, In : Current Drug Targets. 14, 7, p. 777-797 21 p.

Research output: Contribution to journalArticle

irinotecan
Diarrhea
Neutropenia
Toxicity
Hospitalization
2012
58 Citations (Scopus)

Alleviation of gut inflammation by Cdx2/PXR pathway in a mouse model of chemical colitis

Dou, W., Mukherjee, S., Li, H., Venkatesh, M., Wang, H., Kortagere, S., Peleg, A., Chilimuri, S. S., Wang, Z. T., Feng, Y., Fearon, E. R. & Mani, S., Jul 16 2012, In : PLoS One. 7, 7, e36075.

Research output: Contribution to journalArticle

Chemical Models
colitis
Colitis
digestive system
inflammation
48 Citations (Scopus)

Pharmacokinetics and safety of bortezomib in patients with advanced malignancies and varying degrees of liver dysfunction: Phase I NCI Organ Dysfunction Working Group Study NCI-6432

LoRusso, P. M., Venkatakrishnan, K., Ramanathan, R. K., Sarantopoulos, J., Mulkerin, D., Shibata, S. I., Hamilton, A., Dowlati, A., Mani, S., Rudek, M. A., Takimoto, C. H., Neuwirth, R., Esseltine, D. L. & Ivy, P., May 15 2012, In : Clinical Cancer Research. 18, 10, p. 2954-2963 10 p.

Research output: Contribution to journalArticle

Liver Diseases
Pharmacokinetics
Safety
Liver
Neoplasms
13 Citations (Scopus)

Phase i dose escalation study of KOS-1584, a novel epothilone, in patients with advanced solid tumors

Lam, E. T., Goel, S., Schaaf, L. J., Cropp, G. F., Hannah, A. L., Zhou, Y., McCracken, B., Haley, B. I., Johnson, R. G., Mani, S. & Villalona-Calero, M. A., Feb 2012, In : Cancer Chemotherapy and Pharmacology. 69, 2, p. 523-531 9 p.

Research output: Contribution to journalArticle

Epothilones
Tumors
Toxicity
Diarrhea
Pharmacokinetics
30 Citations (Scopus)

Safety, pharmacokinetics, and activity of EZN-2208, a novel conjugate of polyethylene glycol and SN38, in patients with advanced malignancies

Kurzrock, R., Goel, S., Wheler, J., Hong, D., Fu, S., Rezai, K., Morgan-Linnell, S. K., Urien, S., Mani, S., Chaudhary, I., Ghalib, M. H., Buchbinder, A., Lokiec, F. & Mulcahy, M., Dec 15 2012, In : Cancer. 118, 24, p. 6144 1 p.

Research output: Contribution to journalArticle

irinotecan
Pharmacokinetics
Safety
Neoplasms
Glucuronosyltransferase
2011
37 Citations (Scopus)

Acetylation of pregnane X receptor protein determines selective function independent of ligand activation

Biswas, A., Pasquel, D., Tyagi, R. K. & Mani, S., Mar 18 2011, In : Biochemical and Biophysical Research Communications. 406, 3, p. 371-376 6 p.

Research output: Contribution to journalArticle

Acetylation
Chemical activation
Ligands
Proteins
Post Translational Protein Processing
31 Citations (Scopus)

Dose-escalating and pharmacological study of bortezomib in adult cancer patients with impaired renal function: A National Cancer Institute Organ Dysfunction Working Group Study

Leal, T. B., Remick, S. C., Takimoto, C. H., Ramanathan, R. K., Davies, A., Egorin, M. J., Hamilton, A., Lorusso, P. A., Shibata, S., Lenz, H. J., Mier, J., Sarantopoulos, J., Mani, S., Wright, J. J., Ivy, S. P., Neuwirth, R., Von Moltke, L., Venkatakrishnan, K. & Mulkerin, D., Dec 2011, In : Cancer Chemotherapy and Pharmacology. 68, 6, p. 1439-1447 9 p.

Research output: Contribution to journalArticle

National Cancer Institute (U.S.)
Pharmacology
Kidney
Neoplasms
Dialysis
33 Citations (Scopus)

In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation

Venkatesh, M., Wang, H., Cayer, J., Leroux, M., Salvail, D., Das, B., Wrobel, J. E. & Mani, S., Jul 2011, In : Molecular Pharmacology. 80, 1, p. 124-135 12 p.

Research output: Contribution to journalArticle

Azoles
irinotecan
Acetaminophen
In Vitro Techniques
pregnane X receptor
47 Citations (Scopus)

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

Krausova, L., Stejskalova, L., Wang, H., Vrzal, R., Dvorak, Z., Mani, S. & Pavek, P., Dec 1 2011, In : Biochemical Pharmacology. 82, 11, p. 1771-1780 10 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP3A
Metformin
Transcriptional Activation
Genes
Hepatocytes
50 Citations (Scopus)

Post-translational modification of pregnane x receptor

Staudinger, J. L., Xu, C., Biswas, A. & Mani, S., Jul 2011, In : Pharmacological Research. 64, 1, p. 4-10 7 p.

Research output: Contribution to journalArticle

Pregnanes
Post Translational Protein Processing
Xenobiotics
Ligands
Gene Expression
86 Citations (Scopus)

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

Wang, H., Venkatesh, M., Li, H., Goetz, R., Mukherjee, S., Biswas, A., Zhu, L., Kaubisch, A., Wang, L., Pullman, J. M., Whitney, K. D., Kuro-o, M., Roig, A. I., Shay, J. W., Mohammadi, M. & Mani, S., Aug 1 2011, In : Journal of Clinical Investigation. 121, 8, p. 3220-3232 13 p.

Research output: Contribution to journalArticle

Colon
Neoplasms
Colonic Neoplasms
Growth
Ligands
4 Citations (Scopus)

Sixth international congress on shwachman-diamond syndrome: From patients to genes and back

Liu, J. M., Lipton, J. M. & Mani, S., Dec 2011, In : Annals of the New York Academy of Sciences. 1242, 1, p. 26-39 14 p.

Research output: Contribution to journalArticle

Diamond
Genes
Research Personnel
Shwachman syndrome
Gene