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1978 …2023

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2020

Antimigraine drug avitriptan is a ligand and agonist of human aryl hydrocarbon receptor that induces cyp1a1 in hepatic and intestinal cells

Vyhlídalová, B., Krasulová, K., Pečinková, P., Poulíková, K., Vrzal, R., Andrysík, Z., Chandran, A., Mani, S. & Dvorak, Z., Apr 2 2020, In : International Journal of Molecular Sciences. 21, 8, 2799.

Research output: Contribution to journalArticle

Open Access

Differential activation of human pregnane X receptor PXR by isomeric mono-methylated indoles in intestinal and hepatic in vitro models

Vyhlídalová, B., Bartoňková, I., Jiskrová, E., Li, H., Mani, S. & Dvořák, Z., May 15 2020, In : Toxicology Letters. 324, p. 104-110 7 p.

Research output: Contribution to journalArticle

Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor

Bartolini, D., De Franco, F., Torquato, P., Marinelli, R., Cerra, B., Ronchetti, R., Schon, A., Fallarino, F., De Luca, A., Bellezza, G., Ferri, I., Sidoni, A., Walton, W. G., Pellock, S. J., Redinbo, M. R., Mani, S., Pellicciari, R., Gioiello, A. & Galli, F., Apr 9 2020, In : Journal of Medicinal Chemistry. 63, 7, p. 3701-3712 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Gut microbial catabolites of tryptophan are ligands and agonists of the aryl hydrocarbon receptor: A detailed characterization

Vyhlídalová, B., Krasulová, K., Pečinková, P., Marcalíková, A., Vrzal, R., Zemánková, L., Vančo, J., Trávníček, Z., Vondráček, J., Karasová, M., Mani, S. & Dvořák, Z., Apr 1 2020, In : International Journal of Molecular Sciences. 21, 7, 2614.

Research output: Contribution to journalArticle

Open Access

The xenobiotic sensing pregnane X receptor regulates tissue damage and inflammation triggered by C difficile toxins

Erickson, S. L., Alston, L., Nieves, K., Chang, T. K. H., Mani, S., Flannigan, K. L. & Hirota, S. A., Feb 1 2020, In : FASEB Journal. 34, 2, p. 2198-2212 15 p.

Research output: Contribution to journalArticle

Open Access
2019

Belinostat, at its clinically relevant concentrations, inhibits rifampicin-induced CYP3A4 and MDR1 gene expressions

Abbott, K. L., Chaudhury, C. S., Chandran, A., Vishveshwara, S., Dvorak, Z., Jiskrova, E., Poulikova, K., Vyhlidalova, B., Mani, S. & Pondugula, S. R., Mar 2019, In : Molecular Pharmacology. 95, 3, p. 324-334 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens

Ervin, S. M., Li, H., Lim, L., Roberts, L. R., Liang, X., Mani, S. & Redinbo, M. R., Dec 6 2019, In : Journal of Biological Chemistry. 294, 49, p. 18586-18599 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells

Vyhlídalová, B., Poulíková, K., Bartoňková, I., Krasulová, K., Vančo, J., Trávníček, Z., Mani, S. & Dvořák, Z., Oct 1 2019, In : Toxicology Letters. 313, p. 66-76 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Orbiting of Flagellated Bacteria within a Thin Fluid Film around Micrometer-Sized Particles

Araujo, G., Chen, W., Mani, S. & Tang, J. X., Jan 1 2019, In : Biophysical journal.

Research output: Contribution to journalArticle

Polybrominated diphenyl ethers and gut microbiome modulate metabolic syndrome-related aqueous metabolites in mice

Scoville, D. K., Li, C. Y., Wang, D., Dempsey, J. L., Raftery, D., Mani, S., Gu, H. & Cui, J. Y., Jan 1 2019, In : Drug Metabolism and Disposition. 47, 8, p. 928-940 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Pregnane X receptor activation triggers rapid ATP release in primed macrophages that mediates NLRP3 inflammasome activation

Hudson, G., Flannigan, K. L., Venu, V. K. P., Alston, L., Sandall, C. F., MacDonald, J. A., Muruve, D. A., Chang, T. K. H., Mani, S. & Hirota, S. A., Jan 1 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 1, p. 44-53 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation

Venu, V. K. P., Saifeddine, M., Mihara, K., Tsai, Y. C., Nieves, K., Alston, L., Mani, S., McCoy, K. D., Hollenberg, M. D. & Hirota, S. A., Aug 2019, In : American Journal of Physiology - Endocrinology and Metabolism. 317, 2, p. E350-E361

Research output: Contribution to journalArticle

1 Scopus citations
2018

Methylindoles and methoxyindoles are agonists and antagonists of human aryl hydrocarbon receptor

Stepankova, M., Bartonkova, I., Jiskrova, E., Vrzal, R., Mani, S., Kortagere, S. & Dvorak, Z., Jun 1 2018, In : Molecular Pharmacology. 93, 6, p. 631-644 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis

Huang, K., Mukherjee, S., Desmarais, V., Albanese, J. M., Rafti, E., Draghi, A., Maher, L. A., Khanna, K. M., Mani, S. & Matson, A. P., May 1 2018, In : Pediatric Research. 83, 5, p. 1031-1040 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2017

Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice

Luo, X., Yu, Z., Deng, C., Zhang, J., Ren, G., Sun, A., Mani, S., Wang, Z. & Dou, W., Dec 1 2017, In : Scientific reports. 7, 1, 16374.

Research output: Contribution to journalArticle

32 Scopus citations

Constitutive androstane receptor regulates the intestinal mucosal response to injury

Hudson, G. M., Flannigan, K. L., Erickson, S. L., Vicentini, F. A., Zamponi, A., Hirota, C. L., Alston, L., Altier, C., Ghosh, S., Rioux, K. P., Mani, S., Chang, T. K. & Hirota, S. A., Jan 1 2017, In : British Journal of Pharmacology. 174, 12, p. 1857-1871 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

Microbiota and Breast Cancer

Mani, S., 2017, (Accepted/In press) In : Progress in Molecular Biology and Translational Science.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity

Pasquel, D., Doricakova, A., Li, H., Kortagere, S., Krasowski, M. D., Biswas, A., Walton, W. G., Redinbo, M. R., Dvorak, Z. & Mani, S., Sep 1 2016, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1859, 9, p. 1155-1169 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

C-glycosyl flavonoid orientin improves chemically induced inflammatory bowel disease in mice

Sun, A., Ren, G., Deng, C., Zhang, J., Luo, X., Wu, X., Mani, S., Dou, W. & Wang, Z., Mar 1 2016, In : Journal of Functional Foods. 21, p. 418-430 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Pregnane x receptor activation attenuates inflammation-associated intestinal epithelial barrier dysfunction by inhibiting cytokine-induced myosin light-chain kinase expression and c-jun n-terminal kinase 1/2 activation

Garg, A., Zhao, A., Erickson, S. L., Mukherjee, S., Lau, A. J., Alston, L., Chang, T. K. H., Mani, S. & Hirota, S. A., Oct 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 359, 1, p. 91-101 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Pregnane X receptor regulates pathogen-induced inflammation and host defense against an intracellular bacterial infection through toll-like receptor 4

Qiu, Z., Cervantes, J. L., Cicek, B. B., Mukherjee, S., Venkatesh, M., Maher, L. A., Salazar, J. C., Mani, S. & Khanna, K. M., Aug 23 2016, In : Scientific Reports. 6, 31936.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Vétizou, M., Pitt, J. M., Daillère, R., Lepage, P., Waldschmitt, N., Flament, C., Rusakiewicz, S., Routy, B., Roberti, M. P., Duong, C. P. M., Poirier-Colame, V., Roux, A., Becharef, S., Formenti, S., Golden, E., Cording, S., Eberl, G., Schlitzer, A., Ginhoux, F., Mani, S. & 18 others, Yamazaki, T., Jacquelot, N., Enot, D. P., Bérard, M., Nigou, J., Opolon, P., Eggermont, A., Woerther, P. L., Chachaty, E., Chaput, N., Robert, C., Mateus, C., Kroemer, G., Raoult, D., Boneca, I. G., Carbonnel, F., Chamaillard, M. & Zitvogel, L., Nov 27 2015, In : Science. 350, 6264, p. 1079-1084 6 p.

Research output: Contribution to journalArticle

925 Scopus citations

Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR

Pondugula, S. R., Flannery, P. C., Abbott, K. L., Coleman, E. S., Mani, S., Samuel, T. & Xie, W., Feb 3 2015, In : Toxicology Letters. 232, 3, p. 580-589 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Hepatocellular shuttling and recirculation of sorafenib-glucuronide is dependent on Abcc2, Abcc3, and Oatp1a/1b

Vasilyeva, A., Durmus, S., Li, L., Wagenaar, E., Hu, S., Gibson, A. A., Panetta, J. C., Mani, S., Sparreboom, A., Baker, S. D. & Schinkel, A. H., Jul 1 2015, In : Cancer Research. 75, 13, p. 2729-2736 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activations

Zhang, J., Ding, L., Wang, B., Ren, G., Sun, A., Deng, C., Wei, X., Mani, S., Wang, Z. & Dou, W., Jan 1 2015, In : Journal of Pharmacology and Experimental Therapeutics. 352, 2, p. 315-324 10 p., A9.

Research output: Contribution to journalArticle

44 Scopus citations

Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity

Wallace, B. D., Roberts, A. B., Pollet, R. M., Ingle, J. D., Biernat, K. A., Pellock, S. J., Venkatesh, M. K., Guthrie, L., O'Neal, S. K., Robinson, S. J., Dollinger, M., Figueroa, E., McShane, S. R., Cohen, R. D., Jin, J., Frye, S. V., Zamboni, W. C., Pepe-Ranney, C., Mani, S., Kelly, L. & 1 others, Redinbo, M. R., Sep 17 2015, In : Chemistry and Biology. 22, 9, p. 1238-1249 12 p.

Research output: Contribution to journalArticle

92 Scopus citations

The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis

Ren, G., Sun, A., Deng, C., Zhang, J., Wu, X., Wei, X., Mani, S., Dou, W. & Wang, Z., Sep 1 2015, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 309, 7, p. G517-G527

Research output: Contribution to journalArticle

21 Scopus citations
2014

Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation

Dou, W., Zhang, J., Ren, G., Ding, L., Sun, A., Deng, C., Wu, X., Wei, X., Mani, S. & Wang, Z., Nov 2014, In : International Immunopharmacology. 23, 1, p. 170-178 9 p.

Research output: Contribution to journalArticle

64 Scopus citations

Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway

Zhang, J., Dou, W., Zhang, E., Sun, A., Ding, L., Wei, X., Chou, G., Mani, S. & Wang, Z., Jan 1 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 306, 1, p. G27-G36

Research output: Contribution to journalArticle

61 Scopus citations

Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway

Dou, W., Zhang, J., Li, H., Kortagere, S., Sun, K., Ding, L., Ren, G., Wang, Z. & Mani, S., Sep 2014, In : Journal of Nutritional Biochemistry. 25, 9, p. 923-933 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and toll-like receptor 4

Venkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A. P., Qiu, Z., Maher, L., Redinbo, M. R., Phillips, R. S., Fleet, J. C., Kortagere, S., Mukherjee, P., Fasano, A., Le Ven, J., Nicholson, J. K., Dumas, M. E., Khanna, K. M. & Mani, S., Aug 21 2014, In : Immunity. 41, 2, p. 296-310 15 p.

Research output: Contribution to journalArticle

231 Scopus citations
2013

Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-kB signaling pathway

Dou, W., Zhang, J., Zhang, E., Sun, A., Ding, L., Chou, G., Wang, Z. & Mani, S., Jun 1 2013, In : Journal of Pharmacology and Experimental Therapeutics. 345, 3, p. 473-482 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Clinical outcome and prognostic markers for patients with gynecologic malignancies in phase 1 clinical trials: A single institution experience from 1999 to 2010

Hou, J. Y., Aparo, S., Ghalib, M., Chaudhary, I., Shah, U., Swami, U., Einstein, M., Goldberg, G. L., Mani, S. & Goel, S., Oct 2013, In : Gynecologic Oncology. 131, 1, p. 163-168 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity

Roberts, A. B., Wallace, B. D., Venkatesh, M. K., Mani, S. & Redinbo, M. R., Aug 1 2013, In : Molecular Pharmacology. 84, 2, p. 208-217 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR

Li, H., Redinbo, M. R., Venkatesh, M., Ekins, S., Chaudhry, A., Bloch, N., Negassa, A., Mukherjee, P., Kalpana, G. & Mani, S., May 10 2013, In : Journal of Biological Chemistry. 288, 19, p. 13655-13668 14 p.

Research output: Contribution to journalArticle

24 Scopus citations

Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily

Smutny, T., Mani, S. & Pavek, P., Dec 2013, In : Current Drug Metabolism. 14, 10, p. 1059-1069 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signalling

Dou, W., Zhang, J., Sun, A., Zhang, E., Ding, L., Mukherjee, S., Wei, X., Chou, G., Wang, Z. T. & Mani, S., Aug 28 2013, In : British Journal of Nutrition. 110, 4, p. 599-608 10 p.

Research output: Contribution to journalArticle

92 Scopus citations
4 Scopus citations
2012

Alleviation of gut inflammation by Cdx2/PXR pathway in a mouse model of chemical colitis

Dou, W., Mukherjee, S., Li, H., Venkatesh, M., Wang, H., Kortagere, S., Peleg, A., Chilimuri, S. S., Wang, Z. T., Feng, Y., Fearon, E. R. & Mani, S., Jul 16 2012, In : PloS one. 7, 7, e36075.

Research output: Contribution to journalArticle

62 Scopus citations

Pharmacokinetics and safety of bortezomib in patients with advanced malignancies and varying degrees of liver dysfunction: Phase I NCI Organ Dysfunction Working Group Study NCI-6432

LoRusso, P. M., Venkatakrishnan, K., Ramanathan, R. K., Sarantopoulos, J., Mulkerin, D., Shibata, S. I., Hamilton, A., Dowlati, A., Mani, S., Rudek, M. A., Takimoto, C. H., Neuwirth, R., Esseltine, D. L. & Ivy, P., May 15 2012, In : Clinical Cancer Research. 18, 10, p. 2954-2963 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Phase i dose escalation study of KOS-1584, a novel epothilone, in patients with advanced solid tumors

Lam, E. T., Goel, S., Schaaf, L. J., Cropp, G. F., Hannah, A. L., Zhou, Y., McCracken, B., Haley, B. I., Johnson, R. G., Mani, S. & Villalona-Calero, M. A., Feb 1 2012, In : Cancer Chemotherapy and Pharmacology. 69, 2, p. 523-531 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Safety, pharmacokinetics, and activity of EZN-2208, a novel conjugate of polyethylene glycol and SN38, in patients with advanced malignancies

Kurzrock, R., Goel, S., Wheler, J., Hong, D., Fu, S., Rezai, K., Morgan-Linnell, S. K., Urien, S., Mani, S., Chaudhary, I., Ghalib, M. H., Buchbinder, A., Lokiec, F. & Mulcahy, M., Dec 15 2012, In : Cancer. 118, 24, 1 p.

Research output: Contribution to journalArticle

30 Scopus citations
2011

Acetylation of pregnane X receptor protein determines selective function independent of ligand activation

Biswas, A., Pasquel, D., Tyagi, R. K. & Mani, S., Mar 18 2011, In : Biochemical and Biophysical Research Communications. 406, 3, p. 371-376 6 p.

Research output: Contribution to journalArticle

38 Scopus citations

Dose-escalating and pharmacological study of bortezomib in adult cancer patients with impaired renal function: A National Cancer Institute Organ Dysfunction Working Group Study

Leal, T. B., Remick, S. C., Takimoto, C. H., Ramanathan, R. K., Davies, A., Egorin, M. J., Hamilton, A., Lorusso, P. A., Shibata, S., Lenz, H. J., Mier, J., Sarantopoulos, J., Mani, S., Wright, J. J., Ivy, S. P., Neuwirth, R., Von Moltke, L., Venkatakrishnan, K. & Mulkerin, D., Dec 1 2011, In : Cancer Chemotherapy and Pharmacology. 68, 6, p. 1439-1447 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

In vivo and in vitro characterization of a first-in-class novel azole analog that targets pregnane X receptor activation

Venkatesh, M., Wang, H., Cayer, J., Leroux, M., Salvail, D., Das, B., Wrobel, J. E. & Mani, S., Jul 1 2011, In : Molecular Pharmacology. 80, 1, p. 124-135 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

Krausova, L., Stejskalova, L., Wang, H., Vrzal, R., Dvorak, Z., Mani, S. & Pavek, P., Dec 1 2011, In : Biochemical Pharmacology. 82, 11, p. 1771-1780 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

Wang, H., Venkatesh, M., Li, H., Goetz, R., Mukherjee, S., Biswas, A., Zhu, L., Kaubisch, A., Wang, L., Pullman, J., Whitney, K., Kuro-o, M., Roig, A. I., Shay, J. W., Mohammadi, M. & Mani, S., Aug 1 2011, In : Journal of Clinical Investigation. 121, 8, p. 3220-3232 13 p.

Research output: Contribution to journalArticle

88 Scopus citations

Sixth international congress on shwachman-diamond syndrome: From patients to genes and back

Liu, J. M., Lipton, J. M. & Mani, S., Dec 2011, In : Annals of the New York Academy of Sciences. 1242, 1, p. 26-39 14 p.

Research output: Contribution to journalArticle

4 Scopus citations
2010

Alleviating cancer drug toxicity by inhibiting a bacterial enzyme

Wallace, B. D., Wang, H., Lane, K. T., Scott, J. E., Orans, J., Koo, J. S., Venkatesh, M., Jobin, C., Yeh, L. A., Mani, S. & Redinbo, M. R., Nov 5 2010, In : Science. 330, 6005, p. 831-835 5 p.

Research output: Contribution to journalArticle

405 Scopus citations

Clinical Utility of the Modified Segmental Boost Technique for Treatment of the Pelvis and Inguinal Nodes

Moran, M. S., Castrucci, W. A., Ahmad, M., Song, H., Lund, M. W., Mani, S., Chamberlain, D. & Higgins, S. A., Mar 15 2010, In : International Journal of Radiation Oncology Biology Physics. 76, 4, p. 1026-1036 11 p.

Research output: Contribution to journalArticle

8 Scopus citations