• 6791 Citations
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1990 …2020

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Article
2020
2 Scopus citations

Human IgM inhibits the formation of titan-like cells in cryptococcus neoformans

Nuria Trevijano-Contador, T-C., Pianalto, K. M., Nichols, C. B., Zaragoza, O., Alspaugh, J. A. & Pirofski, L. A., Mar 1 2020, In : Infection and immunity. 88, 4, e00046-20.

Research output: Contribution to journalArticle

2019

Antibody responses in HIV-infected patients with advanced immunosuppression and asymptomatic cryptococcal antigenemia

Hlupeni, A., Nakouzi, A., Wang, T., Boyd, K. F., Makadzange, T. A., Ndhlovu, C. E. & Pirofski, L., Jan 1 2019, In : Open Forum Infectious Diseases. 6, 1

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Association Between Plasma Antibody Responses and Risk for Cryptococcus-Associated Immune Reconstitution Inflammatory Syndrome

Yoon, H. A., Nakouzi, A., Chang, C. C., Kuniholm, M. H., Carreño, L. J., Wang, T., Ndung'u, T., Lewin, S. R., French, M. A. & Pirofski, L. A., Jan 9 2019, In : Journal of Infectious Diseases. 219, 3, p. 420-428 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Double-edged role of interleukin 17a in streptococcus pneumoniae pathogenesis during influenza virus coinfection

Ambigapathy, G., Schmit, T., Mathur, R. K., Nookala, S., Bahri, S., Pirofski, L. A. & Khan, M. N., Jul 31 2019, In : Journal of Infectious Diseases. 220, 5, p. 902-912 11 p.

Research output: Contribution to journalArticle

Open Access
Open Access
3 Scopus citations

Risk factors of laryngeal cryptococcosis: A case report

Quintero, O., Trachuk, P., Lerner, M. Z., Sarungbam, J., Pirofski, L. A. & Park, S. O., Jun 2019, In : Medical Mycology Case Reports. 24, p. 82-85 4 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018
4 Scopus citations

Antibody and B cell subset perturbations in human immunodeficiency virus-uninfected patients with cryptococcosis

Rohatgi, S., Nakouzi, A., Carreño, L. J., Slosar-Cheah, M., Kuniholm, M. H., Wang, T., Pappas, P. G. & Pirofski, L. A., Jan 1 2018, In : Open Forum Infectious Diseases. 5, 1, ofx255.

Research output: Contribution to journalArticle

9 Scopus citations

Naïve B cells reduce fungal dissemination in cryptococcus neoformans infected Rag1-/- mice

Dufaud, C., Rivera, J., Rohatgi, S. & Pirofski, L. A., Oct 3 2018, In : Virulence. 9, 1, p. 173-184 12 p.

Research output: Contribution to journalArticle

8 Scopus citations
11 Scopus citations
2017

A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine

Schumann, B., Hahm, H. S., Parameswarappa, S. G., Reppe, K., Wahlbrink, A., Govindan, S., Kaplonek, P., Pirofski, L., Witzenrath, M., Anish, C., Pereira, C. L. & Seeberger, P. H., Mar 8 2017, In : Science Translational Medicine. 9, 380, eaaf5347.

Research output: Contribution to journalArticle

29 Scopus citations

Bundle in the bronx: Impact of a transition-of-care outpatient parenteral antibiotic therapy bundle on all- cause 30-day hospital readmissions

Madaline, T. F., Nori, P., Mowrey, W., Zukowski, E., Gohil, S., Sarwar, U., Weston, G., Urrely, R., Palombelli, M., Pierino, V. F., Parsons, V., Ehrlich, A., Ostrowsky, B., Corpuz, M. & Pirofski, L. A., Mar 1 2017, In : Open Forum Infectious Diseases. 4, 2, ofx097.

Research output: Contribution to journalArticle

12 Scopus citations

Help is on the way: Monoclonal antibody therapy for multi-drug resistant bacteria

Babb, R. & Pirofski, L., Apr 13 2017, (Accepted/In press) In : Virulence. p. 1-4 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Life as an Infectious Diseases Physician Scientist: Science is Humanity's Lifeline

Pirofski, L. A., Jan 1 2017, In : Journal of Infectious Diseases. 216, p. S611-S612

Research output: Contribution to journalArticle

2 Scopus citations
2016

A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection

Parameswarappa, S. G., Reppe, K., Geissner, A., Ménová, P., Govindan, S., Calow, A. D. J., Wahlbrink, A., Weishaupt, M. W., Monnanda, B. P., Bell, R. L., Pirofski, L. A., Suttorp, N., Sander, L. E., Witzenrath, M., Pereira, C. L., Anish, C. & Seeberger, P. H., Nov 17 2016, In : Cell Chemical Biology. 23, 11, p. 1407-1416 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Protease inhibitors do not affect antibody responses to pneumococcal vaccination

De La Rosa, I., Munjal, I. M., Rodriguez-Barradas, M., Yu, X., Pirofski, L. & Mendoza, D., Jun 1 2016, In : Clinical and Vaccine Immunology. 23, 6, p. 524-529 6 p.

Research output: Contribution to journalArticle

Reduction of Streptococcus pneumoniae colonization and dissemination by a nonopsonic capsular polysaccharide antibody

Doyle, C. R. & Pirofski, L. A., Feb 2 2016, In : mBio. 7, 1, e02260-15.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Quantitative and qualitative antibody responses to immunization with the pneumococcal polysaccharide vaccine in HIV-infected patients after initiation of antiretroviral treatment: Results from a randomized clinical trial

Rodriguez-Barradas, M. C., Serpa, J. A., Munjal, I., Mendoza, D., Rueda, A. M., Mushtaq, M. & Pirofski, L. A., Jun 1 2015, In : Journal of Infectious Diseases. 211, 11, p. 1703-1711 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
2014

An ahemolytic pneumolysin of streptococcus pneumoniae manipulates human innate and CD4+ T-cell responses and reduces resistance to colonization in mice in a serotype-independent manner

Nadeem Khan, M., Coleman, J. R., Vernatter, J., Varshney, A. K., Dufaud, C. & Pirofski, L. A., Nov 15 2014, In : Journal of Infectious Diseases. 210, 10, p. 1658-1669 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Characterization of protective extracellular membrane-derived vesicles produced by Streptococcus pneumoniae

Olaya-Abril, A., Prados-Rosales, R., McConnell, M. J., Martín-Peña, R., González-Reyes, J. A., Jiménez-Munguía, I., Gómez-Gascón, L., Fernández, J., Luque-García, J. L., García-Lidón, C., Estévez, H., Pachón, J., Obando, I., Casadevall, A., Pirofski, L. A. & Rodríguez-Ortega, M. J., Jun 25 2014, In : Journal of Proteomics. 106, p. 46-60 15 p.

Research output: Contribution to journalArticle

75 Scopus citations
2013

Fc gamma receptor 3A polymorphism and risk for HIV-associated cryptococcal disease

Rohatgi, S., Gohil, S., Kuniholm, M. H., Schultz, H., Dufaud, C., Armour, K. L., Badri, S., Mailliard, R. B. & Pirofski, L. A., Aug 27 2013, In : mBio. 4, 5, e00573-13.

Research output: Contribution to journalArticle

41 Scopus citations

X-linked immunodeficient mice exhibit enhanced susceptibility to Cryptococcus neoformans infection

Szymczak, W. A., Davis, M. J., Lundy, S. K., Dufaud, C., Olszewski, M. & Pirofski, L. A., Jul 2 2013, In : mBio. 4, 4, e00265-13.

Research output: Contribution to journalArticle

50 Scopus citations
2012
20 Scopus citations

CD8 + T cells and risk for bacterial pneumonia and all-cause mortality among HIV-infected women

Gohil, S. K., Heo, M., Schoenbaum, E. E., Celentano, D. & Pirofski, L. A., Jun 1 2012, In : Journal of Acquired Immune Deficiency Syndromes. 60, 2, p. 191-198 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

IL-23 dampens the allergic response to Cryptococcus neoformans through IL-17-independent and - Dependent mechanisms

Szymczak, W. A., Sellers, R. S. & Pirofski, L. A., Apr 1 2012, In : American Journal of Pathology. 180, 4, p. 1547-1559 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Molecular characterization of the early B cell response to pulmonary Cryptococcus neoformans infection

Rohatgi, S. & Pirofski, L. A., Dec 15 2012, In : Journal of Immunology. 189, 12, p. 5820-5830 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Tissue-expressed B7x affects the immune response to and outcome of lethal pulmonary infection

Hofmeyer, K. A., Scandiuzzi, L., Ghosh, K., Pirofski, L. A. & Zang, X., Sep 15 2012, In : Journal of Immunology. 189, 6, p. 3054-3063 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2011

Antibodies to streptococcus pneumoniae capsular polysaccharide enhance pneumococcal quorum sensing

Yano, M., Gohil, S., Coleman, J. R., Manix, C. & Pirofski, L. A., 2011, In : mBio. 2, 5, e00176-11.

Research output: Contribution to journalArticle

25 Scopus citations

CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in mice

Weber, S. E., Tian, H. & Pirofski, L. A., Jan 1 2011, In : Journal of Immunology. 186, 1, p. 432-442 11 p.

Research output: Contribution to journalArticle

50 Scopus citations
8 Scopus citations

Designed reduction of Streptococcus pneumoniae pathogenicity via synthetic changes in virulence factor codon-pair bias

Coleman, J. R., Papamichail, D., Yano, M., Del Mar García-Suárez, M. & Pirofski, L. A., May 1 2011, In : Journal of Infectious Diseases. 203, 9, p. 1264-1273 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Microbial virulence as an emergent property: Consequences and opportunities

Casadevall, A., Fang, F. C. & Pirofski, L. A., Jul 2011, In : PLoS pathogens. 7, 7, e1002136.

Research output: Contribution to journalArticle

53 Scopus citations

The innate immune response to Streptococcus pneumoniae in the lung depends on serotype and host response

Seyoum, B., Yano, M. & Pirofski, L. A., Oct 19 2011, In : Vaccine. 29, 45, p. 8002-8011 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

VH3 antibody response to immunization with pneumococcal polysaccharide vaccine in middle-aged and elderly persons

Serpa, J. A., Valayam, J., Musher, D. M., Rossen, R. D., Pirofski, L. A. & Rodriguez-Barradas, M. C., Mar 1 2011, In : Clinical and Vaccine Immunology. 18, 3, p. 362-366 5 p.

Research output: Contribution to journalArticle

5 Scopus citations
2010
15 Scopus citations

Improved survival of mice deficient in secretory immunoglobulin M following systemic infection with Cryptococcus neoformans

Subramaniam, K. S., Datta, K., Marks, M. S. & Pirofski, L. A., Jan 2010, In : Infection and immunity. 78, 1, p. 441-452 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

The absence of serum IgM enhances the susceptibility of mice to pulmonary challenge with Cryptococcus neoformans

Subramaniam, K. S., Datta, K., Quintero, E., Manix, C., Marks, M. S. & Pirofski, L. A., May 15 2010, In : Journal of Immunology. 184, 10, p. 5755-5767 13 p.

Research output: Contribution to journalArticle

69 Scopus citations

The efficacy of pneumococcal capsular polysaccharide-specific antibodies to serotype 3 Streptococcus pneumoniae requires macrophages

Fabrizio, K., Manix, C., Tian, H., van Rooijen, N. & Pirofski, L. A., Nov 3 2010, In : Vaccine. 28, 47, p. 7542-7550 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2009

244-251 IgM + memory B cell expression predicts HIV-associated cryptococcosis status

Subramaniam, K., Metzger, B., Hanau, L. H., Guh, A., Rucker, L., Badri, S. & Pirofski, L. A., Jul 15 2009, In : Journal of Infectious Diseases. 200, 2, p. 244-251 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Efficacy of opsonic and nonopsonic serotype 3 pneumococcal capsular polysaccharide-specific monoclonal antibodies against intranasal challenge with streptococcus pneumoniae in mice

Tian, H., Weber, S., Thorkildson, P., Kozel, T. R. & Pirofski, L. A., Apr 1 2009, In : Infection and immunity. 77, 4, p. 1502-1513 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

The outcome of Cryptococcus neoformans intracellular pathogenesis in human monocytes

Alvarez, M., Burn, T., Luo, Y. & Pirofski, L. A., 2009, In : BMC Microbiology. 9, 51.

Research output: Contribution to journalArticle

34 Scopus citations
2008
30 Scopus citations
2007

A human monoclonal immunoglobulin M reduces bacteremia and inflammation in a mouse model of systemic pneumococcal infection

Fabrizio, K., Groner, A., Boes, M. & Pirofski, L. A., Apr 1 2007, In : Clinical and Vaccine Immunology. 14, 4, p. 382-390 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Influence of neutropenia on the course of serotype 8 pneumococcal pneumonia in mice

Marks, M., Burns, T., Abadi, M., Seyoum, B., Thornton, J., Tuomanen, E. & Pirofski, L. A., Apr 1 2007, In : Infection and immunity. 75, 4, p. 1586-1597 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

Pneumococcal capsular polysaccharide vaccine-mediated protection against serotype 3 Streptococcus pneumoniae in immunodeficient mice

Tian, H., Groner, A., Boes, M. & Pirofski, L. A., Apr 1 2007, In : Infection and immunity. 75, 4, p. 1643-1650 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

The role of pneumolysin in mediating lung damage in a lethal pneumococcal pneumonia murine model

García-Suárez, M. D. M., Flórez, N., Astudillo, A., Vázquez, F., Villaverde, R., Fabrizio, K., Pirofski, L. A. & Méndez, F. J., Jan 26 2007, In : Respiratory Research. 8, 3.

Research output: Contribution to journalArticle

39 Scopus citations
2006

Antibody response to cryptococcus neoformans capsular polysaccharide glucuronoxylomannan in patients after solid-organ transplantation

Jalali, Z., Ng, L., Singh, N. & Pirofski, L. A., Jul 1 2006, In : Clinical and Vaccine Immunology. 13, 7, p. 740-746 7 p.

Research output: Contribution to journalArticle

22 Scopus citations