• 1050 Citations
  • 15 h-Index
1998 …2024

Research output per year

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Publications

  • 1050 Citations
  • 15 h-Index
  • 20 Article
  • 2 Review article
  • 1 Chapter
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Article
2019

Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance

Chen, K., Luan, X., Liu, Q., Wang, J., Chang, X., Snijders, A. M., Mao, J. H., Secombe, J., Dan, Z., Chen, J. H., Wang, Z., Dong, X., Qiu, C., Chang, X., Zhang, D., Celniker, S. E. & Liu, X., Apr 10 2019, In : Cell Host and Microbe. 25, 4, p. 537-552.e8

Research output: Contribution to journalArticle

10 Scopus citations

The histone demethylase KDM5 controls developmental timing in Drosophila by promoting prothoracic gland endocycles

Drelon, C., Rogers, M. F., Belalcazar, H. M. & Secombe, J., Jan 1 2019, In : Development (Cambridge). 146, 24, dev182568.

Research output: Contribution to journalArticle

Open Access
2018

A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5

Zamurrad, S., Hatch, H. A. M., Drelon, C., Belalcazar, H. M. & Secombe, J., Feb 27 2018, In : Cell Reports. 22, 9, p. 2359-2369 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

The histone demethylase KDM5 is essential for larval growth in Drosophila

Drelon, C., Belalcazar, H. M. & Secombe, J., Jul 2018, In : Genetics. 209, 3, p. 773-787 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Early programming of the oocyte epigenome temporally controls late prophase i transcription and chromatin remodelling

Navarro-Costa, P., McCarthy, A., Prudêncio, P., Greer, C., Guilgur, L. G., Becker, J. D., Secombe, J., Rangan, P. & Martinho, R. G., Aug 10 2016, In : Nature communications. 7, 12331.

Research output: Contribution to journalArticle

22 Scopus citations
2015

The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif

Liu, X. & Secombe, J., Jan 1 2015, In : Cell Reports. 13, 10, p. 2219-2231 13 p.

Research output: Contribution to journalArticle

22 Scopus citations
2014

KDM5 Interacts with Foxo to Modulate Cellular Levels of Oxidative Stress

Liu, X., Greer, C. & Secombe, J., Oct 1 2014, In : PLoS genetics. 10, 10

Research output: Contribution to journalArticle

22 Scopus citations
2013

Myc-Dependent Genome Instability and Lifespan in Drosophila

Greer, C., Lee, M., Westerhof, M., Milholland, B., Spokony, R., Vijg, J. & Secombe, J., Sep 6 2013, In : PloS one. 8, 9, e74641.

Research output: Contribution to journalArticle

23 Scopus citations

The Drosophila ubiquitin-specific protease Puffyeye regulates dMyc-mediated growth

Li, L., Anderson, S., Secombe, J. & Eisenman, R. N., Dec 1 2013, In : Development (Cambridge). 140, 23, p. 4776-4787 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
2011

Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock

DiTacchio, L., Le, H. D., Vollmers, C., Hatori, M., Witcher, M., Secombe, J. & Panda, S., Sep 30 2011, In : Science. 333, 6051, p. 1881-1885 5 p.

Research output: Contribution to journalArticle

138 Scopus citations
2010

Essential functions of the histone demethylase Lid

Li, L., Greer, C., Eisenman, R. N. & Secombe, J., Nov 1 2010, In : PLoS genetics. 6, 11, e1001221.

Research output: Contribution to journalArticle

81 Scopus citations
2007

Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye

Grzeschik, N. A., Amin, N., Secombe, J., Brumby, A. M. & Richardson, H. E., Nov 1 2007, In : Developmental Biology. 311, 1, p. 106-123 18 p.

Research output: Contribution to journalArticle

74 Scopus citations

The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth

Secombe, J., Li, L., Carlos, L. & Eisenman, R. N., Mar 1 2007, In : Genes and Development. 21, 5, p. 537-551 15 p.

Research output: Contribution to journalArticle

198 Scopus citations
2005

The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster

Loo, L. W. M., Secombe, J., Little, J. T., Carlos, L. S., Yost, C., Cheng, P. F., Flynn, E. M., Edgar, B. A. & Eisenman, R. N., Aug 1 2005, In : Molecular and cellular biology. 25, 16, p. 7078-7091 14 p.

Research output: Contribution to journalArticle

41 Scopus citations
2004

A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in drosophila

Brumby, A., Secombe, J., Horsfield, J., Coombe, M., Amin, N., Coates, D., Saint, R. & Richardson, H., Sep 1 2004, In : Genetics. 168, 1, p. 227-251 25 p.

Research output: Contribution to journalArticle

42 Scopus citations
13 Scopus citations
2002
15 Scopus citations

Drosophila cyclin E interacts with components of the brahma complex

Brumby, A. M., Zraly, C. B., Horsfield, J. A., Secombe, J., Saint, R., Dingwall, A. K. & Richardson, H., Jul 1 2002, In : EMBO Journal. 21, 13, p. 3377-3389 13 p.

Research output: Contribution to journalArticle

39 Scopus citations
1998

Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development

Secombe, J., Pispa, J., Saint, R. & Richardson, H., Aug 1 1998, In : Genetics. 149, 4, p. 1867-1882 16 p.

Research output: Contribution to journalArticle

39 Scopus citations

decapentaplegic is required for arrest in G1 phase during Drosophila eye development

Horsfield, J., Penton, A., Secombe, J., Michael Hoffman, F. & Richardson, H., Dec 1 1998, In : Development. 125, 24, p. 5069-5078 10 p.

Research output: Contribution to journalArticle

77 Scopus citations