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  • 13 Similar Profiles
Drosophila Medicine & Life Sciences
Histone Demethylases Medicine & Life Sciences
Imaginal Discs Medicine & Life Sciences
Cyclin E Medicine & Life Sciences
S Phase Medicine & Life Sciences
Genes Chemical Compounds
Mutation Medicine & Life Sciences
Growth Medicine & Life Sciences

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Grants 2015 2022

Activation of Endogenous Transposable Elements by Myc During Aging

Secombe, J.

National Institutes of Health

9/30/164/30/22

Project: Research projectResearch Project, High Priority, Short Term Project Award

DNA Transposable Elements
Diptera
Genome
Single-Cell Analysis
Phenotype

Distinct Modes of Gene Regulation by KDM5

Secombe, J.

National Institutes of Health

1/15/1512/31/19

Project: Research projectResearch Project

Intellectual Disability
Diptera
Mutation
Transcription Factors
Genes

Publications 1998 2018

  • 888 Citations
  • 13 h-Index
  • 19 Article
  • 1 Chapter

A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5

Zamurrad, S., Hatch, H. A. M., Drelon, C., Belalcazar, H. M. & Secombe, J. Feb 27 2018 In : Cell Reports. 22, 9, p. 2455-2468 14 p.

Research output: Contribution to journalArticle

Histone Demethylases
Diptera
Intellectual Disability
Drosophila
Genes
6 Citations

Early programming of the oocyte epigenome temporally controls late prophase i transcription and chromatin remodelling

Navarro-Costa, P., McCarthy, A., Prudêncio, P., Greer, C., Guilgur, L. G., Becker, J. D., Secombe, J., Rangan, P. & Martinho, R. G. Aug 10 2016 In : Nature Communications. 7, 12331

Research output: Contribution to journalArticle

gametocytes
Prophase
chromatin
Chromatin Assembly and Disassembly
Meiotic Prophase I
12 Citations

The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif

Liu, X. & Secombe, J. Jul 31 2015 (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

Histone Demethylases
Gene expression
Chromatin
Genes
Gene Expression
17 Citations

KDM5 Interacts with Foxo to Modulate Cellular Levels of Oxidative Stress

Liu, X., Greer, C. & Secombe, J. Oct 1 2014 In : PLoS Genetics. 10, 10

Research output: Contribution to journalArticle

Oxidative Stress
oxidative stress
gene
Transcription Factors
Genes
11 Citations

Myc-Dependent Genome Instability and Lifespan in Drosophila

Greer, C., Lee, M., Westerhof, M., Milholland, B., Spokony, R., Vijg, J. & Secombe, J. Sep 6 2013 In : PLoS One. 8, 9, e74641

Research output: Contribution to journalArticle

Genomic Instability
Drosophila
Genes
Aging of materials
mutation