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Julie Secombe, Ph.D.

  • 989 Citations
  • 15 h-Index
19982022
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  • 18 Similar Profiles
Drosophila Medicine & Life Sciences
Histone Demethylases Medicine & Life Sciences
Imaginal Discs Medicine & Life Sciences
Cyclin E Medicine & Life Sciences
S Phase Medicine & Life Sciences
Genes Chemical Compounds
Growth Medicine & Life Sciences
Mutation Medicine & Life Sciences

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Grants 2015 2022

Activation of Endogenous Transposable Elements by Myc During Aging

Secombe, J.

National Institutes of Health

9/30/16 → 4/30/22

Project: Research project

DNA Transposable Elements
Diptera
Genome
Single-Cell Analysis
Phenotype

Distinct Modes of Gene Regulation by KDM5

Secombe, J.

National Institutes of Health

1/15/15 → 12/31/19

Project: Research project

Intellectual Disability
Diptera
Mutation
Transcription Factors
Genes

Publications 1998 2019

  • 989 Citations
  • 15 h-Index
  • 21 Article
  • 1 Chapter
1 Citation (Scopus)

Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance

Chen, K., Luan, X., Liu, Q., Wang, J., Chang, X., Snijders, A. M., Mao, J. H., Secombe, J., Dan, Z., Chen, J. H., Wang, Z., Dong, X., Qiu, C., Chang, X., Zhang, D., Celniker, S. E. & Liu, X., Apr 10 2019, In : Cell Host and Microbe. 25, 4, p. 537-552.e8

Research output: Contribution to journal › Article

Histone Demethylases
Social Behavior
Intellectual Disability
Drosophila
Maintenance
10 Citations (Scopus)

A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5

Zamurrad, S., Hatch, H. A. M., Drelon, C., Belalcazar, H. M. & Secombe, J., Feb 27 2018, In : Cell Reports. 22, 9, p. 2455-2468 14 p.

Research output: Contribution to journal › Article

Histone Demethylases
Diptera
Intellectual Disability
Drosophila
Genes
1 Citation (Scopus)

The histone demethylase KDM5 is essential for larval growth in Drosophila

Drelon, C., Belalcazar, H. M. & Secombe, J., Jul 1 2018, In : Genetics. 209, 3, p. 773-787 15 p.

Research output: Contribution to journal › Article

Histone Demethylases
Imaginal Discs
Drosophila
Growth
Gene Expression Profiling
15 Citations (Scopus)

Early programming of the oocyte epigenome temporally controls late prophase i transcription and chromatin remodelling

Navarro-Costa, P., McCarthy, A., Prudêncio, P., Greer, C., Guilgur, L. G., Becker, J. D., Secombe, J., Rangan, P. & Martinho, R. G., Aug 10 2016, In : Nature Communications. 7, 12331.

Research output: Contribution to journal › Article

gametocytes
Prophase
chromatin
Chromatin Assembly and Disassembly
Meiotic Prophase I
19 Citations (Scopus)

The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif

Liu, X. & Secombe, J., Jul 31 2015, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journal › Article

Histone Demethylases
Gene expression
Chromatin
Genes
Gene Expression