Projects per year
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- 13 Similar Profiles
Drosophila
Medicine & Life Sciences
Histone Demethylases
Medicine & Life Sciences
Imaginal Discs
Medicine & Life Sciences
Cyclin E
Medicine & Life Sciences
S Phase
Medicine & Life Sciences
Genes
Chemical Compounds
Mutation
Medicine & Life Sciences
Growth
Medicine & Life Sciences
Network
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Grants 2015 2022
- 2 Active
Activation of Endogenous Transposable Elements by Myc During Aging
9/30/16 → 4/30/22
Project: Research project › Research Project, High Priority, Short Term Project Award
DNA Transposable Elements
Diptera
Genome
Single-Cell Analysis
Phenotype
Distinct Modes of Gene Regulation by KDM5
1/15/15 → 12/31/19
Project: Research project › Research Project
Intellectual Disability
Diptera
Mutation
Transcription Factors
Genes
Publications 1998 2018
A Drosophila Model of Intellectual Disability Caused by Mutations in the Histone Demethylase KDM5
Zamurrad, S., Hatch, H. A. M., Drelon, C., Belalcazar, H. M. & Secombe, J. Feb 27 2018 In : Cell Reports. 22, 9, p. 2455-2468 14 p.Research output: Contribution to journal › Article
Histone Demethylases
Diptera
Intellectual Disability
Drosophila
Genes
Early programming of the oocyte epigenome temporally controls late prophase i transcription and chromatin remodelling
Navarro-Costa, P., McCarthy, A., Prudêncio, P., Greer, C., Guilgur, L. G., Becker, J. D., Secombe, J., Rangan, P. & Martinho, R. G. Aug 10 2016 In : Nature Communications. 7, 12331Research output: Contribution to journal › Article
gametocytes
Prophase
chromatin
Chromatin Assembly and Disassembly
Meiotic Prophase I
The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif
Liu, X. & Secombe, J. Jul 31 2015 (Accepted/In press) In : Cell Reports.Research output: Contribution to journal › Article
Histone Demethylases
Gene expression
Chromatin
Genes
Gene Expression
KDM5 Interacts with Foxo to Modulate Cellular Levels of Oxidative Stress
Liu, X., Greer, C. & Secombe, J. Oct 1 2014 In : PLoS Genetics. 10, 10Research output: Contribution to journal › Article
Oxidative Stress
oxidative stress
gene
Transcription Factors
Genes
Myc-Dependent Genome Instability and Lifespan in Drosophila
Greer, C., Lee, M., Westerhof, M., Milholland, B., Spokony, R., Vijg, J. & Secombe, J. Sep 6 2013 In : PLoS One. 8, 9, e74641Research output: Contribution to journal › Article
Genomic Instability
Drosophila
Genes
Aging of materials
mutation