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Hernando J. Sosa, Ph.D.

  • 1500 Citations
  • 21 h-Index
1986 …2023
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  • 7 Similar Profiles
Kinesin Medicine & Life Sciences
Microtubules Medicine & Life Sciences
Tubulin Medicine & Life Sciences
Polarization Microscopy Medicine & Life Sciences
Fluorescence Polarization Medicine & Life Sciences
Fluorescence Microscopy Medicine & Life Sciences
X-Ray Diffraction Medicine & Life Sciences
Myosins Medicine & Life Sciences

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Grants 2002 2023

MECHANISM OF MICROTUBULE DYNAMICS REGULATION BY KINESINS

Sosa, H. J.

National Institutes of Health

3/1/15 → 1/31/23

Project: Research project

Kinesin
Microtubules
Tubulin
Polymers
Centrioles

Phosphoregulation of the Kinesin Motor Domain: Structure, Dynamics and Function

Sosa, H. J., Ma, A. O., Ma, A. O., Sharp, D. J. & Gerfen, G. J.

National Institutes of Health

5/1/12 → 4/30/16

Project: Research project

Kinesin
Phosphorylation
Microtubules
Catalytic Domain
Hydrolysis

Structural Basis of Kinesin Motor Movement

Sosa, H. J.

National Institutes of Health

7/1/02 → 8/31/14

Project: Research project

Kinesin
Microtubules
Walkers
Catalytic Domain
Neoplasms

STRUCTURAL BASIS OF KINESIN MOTOR MOVEMENT

Sosa, H. J.

National Institutes of Health

7/1/02 → 6/30/07

Project: Research project

Kinesin
Microtubules
Adenosine Triphosphate
Hydrolysis
Hand

Publications 1986 2019

  • 1500 Citations
  • 21 h-Index
  • 30 Article
  • 1 Book
  • 1 Chapter
  • 1 Comment/debate

Kinesin-5 Promotes Microtubule Nucleation and Assembly by Stabilizing a Lattice-Competent Conformation of Tubulin

Chen, G. Y., Cleary, J. M., Asenjo, A. B., Chen, Y., Mascaro, J. A., Arginteanu, D. F. J., Sosa, H. J. & Hancock, W. O., Jul 22 2019, In : Current Biology. 29, 14, p. 2259-2269.e4

Research output: Contribution to journal › Article

Kinesin
kinesin
Tubulin
tubulin
Microtubules

Correction: Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13sd (Nature Communications DOI: 10.1038/s41467-018-04044-8)

Benoit, M. P. M. H., Asenjo, A. B. & Sosa, H. J., Dec 1 2018, In : Nature Communications. 9, 1, 2748.

Research output: Contribution to journal › Comment/debate

depolymerization
Kinesin
Depolymerization
Microtubules
communication
9 Citations (Scopus)

Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s

Benoit, M. P. M. H., Asenjo, A. B. & Sosa, H. J., Dec 1 2018, In : Nature Communications. 9, 1, 1662.

Research output: Contribution to journal › Article

depolymerization
Kinesin
Depolymerization
Microtubules
nucleotides
1 Citation (Scopus)

Use of single molecule fluorescence polarization microscopy to study protein conformation and dynamics of kinesin–microtubule complexes

Benoit, M. P. M. H. & Sosa, H. J., 2018, Methods in Molecular Biology. Humana Press Inc., Vol. 1665. p. 199-216 18 p. (Methods in Molecular Biology; vol. 1665).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Polarization Microscopy
Protein Conformation
Fluorescence Polarization
Fluorescence Microscopy
Cytoskeletal Proteins
5 Citations (Scopus)

Distinct Interaction Modes of the Kinesin-13 Motor Domain with the Microtubule

Chatterjee, C., Benoit, M. P. M. H., DePaoli, V., Diaz-Valencia, J. D., Asenjo, A. B., Gerfen, G. J., Sharp, D. J. & Sosa, H. J., Apr 12 2016, In : Biophysical Journal. 110, 7, p. 1593-1604 12 p.

Research output: Contribution to journal › Article

Kinesin
Microtubules
Neck
Polarization Microscopy
Microtubule Proteins