• 1567 Citations
  • 21 h-Index
1986 …2019

Research output per year

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Publications

  • 1567 Citations
  • 21 h-Index
  • 31 Article
  • 1 Chapter
  • 1 Comment/debate
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Article
2019

Kinesin-5 Promotes Microtubule Nucleation and Assembly by Stabilizing a Lattice-Competent Conformation of Tubulin

Chen, G. Y., Cleary, J. M., Asenjo, A. B., Chen, Y., Mascaro, J. A., Arginteanu, D. F. J., Sosa, H. & Hancock, W. O., Jul 22 2019, In : Current Biology. 29, 14, p. 2259-2269.e4

Research output: Contribution to journalArticle

6 Scopus citations
2018
13 Scopus citations
2016

Distinct Interaction Modes of the Kinesin-13 Motor Domain with the Microtubule

Chatterjee, C., Benoit, M. P. M. H., DePaoli, V., Diaz-Valencia, J. D., Asenjo, A. B., Gerfen, G. J., Sharp, D. J. & Sosa, H., Apr 12 2016, In : Biophysical Journal. 110, 7, p. 1593-1604 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2014

KIF14 binds tightly to microtubules and adopts a rigor-like conformation

Arora, K., Talje, L., Asenjo, A. B., Andersen, P., Atchia, K., Joshi, M., Sosa, H., Allingham, J. S. & Kwok, B. H., Aug 26 2014, In : Journal of Molecular Biology. 426, 17, p. 2997-3015 19 p.

Research output: Contribution to journalArticle

26 Scopus citations
2013

A Second Tubulin Binding Site on the Kinesin-13 Motor Head Domain Is Important during Mitosis

Zhang, D., Asenjo, A. B., Greenbaum, M., Xie, L., Sharp, D. J. & Sosa, H., Aug 28 2013, In : PloS one. 8, 8, e73075.

Research output: Contribution to journalArticle

13 Scopus citations

Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases

Asenjo, A. B., Chatterjee, C., Tan, D., DePaoli, V., Rice, W. J., Diaz-Avalos, R., Silvestry, M. & Sosa, H., 2013, In : Cell Reports. 3, 3, p. 759-768 10 p.

Research output: Contribution to journalArticle

42 Scopus citations
2012

Human fidgetin is a microtubule severing enzyme and minus-end depolymerase that regulates mitosis

Mukherjee, S., Diaz Valencia, J. D., Stewman, S., Metz, J., Monnier, S., Rath, U., Asenjo, A. B., Charafeddine, R. A., Sosa, H. J., Ross, J. L., Ma, A. & Sharp, D. J., Jun 15 2012, In : Cell Cycle. 11, 12, p. 2359-2366 8 p.

Research output: Contribution to journalArticle

37 Scopus citations
2011

Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration

Zhang, D., Grode, K. D., Stewman, S. F., Diaz-Valencia, J. D., Liebling, E., Rath, U., Riera, T., Currie, J. D., Buster, D. W., Asenjo, A. B., Sosa, H. J., Ross, J. L., Ma, A., Rogers, S. L. & Sharp, D. J., Apr 2011, In : Nature Cell Biology. 13, 4, p. 361-372 12 p.

Research output: Contribution to journalArticle

79 Scopus citations
2010

Structure and dynamics of the kinesin-microtubule interaction revealed by fluorescence polarization microscopy

Sosa, H., Asenjo, A. B. & Peterman, E. J. G., Jan 1 2010, In : Methods in Cell Biology. 95, C, p. 505-519 15 p.

Research output: Contribution to journalArticle

6 Scopus citations
2009
47 Scopus citations

Motor domain phosphorylation and regulation of the Drosophila kinesin 13, KLP10A

Mennella, V., Tan, D. Y., Buster, D. W., Asenjo, A. B., Rath, U., Ma, A., Sosa, H. J. & Sharp, D. J., Aug 24 2009, In : Journal of Cell Biology. 186, 4, p. 481-490 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

The drosophila kinesin-13, KLP59D, impacts Pacman- and flux-based chromosome movement

Rath, U., Rogers, G. C., Tan, D., Gomez-Ferreria, M. A., Buster, D. W., Sosa, H. J. & Sharp, D. J., 2009, In : Molecular biology of the cell. 20, 22, p. 4696-4705 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2008

A Stable Prefusion Intermediate of the Alphavirus Fusion Protein Reveals Critical Features of Class II Membrane Fusion

Sánchez-San Martín, C., Sosa, H. & Kielian, M., Dec 11 2008, In : Cell Host and Microbe. 4, 6, p. 600-608 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Structure of the Kinesin13-Microtubule Ring Complex

Tan, D., Rice, W. J. & Sosa, H., Nov 12 2008, In : Structure. 16, 11, p. 1732-1739 8 p.

Research output: Contribution to journalArticle

38 Scopus citations
2006

Kinesin-13s form rings around microtubules

Tan, D., Asenjo, A. B., Mennella, V., Sharp, D. J. & Sosa, H., Oct 9 2006, In : Journal of Cell Biology. 175, 1, p. 25-31 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Nucleotide binding and hydrolysis induces a disorder-order transition in the kinesin neck-linker region

Asenjo, A. B., Weinberg, Y. & Sosa, H., Jul 1 2006, In : Nature Structural and Molecular Biology. 13, 7, p. 648-654 7 p.

Research output: Contribution to journalArticle

60 Scopus citations
2004

Single-molecule fluorescence spectroscopy and microscopy of biomolecular motors

Peterman, E. J. G., Sosa, H. & Moerner, W. E., 2004, In : Annual Review of Physical Chemistry. 55, p. 79-96 18 p.

Research output: Contribution to journalArticle

119 Scopus citations
2003

Configuration of the two kinesin motor domains during ATP hydrolysis

Asenjo, A. B., Krohn, N. & Sosa, H., Oct 1 2003, In : Nature structural biology. 10, 10, p. 836-842 7 p.

Research output: Contribution to journalArticle

66 Scopus citations
2001

ADP-induced rocking of the kinesin motor domain revealed by single-molecule fluorescence polarization microscopy

Sosa, H., Peterman, E. J. G., Moerner, W. E. & Goldstein, L. S. B., Jun 21 2001, In : Nature structural biology. 8, 6, p. 540-544 5 p.

Research output: Contribution to journalArticle

123 Scopus citations

Polarized fluorescence microscopy of individual and many kinesin motors bound to axonemal microtubules

Peterman, E. J. G., Sosa, H., Goldstein, L. S. B. & Moerner, W. E., Jan 1 2001, In : Biophysical journal. 81, 5, p. 2851-2863 13 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations
1998

Relationship between Moire patterns, tubulin shape, and microtubule polarity

Sosa, H. & Chrétien, D., 1998, In : Cell motility and the cytoskeleton. 40, 1, p. 38-43 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
1997

A model for the microtubule-Ncd motor protein complex obtained by cryo- electron microscopy and image analysis

Sosa, H., Prabha Dias, D., Hoenger, A., Whittaker, M., Wilson-Kubalek, E., Sablin, E., Fletterick, R. J., Vale, R. D. & Milligan, R. A., Jul 25 1997, In : Cell. 90, 2, p. 217-224 8 p.

Research output: Contribution to journalArticle

135 Scopus citations

Three different approaches for calculating the three-dimensional structure of microtubules decorated with kinesin motor domains

Sosa, H., Hoenger, A. & Milligan, R. A., Mar 1997, In : Journal of Structural Biology. 118, 2, p. 149-158 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
1996

Three-dimensional structure of ncd-decorated microtubules obtained by a back-projection method

Sosa, H. & Milligan, R. A., Aug 2 1996, In : Journal of Molecular Biology. 260, 5, p. 743-755 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
1994

Ultrastructure of skeletal muscle fibers studied by a plunge quick freezing method: myofilament lengths

Sosa, H., Popp, D., Ouyang, G. & Huxley, H. E., Jan 1 1994, In : Biophysical journal. 67, 1, p. 283-292 10 p.

Research output: Contribution to journalArticle

Open Access
86 Scopus citations

X-ray diffraction measurements of the extensibility of actin and myosin filaments in contracting muscle

Huxley, H. E., Stewart, A., Sosa, H. & Irving, T., 1994, In : Biophysical journal. 67, 6, p. 2411-2421 11 p.

Research output: Contribution to journalArticle

Open Access
369 Scopus citations
1991

X-ray diffraction study of the structural changes accompanying phosphorylation of tarantula muscle

Padrón, R., Panté, N., Sosa, H. & Kendrick-Jones, J., Jun 1 1991, In : Journal of Muscle Research and Cell Motility. 12, 3, p. 235-241 7 p.

Research output: Contribution to journalArticle

22 Scopus citations
1988

Análisis de la sección ecuatorial del patrón de difracción de rayos -X de músculos estriados de tarántula en diferentes condiciones experimentales.

Translated title of the contribution: Analysis of the equatorial section of X-ray diffraction patterns of striated muscles of tarantulas under various experimental conditionsSosa, H., Pante, N. & Padrón, R., Dec 1 1988, In : Acta Cientifica Venezolana. 39, 1, p. 51-59 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Estudio por difracción de rayos-X de los cambios estructurales que acompañan la fosforilación de los filamentos gruesos de músculo de tarántula.

Translated title of the contribution: X-ray diffraction study of the structural changes that follow phosphorylation of thick muscle filaments in tarantulasPanté, N., Sosa, H. & Padrón, R., Dec 1 1988, In : Acta Cientifica Venezolana. 39, 3, p. 230-236 7 p.

Research output: Contribution to journalArticle

5 Scopus citations
1987

Método por difracción de rayos X para cuantificar cambios en la capacidad de retención de agua asociada a los sarcomeros de la carne.

Translated title of the contribution: X-ray diffraction method to quantify changes in water retention capacity associated with sarcomeres in meatPadrón, R., Queralt, V. & Sosa, H., Dec 1 1987, In : Acta Cientifica Venezolana. 38, 2, p. 287-288 2 p.

Research output: Contribution to journalArticle

1986

Predicción de cambios relativos en el patrón ecuatorial de difracción de rayos-X de músculo estriado causados por la activación de la contracción muscular.

Translated title of the contribution: Prediction of relative changes in the equatorial x-ray diffraction pattern of striated muscle caused by the activation of muscle contractionPanté, N., Sosa, H. & Padrón, R., Dec 1 1986, In : Acta Cientifica Venezolana. 37, 2, p. 223-225 3 p.

Research output: Contribution to journalArticle

3 Scopus citations