• 9277 Citations
  • 53 h-Index
1964 …2022
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Publications 1964 2019

  • 9277 Citations
  • 53 h-Index
  • 135 Article
  • 1 Review article
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Article
2019
1 Citation (Scopus)
Lenses
Genes
Cell Nucleus
Crystallins
Alleles

Histone 1 Mutations Drive Lymphomagenesis By Inducing Primitive Stem Cell Functions and Epigenetic Instructions through Profound 3D Re-Organization of the B-Cell Genome

Yusufova, N., Teater, M. R., Soshnev, A., Kloetgen, A., Osunsade, A., Conway, J., Doane, A., Skoultchi, A., Tsirigos, A., David, Y., Allis, C. D., Cesarman, E. & Melnick, A., Nov 13 2019, In : Blood. 134, 1, 1 p.

Research output: Contribution to journalArticle

Stem cells
Epigenomics
Histones
B-Lymphocytes
Stem Cells

ISWI ATPase SMARCA5 regulates differentiation of thymocytes undergoing β-selection

Zikmund, T., Kokavec, J., Turkova, T., Savvulidi, F., Paszekova, H., Vodenkova, S., Sedlacek, R., Skoultchi, A. I. & Stopka, T., Jun 15 2019, In : Journal of Immunology. 202, 12, p. 3434-3446 13 p.

Research output: Contribution to journalArticle

Thymocytes
Adenosine Triphosphatases
Gene Rearrangement
B-Lymphocytes
T-Lymphoid Precursor Cells

Runx1 promotes murine erythroid progenitor proliferation and inhibits differentiation by preventing Pu.1 downregulation

Willcockson, M. A., Taylor, S. J., Ghosh, S., Healton, S. E., Wheat, J. C., Wilson, T. J., Steidl, U. G. & Skoultchi, A. I., Sep 3 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 36, p. 17841-17847 7 p.

Research output: Contribution to journalArticle

Open Access
Down-Regulation
Erythropoiesis
Erythroid Cells
Chromatin
Transcription Factors
2018
5 Citations (Scopus)

Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process

Limi, S., Senecal, A., Coleman, R. A., Lopez-Jones, M., Guo, P., Polumbo, C., Singer, R. H., Skoultchi, A. I. & Cvekl, A., Jan 1 2018, In : Journal of Biological Chemistry. 293, 34, p. 13176-13190 15 p.

Research output: Contribution to journalArticle

Lenses
Cell Differentiation
Fibers
Genes
Chromatin
2017
12 Citations (Scopus)

Regulatory functions and chromatin loading dynamics of linker histone H1 during endoreplication in Drosophila

Andreyeva, E. N., Bernardo, T. J., Kolesnikova, T. D., Lu, X., Yarinich, L. A., Bartholdy, B. A., Guo, X., Posukh, O. V., Healton, S., Willcockson, M. A., Pindyurin, A. V., Zhimulev, I. F., Skoultchi, A. I. & Fyodorov, D., Mar 15 2017, In : Genes & development. 31, 6, p. 603-616 14 p.

Research output: Contribution to journalArticle

Endoreduplication
Histones
Drosophila
Chromatin
S Phase
8 Citations (Scopus)

The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells

Kokavec, J., Zikmund, T., Savvulidi, F., Kulvait, V., Edelmann, W., Skoultchi, A. I. & Stopka, T., Jun 1 2017, In : Stem Cells. 35, 6, p. 1614-1623 10 p.

Research output: Contribution to journalArticle

Erythroblasts
Erythroid Cells
Hematopoiesis
Hematopoietic Stem Cells
Adenosine Triphosphatases
2016
1 Citation (Scopus)

BEN domain protein Elba2 can functionally substitute for linker histone H1 in Drosophila in vivo

Xu, N., Lu, X., Kavi, H., Emelyanov, A., Bernardo, T. J., Vershilova, E., Skoultchi, A. I. & Fyodorov, D., Sep 30 2016, In : Scientific Reports. 6, 34354.

Research output: Contribution to journalArticle

Histones
Drosophila
Embryonic Structures
Protein Isoforms
Chromatin
15 Citations (Scopus)

Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation

He, S., Limi, S., Estrada, R. S., Xie, Q., Brennan, L. A., Kantorow, W. L., Kokavec, J., Majumdar, R., Hou, H., Edelmann, W., Liu, W., Ashery-Padan, R., Zavadil, J., Kantorow, M., Skoultchi, A. I., Stopka, T. & Cvekl, A., Jun 1 2016, In : Development (Cambridge). 143, 11, p. 1937-1947 11 p.

Research output: Contribution to journalArticle

Chromatin Assembly and Disassembly
Lenses
Enzymes
Cell Differentiation
Gene Expression
2 Citations (Scopus)
Histones
Drosophila
Chromosomes
Heterochromatin
Polytene Chromosomes
2015
5 Citations (Scopus)

A genetic screen and transcript profiling reveal a shared regulatory program for Drosophila linker histone H1 and chromatin remodeler CHD1

Kavi, H., Lu, X., Xu, N., Bartholdy, B. A., Vershilova, E., Skoultchi, A. I. & Fyodorov, D., Apr 1 2015, In : G3 (Bethesda, Md.). 5, 4, p. 677-687 11 p.

Research output: Contribution to journalArticle

Histones
Drosophila
Chromatin
Nucleosomes
Adenosine Triphosphate
25 Citations (Scopus)

Local compartment changes and regulatory landscape alterations in histone H1-depleted cells

Geeven, G., Zhu, Y., Kim, B. J., Bartholdy, B. A., Yang, S. M., Macfarlan, T. S., Gifford, W. D., Pfaff, S. L., Verstegen, M. J. A. M., Pinto, H., Vermunt, M. W., Creyghton, M. P., Wijchers, P. J., Stamatoyannopoulos, J. A., Skoultchi, A. I. & de Laat, W., Dec 23 2015, In : Genome Biology. 16, 1, 289.

Research output: Contribution to journalArticle

histones
Histones
Chromatin
Epigenomics
genome
20 Citations (Scopus)

Proteomic Characterization of the Nucleolar Linker Histone H1 Interaction Network

Szerlong, H. J., Herman, J. A., Krause, C. M., Deluca, J. G., Skoultchi, A. I., Winger, Q. A., Prenni, J. E. & Hansen, J. C., Jun 5 2015, In : Journal of Molecular Biology. 427, 11, p. 2056-2071 16 p.

Research output: Contribution to journalArticle

Proteomics
Histones
Knockout Mice
Proteins
Protein Isoforms
2014
606 Citations (Scopus)

A comparative encyclopedia of DNA elements in the mouse genome

Yue, F., Cheng, Y., Breschi, A., Vierstra, J., Wu, W., Ryba, T., Sandstrom, R., Ma, Z., Davis, C., Pope, B. D., Shen, Y., Pervouchine, D. D., Djebali, S., Thurman, R. E., Kaul, R., Rynes, E., Kirilusha, A., Marinov, G. K., Williams, B. A., Trout, D. & 117 others, Amrhein, H., Fisher-Aylor, K., Antoshechkin, I., DeSalvo, G., See, L. H., Fastuca, M., Drenkow, J., Zaleski, C., Dobin, A., Prieto, P., Lagarde, J., Bussotti, G., Tanzer, A., Denas, O., Li, K., Bender, M. A., Zhang, M., Byron, R., Groudine, M. T., McCleary, D., Pham, L., Ye, Z., Kuan, S., Edsall, L., Wu, Y. C., Rasmussen, M. D., Bansal, M. S., Kellis, M., Keller, C. A., Morrissey, C. S., Mishra, T., Jain, D., Dogan, N., Harris, R. S., Cayting, P., Kawli, T., Boyle, A. P., Euskirchen, G., Kundaje, A., Lin, S., Lin, Y., Jansen, C., Malladi, V. S., Cline, M. S., Erickson, D. T., Kirkup, V. M., Learned, K., Sloan, C. A., Rosenbloom, K. R., De Sousa, B. L., Beal, K., Pignatelli, M., Flicek, P., Lian, J., Kahveci, T., Lee, D., Kent, W. J., Santos, M. R., Herrero, J., Notredame, C., Johnson, A., Vong, S., Lee, K., Bates, D., Neri, F., Diegel, M., Canfield, T., Sabo, P. J., Wilken, M. S., Reh, T. A., Giste, E., Shafer, A., Kutyavin, T., Haugen, E., Dunn, D., Reynolds, A. P., Neph, S., Humbert, R., Hansen, R. S., De Bruijn, M., Selleri, L., Rudensky, A., Josefowicz, S., Samstein, R., Eichler, E. E., Orkin, S. H., Levasseur, D., Papayannopoulou, T., Chang, K. H., Skoultchi, A. I., Gosh, S., Disteche, C., Treuting, P., Wang, Y., Weiss, M. J., Blobel, G. A., Cao, X., Zhong, S., Wang, T., Good, P. J., Lowdon, R. F., Adams, L. B., Zhou, X. Q., Pazin, M. J., Feingold, E. A., Wold, B., Taylor, J., Mortazavi, A., Weissman, S. M., Stamatoyannopoulos, J. A., Snyder, M. P., Guigo, R., Gingeras, T. R., Gilbert, D. M., Hardison, R. C., Beer, M. A. & Ren, B., Nov 20 2014, In : Nature. 515, 7527, p. 355-364 10 p.

Research output: Contribution to journalArticle

Encyclopedias
Genome
Chromatin
DNA
Nucleic Acid Regulatory Sequences
15 Citations (Scopus)
Janus Kinases
Heterochromatin
Transducers
Histones
Drosophila
112 Citations (Scopus)

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution

Vierstra, J., Rynes, E., Sandstrom, R., Zhang, M., Canfield, T., Scott Hansen, R., Stehling-Sun, S., Sabo, P. J., Byron, R., Humbert, R., Thurman, R. E., Johnson, A. K., Vong, S., Lee, K., Bates, D., Neri, F., Diegel, M., Giste, E., Haugen, E., Dunn, D. & 17 others, Wilken, M. S., Josefowicz, S., Samstein, R., Chang, K. H., Eichler, E. E., De Bruijn, M., Reh, T. A., Skoultchi, A. I., Rudensky, A., Orkin, S. H., Papayannopoulou, T., Treuting, P. M., Selleri, L., Kaul, R., Groudine, M., Bender, M. A. & Stamatoyannopoulos, J. A., Nov 21 2014, In : Science. 346, 6212, p. 1007-1012 6 p.

Research output: Contribution to journalArticle

Deoxyribonuclease I
DNA
Transcription Factors
Nucleic Acid Regulatory Sequences
Human Genome
35 Citations (Scopus)

Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation

Alvarez-Saavedra, M., De Repentigny, Y., Lagali, P. S., Raghu Ram, E. V. S., Yan, K., Hashem, E., Ivanochko, D., Huh, M. S., Yang, D., Mears, A. J., Todd, M. A. M., Corcoran, C. P., Bassett, E. A., Tokarew, N. J. A., Kokavec, J., Majumder, R., Ioshikhes, I., Wallace, V. A., Kothary, R., Meshorer, E. & 3 others, Stopka, T., Skoultchi, A. I. & Picketts, D. J., Jun 20 2014, In : Nature Communications. 5, 4181.

Research output: Contribution to journalArticle

chromatin
Morphogenesis
Histones
Chromatin
gene expression
5 Citations (Scopus)
embryonic stem cells
Embryonic Stem Cells
Stem cells
histones
Histones
2013
31 Citations (Scopus)

Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina

Popova, E. Y., Grigoryev, S. A., Fan, Y., Skoultchi, A. I., Zhang, S. S. & Barnstable, C. J., Jun 14 2013, In : Journal of Biological Chemistry. 288, 24, p. 17895-17907 13 p.

Research output: Contribution to journalArticle

Retinal Rod Photoreceptor Cells
Heterochromatin
Structural integrity
Histones
Retina
52 Citations (Scopus)

Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9

Lu, X., Wontakal, S. N., Kavi, H., Kim, B. J., Guzzardo, P. M., Emelyanov, A., Xu, N., Hannon, G. J., Zavadil, J., Fyodorov, D. & Skoultchi, A. I., Apr 5 2013, In : Science. 340, 6128, p. 78-81 4 p.

Research output: Contribution to journalArticle

Personnel Selection
Heterochromatin
Histones
Drosophila
Chromatin
64 Citations (Scopus)

H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation

Yang, S. M., Kim, B. J., Toro, L. N. & Skoultchi, A. I., Jan 29 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 5, p. 1708-1713 6 p.

Research output: Contribution to journalArticle

DNA Methylation
Epigenomics
Histones
Methylation
Methyltransferases
23 Citations (Scopus)

High resolution methylome analysis reveals widespread functional hypomethylation during adult human erythropoiesis

Yu, Y., Mo, Y., Ebenezer, D., Bhattacharyya, S., Liu, H., Sundaravel, S., Giricz, O., Wontakal, S., Cartier, J., Caces, B., Artz, A., Nischal, S., Bhagat, T., Bathon, K., Maqbool, S., Gligich, O., Suzuki, M., Steidl, U., Godley, L., Skoultchi, A. & 3 others, Greally, J., Wickrema, A. & Verma, A., Mar 29 2013, In : Journal of Biological Chemistry. 288, 13, p. 8805-8814 10 p.

Research output: Contribution to journalArticle

Erythropoiesis
Epigenomics
Genes
Binding Sites
Gene Expression
2012
41 Citations (Scopus)

A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation

Wontakal, S. N., Guo, X., Smith, C., MacCarthy, T., Bresnick, E. H., Bergman, A., Snyder, M. P., Weissman, S. M., Zheng, D. & Skoultchi, A. I., Mar 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 10, p. 3832-3837 6 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Genes
Transcription Factors
63 Citations (Scopus)

Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway

Nishiyama, M., Skoultchi, A. I. & Nakayama, K. I., Jan 2012, In : Molecular and Cellular Biology. 32, 2, p. 501-512 12 p.

Research output: Contribution to journalArticle

Catenins
Wnt Signaling Pathway
Histones
DNA-Binding Proteins
Transcriptional Activation
88 Citations (Scopus)

Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation

Melcer, S., Hezroni, H., Rand, E., Nissim-Rafinia, M., Skoultchi, A. I., Stewart, C. L., Bustin, M. & Meshorer, E., 2012, In : Nature Communications. 3, 910.

Research output: Contribution to journalArticle

Histone Code
Lamin Type A
chromatin
stem cells
Embryonic Stem Cells
2011
29 Citations (Scopus)

A large gene network in immature Erythroid cells is controlled by the myeloid and B cell transcriptional regulator PU.1

Wontakal, S. N., Guo, X., Will, B., Shi, M., Raha, D., Mahajan, M. C., Weissman, S., Snyder, M., Steidl, U. G., Zheng, D. & Skoultchi, A. I., Jun 2011, In : PLoS Genetics. 7, 6, e1001392.

Research output: Contribution to journalArticle

Erythroid Cells
Gene Regulatory Networks
Myeloid Cells
B-lymphocytes
B-Lymphocytes
27 Citations (Scopus)

The Rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone H1 and DNA methylation

MacLean, J. A., Bettegowda, A., Kim, B. J., Lou, C. H., Yang, S. M., Bhardwaj, A., Shanker, S., Hu, Z., Fan, Y., Eckardt, S., McLaughlin, K. J., Skoultchi, A. I. & Wilkinson, M. F., Mar 2011, In : Molecular and Cellular Biology. 31, 6, p. 1275-1287 13 p.

Research output: Contribution to journalArticle

Homeobox Genes
DNA Methylation
Embryonic Stem Cells
Multigene Family
Histones
2010
22 Citations (Scopus)

GATA-1 directly regulates p21 gene expression during erythroid differentiation

Papetti, M., Wontakal, S. N., Stopka, T. & Skoultchi, A. I., May 15 2010, In : Cell Cycle. 9, 10, p. 1972-1980 9 p.

Research output: Contribution to journalArticle

Leukemia, Erythroblastic, Acute
Gene Expression
Genes
Cell Differentiation
Binding Sites
19 Citations (Scopus)

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep

Funato, H., Sato, M., Sinton, C. M., Gautron, L., Williams, S. C., Skach, A., Elmquist, J. K., Skoultchi, A. I. & Yanagisawa, M., Oct 19 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 42, p. 18155-18160 6 p.

Research output: Contribution to journalArticle

DiGeorge Syndrome
REM Sleep
Sleep
Wakefulness
Brain Stem
22 Citations (Scopus)

PU.1 directly regulates cdk6 gene expression, linking the cell proliferation and differentiation programs in erythroid cells

Choe, K. S., Ujhelly, O., Wontakal, S. N. & Skoultchi, A. I., Jan 29 2010, In : Journal of Biological Chemistry. 285, 5, p. 3044-3052 9 p.

Research output: Contribution to journalArticle

Leukemia, Erythroblastic, Acute
Erythroid Cells
Cell proliferation
G1 Phase
Gene expression
332 Citations (Scopus)

Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination

Eskeland, R., Leeb, M., Grimes, G. R., Kress, C., Boyle, S., Sproul, D., Gilbert, N., Fan, Y., Skoultchi, A. I., Wutz, A. & Bickmore, W. A., May 14 2010, In : Molecular Cell. 38, 3, p. 452-464 13 p.

Research output: Contribution to journalArticle

Ubiquitination
Histones
Chromatin
Gene Expression
Polycomb-Group Proteins
2009
94 Citations (Scopus)

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis

Nishiyama, M., Oshikawa, K., Tsukada, Y. I., Nakagawa, T., Iemura, S. I., Natsume, T., Fan, Y., Kikuchi, A., Skoultchi, A. I. & Nakayama, K. I., 2009, In : Nature Cell Biology. 11, 2, p. 172-182 11 p.

Research output: Contribution to journalArticle

Histones
Embryonic Development
Apoptosis
Transcriptional Activation
DNA Helicases
60 Citations (Scopus)

Linker histone H1 is essential for Drosophila development, the establishment of pericentric heterochromatin, and a normal polytene chromosome structure

Lu, X., Wontakal, S. N., Emelyanov, A., Morcillo, P., Konev, A. Y., Fyodorov, D. & Skoultchi, A. I., Feb 15 2009, In : Genes and Development. 23, 4, p. 452-465 14 p.

Research output: Contribution to journalArticle

Polytene Chromosomes
Chromosome Structures
Heterochromatin
Histones
Drosophila
3 Citations (Scopus)

Nuclear localization of ISWI ATPase Smarca5 (Sni2h) in mouse

Vargova, J., Vargova, K., Skoultchi, A. I. & Stopka, T., Jun 1 2009, In : Frontiers in Bioscience - Elite. 1 E, 2, p. 553-559 7 p.

Research output: Contribution to journalArticle

Histone Code
Heterochromatin
Histones
Chromatin
Adenosine Triphosphatases
18 Citations (Scopus)

PU.1 activation relieves GATA-1-mediated repression of Cebpa and Cbfb during leukemia differentiation

Burda, P., Curik, N., Kokavec, J., Basova, P., Mikulenkova, D., Skoultchi, A. I., Zavadil, J. & Stopka, T., Oct 2009, In : Molecular Cancer Research. 7, 10, p. 1693-1703 11 p.

Research output: Contribution to journalArticle

Core Binding Factors
Leukemia, Erythroblastic, Acute
Leukemia
Histone Code
CCAAT-Enhancer-Binding Proteins
2008
37 Citations (Scopus)

Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3′ regulatory region of the immunoglobulin heavy chain locus

Giambra, V., Volpi, S., Emelyanov, A., Pflugh, D., Bothwell, A. L. M., Norio, P., Fan, Y., Ju, Z., Skoultchi, A. I., Hardy, R. R., Frezza, D. & Birshtein, B. K., Oct 2008, In : Molecular and Cellular Biology. 28, 19, p. 6123-6133 11 p.

Research output: Contribution to journalArticle

Histone Code
Immunoglobulin Heavy Chains
B-Lymphoid Precursor Cells
Nucleic Acid Regulatory Sequences
DNA Methylation
2007
170 Citations (Scopus)

Global chromatin compaction limits the strength of the DNA damage response

Murga, M., Jaco, I., Fan, Y., Soria, R., Martinez-Pastor, B., Cuadrado, M., Yang, S. M., Blasco, M. A., Skoultchi, A. I. & Fernandez-Capetillo, O., Sep 24 2007, In : Journal of Cell Biology. 178, 7, p. 1101-1108 8 p.

Research output: Contribution to journalArticle

DNA Damage
Chromatin
DNA Breaks
Chromosome Structures
Histone Deacetylase Inhibitors
130 Citations (Scopus)

Modifiers of epigenetic reprogramming show paternal effects in the mouse

Chong, S., Vickaryous, N., Ashe, A., Zamudio, N., Youngson, N., Hemley, S., Stopka, T., Skoultchi, A. I., Matthews, J., Scott, H. S., De Kretser, D., O'Bryan, M., Blewitt, M. & Whitelaw, E., May 2007, In : Nature Genetics. 39, 5, p. 614-622 9 p.

Research output: Contribution to journalArticle

Epigenomics
Germ Cells
Mammals
Phenotype
Ploidies
18 Citations (Scopus)

Reprogramming leukemia cells to terminal differentiation and growth arrest by RNA interference of PU.1

Papetti, M. & Skoultchi, A. I., Oct 1 2007, In : Molecular Cancer Research. 5, 10, p. 1053-1062 10 p.

Research output: Contribution to journalArticle

RNA Interference
Leukemia, Erythroblastic, Acute
Leukemia
Growth
Transcription Factors
2006
65 Citations (Scopus)

Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome

Long, J. M., LaPorte, P., Merscher, S., Funke, B., Saint-Jore, B., Puech, A., Kucherlapati, R., Morrow, B. E., Skoultchi, A. I. & Wynshaw-Boris, A., Nov 2006, In : Neurogenetics. 7, 4, p. 247-257 11 p.

Research output: Contribution to journalArticle

DiGeorge Syndrome
Mutation
Sensory Gating
Nociception
Gene Deletion
87 Citations (Scopus)

Regulation of αA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin

Yang, Y., Stopka, T., Golestaneh, N., Wang, Y., Wu, K., Li, A., Chauhan, B. K., Gao, C. Y., Cveklová, K., Duncan, M. K., Pestell, R. G., Chepelinsky, A. B., Skoultchi, A. I. & Cvekl, A., May 17 2006, In : EMBO Journal. 25, 10, p. 2107-2118 12 p.

Research output: Contribution to journalArticle

Crystallins
Lenses
Chromatin
Chromatin Assembly and Disassembly
Fibers
292 Citations (Scopus)

Role of linker histone in chromatin structure and function: H1 stoichiometry and nucleosome repeat length

Woodcock, C. L., Skoultchi, A. I. & Fan, Y., Feb 2006, In : Chromosome Research. 14, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Nucleosomes
Histones
Chromatin
Eukaryota
Static Electricity
2005
353 Citations (Scopus)

Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation

Fan, Y., Nikitina, T., Zhao, J., Fleury, T. J., Bhattacharyya, R., Bouhassira, E. E., Stein, A., Woodcock, C. L. & Skoultchi, A. I., Dec 29 2005, In : Cell. 123, 7, p. 1199-1212 14 p.

Research output: Contribution to journalArticle

Mammals
Gene expression
Histones
Chromatin
DNA Methylation
40 Citations (Scopus)

MAPK-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival

Yu, Y. L., Chiang, Y. J., Chen, Y. C., Papetti, M., Juo, C. G., Skoultchi, A. I. & Yen, J. J. Y., Aug 19 2005, In : Journal of Biological Chemistry. 280, 33, p. 29533-29542 10 p.

Research output: Contribution to journalArticle

Phosphorylation
Cell Survival
Cells
Interleukin-3
Genes
274 Citations (Scopus)

Pax3 functions at a nodal point in melanocyte stem cell differentiation

Lang, D., Lu, M. M., Huang, L., Engleka, K. A., Zhang, M., Chu, E. Y., Lipner, S., Skoultchi, A. I., Millar, S. E. & Epstein, J. A., Feb 24 2005, In : Nature. 433, 7028, p. 884-887 4 p.

Research output: Contribution to journalArticle

Melanocytes
Cell Differentiation
Stem Cells
Totipotent Stem Cells
Transcription Factors
119 Citations (Scopus)

PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure

Stopka, T., Amanatullah, D. F., Papetti, M. & Skoultchi, A. I., Nov 2 2005, In : EMBO Journal. 24, 21, p. 3712-3723 12 p.

Research output: Contribution to journalArticle

Chromatin
Transcription Factors
Histones
DNA
Nucleosomes
2004
20 Citations (Scopus)

Genetic Analysis of H1 Linker Histone Subtypes and Their Functions in Mice

Fan, Y. & Skoultchi, A. I., 2004, In : Methods in Enzymology. 377, p. 85-107 23 p.

Research output: Contribution to journalArticle

Histones
41 Citations (Scopus)

Reductions in linker histone levels are tolerated in developing spermatocytes but cause changes in specific gene expression

Lin, Q., Inselman, A., Han, X., Xu, H., Zhang, W., Handel, M. A. & Skoultchi, A. I., May 28 2004, In : Journal of Biological Chemistry. 279, 22, p. 23525-23535 11 p.

Research output: Contribution to journalArticle

Spermatocytes
Gene expression
Germ Cells
Histones
Nucleosomes
2003
63 Citations (Scopus)

CDK6 blocks differentiation: Coupling cell proliferation to the block to differentiation in leukemic cells

Matushansky, I., Radparvar, F. & Skoultchi, A. I., Jul 3 2003, In : Oncogene. 22, 27, p. 4143-4149 7 p.

Research output: Contribution to journalArticle

Cell Proliferation
Leukemia, Erythroblastic, Acute
Cell Differentiation
Cell Cycle
Proto-Oncogene Proteins c-ets
199 Citations (Scopus)

H1 linker histones are essential for mouse development and affect nucleosome spacing in vivo

Fan, Y., Nikitina, T., Morin-Kensicki, E. M., Zhao, J., Magnuson, T. R., Woodcock, C. L. & Skoultchi, A. I., Jul 2003, In : Molecular and Cellular Biology. 23, 13, p. 4559-4572 14 p.

Research output: Contribution to journalArticle

Nucleosomes
Histones
Embryonic Structures
Gene Silencing
Eukaryotic Cells