• 9308 Citations
  • 53 h-Index
1964 …2022

Research output per year

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Publications

  • 9308 Citations
  • 53 h-Index
  • 133 Article
  • 3 Review article
  • 1 Comment/debate
2020

The chromatin remodeler Snf2h is essential for oocyte meiotic cell cycle progression

Zhang, C., Chen, Z., Yin, Q., Fu, X., Li, Y., Stopka, T., Skoultchi, A. I. & Zhang, Y., Feb 1 2020, In : Genes and Development. 34, 3, p. 166-178 13 p.

Research output: Contribution to journalArticle

Open Access
2019
1 Scopus citations

Histone 1 Mutations Drive Lymphomagenesis By Inducing Primitive Stem Cell Functions and Epigenetic Instructions through Profound 3D Re-Organization of the B-Cell Genome

Yusufova, N., Teater, M. R., Soshnev, A., Kloetgen, A., Osunsade, A., Conway, J., Doane, A., Skoultchi, A., Tsirigos, A., David, Y., Allis, C. D., Cesarman, E. & Melnick, A., Nov 13 2019, In : Blood. 134, 1, 1 p.

Research output: Contribution to journalArticle

ISWI ATPase SMARCA5 regulates differentiation of thymocytes undergoing β-selection

Zikmund, T., Kokavec, J., Turkova, T., Savvulidi, F., Paszekova, H., Vodenkova, S., Sedlacek, R., Skoultchi, A. I. & Stopka, T., Jun 15 2019, In : Journal of Immunology. 202, 12, p. 3434-3446 13 p.

Research output: Contribution to journalArticle

Runx1 promotes murine erythroid progenitor proliferation and inhibits differentiation by preventing Pu.1 downregulation

Willcockson, M. A., Taylor, S. J., Ghosh, S., Healton, S. E., Wheat, J. C., Wilson, T. J., Steidl, U. & Skoultchi, A. I., Sep 3 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 36, p. 17841-17847 7 p.

Research output: Contribution to journalArticle

Open Access
2018

Emerging roles of linker histones in regulating chromatin structure and function

Fyodorov, D. V., Zhou, B. R., Skoultchi, A. I. & Bai, Y., Mar 1 2018, In : Nature Reviews Molecular Cell Biology. 19, 3, p. 192-206 15 p.

Research output: Contribution to journalReview article

54 Scopus citations

Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process

Limi, S., Senecal, A., Coleman, R. A., Lopez-Jones, M., Guo, P., Polumbo, C., Singer, R. H., Skoultchi, A. I. & Cvekl, A., Jan 1 2018, In : Journal of Biological Chemistry. 293, 34, p. 13176-13190 15 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Regulatory functions and chromatin loading dynamics of linker histone H1 during endoreplication in Drosophila

Andreyeva, E. N., Bernardo, T. J., Kolesnikova, T. D., Lu, X., Yarinich, L. A., Bartholdy, B. A., Guo, X., Posukh, O. V., Healton, S., Willcockson, M. A., Pindyurin, A. V., Zhimulev, I. F., Skoultchi, A. I. & Fyodorov, D. V., Mar 15 2017, In : Genes & development. 31, 6, p. 603-616 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells

Kokavec, J., Zikmund, T., Savvulidi, F., Kulvait, V., Edelmann, W., Skoultchi, A. I. & Stopka, T., Jun 2017, In : STEM CELLS. 35, 6, p. 1614-1623 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

BEN domain protein Elba2 can functionally substitute for linker histone H1 in Drosophila in vivo

Xu, N., Lu, X., Kavi, H., Emelyanov, A. V., Bernardo, T. J., Vershilova, E., Skoultchi, A. I. & Fyodorov, D. V., Sep 30 2016, In : Scientific reports. 6, 34354.

Research output: Contribution to journalArticle

1 Scopus citations

Chromatin remodeling enzyme Snf2h regulates embryonic lens differentiation and denucleation

He, S., Limi, S., Estrada, R. S., Xie, Q., Brennan, L. A., Kantorow, W. L., Kokavec, J., Majumdar, R., Hou, H., Edelmann, W., Liu, W., Ashery-Padan, R., Zavadil, J., Kantorow, M., Skoultchi, A. I., Stopka, T. & Cvekl, A., Jun 1 2016, In : Development (Cambridge). 143, 11, p. 1937-1947 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
2 Scopus citations
2015
5 Scopus citations

Local compartment changes and regulatory landscape alterations in histone H1-depleted cells

Geeven, G., Zhu, Y., Kim, B. J., Bartholdy, B. A., Yang, S. M., Macfarlan, T. S., Gifford, W. D., Pfaff, S. L., Verstegen, M. J. A. M., Pinto, H., Vermunt, M. W., Creyghton, M. P., Wijchers, P. J., Stamatoyannopoulos, J. A., Skoultchi, A. I. & de Laat, W., Dec 23 2015, In : Genome biology. 16, 1, 289.

Research output: Contribution to journalArticle

26 Scopus citations

Proteomic Characterization of the Nucleolar Linker Histone H1 Interaction Network

Szerlong, H. J., Herman, J. A., Krause, C. M., Deluca, J. G., Skoultchi, A., Winger, Q. A., Prenni, J. E. & Hansen, J. C., Jun 5 2015, In : Journal of Molecular Biology. 427, 11, p. 2056-2071 16 p.

Research output: Contribution to journalArticle

20 Scopus citations
2014

A comparative encyclopedia of DNA elements in the mouse genome

Yue, F., Cheng, Y., Breschi, A., Vierstra, J., Wu, W., Ryba, T., Sandstrom, R., Ma, Z., Davis, C., Pope, B. D., Shen, Y., Pervouchine, D. D., Djebali, S., Thurman, R. E., Kaul, R., Rynes, E., Kirilusha, A., Marinov, G. K., Williams, B. A., Trout, D. & 117 others, Amrhein, H., Fisher-Aylor, K., Antoshechkin, I., DeSalvo, G., See, L. H., Fastuca, M., Drenkow, J., Zaleski, C., Dobin, A., Prieto, P., Lagarde, J., Bussotti, G., Tanzer, A., Denas, O., Li, K., Bender, M. A., Zhang, M., Byron, R., Groudine, M. T., McCleary, D., Pham, L., Ye, Z., Kuan, S., Edsall, L., Wu, Y. C., Rasmussen, M. D., Bansal, M. S., Kellis, M., Keller, C. A., Morrissey, C. S., Mishra, T., Jain, D., Dogan, N., Harris, R. S., Cayting, P., Kawli, T., Boyle, A. P., Euskirchen, G., Kundaje, A., Lin, S., Lin, Y., Jansen, C., Malladi, V. S., Cline, M. S., Erickson, D. T., Kirkup, V. M., Learned, K., Sloan, C. A., Rosenbloom, K. R., De Sousa, B. L., Beal, K., Pignatelli, M., Flicek, P., Lian, J., Kahveci, T., Lee, D., Kent, W. J., Santos, M. R., Herrero, J., Notredame, C., Johnson, A., Vong, S., Lee, K., Bates, D., Neri, F., Diegel, M., Canfield, T., Sabo, P. J., Wilken, M. S., Reh, T. A., Giste, E., Shafer, A., Kutyavin, T., Haugen, E., Dunn, D., Reynolds, A. P., Neph, S., Humbert, R., Hansen, R. S., De Bruijn, M., Selleri, L., Rudensky, A., Josefowicz, S., Samstein, R., Eichler, E. E., Orkin, S. H., Levasseur, D., Papayannopoulou, T., Chang, K. H., Skoultchi, A., Gosh, S., Disteche, C., Treuting, P., Wang, Y., Weiss, M. J., Blobel, G. A., Cao, X., Zhong, S., Wang, T., Good, P. J., Lowdon, R. F., Adams, L. B., Zhou, X. Q., Pazin, M. J., Feingold, E. A., Wold, B., Taylor, J., Mortazavi, A., Weissman, S. M., Stamatoyannopoulos, J. A., Snyder, M. P., Guigo, R., Gingeras, T. R., Gilbert, D. M., Hardison, R. C., Beer, M. A. & Ren, B., Nov 20 2014, In : Nature. 515, 7527, p. 355-364 10 p.

Research output: Contribution to journalArticle

616 Scopus citations
16 Scopus citations

Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution

Vierstra, J., Rynes, E., Sandstrom, R., Zhang, M., Canfield, T., Scott Hansen, R., Stehling-Sun, S., Sabo, P. J., Byron, R., Humbert, R., Thurman, R. E., Johnson, A. K., Vong, S., Lee, K., Bates, D., Neri, F., Diegel, M., Giste, E., Haugen, E., Dunn, D. & 17 others, Wilken, M. S., Josefowicz, S., Samstein, R., Chang, K. H., Eichler, E. E., De Bruijn, M., Reh, T. A., Skoultchi, A., Rudensky, A., Orkin, S. H., Papayannopoulou, T., Treuting, P. M., Selleri, L., Kaul, R., Groudine, M., Bender, M. A. & Stamatoyannopoulos, J. A., Nov 21 2014, In : Science. 346, 6212, p. 1007-1012 6 p.

Research output: Contribution to journalArticle

113 Scopus citations

Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation

Alvarez-Saavedra, M., De Repentigny, Y., Lagali, P. S., Raghu Ram, E. V. S., Yan, K., Hashem, E., Ivanochko, D., Huh, M. S., Yang, D., Mears, A. J., Todd, M. A. M., Corcoran, C. P., Bassett, E. A., Tokarew, N. J. A., Kokavec, J., Majumder, R., Ioshikhes, I., Wallace, V. A., Kothary, R., Meshorer, E. & 3 others, Stopka, T., Skoultchi, A. I. & Picketts, D. J., Jun 20 2014, In : Nature communications. 5, 4181.

Research output: Contribution to journalArticle

35 Scopus citations
5 Scopus citations
2013

Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina

Popova, E. Y., Grigoryev, S. A., Fan, Y., Skoultchi, A. I., Zhang, S. S. & Barnstable, C. J., Jun 14 2013, In : Journal of Biological Chemistry. 288, 24, p. 17895-17907 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Drosophila H1 regulates the genetic activity of heterochromatin by recruitment of Su(var)3-9

Lu, X., Wontakal, S. N., Kavi, H., Kim, B. J., Guzzardo, P. M., Emelyanov, A. V., Xu, N., Hannon, G. J., Zavadil, J., Fyodorov, D. V. & Skoultchi, A. I., Apr 5 2013, In : Science. 340, 6128, p. 78-81 4 p.

Research output: Contribution to journalArticle

52 Scopus citations

H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation

Yang, S. M., Kim, B. J., Toro, L. N. & Skoultchi, A. I., Jan 29 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 5, p. 1708-1713 6 p.

Research output: Contribution to journalArticle

64 Scopus citations

High resolution methylome analysis reveals widespread functional hypomethylation during adult human erythropoiesis

Yu, Y., Mo, Y., Ebenezer, D., Bhattacharyya, S., Liu, H., Sundaravel, S., Giricz, O., Wontakal, S., Cartier, J., Caces, B., Artz, A., Nischal, S., Bhagat, T., Bathon, K., Maqbool, S., Gligich, O., Suzuki, M., Steidl, U., Godley, L., Skoultchi, A. & 3 others, Greally, J., Wickrema, A. & Verma, A., Mar 29 2013, In : Journal of Biological Chemistry. 288, 13, p. 8805-8814 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2012

A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation

Wontakal, S. N., Guo, X., Smith, C., MacCarthy, T., Bresnick, E. H., Bergman, A., Snyder, M. P., Weissman, S. M., Zheng, D. & Skoultchi, A. I., Mar 6 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 10, p. 3832-3837 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway

Nishiyama, M., Skoultchi, A. I. & Nakayama, K. I., Jan 1 2012, In : Molecular and cellular biology. 32, 2, p. 501-512 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation

Melcer, S., Hezroni, H., Rand, E., Nissim-Rafinia, M., Skoultchi, A., Stewart, C. L., Bustin, M. & Meshorer, E., Jul 6 2012, In : Nature communications. 3, 910.

Research output: Contribution to journalArticle

89 Scopus citations
2011

A large gene network in immature Erythroid cells is controlled by the myeloid and B cell transcriptional regulator PU.1

Wontakal, S. N., Guo, X., Will, B., Shi, M., Raha, D., Mahajan, M. C., Weissman, S., Snyder, M., Steidl, U., Zheng, D. & Skoultchi, A. I., Jun 1 2011, In : PLoS genetics. 7, 6, e1001392.

Research output: Contribution to journalArticle

29 Scopus citations

The Rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone H1 and DNA methylation

MacLean, J. A., Bettegowda, A., Kim, B. J., Lou, C. H., Yang, S. M., Bhardwaj, A., Shanker, S., Hu, Z., Fan, Y., Eckardt, S., McLaughlin, K. J., Skoultchi, A. I. & Wilkinson, M. F., Mar 1 2011, In : Molecular and cellular biology. 31, 6, p. 1275-1287 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2010

GATA-1 directly regulates p21 gene expression during erythroid differentiation

Papetti, M., Wontakal, S. N., Stopka, T. & Skoultchi, A. I., May 15 2010, In : Cell Cycle. 9, 10, p. 1972-1980 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep

Funato, H., Sato, M., Sinton, C. M., Gautron, L., Williams, S. C., Skach, A., Elmquist, J. K., Skoultchi, A. I. & Yanagisawa, M., Oct 19 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 42, p. 18155-18160 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

PU.1 directly regulates cdk6 gene expression, linking the cell proliferation and differentiation programs in erythroid cells

Choe, K. S., Ujhelly, O., Wontakal, S. N. & Skoultchi, A. I., Jan 29 2010, In : Journal of Biological Chemistry. 285, 5, p. 3044-3052 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ring1B Compacts Chromatin Structure and Represses Gene Expression Independent of Histone Ubiquitination

Eskeland, R., Leeb, M., Grimes, G. R., Kress, C., Boyle, S., Sproul, D., Gilbert, N., Fan, Y., Skoultchi, A. I., Wutz, A. & Bickmore, W. A., May 14 2010, In : Molecular Cell. 38, 3, p. 452-464 13 p.

Research output: Contribution to journalArticle

333 Scopus citations
2009

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis

Nishiyama, M., Oshikawa, K., Tsukada, Y. I., Nakagawa, T., Iemura, S. I., Natsume, T., Fan, Y., Kikuchi, A., Skoultchi, A. I. & Nakayama, K. I., Jan 19 2009, In : Nature Cell Biology. 11, 2, p. 172-182 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Linker histone H1 is essential for Drosophila development, the establishment of pericentric heterochromatin, and a normal polytene chromosome structure

Lu, X., Wontakal, S. N., Emelyanov, A. V., Morcillo, P., Konev, A. Y., Fyodorov, D. V. & Skoultchi, A. I., Feb 15 2009, In : Genes and Development. 23, 4, p. 452-465 14 p.

Research output: Contribution to journalArticle

60 Scopus citations

Nuclear localization of ISWI ATPase Smarca5 (Sni2h) in mouse

Vargova, J., Vargova, K., Skoultchi, A. I. & Stopka, T., Jun 1 2009, In : Frontiers in Bioscience - Elite. 1 E, 2, p. 553-559 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

PU.1 activation relieves GATA-1-mediated repression of Cebpa and Cbfb during leukemia differentiation

Burda, P., Curik, N., Kokavec, J., Basova, P., Mikulenkova, D., Skoultchi, A. I., Zavadil, J. & Stopka, T., Oct 1 2009, In : Molecular Cancer Research. 7, 10, p. 1693-1703 11 p.

Research output: Contribution to journalArticle

18 Scopus citations
2008

Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3′ regulatory region of the immunoglobulin heavy chain locus

Giambra, V., Volpi, S., Emelyanov, A. V., Pflugh, D., Bothwell, A. L. M., Norio, P., Fan, Y., Ju, Z., Skoultchi, A. I., Hardy, R. R., Frezza, D. & Birshtein, B. K., Oct 1 2008, In : Molecular and cellular biology. 28, 19, p. 6123-6133 11 p.

Research output: Contribution to journalArticle

37 Scopus citations
2007

Global chromatin compaction limits the strength of the DNA damage response

Murga, M., Jaco, I., Fan, Y., Soria, R., Martinez-Pastor, B., Cuadrado, M., Yang, S. M., Blasco, M. A., Skoultchi, A. I. & Fernandez-Capetillo, O., Sep 24 2007, In : Journal of Cell Biology. 178, 7, p. 1101-1108 8 p.

Research output: Contribution to journalArticle

170 Scopus citations

Modifiers of epigenetic reprogramming show paternal effects in the mouse

Chong, S., Vickaryous, N., Ashe, A., Zamudio, N., Youngson, N., Hemley, S., Stopka, T., Skoultchi, A., Matthews, J., Scott, H. S., De Kretser, D., O'Bryan, M., Blewitt, M. & Whitelaw, E., May 1 2007, In : Nature Genetics. 39, 5, p. 614-622 9 p.

Research output: Contribution to journalArticle

130 Scopus citations

Reprogramming leukemia cells to terminal differentiation and growth arrest by RNA interference of PU.1

Papetti, M. & Skoultchi, A. I., Oct 1 2007, In : Molecular Cancer Research. 5, 10, p. 1053-1062 10 p.

Research output: Contribution to journalArticle

18 Scopus citations
2006

Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome

Long, J. M., LaPorte, P., Merscher, S., Funke, B., Saint-Jore, B., Puech, A., Kucherlapati, R., Morrow, B. E., Skoultchi, A. I. & Wynshaw-Boris, A., Nov 1 2006, In : Neurogenetics. 7, 4, p. 247-257 11 p.

Research output: Contribution to journalArticle

65 Scopus citations

Regulation of αA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin

Yang, Y., Stopka, T., Golestaneh, N., Wang, Y., Wu, K., Li, A., Chauhan, B. K., Gao, C. Y., Cveklová, K., Duncan, M. K., Pestell, R. G., Chepelinsky, A. B., Skoultchi, A. I. & Cvekl, A., May 17 2006, In : EMBO Journal. 25, 10, p. 2107-2118 12 p.

Research output: Contribution to journalArticle

87 Scopus citations

Role of linker histone in chromatin structure and function: H1 stoichiometry and nucleosome repeat length

Woodcock, C. L., Skoultchi, A. I. & Fan, Y., Feb 1 2006, In : Chromosome Research. 14, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

293 Scopus citations
2005

Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation

Fan, Y., Nikitina, T., Zhao, J., Fleury, T. J., Bhattacharyya, R., Bouhassira, E. E., Stein, A., Woodcock, C. L. & Skoultchi, A. I., Dec 29 2005, In : Cell. 123, 7, p. 1199-1212 14 p.

Research output: Contribution to journalArticle

355 Scopus citations

MAPK-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival

Yu, Y. L., Chiang, Y. J., Chen, Y. C., Papetti, M., Juo, C. G., Skoultchi, A. I. & Yen, J. J. Y., Aug 19 2005, In : Journal of Biological Chemistry. 280, 33, p. 29533-29542 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Pax3 functions at a nodal point in melanocyte stem cell differentiation

Lang, D., Lu, M. M., Huang, L., Engleka, K. A., Zhang, M., Chu, E. Y., Lipner, S., Skoultchi, A., Millar, S. E. & Epstein, J. A., Feb 24 2005, In : Nature. 433, 7028, p. 884-887 4 p.

Research output: Contribution to journalArticle

276 Scopus citations

PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure

Stopka, T., Amanatullah, D. F., Papetti, M. & Skoultchi, A. I., Nov 2 2005, In : EMBO Journal. 24, 21, p. 3712-3723 12 p.

Research output: Contribution to journalArticle

119 Scopus citations
2004

Reductions in linker histone levels are tolerated in developing spermatocytes but cause changes in specific gene expression

Lin, Q., Inselman, A., Han, X., Xu, H., Zhang, W., Handel, M. A. & Skoultchi, A. I., May 28 2004, In : Journal of Biological Chemistry. 279, 22, p. 23525-23535 11 p.

Research output: Contribution to journalArticle

41 Scopus citations
2003

CDK6 blocks differentiation: Coupling cell proliferation to the block to differentiation in leukemic cells

Matushansky, I., Radparvar, F. & Skoultchi, A. I., Jul 3 2003, In : Oncogene. 22, 27, p. 4143-4149 7 p.

Research output: Contribution to journalArticle

63 Scopus citations