Zinc

Anatoly V. Skalny, Michael Aschner, Alexey A. Tinkov

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Since the discovery of manifest Zn deficiency in 1961, the increasing number of studies demonstrated the association between altered Zn status and multiple diseases. In this chapter, we provide a review of the most recent advances on the role of Zn in health and disease (2010 − 20), with a special focus on the role of Zn in neurodegenerative and neurodevelopmental disorders, diabetes and obesity, male and female reproduction, as well as COVID-19. In parallel with the revealed tight association between ASD risk and severity and Zn status, the particular mechanisms linking Zn2 + and ASD pathogenesis like modulation of synaptic plasticity through ProSAP/Shank scaffold, neurotransmitter metabolism, and gut microbiota, have been elucidated. The increasing body of data indicate the potential involvement of Zn2 + metabolism in neurodegeneration. Systemic Zn levels in Alzheimer's and Parkinson's disease were found to be reduced, whereas its sequestration in brain may result in modulation of amyloid β and α-synuclein processing with subsequent toxic effects. Zn2 + was shown to possess adipotropic effects through the role of zinc transporters, zinc finger proteins, and Zn-α2-glycoprotein in adipose tissue physiology, underlying its particular role in pathogenesis of obesity and diabetes mellitus type 2. Recent findings also contribute to further understanding of the role of Zn2 + in spermatogenesis and sperm functioning, as well as oocyte development and fertilization. Finally, Zn2 + was shown to be the potential adjuvant therapy in management of novel coronavirus infection (COVID-19), underlining the perspectives of zinc in management of old and new threats.

Original languageEnglish (US)
Title of host publicationThe Latest Research and Development of Minerals in Human Nutrition
EditorsN.A. Michael Eskin
PublisherAcademic Press Inc.
Pages251-310
Number of pages60
ISBN (Print)9780128206485
DOIs
StatePublished - Jan 2021

Publication series

NameAdvances in Food and Nutrition Research
Volume96
ISSN (Print)1043-4526

Keywords

  • Autism
  • Diabetes
  • Infertility
  • Neurodegeneration
  • Obesity

ASJC Scopus subject areas

  • Food Science

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